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| 1 | Andrographolide Loaded in Micro-and Nano-Formulations: Improved Bioavailability, Target-Tissue Distribution, and Efficacy of the “King of Bitters”显示文摘Andrographolide (AG) is the characteristic constituent of Andrographis paniculata, of the Acanthaceae family. This plant is a well-known Asian medicinal plant that is widely used in India, China, and Thailand. A monograph of Herba Andrographidis (Chuanxinlian) is included in the Chinese Pharmacopoeia, which reports that this decoction can “remove heat, counteract toxicity, and reduce swellings.” The numerous potential activities of AG range from anti-inflammatory to anti-diabetic action, from neuroprotection to antitumor activity, and from hepatoprotective to anti-obesity properties. However, AG has low bioavailability and poor water solubility, which can limit its distribution and accumulation in the body after administration. In addition, AG is not stable in gastrointestinal alkaline and acidic environments, and has been reported to have a very short half-life. Among the diverse strategies that have been adopted to increase AG water solubility and permeability, the technological approach is the most useful way to develop appropriate delivery systems. This review reports on published studies related to microparticles (MPs) and nanoparticles (NPs) loaded with AG. MPs based on polylactic-glycolic acid (PLGA), alginic acid, and glucan derivatives have been developed for parenteral oral and pulmonary administration, respectively. NPs include vesicles (both liposomes and niosomes);polymeric NPs (based on polyvinyl alcohol, polymerized phenylboronic acid, PLGA, human serum albumin, poly ethylcyanoacrylate, and polymeric micelles);solid lipid NPs;microemulsions and nanoemulsions;gold NPs;nanocrystals;and nanosuspensions. Improved bioavailability, target-tissue distribution, and efficacy of AG loaded in the described drug delivery systems have been reported. | Marta Casamonti Laura Risaliti Giulia Vanti Vieri Piazzini Maria Camilla Bergonzi Anna Rita Bilia | 2019 | Engineering2019，5，1： | 5 |
| 2 | A global convergent filter method for nonlinear programming显示文摘 | Gonzaga C Karas E Vanti M | 2003 | SIAM Journal on Optimization2003，14，3： | 1 |
| 3 | A globally convergent filter method for nonlinear program-ming显示文摘 | GONZAGA C C KARAS E VANTI M | 2003 | SIAM Journal on Optimization2003，14，3： | 1 |
| 4 | Pain, disability, and diag- nostic accuracy of clinical instability and endurance tests in sub- jects with lumbar spondylolisthesis显示文摘 | Ferrari S Vanti C Piccarreta R | 2014 | J Manipulative Physiol Ther2014，37，9： | 1 |
| 5 | Simplified modeling of 2-25 kV AT railway system for the solution of low frequency and large-scale problems显示文摘 | Mariscotti A Pozzobon P Vanti M | 2007 | IEEE Trails on Power Delivery2007，22，1： | 1 |
| 6 | Novel human G-protein-coupled receptors显示文摘 | Vanti W Nguyen T Cheng R | 2003 | Biochem Biophys Res Commun2003，305，1： | 1 |
| 7 | Patent status of the therapeutically important G protein- coupled receptors显示文摘 | VANTI W B SWAMINATHAN S BLEVINS R | 2001 | Exp Opin Ther Patents2001，11，： | 1 |
| 8 | Modeling ofAudio Frequency Track Circuits for Validation, Tuning,and Conducted Interference Prediction显示文摘 | MARISCOTTI A RUSCELLI M VANTI M | 2010 | IEEE Transac-tions on Intelligent Transportation Systems2010，11，1： | 1 |
| 9 | Simplified Modeling of 2× 25-kV AT Railway System for the Solution of Low Frequency and Large-Scale Problems 显示文摘 | MARISCOTTI A POZZOBON P VANTI M | 2007 | IEEE Transactions on Power Delivery2007，22，1： | 1 |
| 10 | Sympathetic dencrvation-in- duced changes in G protein expression in enteric neurons of the guinea pig colon显示文摘 | Giaroni C Zanetti E Vanti A | 2002 | Life Sei2002，71，17： | 1 |
| 11 | Patent status of the therapeutically important G protein coupled receptors显示文摘 | VANTI W B SWAMINATHAN S BLEVINS R | 2001 | Exp Opin Ther Patents2001，11，： | 1 |
| 12 | Distribution of the Traction Return Current in AT Electric Railway System 显示文摘 | Mariscotti A Pozzobon P Vanti M | 2005 | IEEE Transactions on Power Delivery2005，20，3： | 1 |
| 13 | Patent status of the therapeutically important G proteincoupled receptors显示文摘 | VANTI W B SWAMINATHAN S BLEVINS R | 2001 | Exp Opin Ther Patents2001，11，： | 1 |
| 14 | Distribution of the traction return current in AT electric railway systems 显示文摘 | Andrea Mariscotti Paolo Pozzobon Maurizio Vanti | 2005 | IEEE Transactions on PowerDelivery2005，20，3： | 1 |
| 15 | Simplified modeling of 2 ~ 25 kV AT railway system for the solution of low frequency and large-scale problems 显示文摘 | Mariscotti A Pozzobon P Vanti M | 2007 | 1EEE Transactions on Power Delivery2007，22，1： | 1 |
| 16 | Relationship between female pelvic floor dysfunction and sexual dysfunction: an observational study显示文摘 | Bortolami A Vanti C Banchelli F | 2015 | J Sex Med2015，12，5： | 1 |
| 17 | Synthesis,and microbio-logical activity of pyrrole analogs of BM-212,a potent antitubercular agent显示文摘 | Fiora vanti R Porrerta GC | 1999 | Med chem Res1999，9，1： | 1 |
| 18 | Patent status of the therapeutically important G protein-coupled receptors 显示文摘 | Vanti W B Swaminathan S Blevins R | 2001 | Expert Opinion on Therapeutic Patents2001，11，： | 1 |
| 19 | Development of the Italian Version of the Oswestry Disability Index (ODI-I): A Cross-Cultural Adaptation, Reliability, and Validity Study显示文摘 | Marco Monticone Paola Baiardi Silvano Ferrari Calogero Foti Raffaele Mugnai Paolo Pillastrini Carla Vanti Gustavo Zanoli | 2009 | Spine2009，，19： | 1 |
| 20 | Responsiveness of the Oswestry Disability Index and the Roland Morris Disability Questionnaire in Italian subjects with sub-acute and chronic low back pain显示文摘 | MONTICONE M BAIARDI P VANTI C | 2012 | Eur Spine J2012，21，1： | 1 |
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