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| 1 | Sequential algorithms combining non-invasive markers and biopsy for the assessment of liver fibrosis in chronic hepatitis B显示文摘AIM: To assess the performance of several non- invasive markers and of our recently proposed stepwise combination algorithms to diagnose significant fibrosis (F ≥ 2 by METAVIR) and cirrhosis (F4 by METAVIR) in chronic hepatitis B (CHB). METHODS: One hundred and ten consecutive patients (80 males, 30 females, mean age: 42.6 ± 11.3) with CHB undergoing diagnostic liver biopsy were included. AST- to-Platelet ratio (APRI), Forns’ index, AST-to-ALT Ratio, Goteborg University Cirrhosis Index (GUCI), Hui’s model and Fibrotest were measured on the day of liver biopsy. The performance of these methods and of sequential algorithms combining Fibrotest, APRI and biopsy was defined by positive (PPV) and negative (NPV) predictive values, accuracy and area under the curve (AUC). RESULTS: PPV for significant fibrosis was excellent (100%) with Forns and high (> 92%) with APRI, GUCI, Fibrotest and Hui. However, significant fibrosis could not be excluded by any marker (NPV < 65%). Fibro- test had the best PPV and NPV for cirrhosis (87% and 90%, respectively). Fibrotest showed the best AUC for both significant fibrosis and cirrhosis (0.85 and 0.76, respectively). Stepwise combination algorithms of APRI, Fibrotest and biopsy showed excellent performance (0.96 AUC, 100% NPV) for significant fibrosis and 0.95 AUC, 98% NPV for cirrhosis, with 50%-80% reduced need for liver biopsy. CONCLUSION: In CHB sequential combination of APRI, Fibrotest and liver biopsy greatly improves the diagnostic performance of the single non-invasive markers. Need for liver biopsy is reduced by 50%-80% but cannot be completely avoided. Non-invasive markers and biopsy should be considered as agonists and not antagonists towards the common goal of estimating liver fibrosis. | Giada Sebastiani Alessandro Vario Maria Guido Alfredo Alberti | 2007 | World Journal of Gastroenterology2007，13，4： | 26 |
| 2 | Association between hepatocellular carcinoma and type 2 diabetes mellitus in Italy:Potential role of insulin显示文摘AIM: To investigate the relationships between Type 2 diabetes mellitus (DM2) and the risk of hepatocellular carcinoma (HCC). METHODS: We studied the association between DM2 and HCC in a large case-control study that enrolled 465 consecutive Caucasian patients with HCC (78.3% males, mean age 68.5 ± 8.9 years) compared with an age and sex matched control group of 490 subjects. RESULTS: Prevalence of DM2 was significantly higher in HCC patients (31.2% vs 12.7%; OR = 3.12, 95% CI: 2.22-4.43) and in HCC cases with alcohol abuse. DM2 has been diagnosed before the appearance of HCC in 84.1% of diabetic HCC subjects with mean duration of 141.5 mo, higher in cases treated with insulin than in those with oral antidiabetic agents (171.5 vs 118.7 mo). Compared to controls, males DM2 with HCC were more frequently treated with insulin (38.1% vs 17.6%, P = 0.009) and with sulfonylurea with or without metformin than with diet with or without metformin (84% vs 68.3%, P = 0.049). CONCLUSION: DM2 in our patients is associated with a 3-fold increase risk of HCC. In most of our cases DM2 pre-existed to HCC. Patients with DM2 and chronic liver disease, particularly insulin treated males, should be considered for HCC close surveillance programs. | Valter Donadon Massimiliano Balbi Pietro Casarin Alessandro Vario Alfredo Alberti | 2008 | World Journal of Gastroenterology2008，14，37： | 11 |
| 3 | Stepwise combination algorithms of non-invasive markers to diagnose significant fibrosis in chronic hepatitis C显示文摘 | Giada Sebastiani Alessandro Vario Maria Guido Franco Noventa Mario Plebani Roberta Pistis Alessia Ferrari Alfredo Alberti | 2006 | Journal of Hepatology2006，，4： | 2 |
| 4 | Performance of noninvasive markers for liver fibrosis is reduced in chronic hepatitis C with normal transaminases显示文摘 | Sebastiani G Vario A Guido M | 2008 | J Viral Hepat2008，15，3： | 1 |
| 5 | Drug release from coronary eluting stents: A multidomain approach 显示文摘 | VARIO G CIOFFI M SETF S | 2010 | J Biomech2010，43，： | 1 |
| 6 | Genotype-specific mutations in the polymerase gene of hepatitis B virus potentially associated with resistance to oral antiviral therapy显示文摘 | Silvia Mirandola Giada Sebastiani Cristina Rossi Emanuela Velo Elke Maria Erne Alessandro Vario Diego Tempesta Chiara Romualdi Davide Campagnolo Alfredo Alberti | 2012 | Antiviral Research2012，，3： | 1 |
| 7 | Stepwise combination algorithms of non-invasive markers to diagnose significant fibrosis in chronic hepatitis C 显示文摘 | Sebastiani G Vario A Guido M | 2006 | J Hepatol2006，44，4： | 1 |
| 8 | Liver Microsomal Triglyceride Transfer Protein Is Involved in Hepatitis C Liver Steatosis显示文摘 | Silvia Mirandola Stefano Realdon Jahangir Iqbal Martina Gerotto Francesca Dal Pero Gladis Bortoletto Moira Marcolongo Alessandro Vario Christian Datz M. Mahmood Hussain Alfredo Alberti | 2006 | Gastroenterology2006，，6： | 1 |
| 9 | Fast algorithm for multiple-circle detection on ima- ges using learning automata显示文摘 | CUEVAS E VARIO F ENCISO V O | 2012 | Image Process- ing2012，6，8： | 1 |
| 10 | Stepwise combination algorithms of non-invasive markers to diagnose significant fibrosis in chronic hepatitis C显示文摘 | Sebastiani G Vario A Guido M | 2006 | J Hepatol2006，44，4： | 1 |
| 11 | Cytometric head array: a multiplexed assay platform with applications in various areas of biology显示文摘 | Morgan E Vario R Sepulveda H | 2004 | Clin Immunol2004，110，3： | 1 |
| 12 | Mechanical behaviour of endodontic restorations with multiple prefabricated posts:A finiteelement approach显示文摘 | Maceri F Martignoni M Vario G | | 0，，11： | 1 |
| 13 | Absence of an independent association between serum uric acid and left ventricular mass in Caucasian hypertensive women and men显示文摘 | G. Mulè E. Nardi M. Costanzo M. Mogavero L. Guarino T. Viola M.G. Vario V. Cacciatore G. Andronico G. Cerasola S. Cottone | 2013 | Nutrition Metabolism and Cardiovascular Diseases2013，，8： | 1 |
| 14 | Hepatic iron, liver steatosis and viral genotypes in patients with chronic hepatitis C显示文摘 | Sebastiani G Vario A Ferrari A | 2006 | J Viral Hepat2006，13，3： | 1 |
| 15 | Prevalence of Chlamydia pneumonia and Mycoplasma pneumoniae immunoglobulin G and A antibodies in a healthy Finnish population as analyzed by quantita tire enzyme immunoassays显示文摘 | Tuuminea T Vario S Ingraan H | 2000 | Clin Diagn Lab Immunol2000，7，5： | 1 |
| 16 | Bcl-2 retards cell cycle entry through p27(KipI), pRB relative p130,and altered E2F 4 regulation 显示文摘 | Vario G Soos TJ Upton TM | 2000 | Mol Cell Biol2000，20，1： | 1 |
| 17 | Soil warming alters nitrogen cycling in a New England forest: implications for ecosystem function and structure显示文摘 | S. M. Butler J. M. Melillo J. E. Johnson J. Mohan P. A. Steudler H. Lux E. Burrows R. M. Smith C. L. Vario L. Scott T. D. Hill N. Aponte F. Bowles | 2012 | Oecologia2012，，3： | 1 |
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