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| 1 | Bactcremia due to Roseomonas spp显示文摘 | Vasallo FJ Alcala L Cercenado E etal | 1998 | Clin Microbiol lnfect1998，4，2： | 1 |
| 2 | Bacteremia due to Roseomonas spp显示文摘 | Vasallo FJ Alcala L Cercenado E | 1998 | Clin Microbiol Infect1998，4，2： | 1 |
| 3 | HCV-specific immune responses induced by CIGB-230 in combination with IFN-α plus ribavirin显示文摘AIM:To analyze hepatitis C virus(HCV)-specific immune responses in chronically infected patients under triple therapy with interferon-α(IFN-α)plus ribavirin and CIGB-230.METHODS:CIGB-230 was administered in different schedules with respect to IFN-αplus ribavirin therapy.Paired serum and peripheral blood mononuclear cells(PBMC)samples from baseline and end of treatment were analyzed.The HCV-specific humoral response was tested by enzyme-linked immunosorbent assay,neutralizing antibodies were evaluated by cell culture HCV neutralization assays,PBMC proliferation was assayed by carboxyfluorescein succinimidyl ester staining and IFN-γsecretion was assessed by enzyme-linked immunospot.Data on virological and histological response and their association with immune variables are also provided.RESULTS:From week 12 to week 48,all groups of patients showed a significant reduction in mean leukocyte counts.Statistically significant reductions in antibody titers were frequent,but only individuals immunized with CIGB-230 as early add-on treatment sustained the core-IgG response,and the neutralizing antibody response was enhanced only in patients receiving CIGB-230.Cell-mediated immune responses also tended to decline,but significant reductions in IFN-γsecretion and total absence of core-specific lymphoproliferation were exclusive of the control group.Only CIGB-230-immunized individuals showed de novo induced lymphoproliferative responses against the structural antigens.Importantly,it was demonstrated that thequality of the CIGB-230-induced immune response depended on the number of doses and timing of administration in relation to the antiviral therapy.Specifically,the administration of 6 doses of CIGB-230 as late addon to therapy increased the neutralizing antibody activity and the de novo core-specific IFN-γsecretion,both of which were associated with the sustained virological response.CONCLUSION:CIGB-230,combined with IFN-α-based therapy,modifies the immune response in chronic patients.The study provides evidence for the design of more effective therapeutic vaccine interventions against HCV. | Yalena Amador-Caizares Gillian Martínez-Donato Liz lvarez-Lajonchere Claudia Vasallo Mariacarla Dausá Daylen Aguilar-Noriega Carmen Valenzuela Ivette Raíces Jean Dubuisson Czeslaw Wychowski Zurina Cinza-Estévez Marlén Castellanos Magdalys Núez Anny Armas Yaimé González Ismariley Revé Ivis Guerra ngel Pérez Aguiar Santiago Dueas-Carrera | 2014 | World Journal of Gastroenterology2014，20，1： | 1 |
| 4 | Adenomatous polyps in colon and rectum after choleeystectomy显示文摘 | Vasallo A ()liver G Rojas Y | 1991 | GEN1991，45，1： | 1 |
| 5 | Apparently 显示文摘 | Vasallo FJ Lopez-Miragaya L Rodriguez A | 2000 | Clin Microbiol Infect2000，6，68： | 1 |
| 6 | Mediastinal tumors: biopsy under US-guidance显示文摘 | WERNECKE K VASALLO P PRTERS PE | 1989 | Radiology:1989，172，： | 1 |
| 7 | Antennas and propagation society international symposium 显示文摘 | De Matey J M A Palacios H Vasallo J | | IEEE0，3，7： | 1 |
| 8 | Isoforms of Na + , K +- ATPase alpha and beta subunits in the rat cerebellum and in gran- ule cell cultures 显示文摘 | Peng L Martin- Vasallo P Sweadner KJ | 1997 | J Neurosci1997，17，10： | 1 |
| 9 | Real per capita health spending by age and sex in Spain(1998-2008):changes and effects on public healthcare expenditure projections 显示文摘 | Blanco Moreno A Urbanos Garrido R Thuissard Vasallo IJ | 2013 | Gac Sanit2013，27，3： | 1 |
| 10 | Cell wall proteins of Kluyveromyces fragilis : Surface and emulsifying properties显示文摘 | María del Carmen Vasallo María C. Puppo Gonzalo G. Palazolo Miguel A. Otero Laszlo Beress Jorge R. Wagner | 2005 | LWT - Food Science and Technology2005，，7： | 1 |
| 11 | A Methodolo-gy for Sizing Backup Fuel-Cell/Battery Hybrid PowerSystems显示文摘 | Vasallo M Andujar J Garcia C | 2010 | IEEE Transactions on Industrial Elec-tronics2010，57，6： | 1 |
| 12 | Mediastinal tumors:biopsy under US guidance显示文摘 | Vasallo P Prters PE | 1989 | Radiology1989，172，2： | 1 |
| 13 | Integrins and stretch activated ion channels;putative components of functional cell surface mechanoreceptors in articular chondrocytes显示文摘 | Carter SD Vasallo PM | 2002 | Cell Biol Int2002，26，1： | 1 |
| 14 | Failure of ciprofloxacin therapy for invasive nontyphoidal salmonellosis显示文摘 | Vasallo F J Martin-Rabadan P Alcala L | 1998 | Clin Infect Dis1998，26，2： | 1 |
| 15 | Thermal behavior and hydration properties of yeast proteins from Saccharomyces cerevisiae and Kluyveromycesfragilis显示文摘 | OTERO M A WAGNER J R VASALLO M C | 2000 | Food Chemistry2000，69，2： | 1 |
| 16 | Integrins and stretch activated ion channels; putative components of functional cell surface mechanoreceptors in articular chondrocytes显示文摘 | Mobasheri A Carter SD Martin -Vasallo P | 2002 | Cell Biol Int2002，26，1： | 1 |
| 17 | Trfic risk mitigation in highway concession projects显示文摘 | Vasallo J | 2006 | Journal of Transport Economics and Policy2006，40，3： | 1 |
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