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| 1 | Micro and Nanofabrication methods to control cell-substrate interactions and cell behavior: A review from the tissue engineering perspective显示文摘Cell-substrate interactions play a crucial role in the design of better biomaterials and integration ofimplants with the tissues. Adhesion is the binding process of the cells to the substrate through interactionsbetween the surface molecules of the cell membrane and the substrate. There are severalfactors that affect cell adhesion including substrate surface chemistry, topography, and stiffness. Thesefactors physically and chemically guide and influence the adhesion strength, spreading, shape and fate ofthe cell. Recently, technological advances enabled us to precisely engineer the geometry and chemistry ofsubstrate surfaces enabling the control of the interaction cells with the substrate. Some of the mostcommonly used surface engineering methods for eliciting the desired cellular responses on biomaterialsare photolithography, electron beam lithography, microcontact printing, and microfluidics. Thesemethods allow production of nano- and micron level substrate features that can control cell adhesion,migration, differentiation, shape of the cells and the nuclei as well as measurement of the forces involvedin such activities. This review aims to summarize the current techniques and associate these techniqueswith cellular responses in order to emphasize the effect of chemistry, dimensions, density and design ofsurface patterns on cell-substrate interactions. We conclude with future projections in the field of cellsubstrateinteractions in the hope of providing an outlook for the future studies. | Menekse Ermis Ezgi Antmen Vasif Hasirci | 2018 | Bioactive Materials2018，3，3： | 13 |
| 2 | Human adipose derived stem cells are superior to human osteoblasts (HOB) in bone tissue engineering on a collagen-fibroin-ELR blend显示文摘The ultrastructure of the bone provides a unique mechanical strength against compressive, torsional andtensional stresses. An elastin-like recombinamer (ELR) with a nucleation sequence for hydroxyapatitewas incorporated into films prepared from a collagen-silk fibroin blend carrying microchannel patternsto stimulate anisotropic osteogenesis. SEM and fluorescence microscopy showed the alignment ofadipose-derived stem cells (ADSCs) and the human osteoblasts (HOBs) on the ridges and in the groovesof microchannel patterned collagen-fibroin-ELR blend films. The Young's modulus and the ultimatetensile strength (UTS) of untreated films were 0.58 ± 0.13 MPa and 0.18 ± 0.05 MPa, respectively. After 28days of cell culture, ADSC seeded film had a Young's modulus of 1.21 ± 0.42 MPa and UTS of0.32 ± 0.15 MPa which were about 3 fold higher than HOB seeded films. The difference in Young'smodulus was statistically significant (p: 0.02). ADSCs attached, proliferated and mineralized better thanthe HOBs. In the light of these results, ADSCs served as a better cell source than HOBs for bone tissueengineering of collagen-fibroin-ELR based constructs used in this study. We have thus shown theenhancement in the tensile mechanical properties of the bone tissue engineered scaffolds by usingADSCs. | Esen Sayin Rosti Hama Rashid JoséCarlos Rodríguez-Cabello Ahmed Elsheikh Erkan Türker Baran Vasif Hasirci | 2017 | Bioactive Materials2017，2，2： | 2 |
| 3 | Down syndrome recognition using local binary patterns and statistical evaluation of the system显示文摘 | Burcin K Vasif N V | 2011 | Expert Systems with Applications2011，38，7： | 1 |
| 4 | Chitosan‐based wet‐spun scaffolds for bioactive agent delivery显示文摘 | Seniz Ucar Pinar Yilgor Vasif Hasirci Nesrin Hasirci | 2013 | J Appl Polym Sci2013，，5： | 1 |
| 5 | Immobilization of acetylcholinesterase and choline oxidase in/on pHEMA membrane for biosensor construction 显示文摘 | Fatma N Kok Faruk Bozoglu Vasif Hasirci | 2001 | Journal of Biomaterials Science Polymer Edition2001，12，11： | 1 |
| 6 | Hydroxyapatite reinforced poly(3-hydroxybutyrate) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) based degradable composite bone plate显示文摘 | Suleyman Coskun Feza Korkusuz Vasif Hasirci | 2005 | Journal of Biomaterials Science Polymer Edition2005，，12： | 1 |
| 7 | Electrospun biodegradable nanofibrous mats for tissue engineering显示文摘 | Albana Ndreu Lila Nikkola Hanna Ylikauppila Nureddin Ashammakhi Vasif Hasirci | 2008 | Nanomedicine2008，，1： | 1 |
| 8 | On the finite horizon Nash equilibrium solution in the differential game approach to formation control显示文摘The solvability of the coupled Riccati differential equations appearing in the differential game approach to the formation control problem is vital to the finite horizon Nash equilibrium solution.These equations(if solvable)can be solved numerically by using the terminal value and the backward iteration.To investigate the solvability and solution of these equations the formation control problem as the differential game is replaced by a discrete-time dynamic game.The main contributions of this paper are as follows.First,the existence of Nash equilibrium controls for the discretetime formation control problem is shown.Second,a backward iteration approximate solution to the coupled Riccati differential equations in the continuous-time differential game is developed.An illustrative example is given to justify the models and solution. | JOND Hossein Barghi NABIYEV Vasif | 2019 | Journal of Systems Engineering and Electronics2019，30，6： | 0 |
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