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| 1 | Liver insulin-like growth factor 2 methylation in hepatitis C virus cirrhosis and further occurrence of hepatocellular carcinoma显示文摘AIM: To assess the predictive value of the insulinlike growth factor 2 (Igf2) methylation profile for the occurrence of Hepatocellular Carcinoma (HCC) in hepatitis C (HCV) cirrhosis. METHODS: Patients with: (1) biopsy-proven compensated HCV cirrhosis; (2) available baseline frozen liver sample; (3) absence of detectable HCC; (4) regular screening for HCC; (5) informed consent for genetic analysis were studied. After DNA extraction from liver samples and bisulfite treatment, unbiased PCR and DHPLC analysis were performed for methylation analysis at the Igf2 locus. The predictive value of the Igf2 methylation profile for HCC wasassessed by Kaplan-Meier and Cox methods. RESULTS: Among 94 included patients, 20 developed an HCC during follow-up (6.9 ± 3.2 years). The methylation profile was hypomethylated, intermediate and hypermethylated in 13, 64 and 17 cases, respectively. In univariate analysis, two baseline parameters were associated with the occurrence of HCC: age (P = 0.01) and prothrombin (P = 0.04). The test of linear tendency between the three ordered levels of Igf2 methylation and probability of HCC occurrence was significant (Log Rank, P = 0.043; Breslow, P = 0.037; Tarone-Ware, P = 0.039). CONCLUSION: These results suggest that hypomethylation at the Igf2 locus in the liver could be predictive for HCC occurrence in HCV cirrhosis. | Philippe Couvert Alain Carrié Jacques Pariès Jenny Vaysse Audrey Miroglio Antoine Kerjean Pierre Nahon Jamel Chelly Jean-Claude Trinchet Michel Beaugrand Nathalie Ganne-Carrié | 2008 | World Journal of Gastroenterology2008，14，35： | 6 |
| 2 | Identification of biomarkers of human pancreatic adenocarcinomas by expression profiling and validation with gene expression analysis in endoscopic ultrasound-guided fine needle aspiration samples显示文摘瞄准:比较胰腺的腺癌织物标本的基因表示侧面,胰腺的人和腺癌和白血病房间线和正常的胰取样以便区分差别的冒号表示了基因并且在内视镜的指导超声的好针渴望( 指导EUS 的 FNA )由量的即时 RT-PCR ( RT-QPCR )验证基因的一个子集的微分表示标本。方法:包含 1176 基因的商业地奉献的癌症 cDNA 宏数组(地图集人癌症 1.2 ) 被使用。不同统计途径(层次聚类的、主要部件分析(PCA ) 和 SAM ) 被用来分析表示数据。RT-QPCR 和免疫组织化学的研究被用于结果的确认。结果:RT-QPCR 验证了 LCN2 的增加的表示(lipocalin 2 ) 并且第一次在恶意的胰的小块地(织物类型 plasminogen 使活跃之物或 tPA ) 同样与正常相比胰。Immunohistochemical 分析证实了在癌入侵的管的上皮细胞局部性的 LCN2 蛋白质的增加的表示。在与胰腺的腺癌从病人通过指导 EUS 的 FNA 获得的 12 件样品的小块地和 LCN2 抄本的分析与在正常纸巾发现的那些比较显示出显著地增加的表示层次,显示高质量的 RNA 的足够的数量能与这种技术被获得。结论:表示介绍是一个有用方法识别简历标记和潜在的目标基因。在胰腺的癌症的指导 EUS 的 FNA 样品的分子的分析为胰腺的腺癌的诊断作为珍贵策略出现。 | Henrik Laurell Michèle Bouisson Philippe Berthelémy Philippe Rochaix Sébastien Déjean Philippe Besse Christiana Susini Lucien Pradayrol Nicole Vaysse Louis Buscail | 2006 | World Journal of Gastroenterology2006，12，21： | 5 |
| 3 | Early stage (IA-IB) primary carcinoma of the fallopian tube:case-control comparison to adenocar-cinoma of the ovary显示文摘 | Vaysse C Touboul C Filleron T | 2011 | J Gynecol Oncol2011，22，1： | 1 |
| 4 | Quality assessment of commercial Magnoliae officinalis Cortex by IH NMR-based metabolomics and HPLC methods 显示文摘 | Jiang Y Vaysse J Gilard V | 2012 | Phytochem Anal2012，23，4： | 1 |
| 5 | 显示文摘 | Vaysse C Guerlou-Demourgues L Duguet E | 2003 | Inorg Chem2003，42，： | 1 |
| 6 | Biochemical characterization of size-separated human red blood cells显示文摘 | Vaysse J | 1992 | Eur-J-Haematol1992，48，2： | 1 |
| 7 | Thermal Behavior of Oxometalate(Mo,W) - intercalated Layered Double Hydroxides:Study on the Grafting Phenomenon 显示文摘 | VAYSSE C Guerlou- Demourgues L DEMOURGUES A DELMAS C | 2002 | J of Solid State Chemistry2002，167，： | 1 |
| 8 | Leucocy- tospermia oxidative stress and male fertility facts and hypotheses显示文摘 | Lemkecher T Dartigues S Vaysse J | 2005 | Gynecol obstet Ferti12005，33，12： | 1 |
| 9 | Re-evaluation of GABA transport in neuronal and glial cell cultures: Correlation of pharmacology and mRNA localization显示文摘 | Borden LA Smith KE Vaysse PJ | 1995 | Receptors Channels1995，3，2： | 1 |
| 10 | Proteolipidic vectors for gene transfer to the lung显示文摘 | Vaysse L Guillaume C Burgelin I | 2002 | Biochem Biophys Res Commun2002，290，5： | 1 |
| 11 | Characterization of the antiproliferative signal mediated by the soma-tostatin receptor subtype sst5显示文摘 | Cordelier P Esteve JP Bousquet C Delesque N OCarroll AM Sehally AV Vaysse N Susini C Buseail L | 1997 | Proe Natl Aead Sci USA1997，94，： | 1 |
| 12 | Bimodal regulation of pancreatic cxocrine function in vitro by somatostatin-28 显示文摘 | Esteve J P Vaysse N Susini C | 1983 | Am J Physiol1983，245，2： | 1 |
| 13 | Analysis of adulterated herbal medicines and dietary supplements marketed for weight loss by DOSY 1HNMR显示文摘 | VAYSSE J BALAYSSAC S GILARD V | 2010 | Food Additives and Contaminants:Part A2010，27，7： | 1 |
| 14 | Fatty hydroxamic acid biosynthesis in aqueous medium in the presenceof the lipase-acyl transferase from Candida parasilosis显示文摘 | VAYSSE L DUBREUCQ E PIRAT J L | 1997 | Biotechnol1997，53，： | 1 |
| 15 | Hypophosphatasia may lead to bone fragility: don't miss it 显示文摘 | Moulin P Vaysse F Bieth E | 2009 | Eur J Pediatr2009，168，： | 1 |
| 16 | Vertebral pedicte anatomy in relation to pedicle screw fixation: a cadaver study 显示文摘 | Chaynes P Sol JC Vaysse P | 2001 | Surg Radiol Anat2001，23，2： | 1 |
| 17 | Identification of a novel sildenafil analogue in an adulterated herbal supplement显示文摘 | Julie Vaysse Véronique Gilard Stéphane Balayssac Chantal Zedde Robert Martino Myriam Malet-Martino | 2011 | Journal of Pharmaceutical and Biomedical Analysis2011，，： | 1 |
| 18 | Cerebral protection by hexamethonium during prolonged circulatory arrest 显示文摘 | Du Bouchet N Halpem B Vaysse J | 1955 | Anesth Anal1955，12，2： | 1 |
| 19 | Acrylate intercalation and in situ polymerizationin iron-, cobalt-, or manganese-substituted nickel hydroxides 显示文摘 | Vaysse C Guerlou-Demourgues L Duguet E | 2003 | Inorg Chem2003，42，： | 1 |
| 20 | Leucocytospermia, oxidative stress and male fertility: facts and hypotheses 显示文摘 | Lemkecher T Dartigues S Vaysse J | 2005 | Gyoneeol Obstet Fertil2005，33，122： | 1 |
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