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| 1 | Structural analysis of Ti1-xSixNy nanocomposite films prepared by magnetron sputtering显示文摘 | Vaz F Rebouta L Almeicla B | 1999 | Surf Coat Tech1999，，： | 2 |
| 2 | Murine model to study brain,behavior and immunity during hepatic encephalopathy显示文摘AIM:To propose an alternative model of hepatic encephalopathy(HE) in mice,resembling the human features of the disease.METHODS:Mice received two consecutive intraperitoneal injections of thioacetamide(TAA) at low dosage(300 mg/kg).Liver injury was assessed by serum transaminase levels(ALT) and liver histology(hematoxylin and eosin).Neutrophil infiltration was estimated by confocal liver intravital microscopy.Coagulopathy was evaluated using prolonged prothrombin and partial thromboplastin time.Hemodynamic parameters were measured through tail cuff.Ammonia levels were quantified in serum and brain samples.Electroencephalography(EEG) and psychomotor activity score were performed to show brain function.Brain edema was evaluated using magnetic resonance imaging.RESULTS:Mice submitted to the TAA regime developed massive liver injury,as shown by elevation of serum ALT levels and a high degree of liver necrosis.An intense hepatic neutrophil accumulation occurred in response to TAA-induced liver injury.This led to mice mortality and weight loss,which was associated with severe coagulopathy.Furthermore,TAA-treated mice presented with increased serum and cerebral levels of ammonia,in parallel with alterations in EEG spectrum and discrete brain edema,as shown by magnetic resonance imaging.In agreement with this,neuropsychomotor abnormalities ensued 36 h after TAA,fulfilling several HE features observed in humans.In this context of liver injury and neurological dysfunction,we observed lung inflammation and alterations in blood pressure and heart rate that were indicative of multiple organ dysfunction syndrome.CONCLUSION:In summary,we describe a new murine model of hepatic encephalopathy comprising multiple features of the disease in humans,which may provide new insights for treatment. | Lindisley Ferreira Gomides Pedro Elias Marques Bruno Engler Faleiros Rafaela Vaz Pereira Sylvia Stella Amaral Thais Reis Lage Gustavo Henrique Souza Resende Patricia Alves Maia Guidine Giselle Foureaux Fabíola Mara Ribeiro Fabiana Paiva Martins Marco Antonio Peliky Fontes Anderson José Ferreira Remo Castro Russo Mauro Martins Teixeira Márcio Flávio Moraes Antonio Lúcio Teixeira Gustavo Batista Menezes | 2014 | World Journal of Hepatology2014，6，4： | 2 |
| 3 | Characterisation of Ti1-xSixNy nanocomposite films显示文摘 | Vaz F Rebouta L Goudeau P | 2000 | Surface and Coatings Technology2000，，： | 1 |
| 4 | Oxidation resistance of(Ti,Al,Si)N coating in air显示文摘 | F Vaz a L Rebouta a | 1998 | Surface and Coating Technology1998，98，： | 1 |
| 5 | Neuritic growth impairment and cell death by unconjugated biliru- bin is mediated by NO and glutamate, modulated by microglia, and prevented by glycoursodeoxycholic acid and interleukin-10 显示文摘 | SILVA S L VAZ A R DIOGENES M J | 2012 | Neuropharmacology2012，62，7： | 1 |
| 6 | Thermal oxidation of Ti-AlxN coatings in air显示文摘 | VAZ F REBOUTA L | 1997 | Journal of the European Ceramic Society1997，，17： | 1 |
| 7 | NetB, a new toxin thatis associated with avian necrotic enteritis caused by Clostrich'um perfringens 显示文摘 | Keybum A L Boyce J D Vaz P | 2008 | Plos Pathog2008，4，： | 1 |
| 8 | Contribution of water content and bulk density to field soil penetration resistance as measured by a combined cone penetrometer-TDR probe显示文摘 | Vaz M P C Bassoi H L Hopmans W Jan | 2001 | Soil and Tillage Research2001，60，12： | 1 |
| 9 | Mechanical characterization of reactively magnetron-sputtered TiN films 显示文摘 | Vaz F Machado P Rebouta L | 2003 | Surface and Coatings Technology2003，，： | 1 |
| 10 | Porosity control of hydroxyapatite implants 显示文摘 | Vaz L Lopes AB Almeida M | 1999 | J Mater Sci: Mater in Medicine1999，10，： | 1 |
| 11 | Prediction of success in external cephalic version under toco- lysis: still a challenge显示文摘 | VAZ DE MACEDO C CLODE N MENDES DA GRA A L | 2015 | Acta Medica Portuguesa2015，28，5： | 1 |
| 12 | Long-term efficacy and safety of biphasic insulin aspart in patients with type 2 diabetes显示文摘 | Boehm BO Vaz JA BrΦndsted L | | 0，，： | 1 |
| 13 | Outcome effective- ness of the lay health advisor model among Latinos in the United States~ an examination by role显示文摘 | Ayala G X Vaz L Earp J A | 2010 | Health Educ Res2010，25，5： | 1 |
| 14 | Long-term efficacy and safety of biphasic insulin aspart in patients with type 2 diabetes显示文摘 | Boehm BO Vaz JA Brondsted L | 2004 | Eur J Inter Med2004，15，8： | 1 |
| 15 | Characterization of Ti1-xSixNy nanocomposite films显示文摘 | Vaz F Rebouta L Goudeau P | 2000 | Surface and Coatings Technology2000，，： | 1 |
| 16 | Characterisation of Ti1-xSixNy nanocomposite films显示文摘 | Vaz F Rebouta L Goudeau P | 2000 | Surf Coat Techn2000，，： | 1 |
| 17 | Association between plasmatic levels of homocysteine and stroke: a transversal analytic study显示文摘 | Harboe-Goncalves L Vaz LS Buzzi M | 2005 | Arq Neuropsiquiatr2005，63，1： | 1 |
| 18 | Direct observation of remanent magnetic states in epitaxial fcc Co small disks 显示文摘 | Vaz CAF Lopez Diaz L Kla ui M | 2003 | Phys Rev B2003，67，： | 1 |
| 19 | Optimization of solid phase microextraction analysis of aroma compounds in a Portuguese muscatel wine must显示文摘 | VAZ FREIRE L M T COSTAS FREITAS A M RELVA A M | 2001 | Journal of Microcolumn Separations2001，13，6： | 1 |
| 20 | Structural analysis of Ti1-xSixNy nanocomposite films prepared by reactive magnetron sputtering显示文摘 | Vaz F Rebouta L Almeida B | 1999 | Surf Coat Techn1999，，： | 1 |
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