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| 1 | IL28B polymorphisms associated with therapy response in Chilean chronic hepatitis C patients显示文摘AIM:To analyze the association of three IL28B single nucleotide polymorphisms with response to therapy in Chilean patients infected with hepatitis C virus CV.METHODS:We studied two groups of patients with chronic CV infection genotype 1,under standard combined treatment with pegylated interferon plus ribavirin.One group consisted of 50 patients with sustained virological response,whereas the second group consisted of 49 null responders.In order to analyze the IL28B single nucleotide polymorphisms rs12979860,rs12980275 and rs8099917,samples were used for polymerase chain reaction amplification,and the genotyping was performed by restriction fragment lengthpolymorphism.RESULTS:The IL28B rs12979860 CC,rs12980275 AA and rs8099917 TT genotypes were much more frequently found in patients with sustained virological response compared to null responders 38%,44% and 50% vs 2%,8.2% and 8.2%,respectively.These differences were highly significant in all three cases(P < 0.0001.CONCLUSION:The three IL28B polymorphisms studied are strongly associated with sustained virological response to therapy in Chilean patients with chronic CV genotype 1. | Mauricio Venegas Rodrigo A Villanueva Katherine González Javier Brahm | 2011 | World Journal of Gastroenterology2011，17，31： | 13 |
| 2 | Staining for p53 and Ki-67 increases the sensitivity of EUS-FNA to detect pancreatic malignancy显示文摘AIM:To investigate whether tumor marker staining can improve the sensitivity of endoscopic ultrasound-guided fine needle aspiration(EUS-FNA)to diagnose pancreatic malignancy. METHODS:Patients who underwent EUS-FNA were retrospectively identified.Each EUS-FNA specimen was evaluated by routine cytology and stained for tumor markers p53,Ki-67,carcinoembryonic antigen(CEA) and CA19-9.Sensitivity,specificity,positive and negative predictive values(PPV and NPV),and positive and negative likelihood ratios(PLR and NLR)were calculated in order to evaluate the performance of each test to detect malignancy. RESULTS:Sixty-one specimens had complete sets of stains,yielding 49 and 12 specimens from pancreatic adenocarcinomas and benign pancreatic lesions due to pancreatitis,respectively.Cytology alone had sensitivity and specificity of 41%and 100%to detect malignancy, respectively.In 46%of the specimens,routine cytology alone was deemed indeterminate.The addition of either p53 or Ki-67 increased the sensitivity to 51%and 53%,respectively,with perfect specificity,PPV and PLR (100%,100%and infinite).Both stains in combination increased the sensitivity to 57%.While additional staining with CEA and CA19-9 further increased the sensitivity to 86%,the specificity,PPV and PLR were significantly reduced(at minimum 42%,84%and 1,respectively).Markers in all combinations performed poorly as a negative test(NPV 26%to 47%,and NLR 0.27 and 0.70).CONCLUSION:Immunohistochemical staining for p53 and Ki-67 can improve the sensitivity of EUS-FNA to diagnose pancreatic adenocarcinoma. | Alexander W Jahng Sonya Reicher David Chung Donna Varela Rahul Chhablani Anil Dev Binh Pham Jose Nieto Rose J Venegas Samuel W French Bruce E Stabile Viktor E Eysselein | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，11： | 3 |
| 3 | Study of cavitation phenomenon using different fuels in a transparent nozzle by hydraulic characterization and visualization显示文摘 | R. Payri F.J. Salvador J. Gimeno O. Venegas | 2013 | Experimental Thermal and Fluid Science2013，，： | 2 |
| 4 | Extrapi- heal melatonin : sources, regulation, and potential functions 显示文摘 | Acufia-Castroviejo D Escames G Venegas C | 2014 | Cellular and Molecular Life Sciences2014，71，16： | 1 |
| 5 | Influence of crossflow ultrafiltration on membrane fouling and apple juice quality显示文摘 | DE Bruij n J Venegas A | 2002 | Desalination2002，148，2： | 1 |
| 6 | A comprehensive equation for the pulmonary Pressure-volume curve显示文摘 | Venegas JG Harris RS Simon BA | 1998 | J Appl Physiol1998，84，： | 1 |
| 7 | Long-tern treatment with eisapride and antibiotics in liver cirrhosis: effect on small intestinal motility, bacterial overgrowth,and liver function显示文摘 | Madrid AM Hurtado C Venegas M | 2001 | Am J Gastroenterol2001，96，4： | 1 |
| 8 | Kinetic and reaction mechanism of CO2 sorption on Li4SiO4: study of the particle size effect显示文摘 | VENEGAS M FREGOSO-ISRAEL E PFEIFFER H | 2007 | Industrial and Engineering Chemistry Research2007，46，8： | 1 |
| 9 | Clenching and grinding: effect on masseter and sternocleidomastoid elec tromyographic activity in healthy subjects 显示文摘 | Venegas M Valdivia J Fresno MJ | 2009 | Cranio2009，27，3： | 1 |
| 10 | Synthesis and purification of structured triacylglycerols from evening primrose and viper’s bugloss seed oils显示文摘 | Miguel ángel Rincón Cervera Elena Venegas Venegas Rebeca Pilar Ramos Bueno José Luis Guil Guerrero | 2012 | Food Research International2012，，2： | 1 |
| 11 | Modelling of urban background pollution in Buenos Aires City(Argentina)显示文摘 | Venegas L E Mazzeo N A | 2006 | Environmental Modelling & Software2006，21，4： | 1 |
| 12 | Optimum hot water temperature for absorption solar cooling 显示文摘 | A Lecuona R Ventas M Venegas | 2009 | Solar Energy2009，83，： | 1 |
| 13 | A simple frequency independent method for calculating th reactive and harmonic current in a nonlinear load显示文摘 | Tepper J S Dixon J W Venegas G | 1996 | IEEE Trans on Industrial Electronics1996，43，6： | 1 |
| 14 | Analysis of NO, NO2, 03 and NOx, concentration measured at a green area of Buenos Aires City during wintertime 显示文摘 | MAZZEO N A VENEGAS L E CHOREN H | 2005 | Atmospheric Environment2005，39，： | 1 |
| 15 | Analysis of NO,NO,O and NO2 3 x concentrations measured at a green area of Buenos Aires City during wintertime显示文摘 | Mazzeo N A Venegas L E Choren H | 2005 | Atmospheric Environment2005，39，17： | 1 |
| 16 | Exclusion of Fluoroscopy Use in Catheter Ablation Procedures: Six Years of Experience at a Single Center显示文摘 | JUAN M. FERNáNDEZ‐GóMEZ PABLO MORI?A‐VáZQUEZ ELENA DEL RIO MORALES JOSé VENEGAS‐GAMERO RAFAEL BARBA‐PICHARDO MANUEL HERRERA CARRANZA | 2014 | J Cardiovasc Electrophysiol2014，，6： | 1 |
| 17 | Heat and mass transfer during absorption of ammonia vapour by LiNO3 - NH3 solution droplets显示文摘 | VENEGAS M IZQUIERDO M RODR i GUEZ P et ol | 2004 | International Journal of Heat and Mass Transfer2004，47，1213： | 1 |
| 18 | Atmospheric deposition of nitrogen emitted in the Metropolitan Area of Buenos Aires to coastal waters of de la Plata River显示文摘 | Andrea L. Pineda Rojas Laura E. Venegas | 2008 | Atmospheric Environment2008，，6： | 1 |
| 19 | An objective analysis of the pressure volume curve in the acute respiratory distress syndrome 显示文摘 | Harris RS Hess DR Venegas JG | 2000 | Am J Respir Crit Care Med2000，161，2： | 1 |
| 20 | Long-term treatment with cispride and antibiotics in liver cirrhosis:effect on small intestinal motility,bacterial overgrwth,and liver function显示文摘 | Madrid AM Hurtado C Venegas M | 2001 | Am J Gastroenterol2001，96，4： | 1 |
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