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| 1 | Microfluidic actuators based on temperature-responsive hydrogels显示文摘The concept of using stimuli-responsive hydrogels to actuate fluids in microfluidic devices is particularly attractive,but limitations,in terms of spatial resolution,speed,reliability and integration,have hindered its development during the past two decades.By patterning and grafting poly(N-isopropylacrylamide)PNIPAM hydrogel films on plane substrates with a 2μm horizontal resolution and closing the system afterward,we have succeeded in unblocking bottlenecks that thermo-sensitive hydrogel technology has been challenged with until now.In this paper,we demonstrate,for the first time with this technology,devices with up to 7800 actuated micro-cages that sequester and release solutes,along with valves actuated individually with closing and opening switching times of 0.6±0.1 and 0.25±0.15 s,respectively.Two applications of this technology are illustrated in the domain of single cell handling and the nuclear acid amplification test(NAAT)for the Human Synaptojanin 1 gene,which is suspected to be involved in several neurodegenerative diseases such as Parkinson’s disease.The performance of the temperature-responsive hydrogels we demonstrate here suggests that in association with their moderate costs,hydrogels may represent an alternative to the actuation or handling techniques currently used in microfluidics,that are,pressure actuated polydimethylsiloxane(PDMS)valves and droplets. | Loïc D'Eramo Benjamin Chollet Marie Leman Ekkachai Martwong Mengxing Li Hubert Geisler Jules Dupire Margaux Kerdraon Clémence Vergne Fabrice Monti Yvette Tran Patrick Tabeling | 2018 | Microsystems & Nanoengineering2018，4，1： | 3 |
| 2 | Concomitant ankylosing spondylitis and S]ogren 's syndrome 显示文摘 | Treves R Vergne P Bonnet C | 1998 | Rev RheumEngEd1998，65，12： | 1 |
| 3 | The interaction of serotonin transporter gene polymorphisms and early adverse life events on vulnerability for major depression显示文摘 | VERGNE D E NEMEROFF C B | 2006 | Curt Psychiatry Rep2006，8，6： | 1 |
| 4 | Multifetal reduction of triplets to twins: a prospective comparison of pregnancy outcome 显示文摘 | Boulot P Vignal J Vergnes C | 2000 | Hum Re- prod2000，15，7： | 1 |
| 5 | Transformation of wheat flour by extrusion cooking:influence of screw configuration and operating conditions显示文摘 | Barres C Vergnes B Tayeb J | 1990 | Ce-real Chemistry1990，，67： | 1 |
| 6 | Absence of placental transfer of pentasaccharide ( Fondaparinux, Arixtra) in the dually peffused human cotyledon in vitro 显示文摘 | Lagrange F Vergnes C Brun JL | 2002 | Thromb Haemost2002，87，5： | 1 |
| 7 | Multifetal reduction of triplets to twins: a prospective comparison of pregnancy outcome显示文摘 | Vignal J Vergnes C | 2000 | Hum Reprod2000，15，7： | 1 |
| 8 | Absence of placental tran st'er of pentasaecharide (fondaparinux, Arixtra) in the dually perfused hu- man cotyledon in vitro 显示文摘 | Lagrange F Vergnes C Brun JL | 2002 | Thromb Haemost2002，87，5： | 1 |
| 9 | Use of N-terminal prohormone brain natriuretic peptide assay for etiologic diagnosis of acute dyspnea in elderly pa tients显示文摘 | Berdague P Caffin PY Barazer I Vergnes C Sedighian S Letrillard S | 2006 | Am Heart J2006，151，69： | 1 |
| 10 | Assessment of oxide scales influence on wear damage of HSM work rolls 显示文摘 | Joos O Boher C Vergne C | 2007 | Wear2007，263，1： | 1 |
| 11 | ZmOCL1, an HDGL2 family homeobox gene,is expressed in the outer ceil layer throughout maize development显示文摘 | INGRAM G C MAGNARD J L VERGNE P | 1999 | Plant Molelcular Biology1999，，： | 1 |
| 12 | Endogenous control of epilepsy: the nigral inhibitory system 显示文摘 | Depaulis A Vergnes M Marescanx C | 1994 | Prog Neurobiol1994，42，1： | 1 |
| 13 | A model of chronic spontaneous petit mal-like seizures in the rat:comparison with pentylenetetrazol-induced seizures显示文摘 | Marescaux C Micheletti G Vergnes M | 1984 | Epilepsia1984，25，3： | 1 |
| 14 | Flow mixing and residence time distribution of maize starch with a twin-screw extruder with a long tudinarty- split barrel 显示文摘 | Colonna P Melcion J P Vergnes B Mercier C | 1983 | Journal of Cereal Sciences1983，1，： | 1 |
| 15 | 显示文摘 | Berdagu6 P Vergnes C Rivallo M | 2012 | Ann Cardiol Angeiol (Paris)2012，61，5： | 1 |
| 16 | Spatial and temporal relationships between C-Fos expression and kindling of audiogenic seizures in W istar rats显示文摘 | Simler S Vergnes M Marescaux C | 1999 | Exp Neurol1999，157，1： | 1 |
| 17 | Experimental characterization of sharkskin in polyethylenes 显示文摘 | Venet C Vergnes B | 1997 | Journal of Rheology1997，41，4： | 1 |
| 18 | Metabolie state of glioma stem cells and nontumorigenic cells 显示文摘 | Vlashi E Lagadec C Vergnes L | 2011 | Proc Natl Acad Sci U S A2011，108，16： | 1 |
| 19 | Adipose subtype - se- lective recruitment of TLE3 or Prdml6 by PPAR~/ specifies lipid storage versus thermogenic gene programs显示文摘 | Villanueva C J Vergnes L Wang J | 2013 | Cell Metab2013，17，3： | 1 |
| 20 | Adipose subtype-selective recruitment of TLE3 or Prdml6 by PPAR/ specifies lipid storage versus thermogenie gene programs显示文摘 | Villanueva C J Vergnes L Wang J | 2013 | Cell Metab2013，17，3： | 1 |
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