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    题名 作者 年代 出处 被引量
1Thermal hypersensitivity in a subset of irritable bowel syndrome patients显示文摘AIM:To characterize thermal hypersensitivity in patients with constipation-and diarrhea-predominant irritable bowel syndrome (IBS).METHODS:Thermal pain sensitivity was tested among patients with diarrhea-predominant IBS (D-IBS) and constipation-predominant IBS (C-IBS) compared to healthy subjects.A total of 42 patients (29 female and 13 male;mean age 27.0±6.4 years) with D-IBS;24 patients (16 female and eight male;mean age 32.5±8.8 years) with C-IBS;and 52 control subjects (34 female and 18 male;mean age 27.3±8.0 years) participated in the study.Thermal stimuli were delivered using a Medoc Thermal Sensory Analyzer with a 3 cm × 3 cm surface area.Heat pain threshold (HPTh) and heat pain tolerance (HPTo) were assessed on the left ventral forearm and left calf using an ascending method of limits.The Functional Bowel Disease Severity Index (FBDSI) was also obtained for all subjects.RESULTS:Controls were less sensitive than C-IBS and D-IBS (both at P < 0.001) with no differences between C-IBS and D-IBS for HPTh and HPTo.Thermal hyperalgesia was present in both groups of IBS patients relative to controls,with IBS patients reporting significantly lower pain threshold and pain tolerance at both test sites.Cluster analysis revealed the presence of subgroups of IBS patients based on thermal hyperalgesia.One cluster (17% of the sample) showed a profile of heat pain sensitivity very similar to that of healthy controls;a second cluster (47% of the sample) showed moderate heat pain sensitivity;and a third cluster (36% of the sample) showed a very high degree of thermal hyperalgesia.CONCLUSION:A subset of IBS patients had thermal hypersensitivity compared to controls,who reported significantly lower HPTh and HPTo.All IBS patients had a higher score on the FBDSI than controls.Interestingly,the subset of IBS patients with high thermal sensitivity (36%) had the highest FBDSI score compared to the other two groups of IBS patients.QiQi Zhou Roger B Fillingim Joseph L Riley Ⅲ G Nicholas Verne 2009World Journal of Gastroenterology2009,15,26:2
2Optimal frames for erasures显示文摘Roderick B Holmes Vern I Paulsen 2003Linear Algebra and Its Applications2003,,:1
3Capacities of mi- grating CDlb + lymph dendritic cells to present Salmo- nella antigens to naive T cells 显示文摘Olivier M Foret B Le Vern Y 2012PLoS One2012,7,30:1
4Enhancing Ultrasonic Bond Development显示文摘VERN H WINCHELL B HOWARD M 1978IEEE Trans Hybrids and Manuf Technol1978,1,3:1
5Effect of extraction solvent, waste fraction and grape variety on the antimicrobial and antioxidant activities of extracts from wine residue from cool climate显示文摘VERN J C ALAA E A B MICHELLE M 2012Food Chemistry2012,134,:1
6The toxoplasma homolog of plasmodium apical membrane antigen-1 (AMA-1) is a microneme protein secreted in response to elerated intracellular calcium levels显示文摘CAROLYN G D VERN B C STACEY D G 2000Mol Biochem Parasitol2000,111,1:1
7Intestinal membrane permeability and hypersensitivity in the irritable bowel syndrome显示文摘Zhou Q Zhang B Verne G N 2009Pain2009,146,12:1
8Enhancing ultrasonic bond development显示文摘VERN H WNCHELL I HOWARD B 1998IEEE Transactions on Manufacturing Technology1998,1,3:1
9Flow cytometric evaluation of mitochondrial activity and membrane integrity in fresh and cryopreserved rainbow trout (Oneorhynehus mykiss ) spermatozoa 显示文摘Baulny B O Vern Y L Kerboeuf D 1997Cryobiology1997,34,:1
10Potential of forage to diversify Cropping system in the northern great plains 显示文摘MARTIN H E VERN S B PARTRIC M C 2002Agronomy Journal2002,94,2:1
11Flow cytometric evaluation of mitochondrial activity and membrane integrity in freshand cryopreserved rainbow trout (Oncorhynchus mykiss) spermatozoa显示文摘Baulny B O Vern Y L Kerboeuf D 1997Cryobiology1997,34,:1
12Efficien generation of infectious recombinant baculovirus by site-spectific transjjponmediated insertion of foreign genes into a baculovirus genome propagated in Escherichia coli显示文摘Verne A L Stephen C L Gerard F b 1993Journal of Virolohy1993,67,8:1
13Estimation of the partitioning characteristics of drugs: a comparison of a large and diverse drug series utilizing chromatographic and electrophoretic methodology显示文摘HANNA M DE BIASI V VERN B 1998Anal Chem1998,70,:1
14Efficient generation of infectious recombinant baculovirus by site-specific transponmediated insertion of foreign genes into aba culovirus genome propagated in Escherichia coli显示文摘Verne A L Stephen C L Gerard F B 1993Journal of Virology1993,67,8:1
15Effects of Toxoplasma gondii infection on the brain 显示文摘Vern B Carruthers Yasuhiro Suzuki 2007Chizophrenia Bulletin2007,33,:1
16Development of Glass-ceramic Scaffolds for Bone Tissue Engineering: Character ization, Proliferation of Human Osteoblasts and Nodule Formation显示文摘Vitale B C Verne E Robiglio L 2007Acta Biomaterialia2007,3,2:1
17Efficacy and mechanisms of action of traditional Chinese medicines for treating asthma and allergy显示文摘Li XM La Verne B 2009J Allergy Clin Immunol2009,123,2:1
18Intestinal membrane permeability and hypersensitivity in the irritable bowel syndrome显示文摘Zhou Q Zhang B Verne GN 2009Pain2009,146,12:1
19Intestinal membrane permeability and hypersensitivity in the irritable bowel syndrome显示文摘Zhou Q Zhang B Verne GN 2009Pain2009,146,12:1
20Flow cytometric evaluation of mitochondrial activity and membrane integrity in fresh and cryoprcscrved rainbow trout (Oncorhynchus mykiss) spermatozoa 显示文摘Ogier de Baulny B Le Vern Y Kerboeuf D 1997Cryobiology1997,34,2:1
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