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| 1 | Proteomics for discovery of candidate colorectal cancer biomarkers显示文摘Colorectal cancer(CRC)is the second most common cause of cancer-related deaths in Europe and other Western countries,mainly due to the lack of wellvalidated clinically useful biomarkers with enough sensitivity and specificity to detect this disease at early stages.Although it is well known that the pathogenesis of CRC is a progressive accumulation of mutations in multiple genes,much less is known at the proteome level.Therefore,in the last years many proteomic studies have been conducted to find new candidate protein biomarkers for diagnosis,prognosis and as therapeutic targets for this malignancy,as well as to elucidate the molecular mechanisms of colorectal carcinogenesis.An important advantage of the proteomic approaches is the capacity to look for multiple differentially expressed proteins in a single study.This review provides an overview of the recent reports describing the different proteomic tools used for the discovery of new protein markers for CRC such as two-dimensional electrophoresis methods,quantitative mass spectrometry-based techniques or protein microarrays.Additionally,we will also focus on the diverse biological samples used for CRC biomarker discovery such as tissue,serum and faeces,besides cell lines and murine models,discussing their advantages and disadvantages,and summarize the most frequently identified candidate CRC markers. | Paula lvarez-Chaver Olalla Otero-Estévez María Páez de la Cadena Francisco J Rodríguez-Berrocal Vicenta S Martínez-Zorzano | 2014 | World Journal of Gastroenterology2014，20，14： | 7 |
| 2 | Potential of soluble CD26 as a serum marker for colorectal cancer detection显示文摘Colorectal cancer is characterized by a low survival rate even though the basis for colon cancer development,which involves the evolution of adenomas to carcinoma,is known.Moreover,the mortality rates continue to rise in economically transitioning countries although there is the opportunity to intervene in the natural history of the adenoma–cancer sequence through risk factors,screening,and treatment.Screening in particular accounted for most of the decline in colorectal cancer mortality achieved in the USA during the period 1975-2000.Patients show a better prognosis when the neoplasm is diagnosed early.Among the variety of screening strategies,the methods range from invasive and costly procedures such as colonoscopy to more low-cost and non-invasive tests such as the fecal occult blood test(guaiac and immunochemical).As a non-invasive biological serum marker would be of great benefit because of the performance of the test,several biomarkers,including cytologic assays,DNA and mRNA,and soluble proteins,have been studied.We found that the soluble CD26(sCD26)concentration is diminished in serum of colorectal cancer patients compared to healthy donors,suggesting the potential utility of a sCD26 immunochemical detection test for early diagnosis.sCD26 originates from plasma membrane CD26 lacking its transmembrane and cytoplasmic domains.Some 90%–95%of sCD26 has been associated with serum dipeptidyl peptidase IV(DPPIV)activity.DPP-IV,assigned to the CD26 cluster,is a pleiotropic enzyme expressed mainly on epithelial cells and lymphocytes.Our studies intended to validate this test for population screening to detect colorectal cancer and advanced adenomas are reviewed here. | Oscar J Cordero Monica Imbernon Loretta De Chiara Vicenta S Martinez-Zorzano Daniel Ayude Maria Paez de la Cadena F Javier Rodriguez-Berrocal | 2011 | World Journal of Clinical Oncology2011，2，6： | 5 |
| 3 | Application of column switching in high-performance liquid chromatography with on-line thermo-oxidation and detection by HGAAS and HG-AFS for the analysis of organoarsenical species in seafood samples显示文摘 | ANGELES SUNER M VICENTA DEVESA OCIEL MUNOZ | 2001 | J Anal At Spectrom2001，16，： | 1 |
| 4 | Groundwater Protection Using Vulnerability Maps and Wellhead Protection Area (WHPA): A Case Study in Mexico显示文摘 | Jose Luis Expósito Maria Vicenta Esteller Jorge Paredes Celso Rico Roberto Franco | 2010 | Water Resources Management2010，，15： | 1 |
| 5 | Early Hormonal Markers of Pregnancy Outcome After In Vitro Fertilization and Embryo Transfer显示文摘 | Francisco Carmona Juan Balasch Montserrat Creus Francisco Fábregues Roser Casamitjana Salvadora Cívico Ester Vidal Josep M. Calafell Vicenta Moreno Juan A. Vanrell | 2003 | Journal of Assisted Reproduction and Genetics2003，，12： | 1 |
| 6 | Early Hormonal Markers of Pregnancy Outcome After In Vitro Fertilization and Embryo Transfer显示文摘 | Francisco Carmona Juan Balasch Montserrat Creus Francisco Fábregues Roser Casamitjana Salvadora Cívico Ester Vidal Josep M. Calafell Vicenta Moreno Juan A. Vanrell | 2003 | Journal of Assisted Reproduction and Genetics2003，，12： | 1 |
| 7 | Novel recombinant gonadotropins显示文摘 | Vicenta G C Irving B | 2001 | Trends in Endocrinology and Metabolism2001，12，2： | 1 |
| 8 | Environmental effects of aquifer overexploitation:a case study in the Highlands of Mexico显示文摘 | Maria Vicenta Esteller and Carlos Diaz-Delgado | 2002 | Environmental Management2002，29，2： | 1 |
| 9 | Mercury retrieval from flue gas by monolithic adsorbents based on sulfurized sepiolite显示文摘 | SAGRARIO M ISABEL G M BERMEJO P J VICENTA M | 1999 | Environmental Science and Technology1999，33，10： | 1 |
| 10 | Preoperative serum alpha-L-Fucosidase activity as a prognostic marker in colorectal cancer显示文摘 | Daniel A MariaPC Vicenta S | 2003 | Oncology2003，64，： | 1 |
| 11 | Vermicomposting of sewage sludge: earthworm population and agronomic advantages 显示文摘 | LUDIBETH S M MARINA I E VICENTA E M | 2012 | Compost Sci Utilization2012，20，1： | 1 |
| 12 | Novel recombinant gonadotropins显示文摘 | Vicenta GC Irving B | 2001 | Trends Endocrinol Metabolism2001，12，2： | 1 |
| 13 | Environmental effects of aquifer overexploitation:a case study in the Highlands of Mexico显示文摘 | Maria Vicenta Esteller Carlos Diaz-Delgado | 2002 | Environmental Management2002，29，2： | 1 |
| 14 | Modelling the integration-performance relation- ship: Collaborative practices, enablers and contextual factors显示文摘 | Taco van der Vaart Dirk Pieter van Donk Cristina Gimenez Vicenta Sierra | 2012 | International Journal of Operations & Production Management2012，32，9： | 1 |
| 15 | Platelet linoleic acid is a potential biomarker of advanced non-small cell lung cancer显示文摘 | Javier de Castro Marina C. Rodríguez Vicenta S. Martínez-Zorzano Marcial Llanillo Jesús Sánchez-Yagüe | 2009 | Experimental and Molecular Pathology2009，，3： | 1 |
| 16 | Novel recombinant gonadotropins显示文摘 | Vicenta G C Irving B | 2001 | Trends in Endocrinology and Metabolism2001，12，2： | 1 |
| 17 | Environmental effects of aquifer overexploitation : a case study in the Highlands of Mexico显示文摘 | Mafia Vicenta Esteller Carlos Diaz-Delgado | 2002 | Environmental Management2002，29，2： | 1 |
| 18 | Oranoarsenical species contents in fresh and processed seafood products 显示文摘 | Angeles suner M Vicenta devesa Maria Jesus | 2002 | Journal Agricultural Food Chemistry2002，50，： | 1 |
| 19 | Isobaric vapor-liquid equilibrium of binary mixtures of 1-propanol + chlorobenzene and 2-propanol + chlorobenzene 显示文摘 | Ana D Vicenta G A Francisco J L | 1997 | Fluid Phase Equilibria1997，134，12： | 1 |
| 20 | Phase equilibria and variation of the azeotropic composition with pressure for binary mixtures of 1-propanol + chlorobenzene and 1-butanol + chlorobenzene 显示文摘 | Ana D Vicenta G A Francisco J L | 1998 | Fluid Phase Equilibria1998，145，2： | 1 |
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