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| 1 | 电针对多囊卵巢综合征模型系统的调控显示文摘通过母体高雄环境建立子代雌性大鼠高雄激素血症和胰岛素抵抗模型,探讨针刺对孕期高雄化大鼠的治疗效果以及针刺调节卵巢局部胰岛素信号传导关键分子磷脂酰肌醇3激酶(PI-3K)和丝裂原激活蛋白激酶(MAPK),明确针刺治疗胰岛素抵抗的分子机制。在Wistar雌性大鼠颈背部皮下注射丙酸睾丸酮,连续3d。以其所生雌鼠作为实验对象,观察其体重及动情周期,检测血清性激素,17-羟孕酮(17-OHP)、雄烯二酮(A2)及OGTT试验测血糖、胰岛素水平,然后给予针刺治疗,观察其对生殖与代谢功能的影响。运用免疫组化及蛋白印迹方法,检测骨骼肌和卵巢组织中胰岛素受体底物-1(IRS-1)、胰岛素受体底物-2(IRS-2)、磷脂酰肌醇3-激酶(PI-3K85)、葡萄糖转运蛋白-4(GLUT4)、细胞外信号激酶-1(ERK-1)和17羟化酶(CYP17)蛋白表达。结果显示:①模型鼠无排卵,高雄、糖耐量减低,胰岛素抵抗;②针刺可以恢复动情周期,降低体重,降低LH、17-OHP、A2、T水平,升高E2水平;降低OGTT试验1h血糖水平,降低空腹和1h胰岛素水平,降低HOMA指数;③骨骼肌和卵巢局部产生胰岛素抵抗后,相应的IRS-1、IRS-2、PI-3K85和GLUT4的蛋白表达下降,ERK-1、CYP17的表达升高;针刺能逆转蛋白的异常表达。由此得出以下结论:①孕期注射丙酸睾丸酮,所生子代雌鼠有生殖和代谢异常,符合PCOS患者临床特征;②针刺能够降低雄激素,降低血糖,提高胰岛素敏感性,降低体重;③针刺能够调节模型动物骨骼肌和卵巢局部胰岛素信号传导蛋白表达和卵巢局部雄激素合成酶表达。 | 彭艳 李琴华 吴效科 侯丽辉 Elisabet Stener VICTORIN | 2008 | 科技导报2008，26，12： | 23 |
| 2 | 孕期高雄大鼠子代实验性多囊卵巢综合征模型构建显示文摘通过母体高雄环境建立子代实验性多囊卵巢综合征(PCOS)大鼠模型,并证明此模型大鼠存在卵巢局部胰岛素抵抗。方法是给孕16d的雌鼠皮下注射丙酸睾丸酮,诱导其子代雌鼠发生PCOS,观察子代大鼠体重、动情周期变化、性激素变化及糖代谢变化、卵巢重量和卵巢形态变化、肌肉组织蛋白印迹测定PI-3K和MAPK通路关键蛋白的表达、卵巢免疫组化和蛋白印迹测定PI-3K和MAPK通路关键蛋白的表达确定。结果显示:①动情周期失去规律变化,提示无排卵;②血清17-OHP,A2,T升高;③卵巢组织学检查可镜下看到早期发育的较多的小卵泡、闭锁卵泡,囊状扩张卵泡明显增加,颗粒细胞层数减少,黄体数量明显减少;④OGTT:1h血糖及胰岛素高于对照组,模型组存在着胰岛素抵抗;⑤卵巢局部PI-3K和MAPK途径关键蛋白有表达;⑥卵巢局部蛋白印迹测定PI-3K和MAPK途径关键蛋白IRS-1,P85,GLUT4降低,ERK1升高。由此表明:①此模型大鼠符合PCOS的诊断标准;②此模型大鼠存在卵巢局部胰岛素抵抗。 | 李琴华 彭艳 吴效科 侯丽辉 Elisabet Stener VICTORIN | 2008 | 科技导报2008，26，12： | 12 |
| 3 | Inventory and action plan for PFOS and related substances in Suriname as basis for Stockholm Convention implementation显示文摘Within the framework of the Stockholm Convention implementation in Suriname,the first inventory of perfluorooctane sulfonic acid(PFOS)has been developed.The major stocks of PFOS are firefighting foams with minor stocks in pesticides(ant baits)and possibly carpets.The inventory of firefighting foams assessed the import,current stocks and major use sites and recent releases.Considerable amount of PFOS and potentially PFOS containing firefighting foams are stored at the military base,the oil company and small firefighting departments throughout the country.The total amount of stored PFAS firefighting foam in Suriname is estimated to be at least 275.6 tonnes,where the major stockpile of 206 tonnes is at the oil storage facilities.For some of these foams PFOS content is confirmed and for others it is not clear if the foam contains PFOS or other per-or polyfluorinated alkylated substances(PFAS).The upper estimate of PFOS content is 4133 kg in these foams.Additionally,PFOS or other PFAS has also been discovered in fire extinguishers in institutions.The total amount of PFOS related substance EtFOSA imported with the pesticide sulfluramid was 75 kg.The imports were banned in 2014 and is controlled.A considerable amount of synthetic carpets are in stores even produced before 2003 where main use of PFOS from 3 M took place possibly containing PFOS related substances.A compilation of potentially PFOS contaminated sites has been made.Potentially contaminated sites result from firefighting foam use,dumpsites and sulfluramid use.The airport where firefighting foam was applied is above a major drinking water reservoir,where an urgent assessment is needed.Due to the lack of analytical capacity for PFOS and precursors,drinking water,firefighting foam or impacted carpets,could not been analysed.An action plan for the control of PFOS and other PFAS has been developed considering the synergy of the Stockholm Convention and the Strategic Approach to International Chemicals Management(SAICM)addressing this emerging pollution issue for developing countries. | Victorine Pinas Carmen Van Dijk Roland Weber | 2020 | Emerging Contaminants2020，6，1： | 3 |
| 4 | Effects of electro - acupuncture on nerve growth factor and ovarian morphology in rats with experimentally induced polycystic ovaries显示文摘 | Stener - Victorin E Lundeberg T Waldenstrom U | 2000 | Biol Re- prod2000，63，5： | 1 |
| 5 | Reduc- tion of blood flow impedance in the uterine arteries of infertile women with electro - acupuncture 显示文摘 | Stener- Victorin E Waldenstr0m U Andersson SA | 1996 | Hum Reprod1996，11，6： | 1 |
| 6 | Influence of Different Fat Emulsion-Based Intravenous Formulations on the Pharmacokinetics and Pharmacodynamics of Propofol显示文摘 | Eugene H. Cox Catherijne A. J. Knibbe Victorine S. Koster Mariska W. E. Langemeijer Erica E. Tukker Rogier Lange Paul F. M. Kuks Han J. M. Langemeijer Loraine Lie-A-Huen Meindert Danhof | 1998 | Pharmaceutical Research1998，，3： | 1 |
| 7 | Steroid induced polycystic ovaries in rats: effect of electro- acupuncture on concentrations of endothelin-1 and nerve growth factor (NGF) , and expression of NGF mRNA in the ovaries, the adrenal glands, and the central nervous system 显示文摘 | Stener - Victorin E Lundeberg T Cajander S e t a l | 2003 | Reprod Biol Endocrinol2003，1，： | 1 |
| 8 | Low - frequency elec- troacupuncture and physical exercise decrease high musle sympathetic nerve activity in polycystic ovary syndrome 显示文摘 | Stener - Victorin V Jedel E Janson PO | 2009 | Am J Physial Regul Integr Comp Physiol2009，297，2： | 1 |
| 9 | Assessment of health - relat- ed quality of life : Swedish version of polycystic ovary syndrome ques- tionnaire显示文摘 | Jedel E Kowalski J Stener - Victorin E | 2008 | Acta Obstet Gynecol Seand2008，87，12： | 1 |
| 10 | Effects of acupuncture and exercise on insulin sensitivity, adipose tissue characteristics, and markers of coagulation and fibrinolysis in women with polycystic ovary syndrome: secondary analyses of a randomizedcontrolled trial 显示文摘 | Stener - Victorin E Baghaei F Holm G | 2012 | Fertility Sterility2012，97，2： | 1 |
| 11 | Low -frequency e- lectro - acupuncture and physical exercise decrease high muscle sym- pathetic nerve activity in polyeystic ovary syndrome 显示文摘 | Stener- Victorin E Jedel E Janson PO | 2009 | American Journal of Physiology - Regulatory Integrative and Comparative Physi- ology2009，297，2： | 1 |
| 12 | Reduction of blood flow impedance in theuterine arteries infertile women with eleetro-aeupuneture显示文摘 | Stener Victorin E W aldenstrom U Andersson S A | 1996 | Hum Reprod1996，11，6： | 1 |
| 13 | ScientificStat e- ment on the Diagnostic Criteria,Epidemiology,Pathophysiology,and Molecular Genetics of Polycystic Ovary Syndrome显示文摘 | Dumesic D A Oberfield S E Stener- Victorin E | 2015 | En- docr Rev2015，36，05： | 1 |
| 14 | Health effects of urban air pollutants: guideline values and conditions in Sweden显示文摘 | VICTORIN K | 1993 | Chemosphere1993，27，： | 1 |
| 15 | Comparing ex-perimental designs for benchmark dose calculations for con-tinuous endpoints显示文摘 | Kuljus K von Rosen D Sand S Victorin K | 2006 | Risk Anal2006，26，4： | 1 |
| 16 | DBU/DMSO Promoted Dehydrobromination of1,1-Dibromoolefins显示文摘 | Victorin R Yolande R | 1994 | Tetrahedron Lett1994，35，27： | 1 |
| 17 | Acupuncture in polycystic ovary syndrome : current experimental and clinical evidence 显示文摘 | Stener - Victorin E Jedel E Manneras L | 2008 | J Neuroendocrinol2008，20，3： | 1 |
| 18 | Influence of different fat emulsion based intravenous formulation on the pharmacokinetics and pharmacodynamics of propfol显示文摘 | Eugene HC Catherijen AK Victorine SK | 1998 | Pharm Res1998，15，： | 1 |
| 19 | Influence of different fat emulsion based intravenous formulation on the pharmacokinetics and pharmaco-dynamics of propfol显示文摘 | Eugene H C Catherijen A K Victorine S K | 1998 | Pharm Res1998，15，： | 1 |
| 20 | A pro- spective randomized study of electro - acupuncture versus al- fentanil as anaesthesia during oocyte aspiration in in - vitro fertilization显示文摘 | Stener - Victorin E Waldenstrom U Nilsson L | 1999 | Hum Reprod1999，14，10： | 1 |
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