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| 1 | Role of CARD15,DLG5 and OCTN genes polymorphisms in children with inflammatory bowel diseases显示文摘AIM: To investigate the contribution of variants of CARD15, OCTN1/2 and DLG5 genes in disease predispo- sition and phenotypes in a large Italian cohort of pediatric patients with inflammatory bowel diseases (IBD). METHODS: Two hundred patients with Crohn’s disease (CD), 186 ulcerative colitis (UC) patients, 434 par- ents (217 trios), and 347 healthy controls (HC) were studied. Polymorphisms of the three major variants of CARD15, 1672C/T and -207G/C SNPs for OCTN genes, IGR2096a_1 and IGR2198a_1 SNPs for the IBD5 locus, and 113G/A variant of the DLG5 gene were evaluated. Potential correlations with clinical sub-phenotypes were investigated. RESULTS: Polymorphisms of CARD15 were significantly associated with CD, and at least one variant was found in 38% of patients (15% in HC, OR = 2.7, P < 0.001). Homozygosis for both OCTN1/2 variants was more com- mon in CD patients (1672TT 24%, -207CC 29%) than in HC (16% and 21%, respectively; P = 0.03), with an in- creased frequency of the TC haplotype (44.8% vs 38.3% in HC, P = 0.04). No association with the DLG5 variant was found. CD carriers of OCTN1/2 and DLG5 variants more frequently had penetrating disease (P = 0.04 and P = 0.01), while carriers of CARD15 more frequently had ileal localization (P = 0.03). No gene-gene interaction was found. In UC patients, the TC haplotype was morefrequent (45.4%, P = 0.03), but no genotype/phenotype correlation was observed. CONCLUSION: Polymorphisms of CARD15 and OCTN genes, but not DLG5 are associated with pediatric on- set of CD. Polymorphisms of CARD15, OCTN, and DLG5 genes exert a weak influence on CD phenotype. | S Cucchiara A Latiano O Palmieri AM Staiano R D'Incà G Guariso G Vieni V Rutigliano O Borrelli MR Valvano V Annese | 2007 | World Journal of Gastroenterology2007，13，8： | 9 |
| 2 | Secretory breast carcinoma with metastatic sentinel lymph node显示文摘 | Vieni S Cabibi D Cipolla C | 2006 | World J Surg Oncol2006，4，： | 1 |
| 3 | Does the use of fibrin glue prevent seroma formation after axillary lymphadeneetomy for breast cancer?A prospective randomized trial in 159 patients显示文摘 | Cipolla C Fricano S Vieni S | 2010 | J Surg Oncol2010，101，： | 1 |
| 4 | A family of cytokine - inducible inhibition of signaling 显示文摘 | Starr R Willson TA Vieny EM | 1997 | Nature1997，387，6636： | 1 |
| 5 | Secretory breastcarcinoma with metastatic sentinel lymph node 显示文摘 | Vieni S Cabibi D Cipolla C | 2006 | World JSurg Oncol2006，488，： | 1 |
| 6 | Secretory breast carcinoma with metastatic sentinel lymph node 显示文摘 | Vieni S Cabibi D Cipolla C | 2006 | World J Surg Oncol2006，4，： | 1 |
| 7 | LigaSure in total thyroidectomy显示文摘 | Calogero Cipolla Giuseppa Graceffa Luigi Sandonato Salvatore Fricano Salvatore Vieni Mario A. Latteri | 2008 | Surgery Today2008，，： | 1 |
| 8 | Does the use of fibrin glue prevent seroma formation after axillary lymphadenectomy for breast cancer? A prospective randomized trial in 159 patients显示文摘 | Cipolla C Fricano S Vieni S | 2010 | J 5urg Oncol2010，101，7： | 1 |
| 9 | Secretory breast carcinoma-with metastatic sentinel lymph node显示文摘 | VIENI S CABIBI D CIPOLLA C | 2006 | World J Surg Oncol2006，4，1： | 1 |
| 10 | Does the use of fibrin glue prevent seroma formation after axillary lymphadenectomy for breast cancer? A prospective randomized trial in 159 patients显示文摘 | CIPOLLA C FRICANO S VIENI S | 2010 | J Surg Oncol2010，101，7： | 1 |
| 11 | A Mathematical Methodology for the Preventive Study of the Failure Rate to Optimize the Maintenance Program of a Public Work: Economic-Management Aspects for Safety and Quality显示文摘In this paper we analyze the problem of the assessment of the failure rate of the complex public work system and the engineering part of it (bridge, tunnel, etc.), examining the case of serious maintenance problems, such as those which occurred in the recent disaster of the 'Morandi bridge'. The original mathematical methodology envisaged makes it possible to optimize the safety and quality scenarios of the operation and infrastructure in question, also from an economic-management point of view, evaluating every aspect in an integrated way and for the entire period life. The scientific results obtained are of particular interest for the study of maximization of the planning protocols of 'terotechnological' interventions, providing a contribution to the science of programmed maintenance for the mobility networks and for more complex parts such as bridges and tunnels. | Giuseppe Caristi Sabrina Lo Bosco Alberto Vieni | 2018 | Journal of Business Administration Research2018，1，1： | 0 |
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