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| 1 | Treatment strategy for colorectal cancer with resectable synchronous liver metastases:Is any evidence-based strategy possible?显示文摘Fifteen percent to twenty-five percent of patients affected by colorectal cancer presents with liver metastases at diagnosis. In resectable cases, surgery is the only potentially curative treatment and achieves survival rates up to 50% at 5 years. Management is complex, as colorectal resection, liver resection, chemotherapy, and, in locally advanced mid/low rectal tumors, radiotherapy have to be integrated. Modern medical practice usually relies on evidence-based protocols. Levels of evidence for synchronous metastases are poor:published studies include few recent prospective series and several retrospective analyses collecting a limited number of patients across long periods of time. Data are difficult to be generalized and are mainly representative of single centre's experience, biased by local recruitment, indications and surgical technique. In this context, surgeons have to renounce to 'evidence-based medicine' and to adopt a sort of 'experience-based medicine'. Anyway, some suggestions are possible. Simultaneous colorectal and liver resection can be safely performed whenever minor hepatectomies are planned, while a case-by-case evaluation is mandatory in case of more complex procedures. Neoadjuvant chemotherapy is preferentially scheduled for patients with advanced metastatic tumors to assess disease biology and to control lesions. It can be safely performed with primarytumor in situ , even planning simultaneous resection at its end. Locally advanced mid/low rectal tumor represents a further indication to neoadjuvant therapies, even if treatment's schedule is not yet standardized. In summary, several issues have to be solved, but every single HPB centre should define its proper strategy to optimize patient's selection, disease control and safety and completeness of surgery. | Luca Viganò | 2012 | World Journal of Hepatology2012，4，8： | 8 |
| 2 | Fertility preservation in female cancer patients:a single center experience显示文摘Advances in cancer treatment allow women to be cured and live longer. However, the necessary chemotherapy and radiotherapy regimens have a negative impact on future fertility. Oncofertility has emerged as a new interdisciplinary field to address the issue of gonadotoxicity associated with cancer treatment and to facilitate fertility preservation, including oocyte and ovarian tissue cryopreservation. These fertility issues are often inadequately addressed, and referral rates to oncofertility centers are low. The aim of this study was to report the 3-year experience of the San Raffaele Oncofertility Unit. A total of 96 patients were referred to the Oncofertility Unit for evaluation after the diagnosis of cancer and before gonadotoxic treatment between April 2011 and June 2014. Of the 96 patients, 30(31.2%) were affected by breast cancers, 20(20.8%) by sarcomas, 28(29.2%) by hematologic malignancies, 13(13.5%) by central nervous system cancers, 3(3.1%) by bowel tumors, 1(1.0%) by Wilms' tumor, and 1(1.0%) by a thyroid tumor; 47(49.0%) were referred for oocyte cryopreservation before starting chemotherapy, 20(20.8%) were referred for ovarian tissue cryopreservation, and 29(30.2%) were not recruited. The mean time between the patients' counseling and oocyte retrieval was 15 days(range, 2–37 days). The mean time between the laparoscopic surgery and the beginning of treatment was 4 days(range, 2–10 days). The number of patients who were referred increased over time, whereas the rate of patients who were not recruited decreased, showing an improvement in referrals to the Oncofertility Unit and in the patients' counseling and understanding. Our results indicate that an effective multidisciplinary oncofertility team is necessary for prompt referrals and treatment. | Cristina Sigismondi Enrico Papaleo Paola Viganò Simona Vailati Massimo Candiani Jessica Ottolina Valentina E. Di Mattei Giorgia Mangili | 2015 | Chinese Journal of Cancer2015，34，1： | 7 |
| 3 | 308nm单色光在皮肤科应用的评价:治疗不同的慢性限局性皮肤病的初步研究 | Aubin F. Vigan M. Puzenat E. 党倩丽 | 2005 | 世界核心医学期刊文摘(皮肤病学分册)2005，0，8： | 4 |
| 4 | Quality of life, physical performance and nutritional status in older patients hospitalized in a cardiology department显示文摘Objectives Quality of life(QoL) is a priority outcome in older adults suffering from cardiovascular diseases. Frailty and poor nutritional status may affect the QoL through mobility disorders and exhaustion. The objective of this study was to determine if physical frailty and nutritional status were associated with QoL, in older cardiology patients. Methods Cross sectional, observational study conducted in a cardiology department from a university hospital. Participants(n = 100) were aged 70 and older. Collected data included age, sex, cardiac diseases, New York Heart Association(NYHA) classification, comorbidities(Charlson Index) and disability. A Short Physical Performance Battery(SPPB), including walking speed assessment was performed;handgrip strength were measured as well as Fried’s frailty phenotype. Nutritional status was assessed using the Mini Nutritional Assessment(MNA) and Body Mass Index(BMI), inflammation by C-reactive protein(CRP). QoL was assessed using the EORTC–QLQ questionnaire. Univariate and multivariate analyses were performed to study the associations between all recorded parameters and QoL. Results In participants(mean age: 79.3 ± 6.7 years;male: 59%), Charlson index, arrhythmia, heart failure, NYHA class III-IV, MNA, disability, walking speed, SPPB score, frailty and CRP were significantly associated with QoL in univariate analysis. Multivariate analysis showed that NYHA class III-IV(P < 0.001), lower MNA score(P = 0.03), frailty(P < 0.0001), and higher CRP(P < 0.001) were independently associated with decreased QoL. Conclusions Frailty, nutritional status and inflammation were independently associated with poor QoL. Further studies are needed to assess the efficacy of nutritional and physical interventions on QoL in this population. | Matthieu Lilamand Mariannick Saintout Marie Vigan Astrid Bichon Laure Tourame Aurélie Brembilla Diet Bernard Iung Dominique Himbert Cédric Laouenan Agathe Raynaud-Simon | 2020 | Journal of Geriatric Cardiology2020，17，7： | 3 |
| 5 | Restored Function of HBV-Specific T Cells After Long-term Effective Therapy With Nucleos(t)ide Analogues显示文摘 | Carolina Boni Diletta Laccabue Pietro Lampertico Tiziana Giuberti Mauro Viganò Simona Schivazappa Arianna Alfieri Marco Pesci Giovanni B. Gaeta Giuseppina Brancaccio Massimo Colombo Gabriele Missale Carlo Ferrari | 2012 | Gastroenterology2012，，4： | 3 |
| 6 | Surgical treatment of synchronous colorectal liver and lung metastases: the usefulness of thoracophrenolaparotomy for single stage resection显示文摘When suitable, surgery still remains the therapeutic option to be preferred for patients carrier of colorectal liver and lung metastases. Since thoracophrenolaparotomy should be helpful during liver resection for some of these patients, simultaneous removal of right lung metastases can be proposed through this approach. Eleven consecutive patients(median age of 53 years) carrier of colorectal liver and lung metastases, underwent single session surgical resection of both liver and right lung lesions by means of J-shaped thoracophrenolaparotomy. The median number of liver metastases removed was 5(range 2-30) and of lung metastases removed was 2(range 1-3). Lung metastases were located in the upper lobe in 1 patient, in the middle lobe in 2, in the lower lobe in 6, and in the upper and lower lobe in 2. Mortality and major morbidity were nil. Two patients had a minor morbidity: one had wound infection and bile leakage treated conservatively and the other had transient fever. Mean overall survival was 24.4 months. An aggressive surgical approach should be undertaken for colorectal metastases: in case of multifocal liver disease with complex presentations, J-shaped thoracophrenolaparotomy could be considered as safe approach for combined liver and right lung metastasectomies. | Daniele Del Fabbro Marco Alloisio Fabio Procopio Matteo Cimino Matteo Donadon Angela Palmisano Luca Viganò Guido Torzilli | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，2： | 3 |
| 7 | Preoperative Biliary Drainage Increases Infectious Complications after Hepatectomy for Proximal Bile Duct Tumor Obstruction显示文摘 | Alessandro Ferrero Roberto Lo Tesoriere Luca Viganò Luisa Caggiano Enrico Sgotto Lorenzo Capussotti | 2009 | World Journal of Surgery2009，，2： | 3 |
| 8 | Safety of Conservative Management of Bile Leakage after Hepatectomy with Biliary Reconstruction显示文摘 | Alessandro Ferrero Nadia Russolillo Luca Viganò Enrico Sgotto Roberto Lo Tesoriere Marco Amisano Lorenzo Capussotti | 2008 | Journal of Gastrointestinal Surgery2008，，12： | 2 |
| 9 | Laparoscopic liver resection: a systematic review显示文摘 | Luca Viganò Claude Tayar Alexis Laurent Daniel Cherqui | 2009 | Journal of Hepato - Biliary - Pancreatic Surgery2009，，4： | 2 |
| 10 | Liver Surgery for Colorectal Metastases: Results after 10?Years of Follow-Up. Long-Term Survivors, Late Recurrences, and Prognostic Role of Morbidity显示文摘 | Luca Viganò MD Alessandro Ferrero MD Roberto Lo Tesoriere MD Lorenzo Capussotti MD | 2008 | Annals of Surgical Oncology2008，，9： | 2 |
| 11 | Anti-TNF drugs in patients with hepatitis B or C virus infection: safety and clinical management显示文摘 | Mauro Viganò Elisabetta Degasperi Alessio Aghemo Pietro Lampertico Massimo Colombo | 2012 | Expert Opinion on Biological Therapy2012，，： | 2 |
| 12 | Long-Term suppression of hepatitis B e antigen-negative chronic hepatitis B by 24-month interferon therapy显示文摘 | Pietro Lampertico Ersilio Del Ninno Mauro Viganò Raffaella Romeo Maria Francesca Donato Erwin Sablon Alberto Morabito Massimo Colombo | 2003 | Hepatology2003，，4： | 1 |
| 13 | Outcomes in adult recipients of right-sided liver grafts in split-liver procedures显示文摘 | Vigan L Laurent A Tayar C | | 0，，： | 1 |
| 14 | Successful medical treatment of multiple brain abscesses due to Nocardia farcinica in a paediatric renal transplant recipient显示文摘 | Sara Maria Viganò Alberto Edefonti Mariano Ferraresso Maria Luisa Ranzi Paolo Grossi Andrea Righini Roberto Rusconi Luigi Santambrogio Luciana Ghio | 2005 | Pediatric Nephrology2005，，8： | 1 |
| 15 | Incidence of surgical site infections in general surgery in Italy显示文摘 | Fiorio M Marvaso A ViganòF | 2006 | Infection2006，34，6： | 1 |
| 16 | Tenofovir- induced Fanconi syndrome in chronic hepatitis B monoinfected patients that reverted after tenofovir withdrawal显示文摘 | VIGAN) M BROCCHIERI A SPINETTI A | 2014 | J Clin Virol2014，61，4： | 1 |
| 17 | Assessment of the environmental significance of heavy metal pollution in surficial sediments of the River Po显示文摘 | Farkas A Erratico C Vigan L | 2007 | Chemosphere2007，68，4： | 1 |
| 18 | Major liver resectionssynchronous with colorectal surgery显示文摘 | Capussotti L Ferrero A ViganòL | 2007 | Ann Surg Oncol2007，14，1： | 1 |
| 19 | Surgery for endometriosis-associated infertility: a pragmatic approach显示文摘 | Vercellini P Somigliana E Vigan b P | 2009 | Hum Reprod2009，24，2： | 1 |
| 20 | Cycling and early pregnant endometrium as a site of regulated expression of the vitamin D system显示文摘 | Vigan P Lattuada D Mangioni S | | 0，，03： | 1 |
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