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18篇 您的检索式：作者名="Vignaud J"

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		题名	作者	年代	出处	被引量
	1	Characterization of two rat models of cystic fibrosis—KO and F508del CFTR—Generated by Crispr-Cas9显示文摘Background: Genetically engineered animals are essential for gaining a proper understanding of the disease mechanisms of cystic fibrosis(CF). The rat is a relevant laboratory model for CF because of its zootechnical capacity, size, and airway characteristics, including the presence of submucosal glands.Methods: We describe the generation of a CF rat model(F508 del) homozygous for the p.Phe508 del mutation in the transmembrane conductance regulator(Cftr) gene. This model was compared to new Cftr-/-rats(CFTR KO). Target organs in CF were examined by histological staining of tissue sections and tooth enamel was quantified by micro-computed tomography. The activity of CFTR was evaluated by nasal potential difference(NPD) and short-circuit current measurements. The effect of VX-809 and VX-770 was analyzed on nasal epithelial primary cell cultures from F508 del rats.Results: Both newborn F508 del and Knock out(KO) animals developed intestinal obstruction that could be partly compensated by special diet combined with an osmotic laxative. The two rat models exhibited CF phenotypic anomalies such as vas deferens agenesis and tooth enamel defects. Histology of the intestine, pancreas, liver, and lungs was normal. Absence of CFTR function in KO rats was confirmed ex vivo by short-circuit current measurements on colon mucosae and in vivo by NPD, whereas residual CFTR activity was observed in F508 del rats. Exposure of F508 del CFTR nasal primary cultures to a combination of VX-809 and VX-770 improved CFTR-mediated Cl-transport.Conclusions: The F508 del rats reproduce the phenotypes observed in CFTR KO animals and represent a novel resource to advance the development of CF therapeutics.	Elise Dreano Marc Bacchetta Juliette Simonin Louise Galmiche Claire Usal Lotfi Slimani Jérémy Sadoine Laurent Tesson Ignacio Anegon Jean-Paul Concordet Aurélie Hatton Lucile Vignaud Danielle Tondelier Isabelle Sermet-Gaudelus Marc Chanson Charles-Henry Cottart	2019	Animal Models and Experimental Medicine2019，2，4：	3
	2	Imaging of the vestibule显示文摘	Vignaud J Marsot - Dupuch K Pharaboz C	1995	Otolaryngol Head Neck Surg1995，112，1：	1
	3	Automation of metabolic stability studies in microsomes, cytosol and plasma using a 215 Gilson liquid handler显示文摘	Linget J M du Vignaud P	1999	J Pharm Biomed Anal1999，19，6：	1
	4	Presence of platelet-derived growth factor in normal and fibrotic lung is specifically associ ated with interstitial macrophages,while both interstitial macrophages and alveolar epithelial cells express the c-sis proto-oncogene显示文摘	M Allam N Martinet	1991	Am J Respir Cell Mol Biol1991，5，：	1
	5	Vascular en- dothelial growth factor gene and protein: strong expression in thyroiditis and thyroid carcinoma显示文摘	KLEIN M PICARD E VIGNAUD J M	1999	J Endocrinol1999，161，1：	1
	6	SYT-SSX fusion is absent in sarcomatoid mesothelioma allowing its distinction from synovial sarcoma of the pleura显示文摘	Weinbreck N Vignaud J M Begueret H	2007	Mod Pathol2007，20，6：	1
	7	Microdoppler analysis of wheels and pedestrians in ISAR imaging显示文摘	Ghaleb A Vignaud J M Nicolas	2008	lET Signal Process2008，2，3：	1
	8	The role of cyto- kines in human lung fibrosis显示文摘	VAILLANT P MENARD O VIGNAUD J M	1996	Monaldi Arch Chest Dis1996，51，2：	1
	9	In situ hybridization fro localization of mRNAs in mononuclear phagocytes in cell culture and tissue sections显示文摘	Vignaud J M Martinet N Martinet Y	1994	J Immunol Methads1994，174，12：	1
	10	Mi-cro-Doppler analysis of wheels and pedestrians in ISAR imaging显示文摘	GHALEB A VIGNAUD L NICOLAS J M	2008	IET Signal Process2008，2，3：	1
	11	Phlebotomographies simultanees du sinus caverneux 显示文摘	Vignaud J Clay CL Kujas A	1972	Neurochirurgie1972，18，：	1
	12	Obstructive congenital gingival granular cell tumor显示文摘	Charrier J B Droulle P Vignaud J M	2003	Ann Otol Rhinol Laryngol2003，112，4：	1
	13	Analysis of SAR Images by multidimensional wavelet transform显示文摘	OVARLEZ J P VIGNAUD L	2003	Radar sonar and navigation IEE Proceedings2003，150，4：	1
	14	Micro-doppler analysis of wheels and pedestrians in ISAR imaging显示文摘	Ghaleb A Vignaud L Nicolas J M	2008	IET signal processing2008，2，3：	1
	15	Micro- Doppler Analysis of Wheels and Pedestrians in ISAR Imaging 显示文摘	GHALEB A VIGNAUD L NICOLAS J M	2008	IET Signal Processing2008，2，3：	1
	16	Micro-Doppler analysis of wheels and pedestrians in ISAR imaging显示文摘	Ghaleb A Vignaud L and Nicolas J M	2008	IET Signal Processing2008，2，3：	1
	17	Micro-Doppler analysis of wheels and pedestrians in ISAR imaging显示文摘	Ghaleb A Vignaud J	2008	IET Signal Processing2008，2，3：	1
	18	Microsatellite analyses of blacktip reef sharks(Carcharhinus melanopterus)in a fragmented environment show structured clusters显示文摘	Vignaud T Clua E Mourier J	2013	PLoS One2013，8，61：	1

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