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| 1 | Impact of gut microbiome in the development and treatment of pancreatic cancer:Newer insights显示文摘The gut microbiome plays an important role in the variation of pharmacologic response.This aspect is especially important in the era of precision medicine,where understanding how and to what extent the gut microbiome interacts with drugs and their actions will be key to individualizing therapy.The impact of the composition of the gut microbiome on the efficacy of newer cancer therapies such as immune checkpoint inhibitors and chimeric antigen receptor T-cell treatment has become an active area of research.Pancreatic adenocarcinoma(PAC)has a poor prognosis even in those with potentially resectable disease,and treatment options are very limited.Newer studies have concluded that there is a synergistic effect for immunotherapy in combination with cytotoxic drugs,in the treatment of PAC.A variety of commensal microbiota can affect the efficacy of conventional chemotherapy and immunotherapy by modulating the tumor microenvironment in the treatment of PAC.This review will provide newer insights on the impact that alterations made in the gut microbial system have in the development and treatment of PAC. | Ayrton I Bangolo Chinmay Trivedi Ishan Jani Silvanna Pender Hirra Khalid Budoor Alqinai Alina Intisar Karamvir Randhawa Joseph Moore Nicoleta De Deugd Shaji Faisal SuchithBoodgere Suresh Parva Gopani Vignesh K Nagesh Tracy Proverbs-Singh Simcha Weissman | 2023 | World Journal of Gastroenterology2023，29，25： | 2 |
| 2 | A comparative study on the binding of single and double chain surfactant-cobalt(Ⅲ) complexes with bovine serum albumin显示文摘 | VIGNESH G SUGUMAR K ARUNACHALAM S | 2013 | Spectrochimica Acta Part A:Molecular and Biomolecular Spectroscopy2013，113，： | 1 |
| 3 | Suganthi fabrication of CdS and CuWO, modified TiO2 nanoparticles and its photocatalytic activity under visible light irradiation显示文摘 | Vignesh K Priyanka R Hariharan R | 2014 | Journal of Industrial and Engineering Chemistry2014，，2： | 1 |
| 4 | Metallur- gical and mechanical characterization of electron beam welded su- per-duplex stainless steel UNS 32750 显示文摘 | RAMKUMAR K D MISHRA D VIGNESH M K | 2014 | Journal of Manufacturing Pr-esses2014，16，4： | 1 |
| 5 | A comparative study on the binding of single and double chain surfactant-cobah (III) complexes with bovine serum albumin 显示文摘 | VIGNESH G SUGUMAR K ARUNACHALAM S | 2013 | Spectrochimica Acta Part A : Molecular and Biomolecular Spectroscopy2013，113，： | 1 |
| 6 | Evaluation of larvicidal activity of the aerial extracts of a medicinal plant, Ammannia baccifera (Linn) against two important species of mosquitoes, Aedes aegypti and Culex quinquefasciatus显示文摘 | TY Suman D Elumalai A Vignesh PK Kaleena K Murugesan | 2012 | Asian Pacific Journal of Tropical Disease2012，，： | 1 |
| 7 | Chitosan DNA nanoparticles for oral gene delivery显示文摘Gene therapy is a promising technology with potential applications in the treatment of medical conditions, both congenital and acquired. Despite its label as breakthrough technology for the 21 st century, the simple concept of gene therapy- the introduction of a functional copy of desired genes in affected individuals- is proving to be more challenging than expected. Oral gene delivery has shown intriguing results and warrants further exploration. In particular, oral administration of chitosan DNA nanoparticles, one the most commonly used formulations of therapeutic DNA, has repeatedly demonstrated successful in vitro and in vivo gene transfection. While oral gene therapy has shown immense promise as treatment options in a variety of diseases, there are still significant barriers to overcome before it can be considered for clinical applications. In this review we provide an overview of the physiologic challenges facing the use of chitosan DNA nanoparticles for oral gene delivery at both the extracellular and intracellular level. From administration at the oral cavity, chitosan nanoparticles must traverse the gastrointestinal tract and protect its DNA contents from significant jumps in pH levels, various intestinal digestive enzymes, thick mucus layers with high turnover, and a proteinaceous glycocalyx meshwork. Once these extracellular barriers are overcome, chitosan DNA nanoparticles must enter intestinal cells, escape endolysosomes, and disassociate from genetic material at the appropriate time allowing transport of genetic material into the nucleus to deliver a therapeutic effect. The properties of chitosan nanoparticles and modified nanoparticles are discussed in this review. An understanding of the barriers to oral gene delivery and how to overcome them would be invaluable for future gene therapy development. | Bhavika J Patel Nithin K Vignesh Gonzalo Hortelano | 2016 | World Journal of Medical Genetics2016，6，3： | 0 |
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