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| 1 | Probiotic Leuconostoc mesenteroides ssp. cremoris and Streptococcus thermophilus induce IL-12 and IFN-γ production显示文摘AIM: To investigate the capacity of potentially probiotic strains from six bacterial genera to induce cytokine production alone or in combinations in order to identify potential enhancing or synergistic effects in order to select probiotic bacteria for in vivo purposes. METHODS: Cytokine production in human peripheral blood mononuclear cells (PBMC) in response to stimulation with eleven different potentially probiotic bacterial strains from Streptococcus , Lactobacillus , Bifidobacterium , Lactococcus , Leuconostoc and Propionibacterium genera was analysed. Production and mRNA expression of TNF-α, IL-12, IFN-γ and IL-10 were determined by ELISA and Northern blotting, respectively. RESULTS: All tested bacteria induced TNF-α production. The best inducers of Th1 type cytokines IL-12 and IFN-γ were Streptococcus and Leuconostoc strains. All Bifidobacterium and Propionibacterium strains induced higher IL-10 production than other studied bacteria. Stimulation of PBMC with any bacterial combinations did not result in enhanced cytokine production suggesting that different bacteria whether gram-positive or gram- negative compete with each other during host cell interactions.CONCLUSION: The probiotic S. thermophilus and Leuconostoc strains are more potent inducers of Th1 type cytokines IL-12 and IFN-γ than the probiotic Lactobacillus strains. Bacterial combinations did not result in enhanced cytokine production. | Riina A Kekkonen Elina Kajasto Minja Miettinen Ville Veckman Riitta Korpela Ilkka Julkunen | 2008 | World Journal of Gastroenterology2008，14，8： | 9 |
| 2 | Potentially probiotic bacteria induce efficient maturation but differential cytokine production in human monocyte-derived dendritic cells显示文摘AIM: To analyze the ability of nine different potentially probiotic bacteria to induce maturation and cytokine production in human monocyte-derived dendritic cells (moDCs). METHODS: Cytokine production and maturation of moDCs in response to bacterial stimulation was analyzed with enzyme-linked immunosorbent assay (ELISA) and flow cytometric analysis (FACS), respectively. The kinetics of mRNA expression of cytokine genes was determined by Northern blotting. The involvement of different signaling pathways in cytokine gene expression was studied using specific pharmacological signaling inhibitors. RESULTS: All studied bacteria induced the maturation of moDCs in a dose-dependent manner. More detailed analysis with S. thermophilus THS, B. breve Bb99, and L. lactis subsp. cremoris ARH74 indicated that these bacteria induced the expression of moDC maturationmarkers HLA class Ⅱ and CD86 as efficiently as pathogenic bacteria. However, these bacteria differed in their ability to induce moDC cytokine gene expression. S. thermophilus induced the expression of pro-inflammatory (TNF-α, IL-12, IL-6, and CCL20) and Th1 type (IL-12 and IFN-γ) cytokines, while B. breve and L. lactis were also potent inducers of anti- inflammatory IL-10. Mitogen-activated protein kinase (MAPK) p38, phosphatidylinositol 3 (PI3) kinase, and nuclear factor-kappa B (NF-κB) signaling pathways were shown to be involved in bacteria-induced cytokine production. CONCLUSION: Our results indicate that potentially probiotic bacteria are able to induce moDC maturation, but their ability to induce cytokine gene expression varies significantly from one bacterial strain to another. | Sinikka Latvala Taija E Pietil Ville Veckman Riina A Kekkonen Soile Tynkkynen Riitta Korpela Ilkka Julkunen | 2008 | World Journal of Gastroenterology2008，14，36： | 8 |
| 3 | Erosion and cavitation-corrosion of titanium and its alloys显示文摘 | Ville A Ne Mc Dougall B A B | 2001 | Wear2001，250，： | 1 |
| 4 | Remifentanil versus morphine-mi- dazolam premedication on the quality of endotracheal intubation in neonates :a noninferiority randomized trial显示文摘 | Avino D Zhang WH De Vill~ A | 2014 | J Pediatr2014，164，5： | 1 |
| 5 | Update on twin-to-twin transfusion syndrome显示文摘 | El Kateb A Ville Y | 2008 | Best Pract Res Clin Obstet Gynaecol2008，22，1： | 1 |
| 6 | Effect of lubricant contamination on friction and wear in an EHL sliding con- tact 显示文摘 | Sari M R Ville F Haiahem A | 2010 | Mechanika2010，2，82： | 1 |
| 7 | Long-term molecular and cellular stability of human neural stem cell lines显示文摘 | Vill A Bueno C Frcuso S | 2004 | Ex- peri-mental Cell Research2004，294，： | 1 |
| 8 | A probability-based approach for high-throughput protein phosphorylation analysis and site localization显示文摘 | Beausoleil S A Villén J Gerber S A Rush J Gygi S P | | 0，，10： | 1 |
| 9 | THE ARTERIAL SYSTEM OF THE FIRST INTERMETATARSAL SPACE AND ITS INFLUENCE IN TOE-TO-HAND TRANSFER: A REPORT OF 53 LONG-PEDICLE TRANSFERS显示文摘 | G. MARTNEZ VILLéN G. GARCíA JULVE | 2002 | Journal of Hand Surgery2002，，1： | 1 |
| 10 | Exerahepatic glucuronidation of propofol in man: possible contribution of gut wall and kidney显示文摘 | Raoof A A Obbergh L J Ville G J | 1996 | Eur J Clin Pharmacol1996，50，12： | 1 |
| 11 | Enblock combined reduced-liver and small boewl transplants:from large donors to small children显示文摘 | De Ville de Goyet J Mitchell A Mayer AD | 2000 | Transplantation2000，2769，4： | 1 |
| 12 | Expression of caspase-3 and structural changes associated with apoptotic cell death of keratinocytes in oral lichen planus显示文摘 | TOBON-ARROYAVE S I VILLE GAS-ACOSTA F A RUIZ-RESTREPO S M | 2004 | Oral Diseases2004，10，3： | 1 |
| 13 | Three-dimensional solid texture analysis in biomedical imaging:Re-view and opportunities显示文摘 | Depeursinge A Foncubierta R A Van de Ville D | 2014 | Medical Image Analysis2014，18，1： | 1 |
| 14 | Update on twin-to-twin transfusion syndrome 显示文摘 | El Kateb A Ville Y | 2008 | Best Pract Res Clin Obstet Gynaecol2008，22，1： | 1 |
| 15 | Interleukin-6-deficient mice develop mature-onset obesity显示文摘 | Ville W Kristian W Bo A | 2002 | Nature Medicine2002，8，1： | 1 |
| 16 | Prognostic impact of isoeitrate dehydrogenase enzyme isoforms 1 and 2 mutations in acute myeloid leukemia: a study by the Acute Leukemia French Association group显示文摘 | Boissel N Nibourel O Renne'ville A | 2010 | J Clin Oneol2010，28，23： | 1 |
| 17 | Insulin/IGF-1 signaling regulates proteasome activity through the deubiquitinating enzyme UBH-4显示文摘 | OLLI M LEENA A VILLE R | 2013 | Cell Reports2013，3，6： | 1 |
| 18 | Remifentanil versus morphine-midazolam premedication on the quality of endotraeheal intubation in neonates: a noninferiority randomized trial 显示文摘 | AVINO D ZHANG WH DE VILLE A | 2014 | J Pediatr2014，164，5： | 1 |
| 19 | Remifentanil versus morphine-midazolam premedication on the quality of endotracheal intubation in neonates: a noninferiority randomized trial显示文摘 | Avino D Zhang WH De Villé A | 2014 | J Pediatr2014，164，5： | 1 |
| 20 | A probability-based approach for high-throghput protein phosphorylation analysis and site localization显示文摘 | BEAUSOLEI S A VILL(E)N J GERBERS | | 0，，： | 1 |
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