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| 1 | Medicinal plants and natural products as neuroprotective agents in age-related macular degeneration显示文摘The retina may suffer neurodegenerative damages,as other tissues of the central nervous system do,and serious eye diseases may develop.One of them is age-related macular degeneration,which causes progressive loss of vision due to retina degeneration.Treatment of age-related macular degeneration focuses on antioxidant agents and anti-vascular endothelial growth factor compounds,among others,that prevent/diminish oxidative stress and reduce neovascularisation respectively.The phytochemicals,medicinal plants and/or plant-diet supplements might be a useful adjunct in prevention or treatment of age-related macular degeneration owing to their antioxidant and anti-vascular endothelial growth factor properties.This review article presents the most investigated plants and natural products in relation to age-related macular degeneration,such as saffron,ginkgo,bilberry and blueberry,curcuma or turmeric,carotenoids,polyphenols,and vitamins C and E.This study provides up-to-date information on the effects,treatments,safety and efficiency of these phytotherapy products. | Francisco Bosch-Morell Victoria Villagrasa Teresa Ortega Nuria Acero Dolores Muñoz-Mingarro MEugenia González-Rosende Encarna Castillo MAmparo Sanahuja Pilar Soriano Isabel Martínez-Solís | 2020 | Neural Regeneration Research2020，15，12： | 2 |
| 2 | Akt2 interacts with Snaill in the E -cadherin promoter 显示文摘 | Villagrasa P Diaz VM Villas - Castells R | 2012 | Oncogene2012，31，36： | 1 |
| 3 | , Matrix effect in liquid chromatography-electrospray ionization mass spectrometry analysis of benzoxazinoid derivatives in plant material 显示文摘 | Villagrasa M Guillamon M Eljarrat E | 2007 | Journal of Chromatography A2007，1157，12： | 1 |
| 4 | Matrix effect in liquid chromatography–electrospray ionization mass spectrometry analysis of benzoxazinoid derivatives in plant material显示文摘 | M. Villagrasa M. Guillamón E. Eljarrat D. Barceló | 2007 | Journal of Chromatography A2007，，1： | 1 |
| 5 | Inhibitory effects of N-acetycysteine on superoxide anion generation in human polymorphonuclearleukocytes显示文摘 | Villagrasa V Cortijo J Marti-Cabrera M | 1997 | Pharm Pharmacol1997，49，5： | 1 |
| 6 | Environmental an alysis of fluorinated alkyl substances by liquid chromatography -(tandem) mass s pectrometry:a review显示文摘 | VILLAGRASA Marta LOPEZ de Alda Maria BARCELO Damia | 2006 | Anal Bioanal Chem2006，，386： | 1 |
| 7 | Exosomes derived from breast cancer cells, small trojan horses? 显示文摘 | Villagrasa A Alvarez PJ Osuna A | 2014 | J Mammary Gland Biol Neoplasia2014，19，34： | 1 |
| 8 | Environmental analysis of fluorinated alkyl substances by liquid chromatography- (tandem) mass spectrometry: a review显示文摘 | Villagrasa M L6pez de Alda M Barcel6 D | 2006 | Anal Bioanal Chem2006，386，4： | 1 |
| 9 | Carriers of hepati tis C: should they all be vaccinated for hepatitis A显示文摘 | Sans M Eseorza S Villagrasa D | 2002 | Aten Primaria2002，3030，2： | 1 |
| 10 | Giant cell myocarditis: Monocytic immunophenotype of giant cells in a case associated with ulcerative colitis显示文摘 | Aurelio Ariza M.Dolores López JoséL Mate Antoni Curós María Villagrasa JoséJ Navas-palacios | 1995 | Human Pathology1995，，1： | 1 |
| 11 | Inhibitory effects of N-acetylcysteine on superoxide anion generation in human polymorphonuclear leukocytes显示文摘 | VILLAGRASA V CORTIJIO J MARTI-CABRERA M | 1977 | J Pharm Pharmacol1977，49，5： | 1 |
| 12 | Exosomes de- rived from breast cancer cells,small Trojan horses? 显示文摘 | Villagrasa A Alvarez PJ Osuna A | 2014 | JMammary Gland Biol Neoplasia2014，19，34： | 1 |
| 13 | Barcelona Scoliosis Physical Therapy School - BSPTS- Based on classical Schroth principles: short term effects on back asymmetry in idiopathic scoliosis显示文摘 | Jelacic M Villagrasa M Pou E | 2012 | Scoliosis2012，7，1： | 1 |
| 14 | Environmental analysis of fluorinated alkyl substances by liquid chromatography-(tandem) mass spectrometry: A review 显示文摘 | Villagrasa M L6pez de Alda M Barcel6 D | 2006 | Analytical and Bioanalytical Chemistry2006，386，4： | 1 |
| 15 | Environmental analysis of fluorinated alkyl substances by liquid chromatography-(tandem) mass spectrometry: a review显示文摘 | M Villagrasa M Lopez de Aida D Barcelo | 2006 | Anal Bioanal Chem2006，386，4： | 1 |
| 16 | Effects of erythromycin on chemoattractant-activated human polymorphonuclear leukocytes显示文摘 | Villagrasa V Berto L Cortijo J | | 0，，04： | 1 |
| 17 | Detection of KRAS G12D in colorectal cancer stool by droplet digital PCR显示文摘AIM To assess KRAS G12 D mutation detection by droplet digital PCR(dd PCR) in stool-derived DNA from colorectal cancer(CRC) patients.METHODS In this study, tumor tissue and stool samples were collected from 70 patients with stage Ⅰ-Ⅳ CRC diagnosed by preoperative biopsy. KRAS mutational status was determined by pyrosequencing analysis of DNA obtained from formalin-fixed paraffinembedded(FFPE) tumor tissues. The KRAS G12 D mutation was then analyzed by dd PCR in FFPE tumors and stool-derived DNA from patients with this point mutation. Wild-type(WT) tumors, as determined by pyrosequencing, were included as controls; analysis of FFPE tissue and stool-derived DNA by dd PCR was performed for these patients as well.RESULTS Among the total 70 patients included, KRAS mutations were detected by pyrosequencing in 32(45.71%), whereas 38(54.29%) had WT tumors. The frequency of KRAS mutations was higher in left-sided tumors(11 located in the right colon, 15 in the left, and 6 in the rectum). The predominant point mutation was KRAS G12 D(14.29%, n = 10), which was more frequent in early-stage tumors(I-IIA, n = 7). In agreement with pyrosequencing results, the KRAS G12 D mutation was detected by dd PCR in FFPE tumor-derived DNA, and only a residual number of mutated copies was found in WT controls. The KRAS G12 D mutation was also detected in stool-derived DNA in 80% of all fecal samples from CRC patients with this point mutation. CONCLUSION dd PCR is a reliable and sensitive method to analyze KRAS G12 D mutation in stool-derived DNA from CRC patients, especially at early stages. This non-invasive approach is potentially applicable to other relevant biomarkers for CRC management. | Susana Olmedillas-López Dennis César Lévano-Linares Carmen Laura Aúz Alexandre Luz Vega-Clemente Edurne León Sánchez Alejandro Villagrasa Jaime Ruíz-Tovar Mariano García-Arranz Damián García-Olmo | 2017 | World Journal of Gastroenterology2017，23，39： | 0 |
| 18 | Kinetic and morphology study of alginate-vineyard pruning waste biocomposite vs. non modified vineyard pruning waste for dye removal显示文摘In this work a comparative bioadsorption study between a biocomposite consisting of hydrolysed vineyard pruning waste entrapped in calcium alginate spheres and non entrapped vineyard residue was carried out.Results have demonstrated that the biocomposite based on lignocellulose-calcium alginate spheres removed 77.3% of dyes,while non entrapped lignocellulose eliminated only removed 27.8% of colour compounds.The experimental data were fitted to several kinetic models(pseudo-first order,pseudo-second order,Chien–Clayton model,intraparticle diffusion model and Bangham model); being pseudo-second order the kinetic model that better described the adsorption of dyes onto both bioadsorbents.In addition,a morphological study(roughness and shape) of alginate-vineyard biocomposite was established under extreme conditions,observing significant differences between hydrated and dehydrated alginate-vineyard biocomposite.The techniques used to carry out this morphological study consisted of scanning electron microscopy(SEM),perfilometry and 3D surface analysis. | Xanel Vecino Rosa Devesa-Rey Salvador Villagrasa Jose M.Cruz Ana B.Moldes | 2015 | Journal of Environmental Sciences2015，27，12： | 0 |
| 19 | Methotrexate induced sprue-like syndrome显示文摘A 52 year-old male patient diagnosed of ankylosing spon-dylitis presented with an iron deficiency anemia after a ten-month treatment of methotrexate. He did not respond to treatment with oral iron not a proton pump inhibitor and an upper endoscopy was performed. The histological study of the duodenal biopsies showed villus atrophy. After removing the methotrexate, administrating intra-muscular iron and undertaking a gluten-free diet, the histological and analytical alterations progressively resolved. | Marta Maia Boscá Ramon Aón Rosana Villagrasa Nelly Balza Cirilo Amorós Adolfo Benages Empar Mayordomo Juan Ramon Corts | 2008 | World Journal of Gastroenterology2008，14，45： | 0 |
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