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| 1 | 髋关节圆韧带损伤的关节镜诊断与治疗显示文摘目的探讨髋关节圆韧带损伤的关节镜下分型并观察其手术疗效。方法68例患者均为1990年2月~1999年12月经关节镜确诊的髋关节圆韧带损伤患者,共73髋。按镜下所见分为髋关节圆韧带完全离断28例28髋、部分离断28例32髋和退行性变12例13髋三组,分别施以关节镜下残端切除术、韧带修整术和关节清理术,平均随访42个月。结果具备完整随访资料者32例34髋,髋关节圆韧带完全离断组随访9例9髋,部分离断组随访13例15髋,退行性变组随访10例髋。三组患者术后髋关节改良Harris评分均较术前显著提高,差异有显著性意义P<0.05或P0.01。结论髋关节镜技术是诊断、治疗髋关节圆韧带损伤的有效手段。 | 周一新 Richard N Villar 周乙雄 张洪 | 2001 | 中华骨科杂志2001，21，7： | 7 |
| 2 | Anticancer effect of linalool via cancer-specific hydroxyl radical generation in human colon cancer显示文摘AIM To investigate the anticancer mechanisms of the monoterpenoid alcohol linalool in human colon cancer cells.METHODS The cytotoxic effect of linalool on the human colon cancer cell lines and a human fibroblast cell line was examined using the WST-8 assay. The apoptosisinducing effect of linalool was measured using the terminal deoxynucleotidyl transferase d UTP nickend labeling assay and flow cytometry with Annexin V. Oxidative stress was investigated by staining for diphenyl-1-pyrenylphosphine, which is a cellular lipid peroxidation marker, and electron spin resonance spectroscopy. Sixteen SCID mice xenografted with human cancer cells were randomized into 3 groups for in vivo analysis: control and low-dose and high-dose linalool groups. The control group was administered tap water orally every 3 d. The linalool treatment groups were administered 100 or 200 μg/kg linalool solution orally for the same period. All mice were sacrificed under anesthesia 21 d after tumor inoculation, and tumors and organs were collected for immunohistochemistry using an anti-4-hydroxynonenal antibody. Tumor weights were measured and compared between groups. RESULTS Linalool induced apoptosis of cancer cells in vitro, following the cancer-specific induction of oxidative stress, which was measured based on spontaneous hydroxyl radical production and delayed lipid peroxidation. Mice in the high-dose linalool group exhibited a 55% reduction in mean xenograft tumor weight compared with mice in the control group(P < 0.05). In addition, tumor-specific lipid peroxidation was observed in the in vivo model.CONCLUSION Linalool exhibited an anticancer effect via cancerspecific oxidative stress, and this agent has potential for application in colon cancer therapy. | Kenichi Iwasaki Yun-Wen Zheng Soichiro Murata Hiromu Ito Ken Nakayama Tomohiro Kurokawa Naoki Sano Takeshi Nowatari Myra O Villareal Yumiko N Nagano Hiroko Isoda Hirofumi Matsui Nobuhiro Ohkohchi | 2016 | World Journal of Gastroenterology2016，22，44： | 5 |
| 3 | Antioxidant properties of phenolic compounds occurring in edible mushrooms显示文摘 | I. Palacios M. Lozano C. Moro M. D’Arrigo M.A. Rostagno J.A. Martínez A. García-Lafuente E. Guillamón A. Villares | 2011 | Food Chemistry2011，，3： | 2 |
| 4 | Enhanced wheat yield by biochar addition under different mineral fertilization levels显示文摘 | José Antonio Alburquerque Pablo Salazar Vidal Barrón José Torrent María del Carmen del Campillo Antonio Gallardo Rafael Villar | 2013 | Agronomy for Sustainable Development2013，，3： | 2 |
| 5 | World Health Organization 2005 Global Survey on Maternal and Perinatal Health Research Group: Maternal and neonatal individual risks and benefits associated with caesarean delivery: multicentre prospective study显示文摘 | Villar J Carroli G Zavaleta N | 2007 | BMJ2007，335，： | 1 |
| 6 | TP53 R249S mutation, genetic variations in HBX and risk of hepatocellular carcinoma in The Gambia显示文摘 | Doriane A. Gouas Stéphanie Villar Sandra Ortiz-Cuaran Pénélope Legros Gilles Ferro Gregory D. Kirk Olufunmilayo A. Lesi Maimuna Mendy Ebrima Bah Marlin D. Friesen John Groopman Isabelle Chemin Pierre Hainaut | 2012 | Carcinogenesis2012，，6： | 1 |
| 7 | Generating the knowledge Base of a Fuzzy rule-based system by the genetic learning of the data base 显示文摘 | CORD(O)N O HERRERA F VILLAR P | 2001 | IEEE Trans on Fuzzy Systems2001，9，4： | 1 |
| 8 | Mode of action of two inhibitory peptides from beptad repeat domains of the fusion protein of Newcastle disease virus显示文摘 | San Román K Villar E Munoz-Barroso I | 2002 | International Journal of Biochemistry & Cell Biology2002，34，10： | 1 |
| 9 | The Linus Pauling File (LPF) and Its Application to Materials Design 显示文摘 | Villars P Onodera N Iwata S | 1998 | Journal of Alloys and Compounds1998，，279： | 1 |
| 10 | Maternal and neonatal individual risks and benefits associated with caesarean delivery: multicentre prospective study 显示文摘 | Villar J Carroli G Zavaleta N | 2007 | BMJ2007，335，7628： | 1 |
| 11 | Weight loss, exercise, or both and physical function in obese olderadults显示文摘 | Villareal DT Chode S Parimi N | 2011 | N EnglJ Med2011，364，： | 1 |
| 12 | Soil compactioneffects on growth and root traits of tobacco depend onlight, water regime and mechanical stress显示文摘 | Alameda D Anten N P R Villar R | 2012 | SOIL &TILLAGE RESEARCH2012，120，： | 1 |
| 13 | Individualism and collectivism:Cross-cultrual perspectives on seff-ingroup relationships显示文摘 | Triandis H.C Bontempo R Villareal M.J Asai M & Lucca N | | 0，，： | 1 |
| 14 | Activation ofthe Wnt/p-Catenin signaling pathway by mechanicalventilation is associated with ventilator-induced pulmo-nary fibrosis in healthy lungs 显示文摘 | Villar J Cabrera N E Valladares F el al | 2011 | PLoS ONE2011，6，23： | 1 |
| 15 | Mechanical ventilation modu- lates Toll-like receptor signaling pathway in a sepsis-induced lung injury model显示文摘 | Villar J Cabrera N Casula M | 2010 | Intensive Care Med2010，36，6： | 1 |
| 16 | Myocardial and circulating levels of microRNA-21 reflect left ventricular fibrosis in aortic stenosis patients显示文摘 | Ana V. Villar Raquel García David Merino Miguel Llano Manuel Cobo Cecilia Montalvo Rafael Martín-Durán María A. Hurlé J. Francisco Nistal | 2012 | International Journal of Cardiology2012，，： | 1 |
| 17 | Rice amylose analysis by near-infrared tranmittance spectroscopy显示文摘 | Villareal C P Delacruz N M Juliano B O | 1994 | Cereal Chem1994，71，3： | 1 |
| 18 | Rapid and high sensitivity test for direct detection of bovine herpesvlrus-1 genome in clinical samples显示文摘 | Santurde G Da Silva N Villares R | 1996 | Vet Microbiol1996，49，： | 1 |
| 19 | Acetabular labral tears:result of arthroscopic partial limbectomy显示文摘 | Santori N Villar RN | 2000 | Arthroscopy2000，16，： | 1 |
| 20 | Genome-wide identification of hypoxia-inducible factor binding sites and target genes by a probabilistic model integrating transcription-profiling data and in silico binding site prediction 显示文摘 | Ortiz-Barahona A Villar D Pescador N | 2010 | Nucleic Acids Res2010，38，7： | 1 |
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