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1“梦想”普通话标准化评估在听障儿童语言测试中的应用显示文摘目的本文讨论了用口语交流的听障儿童语言发展效果评估的最新实证。方法研究强调,语言评估须足够具体,才能捕捉到细微的词汇及语法缺陷。'普通话听力理解和表达能力标准化评估'(Diagnostic Receptive and Expressive Assessment of Mandarin,DREAM,译为'梦想')抓住儿童普通话习得的核心特征,是基于中国大陆地区的普通话儿童来建立常模的综合性的语言测试,可以测量中国大陆儿童在各个年龄阶段的语言技能。声音和图片通过平板电脑呈现,答案以触屏的方式进行记录,减少了人为差异,使操作更加标准化。结果本文报告了DREAM的题目设计、信度和效度研究等内容。试验研究显示,该测试可提供听障儿童语言发展的详细信息。测试可提供诊断儿童具体语言发育缺陷的报告,用来指导康复计划的制定,使更加个性化的康复干预成为可能。结论 DREAM是转化科学的成功范例——把科研结果从语言习得的循证研究转移到临床评估和干预康复的应用领域。以循证医学为基础的综合性普通话语言测试将推动中国听障儿童干预和康复的效果评估研究。刘雪曼 de Villiers,Jill 宁春岩 Rolfhus,Eric Hutchings,Teresa Lee,Wendy 江帆 章依文 2015中华耳科学杂志2015,13,4:7
2New language outcome measures for Mandarin speaking children with hearing loss显示文摘Objective:The paper discusses recent evidence on the assessment of language outcomes in children with hearing loss acquiring oral language.Methods:Research emphasizes that language tests must be specific enough to capture subtle deficits in vocabulary and grammar learning at different developmental ages.The Diagnostic Receptive and Expressive Assessment of Mandarin(DREAM) was carefully designed to be a comprehensive standardized Mandarin assessment normed in China's Mainland.Objective:The paper discusses recent evidence on the assessment of language outcomes in children with hearing loss acquiring oral language.Methods:Research emphasizes that language tests must be specific enough to capture subtle deficits in vocabulary and grammar learning at different developmental ages.The Diagnostic Receptive and Expressive Assessment of Mandarin(DREAM)was carefully designed to be a comprehensive standardized Mandarin assessment normed in China's Mainland.Results:This paper summarizes the evidence-based item design process and validity and reliability results of DREAM.A pilot study reported here shows that DREAM provided detailed information about hearing impaired children's language abilities and can be used to aid intervention planning to maximize progress.Conclusion:DREAM represents an example of translational science,transferring methods from empirical studies of language acquisition in research environments into applied domains such as assessment and intervention.Research on outcomes in China will advance significantly with the availability of evidence-based comprehensive language tests that measure a sufficient age range of skills,are normed on Mandarin speaking children in China's Mainland,and are designed to capture features central to Mandarin language acquisition.Xueman Liu Jill de Villiers Wendy Lee Chunyan Ning Eric Rolfhus Teresa Hutchings Fan Jiang Yiwen Zhang 2016Journal of Otology2016,11,1:4
3Long‐term infliximab maintenance therapy for ulcerative colitis: The ACT‐1 and ‐2 extension studies显示文摘WalterReinisch William J.Sandborn PaulRutgeerts Brian G.Feagan DanielRachmilewitz Stephen B.Hanauer Gary R.Lichtenstein Willem J.S.de Villiers MarionBlank YinghuaLang JewelJohanns Jean FrédéricColombel DanielPresent Bruce E.Sands 2012Inflamm Bowel Dis2012,,2:3
4Lessons from French national guidelines on the treatment of venous thrombosis and central venous catheter thrombosis in cancer patients显示文摘Dominique Farge Cecile Durant Stéphane Villiers Anne Long Alfred Mahr Michel Marty Philippe Debourdeau 2010Thrombosis Research2010,,:2
5Effect of rapamycin on hepatic osteodystrophy in rats with portasystemic shunting显示文摘瞄准:如果与推延的 portasystemic 有关的 T 房间激活通过 RANKL 依赖的小径引起调停骨破折的骨头损失,学习。如果用 rapamycin 的 T 房间抑制将在老鼠免于骨头损失,我们也调查了。方法:推延的 Portasystemic 在男 Sprague-Dawley 老鼠和 rapamycin 被执行 0.1 mg/kg 被管饲法为 15 wk 管理。老鼠收到了 powderized 食物并且补加喂在骨头作文上阻止营养不良的效果。重量获得和生长在推延的动物在外科以后被恢复。在结束,骨头周转和量的骨头组织学的生物化学的参数被估计。T 房间激活,煽动性的 cytokine 生产,和 RANKL 依赖的小径的标记被测量。另外, IGF-1 和性腺机能减退的角色被调查。结果:推延的 Portasystemic 引起了是 RANKL 独立人士的低周转骨质疏松症。包括 IL-1, IL-6 和 TNFalpha,骨头再吞 cytokine 层次没在浆液和 TNFalpha 被增加, RANKL 表示不起来在 PBMC 调整了。推延的 Portasystemic 增加了传播 CD8+T 房间人口。Rapamycin 减少了传播 CD8+T 房间人口,增加了 CD8+CD25+T 规章的房间人口并且改进了骨头周转的所有参数。结论:推延的 portasystemic 引起的骨质疏松症可以被 rapamycin 部分在肝的骨营养不良的老鼠模型改善。Schalk W van der Merwe Maria M Conradie Robert Bond Brenda J Olivier Elongo Fritz Martin Nieuwoudt Rhena Delport Tomas Slavik Gert Engelbrecht Del Kahn Enid G Shephard Maritha J Kotze Nico P de Villiers Stephen Hough 2006World Journal of Gastroenterology2006,12,28:2
6Language and Theory of Mind: A Study of Deaf Children显示文摘BrendaSchick PeterDe Villiers JillDe Villiers RobertHoffmeister 2007Child Development2007,,2:2
7Bioavailability study of a theophylline oral controlled release capsule containing film coated mini-tablets in beagle dogs显示文摘MUNDAY D L FASSIHI A R VILLIERS D C 1991Int J Pharm1991,69,2:1
8Presence of papillomavirus sequences in condylomatous lesions of the mamillae and in invasive carcinoma of the breast显示文摘De Villiers EM Sandstrom RE zur Hausen H 2005Breast Cancer Res2005,7,1:1
9Macrophage scavenger receptors and foam cell formation 显示文摘Willem J Sde Villiers Eric JS 1999J Leukocyte Biology1999,66,5:1
10Esophageal Squamous cell cancer in paitients with head and neckcancer prevalence of human papillom virus DNA sequences显示文摘De Villiers EM Gunst K Stein H 2004Int J Cancer2004,109,2:1
11Papillomavrus and HPV typing显示文摘Ethel-Michele de Villiers 1997Biophys Acta1997,15,:1
12Degradation of microcystin toxins in a falling film photocatalytic reactor with immobilized titanium dioxide catalyst显示文摘Shephard G S Stockenstrom S Villiers D 2002Water Research2002,36,:1
13Backpropagation neural nets with one and two hidden layers显示文摘VILLIERS J D BARNARD E 1993Institute of Electri cal and Electronic Engineers Transaction on Neural Net- works1993,4,1:1
14Identification and geographic doistfibution of serotypes of Potato virus Y显示文摘Ellis P Stace-Smith R Villiers G 1997Plant disease1997,81,:1
15Relationship between steroid hormone contraceptives and HPV,cervical intraepithelial neoplasia and cervical carcinoma显示文摘de Villiers EM 2003Int J Cancer2003,103,6:1
16Mode of Aaction of Fenamidone: Similarities and Differences with Known QoI显示文摘NEUBURGER M BEFFA R VILLIER A 2003Pflanzenschutz-Nachrichten Bayer2003,56,3:1
17Pituitary Apoplexy显示文摘Semple PL Webb MK de Villiers JC 2005Neurosurgery2005,56,1:1
18Global consensus statement on menopausal hormone therapy 显示文摘Villiers TJ Gass ML Haines CJ 2013Maturitas2013,74,4:1
19Evaluation of liquid chromatography and capillary electrophoresis for the elucidation of the artificial colorants brilliant blue and azorubine in red wines 显示文摘VILLIERS A D ALBERTS F LYNEN F 2003Chromatographia2003,58,78:1
20Prevalence, size, number and localization of vascular anastomoses in monochorionic placentas显示文摘Zhao DP de Villiers SF Slaghekke F 2013Placenta2013,34,7:1
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