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| 1 | An overview of PCI in the very elderly显示文摘心血管的疾病,和特别地 ischemic 心疾病(IHD ) ,是病态和死亡的一个主要原因在老(>80 年) 世界范围。这些病人代表为经皮的冠的干预(一种总线标准) 介绍的一个很快成长的队,现在在五个病人组成超过一在真实世界的实践与一种总线标准对待。而且,他们经常比他们的更年轻的对应物有更大的 ischemic 负担,建议他们有从冠的 revascularization 治疗的利益的更大的范围。尽管有这,老在那里在临床的 revascularization 试用并且历史上经常是未被充分代表的是在为一种总线标准过程提交他们的医生勉强的度与令人失望的结果的感觉,低成功和高复杂并发症评价。几个问题贡献了这,包括为有晚介绍的 IHD 的更老的病人的趋势,与不正常的症状或关于他们的程序的 risk-to-benefit 比率的非诊断的 ECG,和保留由于更短的预期寿命,从 antiplatelet 和 anticoagulation 药的 comorbidities 和增加的流血风险的存在。然而,在在过去的十年的一种总线标准技术和技术的进展导致了更好的结果和复杂并发症和存在身体的更低的风险证据现在显示那老实际上比更年轻的人口从一种总线标准导出更相对的利益。重要地,这适用于所有一种总线标准背景:选任,迫切并且紧急情况。这评论在与长期的稳定的 IHD 的老介绍讨论一种总线标准的角色,非圣举起急性冠的症候群,和圣举起心肌的梗塞。当认为在为研究和开发的这个队和进行中的需要的一种总线标准进一步在这些挑战性的病人改进结果时,它也探讨遇见的临床的挑战。 | Vimalraj Bogana Shanmugam Richard Harper Ian Meredith Yuvaraj Malaiapan Peter J Psaltis | 2015 | Journal of Geriatric Cardiology2015，12，2： | 22 |
| 2 | Predictors of malignancy in chronic calcific pancreatitis with head mass显示文摘AIM: To prospectively analyse the clinical, biochemical and radiological characteristics of the mass lesions arising in a background of chronic calcific pancreatitis (CCP). METHODS: Eighty three patients, who presented with chronic pancreatitis (CP) and a mass lesion in the head of pancreas between February 2005 and December 2011, were included in the study. Patients who were identified to have malignancy underwent Whipple' s procedure and patients whose investigations were suggestive of a benign lesion underwent Frey's procedure. Student t-test was used to compare the mean values of imaging findings [common bile duct (CBD), main pancreatic duct (MPD) size] and laboratory data [Serum bilirubin, carbohydrate antigen 19-9 (CA 19-9)] between the groups. Receiver operating characteristic curve (ROC curve) analysis was done to calculate the cutoff valves of serum bilirubin, CA 19-9, MPD and CBD size. The sensitivity, specificity, positive predictive valve (PPV) and negative predictive value (NPV) were calculated using these cut off points. Multivariate analysis was performed using logistic regression model. RESULTS: The study included 56 men (67.5%) and 27 women (32.5%). Sixty (72.3%) patients had tropical calcific pancreatitis and 23 (27.7%) had alcohol related CCP. Histologically, it was confirmed that 55 (66.3%) of the 83 patients had an inflammatory head mass and 28 (33.7%) had a malignant head mass. The mean age of individuals with benign inflammatory mass and those with malignant mass was 38.4 years and 45 years respectively. Significant clinical features that predicted a malignant head mass in CP were presence of a head mass in CCP of tropics, old age, jaundice, sudden worsening abdominal pain, gastric outlet obstruction and significant weight loss (P ≤ 0.05). The ROC curve analysis showed a cut off value of 5.8 mg/dL for serum bilirubin, 127 U/mL for CA 19-9, 11.5 mm for MPD size and 14.5 mm for CBD size. CONCLUSION: Elevated Serum bilirubin and CA 19-9, and dilated MPD and CBD were useful in predicting malignancy in patients with CCP and head mass. | Senthilkumar Perumal Ravichandran Palaniappan Sastha Ahanatha Pillai Vimalraj Velayutham Jeswanth Sathyanesan | 2013 | World Journal of Gastrointestinal Surgery2013，5，4： | 4 |
| 3 | Bleeding outcomes after non-emergency percutaneous coronary intervention in the very elderly显示文摘BackgroundOctogenarians 组成病人为经皮的冠的干预(一种总线标准).MethodsThis 学习评估了的非紧急情况介绍的一个增加的比例在里面医院程序的特征和结果,包括为非紧急情况一种总线标准在 2010 年 1 月和 2012 年 12 月之间介绍给单个大体积的 293 octogenarians 的流血事件第三级的照顾澳大利亚人中心。比较被做, 293 个连续病人,其损害与心肌的梗塞是的 octogenarians.ResultsNon 圣举起被匹配小于等于 60 年变老为在 octogenarians 的非紧急情况一种总线标准的最经常的指示。比作更年轻的队,他们有合作病态和更复杂的冠的疾病的更高的流行,包括更多的类型 C 和钙化的损害。低分子的重量肝磷脂的仙子程序的使用(LMWH;1.0% 对 5.8% ;P < 0.001 ) 并且 glycoprotein IIb/IIIa 禁止者(2.1% 对 9.6% ;P < 0.001 ) 更低,当大腿骨的动脉的存取比在更年轻的病人更通常被使用时(80.9% 对 67.6% ;P < 0.001 ) 。总的来说,向所有流血事件在的更高的发生有一个不重要的趋势老(9.2% 对 5.8% ;P = 0.12 ) 。在存取地点或非存取地点流血和专业或在二个队之间的次要的流血没有重要差别。亚分析没在由 LMWH, glycoprotein IIb/IIIa 禁止者或大腿骨的动脉的存取的使用为率放血上揭示任何重要影响。另外,处于在二 groups.ConclusionsIn 之间的在里面医院死亡,击或尖锐 stent 血栓的率没有重要差别这单个中心研究,我们没包括在经历非紧急情况一种总线标准的 octogenarians 流血的发生在不利在里面医院结果观察重要增加。 | Vimalraj Bogana Shanmugam Dennis T Wong Hashrul Rashid James D Cameron Yuvaraj Malaiapan Peter J Psaltis | 2017 | Journal of Geriatric Cardiology2017，14，10： | 3 |
| 4 | Is bactibilia a predictor of poor outcome of pancreaticoduodenectomy?显示文摘BACKGROUND:Although bile infection has been proposed to increase infective complications following pancreaticoduodenectomy,its association with infective complications and non-infective complications like pancreatic fistula is still controversial.METHODS:Seventy-six patients who had undergone pancreaticoduodenectomy between July 2007 and December 2008 were included in a prospective database and their data analyzed.In all patients intraoperative bile from the bile duct was cultured.Preoperative,intra-operative,and post-operative variables were recorded and analyzed.RESULTS:Bile culture showed positive growth in 35 patients and negative growth in 41.Twenty patients in the positive group underwent ERCP and stenting.The patients with a positive bile culture had a higher incidence of infective complications including intra-abdominal abscess (n=8),wound infection (n=27),bacteremia (n=10),and renal insufficiency (n=9).There was no increase in the rate of non-infective complications of pancreaticoduodenectomy including pancreatic fistula (n=7),delayed gastric emptying (n=9),and post-operative hemorrhage (n=3).The hospital stay was significantly prolonged in the patients with a positive bile culture (P=0.0002).CONCLUSIONS:Pre-operative biliary drainage is significantly associated with bile infection,and bile infection increases the overall rates of infective complications and renal insufficiency.Because of the high incidence of complications is associated with infected bile,routine intra-operative bile culture is recommended in patients undergoing pancreaticoduodenectomy.Pre-operative prophylaxis is dependent on sensitivity of cases to perioperative antibiotics and intraoperative bile culture report.Because of its significant association with infected bile,biliary stenting should be used in strictly selected cases. | Sivanpillay Mahadevan Sivaraj Velayutham Vimalraj Palanichamy Saravanaboopathy Shanmugasundaram Rajendran Sathyanesan Jeswanth Palaniappan Ravichandran Rosy Vennilla Rajagopalan Surendran | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，1： | 2 |
| 5 | Antioxidant activity and anticancer effect of bioactive peptide from enzymatic hydrolysate of oyster(Saccostrea cucullata)显示文摘 | Umayaparvathi S Meenakshi S Vimalraj V | 2014 | Biomedicine&Preventive Nutrition2014，4，3： | 1 |
| 6 | A positive role of microRNA-15b on regulation of osteoblast differentiation 显示文摘 | Vimalraj S Partridge NC Selvamurugan N | 2014 | J Cell Physiol2014，229，9： | 1 |
| 7 | Antioxidant activity and anticancer effect of bioactive peptide from enzymatic hydrolysate of oyster (Saccostrea cucullata) 显示文摘 | Umayaparvathi S Meenakshi S Vimalraj V | 2014 | Biomedicine & Preventive Nutrition2014，4，3： | 1 |
| 8 | Antioxidant activity and anticancer effect of bioactive peptide from enzymatic hydrolysate of oyster (Saccostrea cucullata) 显示文摘 | Umayaparvathia S Meenakshia S Vimalraj V | 2014 | Biomedicine & Preventive Nutrition2014，4，： | 1 |
| 9 | A case of recurrent biliptysis显示文摘 | Vimalraj V Jeswanth S Selvakumar E | 2007 | J Thorac Cardiovasc Surg2007，133，6： | 1 |
| 10 | Reg ulation of breast cancer and bone metastasis by MicroR NAs显示文摘 | Vimalraj S Miranda P J Ramyakrishna B | 2013 | Dis Markers2013，35，5： | 1 |
| 11 | Post pancreaticoduode- nectomy haemorrhage:outcome prediction based on new ISGPS Clinical severity grading显示文摘 | Rajarathinam G Kannan DG Vimalraj V | 2008 | HPB(Oxford)2008，10，5： | 1 |
| 12 | Post pancreati- coduodenectomy haemorrhage: outcome prediction based on new ISGPS Clinical severity grading 显示文摘 | Rajarathinam G Kannan DG Vimalraj V | 2008 | HPB ( Oxford )2008，10，5： | 1 |
| 13 | Runx2:Structure,function,andphosphorylationinosteoblastdifferentiation显示文摘 | VimalrajS ArumugamB MirandaPJ etal | 2015 | IntJBiolMacromol2015，78，： | 1 |
| 14 | Post pancreaticoduodenectomy haemorrhage: outcome prediction based on new ISGPS Clinical severity grading 显示文摘 | RAJARATHINAM G KANNAN DG VIMALRAJ V | 2008 | HPB (Oxford)2008，10，5： | 1 |
| 15 | Expression of microRNA-30c and its target genes in human osteoblastic cells by nano-bioglass ceramic- treatment 显示文摘 | Moorthi A Vimalraj S Avani C | 2013 | Int J Biol Macromo12013，56，： | 1 |
| 16 | Postpancreaticoduodenectomy hemorrhage:outcome prediction based on new ISGPS clinical severity grading显示文摘 | Rajarathinam G Kannan DG Vimalraj V | 2008 | HPB2008，10，5： | 1 |
| 17 | Regulation of breast cancer and bone metastasis by microRNAs 显示文摘 | Vimalraj S Miranda PJ Ramyakrishna B | 2013 | Dis Markers2013，35，5： | 1 |
| 18 | Regulation of proliferation and apoptosis in human osteoblastic cells by microRNA- 15b显示文摘 | Vimalraj S Selvamurugan N | 2015 | International Journal of Biological Macromole- cules2015，79，： | 1 |
| 19 | Pcxst pancreatico- duodenectomy haemorrhage:outcome prediction based on new ISGPS Clinical severity grading 显示文摘 | Rajarthinam G Kannan D G Vimalraj V | 2008 | HPB(Oxford)2008，10，5： | 1 |
| 20 | Hemat- ological changes following early ligation of splenic artery during splenectomy in shunt surgery for portal hypertension显示文摘 | MADHAVAN M VIMALRAJ V SELVAKUMAR E | 2012 | Trop Gas- troenterol2012，33，1： | 1 |
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