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| 1 | Environmental factors in a population-based inception cohort of inflammatory bowel disease patients in Europe — An ECCO-EpiCom study显示文摘 | J. Burisch N. Pedersen S. Cukovic-Cavka N. Turk I. Kaimakliotis D. Duricova M. Bortlik O. Shonová I. Vind S. Avnstr?m N. Thorsgaard S. Krabbe V. Andersen J.F. Dahlerup J. Kjeldsen R. Salupere J. Olsen K.R. Nielsen P. Manninen P. Collin K.H. Katsanos E.V. | 2013 | Journal of Crohn’s and Colitis2013，，： | 1 |
| 2 | 遗传和环境因素对克罗恩病的同卵孪生患者及其直系亲属的影响:病例报道 | Vind I. Jespersgaard C. Hougs L. 李明 | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，0，1： | 0 |
| 3 | 克罗恩病的NOD2/CARD15基因多态性:一项丹麦、葡萄牙患者和对照者中的基因型-表型分析显示文摘Background: A North-South gradient in Crohn’s disease (CD) implying a higher incidence in northern Europe compared to southern Europe has been established. Aims: To investigate whether there is a difference between Denmark and Portugal in the frequency of CARD15 mutations in CD patients compared to a healthy background population and to compare genotype-phenotype relations in the two countries. Methods: 58 Danish patients and 29 Portuguese patients with CD were matched for age, sex and disease behaviour at time of diagnosis and compared with 200 healthy Danish and Portuguese controls. Phenotypes were recorded at year of diagnosis, 3 years after diagnosis and at end of follow-up. Patients were genotyped for Arg702Trp, Gly908Arg and Leu1007InsC. Results: 22%of the Danish patients vs. 9%of Danish controls compared to 21%of the Portuguese patients vs. 16%had at least one mutation. Mutation rates in Danish patients were significantly different (p = 0.02) compared with Danish controls, no difference (p = 0.51) was found between Portuguese patients and controls. However, a possible relationship between CD and presence of genetic mutations was found when comparing the two countries (p = 0.03) using the Mantel-Haenszel test. No difference in evolution of phenotypes and the CARD15 status in CD was found during follow-up between the two matched populations. Ileal disease correlated to high occurrence of CARD15. Conclusion: No North-South gradient regarding occurrence of CARD15 was revealed. Although a trend towards more mutations in the Portuguese controls was seen, a relationship between CD and CARD15 mutations was observed in both countries. | Vind I. Vieira A. Hougs L. 尹勇 | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，0，3： | 0 |
| 4 | Sweet综合征:炎症性肠病的一种肠外表现显示文摘Background/Aims: Sweet’s syndrome (SS) is a severe dermatosis that may be an extraintestinal manifestation of inflammatory bowel disease (IBD). Worldwide, 35 cases of SS associated with IBD have been reported. We present the first case of severe, recurrent SS in combination with amebic infection and ulcerative colitis complicated with multiple other extra intestinal manifestations. Methods: Disease course was monitored by serum YKL-40 and C-reactive protein (CRP), white blood cell count, albumin and the Simple Clinical Colitis Activity Index (SSCAI). The amebic infection was diagnosed by direct microscopy of wet mount scrapings sampled by repetitive sigmoidoscopies. Results: The patient was diagnosed with leftsided ulcerative colitis and SS combined with extraintestinal manifestations: arthropathies, iridocyclitis and erythema nodosum. Cysts of Entamoeba histolytica were detected in the stools in two separate periods of time. Serum YKL-40 increased prior to CRP and correlated with disease activity, SCCAI, CRP, white blood cell count and inversely with serum albumin. Conclusion: This case gives further support for SS being an extraintestinal manifestation of ulcerative colitis. YKL-40 may be useful in monitoring the disease course of IBD. | Ytting H. Vind I. Munkholm P. 尹勇 | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，0，3： | 0 |
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