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| 1 | Fluctuations in butyrate-producing bacteria in ulcerative colitis patients of North India显示文摘AIM: To study the interplay between butyrate concentration and butyrate-producing bacteria in fecal samples of ulcerative colitis (UC) patients vs control individuals. METHODS: Fecal samples were collected from 14 control individuals (hemorrhoid patients only) and 26 UC patients (severe: n = 12, moderate: n = 6, remission: n = 8), recruited by the gastroenterologist at the Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India. Disease activity in UC patients was determined by clinical colitis activity index. We employed fluorescent in situ hybridization in combination with flow cytometry to enumerate the clostridium cluster population targeted by 16S rRNA gene probe. Major butyrate-producing species within this cluster were quantified to see if any change existed in control vs UC patients with different disease activity. This observed change was further validated by quantitative polymerase chain reaction. In addition to this,we carried out gas chromatography to evaluate the changes in concentration of major short chain fatty acids (SCFAs), namely acetate, n -butyrate, iso -butyrate, in the above samples. Student t test and Graph pad prism-6 were used to compare the data statistically. RESULTS: There was a significant decrease of Clostridium coccoides (control, 25.69% ± 1.62% vs severe, 9.8% ± 2.4%, P = 0.0001) and Clostridium leptum clusters (control, 13.74% ± 1.05% vs severe, 6.2% ± 1.8%, P = 0.0001) in fecal samples of UC patients. Furthermore, we demonstrated that some butyrateproducing members of the clostridial cluster, like Fecalibacterium prausnitzii (control, 11.66% ± 1.55% vs severe, 6.01% ± 1.6%, P = 0.0001) and Roseburia intestinalis (control, 14.48% ± 1.52% vs severe, 9% ± 1.83%, P = 0.02) were differentially present in patients with different disease activity. In addition, we also demonstrated decreased concentrations of fecal SCFAs, especially of n -butyrate (control, 24.32 ± 1.86 mmol/μL vs severe, 12.74 ± 2.75 mmol/μL, P = 0.003), iso -butyrate (control, 1.70 ± 0.41 mmol/μL vs severe, 0.68 ± 0.24 mmol/μL, P = 0.0441) and acetate (control, 39.51 ± 1.76 mmol/μL vs severe, 32.12 ± 2.95 mmol/ μL,P = 0.047), in the fecal samples of UC patients. The observed decrease of predominant butyrate producers of clostridial clusters correlated with the reduced SCFA levels in active UC patients. This was further confirmed by the restoration in the population of some butyrate producers with simultaneous increase in the level of SCFA in remission samples. CONCLUSION: Our observations indicate that decreases in members of the clostridial cluster resulting in reduced butyrate levels contribute to the etiology of UC. | Reena Kumari Vineet Ahuja Jaishree Paul | 2013 | World Journal of Gastroenterology2013，19，22： | 21 |
| 2 | Differentiating Crohn's disease from intestinal tuberculosis显示文摘Differentiating Crohn's disease(CD) and intestinal tuberculosis(ITB) has remained a dilemma for most of the clinicians in the developing world, which are endemic for ITB, and where the disease burden of inflammatory bowel disease is on the rise. Although, there are certain clinical(diarrhea/hematochezia/perianal disease common in CD; fever/night sweats common in ITB), endoscopic(longitudinal/aphthous ulcers common in CD; transverse ulcers/patulous ileocaecal valve common in ITB), histologic(caseating/confluent/large granuloma common in ITB; microgranuloma common in CD), microbiologic(positive stain/culture for acid fast-bacillus in ITB), radiologic(long segment involvement/comb sign/skip lesions common in CD; necrotic lymph node/contiguous ileocaecal involvement common in ITB), and serologic differences between CD and ITB, the only exclusive features are caseation necrosis on biopsy, positive smear for acid-fast bacillus(AFB) and/or AFB culture, and necrotic lymph node on cross-sectional imaging in ITB. However,these exclusive features are limited by poor sensitivity, and this has led to the development of multiple multi-parametric predictive models. These models are also limited by complex formulae, small sample size and lack of validation across other populations. Several new parameters have come up including the latest Bayesian meta-analysis, enumeration of peripheral blood T-regulatory cells, and updated computed tomography based predictive score. However, therapeutic anti-tubercular therapy(ATT) trial, and subsequent clinical and endoscopic response to ATT is still required in a significant proportion of patients to establish the diagnosis. Therapeutic ATT trial is associated with a delay in the diagnosis of CD, and there is a need for better modalities for improved differentiation and reduction in the need for ATT trial. | Saurabh Kedia Prasenjit Das Kumble Seetharama Madhusudhan Siddhartha Dattagupta Raju Sharma Peush Sahni Govind Makharia Vineet Ahuja | 2019 | World Journal of Gastroenterology2019，25，4： | 19 |
| 3 | PVD制备TiAlSiN涂层的研究进展显示文摘概述了物理气相沉积(PVD)技术制备TiAlSiN涂层的研究现状及发展趋势,详细分析了Si元素的添加及Si与Al元素的含量对TiAlSiN涂层的微观结构、力学性能、高温抗氧化性和热稳定性的影响。解决PVD制备TiAlSiN涂层较低的膜基结合力和较大的残余应力等问题应是今后重点研究的方向。 | 彭笑 朱丽慧 Vineet Kumar 刘一雄 | 2014 | 材料导报2014，28，3： | 15 |
| 4 | Prospective validation of %p2PSA and the Prostate Health Index, in prostate cancer detection in initial prostate biopsies of Asian men, with total PSA 4-10 ng ml-1显示文摘尽管有它为屏蔽的前列腺癌症的普遍使用,低特性使 PSA 成为非最优的 biomarker,特别在 4-10 ng ml 1 的诊断灰色的地区。假积极与伴随的病态导致不必要的活体检视。这在与在 4.0 和 10 ng ml 1 之间的全部的 PSA 介绍的亚洲人是 % p2PSA 和前列腺健康索引(PHI ) 的第一未来的确认研究。我们学习了在 50 和 75 岁之间的 157 个亚洲人,与每直肠的前列腺考试的正常,经历他们的第一前列腺活体检视,用一个标准化活体检视协议,为 4-10 ng ml 1 的 PSA 层次。(19.1%) 三十被发现在活体检视上有前列腺癌症。有或没有前列腺癌症的病人之间的统计上重要的差别被作出对有利的裁决全部的 PSA, p2PSA, % p2PSA,和 PHI。在为全部的 PSA, % fPSA, % p2PSA,和 PHI 操作典型曲线的接收装置的曲线下面的区域分别地是 0.479, 0.420, 0.695,和 0.794。PHI 最好预言 prostatic 活体检视结果。在 90% 的敏感, PHI 的特性(95% CI ) 是 58.3% ,多于在 17.3% 点使全部的 PSA 的特性增加两倍,潜在地避免 77 (49%) 不必要的活体检视。类似于研究在主要白种人人口,我们有希望地证明了 % p2PSA 和 PHI 极大地超过总数并且释放总计 PSA 比率,在前列腺癌症的察觉起初活体检视。更高的 PHI 层次也对应于增加检测 GS 7 癌症的风险。我们验证了 PHI 的使用与在 4 和 10 ng ml 1 之间的浆液 PSA 在亚洲人关于前列腺活体检视帮助决策。 | Lincoln GL Tan Yung Khan Tan Bee Choo Tai Karen ML Tan Vineet Gauhar Ho Yee Tiong Robert CW Hawkins Thomas P Thamboo Felicia SK Hong Edmund Chiong | 2017 | Asian Journal of Andrology2017，19，3： | 13 |
| 5 | MicroRNA exhibit altered expression in the inflamed colonic mucosa of ulcerative colitis patients显示文摘AIM To investigate the miRNA expression in colonic mucosal biopsies from endoscopically inflamed and non inflamed regions of ulcerative colitis(UC) patients. METHODS Colonic mucosal pinch biopsies were analyzed from the inflamed and non inflamed regions of same UC patient. Total RNA was isolated and differential miRNA profiling was done using microarray platform. Quantitative Real Time PCR was performed in colonic biopsies from inflamed(n = 8) and non-inflamed(n = 8) regions of UC and controls(n = 8) to validate the differential expression of miRNA. Potential targets of dysregulated miRNA were identified by using in silico prediction tools and probable role of these miRNA in inflammatory pathways were predicted.RESULTS The miRNA profile of inflamed colonic mucosa differs significantly from the non-inflamed. Real time PCR analysis showed that some of the miRNA were differentially expressed in the inflamed mucosa as compared to non inflamed mucosa and controls(mi R-125 b, mi R-223, miR-138, and mi R-155), while(miR-200a) did not show any significant changes. In contrast to microarray, where mi R-378 d showed downregulation in the inflamed mucosa, q RT-PCR showed a significant upregulation in the inflamed mucosa as compared to the non inflamed. The in silico prediction analysis revealed that the genes targeted by these mi RNAs play role in the major signaling pathways like MAPK pathway, NF-κB signaling pathway, cell adhesion molecules which are all assciated with UC.CONCLUSION The present study reports disease specific alteration in the expression of mi R-125 b, mi R-155, mi R-223 and mi R-138 in UC patients and also predict their biological significance. | Swati Valmiki Vineet Ahuja Jaishree Paul | 2017 | World Journal of Gastroenterology2017，23，29： | 6 |
| 6 | Multimodality management of gallbladder cancer can lead to a better outcome:Experience from a tertiary care oncology centre in North India显示文摘BACKGROUND Surgical resection is a treatment of choice for gallbladder cancer(GBC)patients but only 10%of patients have a resectable disease at presentation.Even after surgical resection,overall survival(OS)has been poor due to high rates of recurrence.Combination of surgery and systemic therapy can improve outcomes in this aggressive disease.AIM To summarize our single-center experience with multimodality management of resectable GBC patients.METHODS Data of all patients undergoing surgery for suspected GBC from January 2012 to December 2018 was retrieved from a prospectively maintained electronic database.Information extracted included demographics,operative and perioperative details,histopathology,neoadjuvant/adjuvant therapy,follow-up,and recurrence.To know the factors associated with recurrence and OS,univariate and multivariate analysis was done using log rank test and cox proportional hazard analysis for categorical and continuous variables,respectively.Multivariate analysis was done using multiple regression analysis.RESULTS Of 274 patients with GBC taken up for surgical resection,172(62.7%)were female and the median age was 56 years.On exploration,102 patients were found to have a metastatic or unresectable disease(distant metastasis in 66 and locally unresectable in 34).Of 172 patients who finally underwent surgery,93(54%)underwent wedge resection followed by anatomical segment IVb/V resection in 66(38.4%)and modified extended right hepatectomy in 12(7%)patients.The postoperative mortality at 90 d was 4.6%.During a median follow-up period of 20 mo,71(41.2%)patients developed recurrence.Estimated 1-,3-,and 5-years OS rates were 86.5%,56%,and 43.5%,respectively.Estimated 1-and 3-year disease free survival(DFS)rates were 75%and 49.2%,respectively.On multivariate analysis,inferior OS was seen with pT3/T4 tumor(P=0.0001),perineural invasion(P=0.0096),and R+resection(P=0.0125).However,only pT3/T4 tumors were associated with a poor DFS(P<0.0001).CONCLUSION Multimodality treatment significantly improves the 5-year survival rate of patients with GBC up to 43%.R+resection,higher T stage,and perineural invasion adversely affect the outcome and should be considered for systemic therapy in addition to surgery to optimize the outcomes.Multimodality treatment of GBC has potential to improve the survival of GBC patients. | Shaifali Goel Abhishek Aggarwal Assif Iqbal Vineet Talwar Swarupa Mitra Shivendra Singh | 2021 | World Journal of Gastroenterology2021，27，45： | 5 |
| 7 | All ileo-cecal ulcers are not Crohn's:Changing perspectives of symptomatic ileocecal ulcers显示文摘AIM To investigated clinical,endoscopic and histopathological parameters of the patients presenting with ileocecal ulcers on colonoscopy.METHODS Consecutive symptomatic patients undergoing colonoscopy,and diagnosed to have ulcerations in the ileocecal(I/C) region,were enrolled.Biopsy was obtained and theirclinical presentation and outcome were recorded.RESULTS Out of 1632 colonoscopies,104 patients had ulcerations in the I/C region and were included in the study.Their median age was 44.5 years and 59% were males.The predominant presentation was lower GI bleed(55,53%),pain abdomen ± diarrhea(36,35%),fever(32,31%),and diarrhea alone(9,9%).On colonoscopy,terminal ileum was entered in 96(92%) cases.The distribution of ulcers was as follows:Ileum alone 40%(38/96),cecum alone 33%(32/96),and both ileum plus cecum 27%(26/96).The ulcers were multiple in 98% and in 34% there were additional ulcers elsewhere in colon.Based on clinical presentation and investigations,the etiology of ulcers was classified into infective causes(43%) and noninfective causes(57%).Fourteen patients(13%) were diagnosed to have Crohn's disease(CD).CONCLUSION Non-specific ileocecal ulcers are most common ulcers seen in ileo-cecal region.And if all infections are clubbed together then infection is the most common(> 40%) cause of ulcerations of the I/C region.Cecal involvement and fever are important clues to infective cause.On the contrary CD account for only 13% cases as a cause of ileo-cecalulcers.So all symptomatic patients with I/C ulcers on colonoscopy are not Crohn's. | Jay Toshniwal Romesh Chawlani Amit Thawrani Rajesh Sharma Anil Arora Hardik L Kotecha Mohan Goyal Vijendra Kirnake Pankaj Jain Pankaj Tyagi Naresh Bansal Munish Sachdeva Piyush Ranjan Mandhir Kumar Praveen Sharma Vikas Singla Rinkesh Bansal Vineet Shah Sunita Bhalla Ashish Kumar | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，7： | 5 |
| 8 | Promising light converting BaMoO_4:Er^(3+)-Tm^(3+)-Yb^(3+) phosphors for display and optical temperature sensing显示文摘Er^(3+)-Tm3+-Yb^(3+) tri-doped BaMoO_4 phosphors were synthesized by co-precipitation technique and characterized by X-ray diffraction analysis, absorption study and field emission scanning electron microscopy analysis. Upconversion as well as downconversion luminescence studies were performed by using near infrared(980 nm) and ultraviolet(380 nm) excitations. Energy level diagram, pump power dependence and colour coordinate study were utilized to describe the multicolor upconversion emission properties. Under single 980 nm diode laser excitation the dual mode sensing behaviour is realized via Stark sublevels and thermally coupled energy levels of the Tm3+ and Er^(3+) ions in the prepared tri-doped phosphors. A comparative fluorescence intensity ratio analysis for integrated emission intensities arising from the Stark sublevels {~1 G_(4(a)) and ~1 G_(4(b))} and thermally coupled energy levels {~2 H_(11/2) and 4 S3/2} of the Tm3+ and Er3+ ions, respectively was carried out in the prepared tri-doped BaMoO_4 phosphors. The maximum sensitivity for thermally coupled energy levels of the Er3+ and Stark sublevels of the Tm3+ ion was reported. The developed phosphors could be useful in the display devices and optical thermo metric applications. | Abhishek Kumar Soni Vineet Kumar Rai | 2018 | Journal of Rare Earths2018，36，12： | 4 |
| 9 | Er^(3+)/Yb^(3+)/Li^+/Zn^(2+):Gd_2(MoO_4)_3 upconverting nanophosphors in optical thermometry显示文摘Er^(3+)-Yb^(3+)-Li^+:Gd_2(MoO_4)_3 and Er^(3+)-Yb^(3+)-Zn^(2+):Gd_2(MoO_4)_3 nanophosphors, synthesized by chemical co-precipitation technique were characterized through XRD,FESEM,dynamic light scattering(DLS),diffuse reflectance, photoluminescence, photometric and decay time analysis. The enhancement of about~28, ~149 and ~351 times in the green upconversion emission band is observed for the optimized Er^(3+)-Yb^(3+),Er^(3+)-Yb^(3+)-Li^+ and Er^(3+)-Yb^(3+)-Zn^(2+):Gd_2(MoO_4)_3 nanophosphors in comparison to the singly Er^(3+) doped nanophosphors. The electric dipole-dipole interaction is found to be responsible for the concentration quenching. The temperature dependent behaviour of the two green thermally coupled levels of the Er^(3+) ions based on the fluorescence intensity ratio technique was studied. The maximum sensor sensitivity ~38.7 × 10^(-3) K^(-1) at 473 K for optimized Er^(3+)-Yb^(3+)-Zn^(2+) codoped Gd_2(MoO_4)_3 nanophosphors is reported with maximum population redistribution ability~88% among the ~2H_(11/2) and ~4S_(3/2) levels. | Anita Kumari Lakshmi Mukhopadhyay Vineet Kumar Rai | 2019 | Journal of Rare Earths2019，37，3： | 4 |
| 10 | Parallel Fuzzy P+Fuzzy I+Fuzzy D Controller:Design and Performance Evaluation显示文摘In this paper,a parallel fuzzy proportional plus fuzzy integral plus fuzzy derivative (FP+FI+FD) controller is proposed.It is derived from the conventional parallel proportional-integral-derivative (PID) controller.It preserves the linear structure of a conventional parallel PID controller,with analytical formulas.The final shape of the controller is a discrete-time fuzzy version of a conventional parallel PID controller.Computer simulations are performed to evaluate the performance of the FP+FI+FD controller for setpoint tracking and load-disturbance rejection for some complex processes,such as first-and second-order processes with delay,inverse response process with and without delay and higher order processes.Also,the performance of the proposed fuzzy controller is evaluated experimentally on highly nonlinear liquid-flow process with a hysteresis characteristic due to a pneumatic control valve.The simulation and real time control is done using National Instrument TM hardware and software (LabVIEW TM).The response of the FP+FI+FD controller is compared with the conventional parallel PID controller,tuned with the Ziegler-Nichols (Z-H) and Astrm-Hgglund (A-H) tuning technique.It is observed that the FP+FI+FD controller performed much better than the conventional PI/PID controller.Simulation and experimental results demonstrate the effectiveness of the proposed parallel FP+FI+FD controller. | Vineet Kumar A.P.Mittal | 2010 | International Journal of Automation and computing2010，7，4： | 4 |
| 11 | Intestinal permeability and its association with the patient and disease characteristics in Crohn's disease显示文摘AIM:To assess the intestinal permeability (IP) in patients with Crohn's disease (CD) and study the association of IP with the patient and disease characteristics. METHODS: One hundred and twenty five consecutive patients of CD (Males: 66) were diagnosed on the basis of a combination of standard clinical, endoscopic, imaging and histological features. CD activity index (CDAI) was used to calculate the activity of the disease while the behavior of the disease was assessed by the modified Montreal classification. IP was measured by the ratio of the percentage excretion of ingested doses of lactulose and mannitol in urine (LMR). The upper limit of normality of LMR (0.037) was derived from 22 healthy controls. RESULTS: Thirty six percent of patients with CD had increased IP. There was no significant difference in mannitol excretion (patients vs controls = 12.5% vs 14.2%, P = 0.4652), but lactulose excretion was significantly higher in patients compared to healthy controls (patients vs controls = 0.326% vs 0.293%, P = 0.0391). The mean LMR was also significantly higher in the patients as compared to healthy controls [0.027 (0.0029-0.278) vs 0.0164 (0.0018-0.0548), P = 0.0044]. Male patients had a higher LMR compared to females [0.036 (95% CI 0.029, 0.046) vs 0.022 (95% CI 0.0178, 0.028) (P = 0.0024), though there was no difference in the number of patients with abnormal IP in boththe sexes. Patients with an ileo-colonic disease had a higher LMR than those with only colonic disease [0.045 (95% CI 0.033, 0.06) vs 0.021 (95% CI 0.017, 0.025) (P < 0.001)]. Of patients with ileo-colonic disease, 57.8% had an abnormal IP, compared to 26.7% with colonic and 15.6% with small intestinal disease. Patients with a stricturing disease had significantly higher LMR compared to non-fistulising non-stricturing disease [0.043 (95% CI 0.032, 0.058) vs 0.024 (95% CI 0.019, 0.029) (P = 0.0062)]. There was no correlation of IP with age, disease activity, duration of illness, D-xylose absorption, upper GI involvement, perianal disease, and extra- intestinal manifestations. On multiple regression analysis, male gender and ileo-colonic disease were independent factors associated with increased IP. Gender, location, behavior of the disease and upper GI involvement could explain up to 23% of variability in IP (R2 = 0.23). CONCLUSION: IP was increased in 36% of patients with CD. Male gender and an ileo-colonic disease were the independent factors associated with increased IP. | Jaya Benjamin Govind K Makharia Vineet Ahuja Mani Kalaivan Yogendra K Joshi | 2008 | World Journal of Gastroenterology2008，14，9： | 4 |
| 12 | Si对Ti-Al-Si-N涂层微观结构及性能的影响显示文摘Ti-Al-Si-N涂层是在Ti-Al-N涂层基础上发展而来的一种四元复合涂层。本文综述了Si对Ti-Al-Si-N涂层微观结构、硬度、残余应力、抗氧化性能、热稳定性能、摩擦磨损性能及切削性能的影响。分析表明:Si元素能有效细化晶粒,减少柱状晶,形成新型纳米结构,从而显著提高涂层硬度,可达39 GPa;Si的原子分数超过5%后,涂层残余应力逐渐降低;Ti-Al-Si-N涂层在1 100℃下仍具有良好的抗氧化性能;Si元素使涂层的热稳定性能有很大提高,Ti-Al-Si-N涂层1 100℃氧化后硬度无显著变化;与Ti-Al-N涂层相比,添加Si元素后涂层的摩擦系数由0.7下降至0.5;Ti-Al-Si-N涂层刀具的使用寿命与Si原子分数有很大的关系。 | 胡明媚 朱丽慧 王川 刘一雄 Vineet Kumar | 2011 | 硬质合金2011，28，5： | 3 |
| 13 | A six months old neglected anterior shoulder dislocation managed by closed reduction and Latarjet procedure显示文摘忽视的肩膀脱臼是一个更稀罕的实体,仅仅很少案例在文学被报导。肩膀的前面的脱臼很少在诱拐和外部旋转作为与手足在场的病人被错过,对整形外科的外科医生很熟悉的态度。当时,偶尔,如此的案例被错过他们与近似肱骨的骨折在场或当他们从通常在农村区域练习的全然的专业人员接受治疗时。由于很少的报告,有文学的少量,没有标准治疗协议为肩膀的忽视的前面的脱臼存在,尽管最如此的长期的案例被开的减小管理。这份案例报告与重要的山 Sachs 损害描述六个月旧的忽视的前面的脱臼,它被关上的减小和 Latarjet 过程管理。 | Deepak Chaudhary Deepak Joshi Vineet Jain Mukul Mohindra Nitin Mehta | 2016 | Chinese Journal of Traumatology2016，19，5： | 3 |
| 14 | Do we really need to repair the pronator quadratus after distal radius plating?显示文摘Purpose:Fractures of distal radius are one of the common orthopaedic injuries.Placing the plate on volar surface requires release of underlying pronator quadratus(PQ)muscle.No consensus is present in the literature about the repair or not of the PQ.The purpose of this study was to evaluate the influence of PQ repair on functional outcome and complications.Methods:Retrospectively 83 patients of distal radius fractures managed with volar plating between 2014 and 2016 were evaluated.Demographic data,operative notes and physical therapy records were retrieved.Patients were divided into group A where PQ repair was done and group B where no repair was done.Functional data such as range of motion(ROM),grip strength,visual analogue scale(VAS)score and disabilities of arm,shoulder and hand(DASH)score at 4 weeks,3 months,6 months and finial follow-up were retrieved.Results:Totally 63 patients(n=29 in group A and n=34 in group B)with the mean age of 51.64 years were examined.Patients were followed up for a mean of 35.2 months(range 27.2-47.1 months)in group A and 38.6 months(range 28.6-51.0 months)in group B.Though functional outcome of the affected limb was not significantly different between two groups after 3 months,PQ repair did affect the recovery at an early stage.Repair group had significantly better ROM(p=0.0383)and VAS score at 4 weeks(p=0.017)while grip strength(p=0.014)was significantly better at 3 months.Conclusions:Repair of PQ may provide pain relief and increased ROM in early postoperative period and hence every attempt should be made to achieve the repair. | Subodh Pathak Rashid Anjum Rakesh Kumar Gautam Pritam Maheshwari Jatin Aggarwal Aryan Sharma Vineet Pruthi | 2019 | Chinese Journal of Traumatology2019，22，6： | 3 |
| 15 | Analyzing Parabolic Profile Path for Underwater Towed-Cable显示文摘这篇文章讨论动态州的分析在水下拖引电缆线当拖引轮船在成为寓言的一个方向改变它的速度时,介绍路径。一个三维的模型在水下拖引的系统被学习。为系统的确定的管理方程用中央含蓄的有限差别的方法被解决了。获得的差别非线性的联合方程被牛顿鈥檚 方法解决,令人满意的结果被完成。这个问题的答案在动态装载和运动的评价有实际重要性,并且因此它对安全的改进和有效性直接适用近海活动。 | Vineet K. Srivastava | 2014 | Journal of Marine Science and Application2014，13，2： | 2 |
| 16 | Low dose oral curcumin is not effective in induction of remission in mild to moderate ulcerative colitis: Results from a randomized double blind placebo controlled trial显示文摘AIM To evaluate the role of oral curcumin in inducing clinical remission in patients with mild to moderate ulcerative colitis(UC).METHODS A prospective randomized double-blind placebo-controlled trial comparing the remission inducing effect of oral curcumin and mesalamine 2.4 g with placebo and mesalamine 2.4 g in patients of ulcerative colitis with mild to moderate severity was conducted from January 2003 to March 2005. The included patients received 1 capsule thrice a day of placebo or curcumin(150 mg) for 8 wk. Patients were evaluated clinically and endoscopically at 0,4 and 8 wk. The primary outcome was clinical remission at 8 wk and secondary outcomes were clinical response, mucosal healing and treatment failure at 8 wk. The primary analysis was intention to treat worst case scenario(ITT-WCS).RESULTS Of 300 patients with UC, 62 patients(curcumin: 29, placebo: 33) fulfilled the inclusion criteria and were randomized at baseline. Of these, 21 patients did not complete the trial, 41 patients(curcumin: 16, placebo: 25) finally completed 8 wk. There was no significant difference in rates of clinical remission(31.3% vs 27.3%, P = 0.75), clinical response(20.7% vs 36.4%, P = 0.18), mucosal healing(34.5% vs 30.3%, P = 0.72), and treatment failure(25% vs 18.5%, P = 0.59) between curcumin and placebo at 8 wk.CONCLUSION Low dose oral curcumin at a dose of 450 mg/d was ineffective in inducing remission in mild to moderate cases of UC. | Saurabh Kedia Vikram Bhatia Sandeep Thareja Sushil Garg Venigalla Pratap Mouli Sawan Bopanna Veena Tiwari Govind Makharia Vineet Ahuja | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，2： | 2 |
| 17 | The Probiotic Preparation, VSL#3 Induces Remission in Patients With Mild-to-Moderately Active Ulcerative Colitis显示文摘 | Ajit Sood Vandana Midha Govind K. Makharia Vineet Ahuja Dinesh Singal Pooja Goswami Rakesh K. Tandon | 2009 | Clinical Gastroenterology and Hepatology2009，，11： | 2 |
| 18 | Epidemiology of patients admitted to a major trauma centre in northern India显示文摘在印度的 ObjectiveTrauma 是一个逐渐地重要的问题,特别地考虑到快速的开发和增加的动力化。社会变化在损伤的传染病学正在导致改变。学习的目的是估计在同意到一个主要损伤中心进入随机的分类选择的 748 个病人的北 India.MethodsAn 观察学习的病人影响损害的原因的各种各样的流行病学的参数在 1 年(到 2009 年 7 月的 2008 年 8 月) 的一个时期上被执行。年龄,性别,损害类型和模式被注意。上面、更低的手足的损害模式也是 noted.ResultsInjuries 在 15-30 年的年龄组主要发生。男性们与男性一起招致了更多的损害到 6:1 的女比率。最脆弱的组是摩托车用户。在之中伤害,农民们是通常包含的大多数。钝损害(94.92%) 比渗透损害是更普通的。在有头损害的病人之中,二 wheelers 联系了事故最普通(40.3%) 。最针的绳索损害从高度(51.09%) 到下降被引起。大多数更低的手足破裂是简单类型。更低的手足的复合破裂比交通规则的上面的手足 fractures.ConclusionStrict 实施更普通,与改进基础结构和行为变化结合了能减少在印度和另外的发展中的国家的道路交通事故的负担。这研究能在作为需要被称为死亡和病态的一个可防止的原因的一个公共健康问题提起道路交通事故的侧面帮助,并且为这主要挑战计划适当干预。预防策略应该根据这些流行病学的趋势被做。 | Devarshi Rastogi Sanjay Meena Vineet Sharma Girish Kumar Singh | 2014 | Chinese Journal of Traumatology2014，17，2： | 2 |
| 19 | Computerised tomography vs magnetic resonance imaging for modeling of patient-specific instrumentation in total knee arthroplasty显示文摘AIM: To summarise and compare currently available evidence regarding accuracy of pre-operative imaging, which is one of the key choices for surgeons contemplating patient-specific instrumentation(PSI) surgery.METHODS: The MEDLINE and EMBASE medical literature databases were searched, from January 1990 to December 2013, to identify relevant studies. The data from several clinical studies was assimilated to allow appreciation and comparison of the accuracy of each modality. The overall accuracy of each modality was calculated as proportion of outliers > 3% in the coronal plane of both computerised tomography(CT) or magnetic resonance imaging(MRI). RESULTS: Seven clinical studies matched our inclusion criteria for comparison and were included in our study for statistical analysis. Three of these reported series using MRI and four with CT. Overall percentage of outliers > 3% in patients with CT-based PSI systems was 12.5% vs 16.9% for MRI-based systems. These results were not statistically significant. CONCLUSION: Although many studies have been undertaken to determine the ideal pre-operative imaging modality, conclusions remain speculative in the absence of long term data. Ultimately, information regarding accuracy of CT and MRI will be the main determining factor. Increased accuracy of pre-operative imaging could result in longer-term savings, and reduced accumulated dose of radiation by eliminating the need for post-operative imaging and revision surgery. | Paul Stirling Rejith Valsalan Mannambeth Agustin Soler Vineet Batta Rajeev Kumar Malhotra Yegappan Kalairajah | 2015 | World Journal of Orthopedics2015，6，2： | 2 |
| 20 | Indian stock market prediction using artificial neural networks on tick data显示文摘Introduction:Nowadays,the most significant challenges in the stock market is to predict the stock prices.The stock price data represents a financial time series data which becomes more difficult to predict due to its characteristics and dynamic nature.Case description:Support Vector Machines(SVM)and Artificial Neural Networks(ANN)are widely used for prediction of stock prices and its movements.Every algorithm has its way of learning patterns and then predicting.Artificial Neural Network(ANN)is a popular method which also incorporate technical analysis for making predictions in financial markets.Discussion and evaluation:Most common techniques used in the forecasting of financial time series are Support Vector Machine(SVM),Support Vector Regression(SVR)and Back Propagation Neural Network(BPNN).In this article,we use neural networks based on three different learning algorithms,i.e.,Levenberg-Marquardt,Scaled Conjugate Gradient and Bayesian Regularization for stock market prediction based on tick data as well as 15-min data of an Indian company and their results compared.Conclusion:All three algorithms provide an accuracy of 99.9%using tick data.The accuracy over 15-min dataset drops to 96.2%,97.0%and 98.9%for LM,SCG and Bayesian Regularization respectively which is significantly poor in comparison with that of results obtained using tick data. | Dharmaraja Selvamuthu Vineet Kumar Abhishek Mishra | 2019 | Financial Innovation2019，5，1： | 2 |
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