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| 1 | WJD 5^(th) Anniversary Special Issues(2): Type 2 diabetes Inflammation in diabetic kidney disease显示文摘Diabetes mellitus entails significant health problems worldwide.The pathogenesis of diabetes is multifactorial,resulting from interactions of both genetic and environmental factors that trigger a complex network of pathophysiological events,with metabolic and hemodynamic alterations.In this context,inflammation has emerged as a key pathophysiology mechanism.New pathogenic pathways will provide targets for prevention or future treatments.This review will focus on the implications of inflammation in diabetes mellitus,with special attention to inflammatory cytokines. | Patricia M García-García María A Getino-Melian Virginia Domínguez-Pimentel Juan F Navarro-Gonzalez | 2014 | World Journal of Diabetes2014，5，4： | 26 |
| 2 | Transcatheter aortic valve replacement and stroke: a comprehensive review显示文摘Transcatheter 大动脉的阀门培植(TAVR ) 与严重大动脉的狭窄和高外科的风险为病人作为一种其他的、很快演变的治疗选择出现了。此后摸破坏复杂并发症主要在 periprocedural 和 30 天的时期追随者 TAVR 正在被限制,与更低、相对经常的频率。早击在过程期间主要由于碎片 embolization,而以后的事件与耐心的特定的因素被联系。尽管临床的击的率常常与起始的 TAVR 经验相比一直在减少,有 MRI 的现代 neuro 成像建议新 ischemic 损害 post-TAVR 是几乎通用的。后者的影响大部分是未知的。然而,他们似乎在 neurocognitive 功能与减小相关。因为 TAVR 被设置扩展它的指示降低外科风险的病人,摸预防在期间并且在 TAVR 以后降临到首要的重要性。基于临床并且 pathophysiological 证据,研究的三根线活跃地向这个方向被采用:在有到有钙化的大动脉的拱门的还原剂操作和接触的一个目的阀门和本国的阀门, antithrombotic 治疗,和插子的保护设备的改进。小心的耐心的选择,过程的设计,和尊重这张易碎的人口的流血风险的定制的 antithrombotic 策略对击追随者 TAVR 组成主要防卫。 | Periklis A Davlouros Virginia C Mplani Ioanna Koniari Grigorios Tsigkas George Hahalis | 2018 | Journal of Geriatric Cardiology2018，15，1： | 7 |
| 3 | Subclinical carotid atherosclerosis predicts all-cause mortality and cardiovascular events in obese patients with negative exercise echocardiography显示文摘BACKGROUND Obesity is a major health problem due to its high prevalence. The relationship between obesity and cardiovascular disease is unclear. Some studies agree that certain conditions associated with obesity, such as physical inactivity or cardiovascular risk factors, are responsible for cardiovascular risk excess among obese people. Carotid intima-media thickness and carotid plaques(CP) have been associated with cardiovascular adverse events in healthy populations, and recent data suggest a higher prevalence of subclinical carotid atherosclerosis in obese and metabolically unhealthy patients. However, there are no studies correlating subclinical atherosclerosis and adverse events(AE) in obese subjects.AIM To determine the association between carotid disease and AE in obese patients with negative exercise echocardiography(EE).METHODS From January 1, 2006 to December 31, 2010, 2000 consecutive patients with a suspicion of coronary artery disease were submitted for EE and carotid ultrasonography. Exclusion criteria included previous vascular disease, left ventricular ejection fraction < 50%, positive EE, significant valvular heart disease and inferior to submaximal EE. An AE was defined as all-cause mortality,myocardial infarction and cerebrovascular accident. Subclinical atherosclerosis was defined as CP presence according to Manheim and the American Society of Echocardiography Consensus.RESULTS Of the 652 patients who fulfilled the inclusion criteria, 226(34.7%) had body mass indexes ≥ 30 kg/m2, and 76 of them(33.6%) had CP. During a mean follow-up time of 8.2(2.1) years, 27 AE were found(11.9%). Mean event-free survival at 1, 5 and 10 years was 99.1%(0.6), 95.1%(1.4) and 86.5%(2.7), respectively. In univariate analysis, CP predicted AE [hazard ratio(HR) 2.52, 95% confidence interval(CI) 1.17-5.46; P = 0.019]. In multivariable analysis, the presence of CP remained a predictor of AE(HR 2.26, 95%CI 1.04-4.95, P = 0.041). Other predictors identified were glomerular filtration rate(HR 0.98, 95%CI 0.96-0.99; P= 0.023), peak metabolic equivalents(HR 0.83, 95%CI 0.70–0.99, P = 0.034) and moderate mitral regurgitation(HR 5.02, 95%CI 1.42–17.75, P = 0.012).CONCLUSION Subclinical atherosclerosis defined by CP predicts AE in obese patients with negative EE. These patients could benefit from aggressive prevention measures. | Rafael Vidal-Perez Raúl Franco-Gutiérrez Alberto J Pérez-Pérez Virginia Franco-Gutiérrez Alberto Gascón-Vázquez Andrea López-López Ana María Testa-Fernández Carlos González-Juanatey | 2019 | World Journal of Cardiology2019，11，1： | 7 |
| 4 | T_3-induced liver AMP-activated protein kinase signaling:Redox dependency and upregulation of downstream targets显示文摘AIM:To investigate the redox dependency and promotion of downstream targets in thyroid hormone(T3)-induced AMP-activated protein kinase(AMPK)signaling as cellular energy sensor to limit metabolic stresses in the liver.METHODS:Fed male Sprague-Dawley rats were given a single ip dose of 0.1 mg T3/kg or T3 vehicle(Na OH0.1 N;controls)and studied at 8 or 24 h after treatment.Separate groups of animals received 500 mg N-acetylcysteine(NAC)/kg or saline ip 30 min prior T3.Measurements included plasma and liver 8-isoprostane and serumβ-hydroxybutyrate levels(ELISA),hepaticlevels of m RNAs(q PCR),proteins(Western blot),and phosphorylated AMPK(ELISA).RESULTS:T3 upregulates AMPK signaling,including the upstream kinases Ca2+-calmodulin-dependent protein kinase kinase-βand transforming growth factor-β-activated kinase-1,with T3-induced reactive oxygen species having a causal role due to its suppression by pretreatment with the antioxidant NAC.Accordingly,AMPK targets acetyl-Co A carboxylase and cyclic AMP response element binding protein are phosphorylated,with the concomitant carnitine palmitoyltransferase-1α(CPT-1α)activation and higher expression of peroxisome proliferator-activated receptor-γco-activator-1αand that of the fatty acid oxidation(FAO)-related enzymes CPT-1α,acyl-Co A oxidase 1,and acylCo A thioesterase 2.Under these conditions,T3 induced a significant increase in the serum levels ofβ-hydroxybutyrate,a surrogate marker for hepatic FAO.CONCLUSION:T3 administration activates liver AMPK signaling in a redox-dependent manner,leading to FAO enhancement as evidenced by the consequent ketogenic response,which may constitute a key molecular mechanism regulating energy dynamics to support T3preconditioning against ischemia-reperfusion injury. | Luis A Videla Virginia Fernández Pamela Cornejo Romina Vargas Paula Morales Juan Ceballo Alvaro Fischer Nicolás Escudero Oscar Escobar | 2014 | World Journal of Gastroenterology2014，20，46： | 3 |
| 5 | Mechanisms implicated in the contralateral effect in the central nervous system after unilateral injury:focus on the visual system显示文摘The retina,as part of the central nervous system is an ideal model to study the response of neurons to injury and disease and to test new treatments.During the last decade is becoming clear that unilateral lesions in bilateral areas of the central nervous system trigger an inflammatory response in the contralateral uninjured site.This effect has been better studied in the visual system where,as a rule,one retina is used as experimental and the other as control.Contralateral retinas in unilateral models of retinal injury show neuronal degeneration and glial activation.The mechanisms by which this adverse response in the central nervous system occurs are discussed in this review,focusing primarily on the visual system. | Fernando Lucas-Ruiz Caridad Galindo-Romero Virginia Albaladejo-García Manuel Vidal-Sanz Marta Agudo-Barriuso | 2021 | Neural Regeneration Research2021，16，11： | 2 |
| 6 | 在肝 preconditioning 的最近的进展: 甲状腺荷尔蒙, n-3 长链的多元不堡和丰满的酸和熨斗显示文摘 Liver preconditioning (PC), defined as an enhanced tolerance to injuring stimuli induced by previous specific maneuvers triggering beneficial functional and molecular changes, is of crucial importance in human liver transplantation and major hepatic resection. For these reasons, numerous PC strategies have been evaluated in experimental models of ischemia-reperfusion liver injury, which have not been transferred to clinical application due to side effects, toxicity and difficulties in implementation, with the exception of the controversial ischemic PC. In recent years, our group has undertaken the assessment of alternate experimental liver PC protocols that might have application in the clinical setting. These include thyroid hormone (T3), n-3 long-chain polyunsaturated fatty acids (n-3 LCPUFA), or iron, which suppressed liver damage due to the 1 h ischemia-20 h reperfusion protocol. T3, n-3 LCPUFA and iron are hormetic agents that trigger biologically beneficial effects in the low-dose range, whose multifactorial mechanisms of action are discussed in the work. | Virginia Fernández Gladys Tapia Luis A Videla | 2012 | World Journal of Hepatology2012，4，4： | 2 |
| 7 | A comparative evaluation of microalgae for the degradation of piggery wastewater under photosynthetic oxygenation显示文摘 | Ignacio de Godos Virginia A. Vargas Saúl Blanco María C. García González Roberto Soto Pedro A. García-Encina Eloy Becares Raúl Mu?oz | 2010 | Bioresource Technology2010，，14： | 2 |
| 8 | Trial of complete weaning from immunosuppression for liver transplant recipients: Factors predictive of tolerance显示文摘 | Rocío García Garza Pablo Sarobe Juana Merino Juan J. Lasarte Delia D’Avola Virginia Belsue José A. Delgado Leyre Silva Mercedes I?arrairaegui Bruno Sangro Jesus J. Sola Fernando Pardo Jorge Quiroga J. Ignacio Herrero | 2013 | Liver Transpl2013，，9： | 1 |
| 9 | Bioactive peptides in water-soluble extracts of ovine cheeses from Southern Brazil and Uruguay显示文摘 | Stela Maris Meister Meira Daniel Joner Daroit Virginia Etges Helfer Ana Paula Folmer Corrêa Jéferson Segalin Silvana Carro Adriano Brandelli | 2012 | Food Research International2012，，1： | 1 |
| 10 | Characterization of a bacteriocin-like substance produced by a vaginal lactobacillus salivarius strain显示文摘 | Virginia S O Aida A P Maria E N | 1999 | Appl Environ Microbiol1999，65，5： | 1 |
| 11 | Estimating Net Benefits of Recreation under Conditions of Excess Demand 显示文摘 | McConneU K E Duff Virginia A | 1976 | Journal of Environmental Economics and Management1976，2，1： | 1 |
| 12 | Carbon Isotopes Reveal Soil Organic Matter Dynamics Following arid Land Shrub Expansion显示文摘 | Connin S L Virginia R A Chamberlain C P | 1997 | Oecologia1997，110，： | 1 |
| 13 | Decline in a dominant invertebrate species contributes to altered carbon cy- cling in a low- diversity soil ecosystem 显示文摘 | Barrett J E Virginia R A Wall D H | 2008 | Global Change Biology2008，14，： | 1 |
| 14 | Impact of drought on desert shrubs: effects of seasonality and degree of resource island development显示文摘 | Reynolds J F Virginia R A Kemp P R | 1999 | Ecological Monographs1999，69，1： | 1 |
| 15 | Effect of the treatment with achyrocline satureioides (free and nanocapsules essential oil) and diminazene aceturate on hematological and biochemical parameters in rats infected by trypanosoma evansi显示文摘 | Guilherme M. Do Carmo Matheus D. Baldissera Rodrigo A. Vaucher Virginia Cielo Rech Camila B. Oliveira Michele Rorato Sagrillo Aline A. Boligon Margareth L. Athayde Marta P. Alves Raqueli T. Fran?a Sonia T.A. Lopes Claiton I. Schwertz Ricardo E. Mendes Sil | 2014 | Experimental Parasitology2014，，： | 1 |
| 16 | Regulation of protein kinase B/Akt - serine 473 phosphorylation by integrin - linked kinase: Critical roles for kinase activity and amino acids arginine211 and serine 343 显示文摘 | Sujata P Sarah A Virginia G | 2001 | J Biol Chero2001，276，27： | 1 |
| 17 | Relationship of Mor- phology and Other Language Skills to Literacy Skills in at-risk Second-grade Readers and at-risk Fourth-grade Writers 显示文摘 | William N Virginia B Robert A | 2003 | Journal of Educational Psychology2003，95，4： | 1 |
| 18 | Growth and root NH4^+ and NO3^- uptake capacity of three desert species in response to atmospheric CO2 enrichment 显示文摘 | Bassirirad H Reynolds J F Virginia A | 1997 | A ust J Plant Physiol1997，24，： | 1 |
| 19 | Polyurethane foams based on modified tung oil and reinforced with rice husk ash I: Synthesis and physical chemical characterization 显示文摘 | Virginia R Mima A Maria I | 2013 | Pol- 3 mer Testing2013，32，2： | 1 |
| 20 | Confirmation of Gnathostoma binucleatum Almeyda - Artigas, 1991, advanced third - stage larvae in Tres Palos Lagoon, Mexico, by morphological and molecular data 显示文摘 | Elizabeth A Martinez S Virginia LR | 2005 | J Parasitol2005，91，4： | 1 |
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