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| 1 | Present and future of metastatic colorectal cancer treatment: A review of new candidate targets显示文摘In the last two decades, great efforts have been made in the treatment of metastatic colorectal cancer(m CRC) due to the approval of new target agents for cytotoxic drugs. Unfortunately, a large percentage of patients present with metastasis at the time of diagnosis or relapse after a few months. The complex molecular heterogeneity of this disease is not completely understood; to date, there is a lack of predictive biomarkers that can be used to select subsets of patients who may respond to target drugs. Only the RAS-mutation status is used to predict resistance to anti-epidermal growth factor receptor agents in patients with m CRC. In this review, we describe approved targeted therapies for the management of metastatic m CRC and discuss new candidate targets on the horizon. | Giulia Martini Teresa Troiani Claudia Cardone Pietropaolo Vitiello Vincenzo Sforza Davide Ciardiello Stefania Napolitano Carminia Maria Della Corte Floriana Morgillo Antonio Raucci Antonio Cuomo Francesco Selvaggi Fortunato Ciardiello Erika Martinelli | 2017 | World Journal of Gastroenterology2017，23，26： | 7 |
| 2 | Costs of laparoscopic and open liver and pancreatic resection:A systematic review显示文摘AIM:To study costs of laparoscopic and open liver and pancreatic resections,all the compiled data from available observational studies were systematically reviewed.METHODS:A systematic review of the literature was performed using the Medline,Embase,Pub Med,and Cochrane databases to identify all studies published up to 2013 that compared laparoscopic and open liver[laparoscopic hepatic resection(LLR)vs open liver resection(OLR)]and pancreatic[laparoscopic pancreatic resection(LPR)vs open pancreatic resection]resection.The last search was conducted on October 30,2013.RESULTS:Four studies reported that LLR was associated with lower ward stay cost than OLR(2972 USD vs 5291 USD).The costs related to equipment(3345USD vs 2207 USD)and theatre(14538 vs 11406)were reported higher for LLR.The total cost was lower in patients managed by LLR(19269 USD)compared to OLR(23419 USD).Four studies reported that LPR was associated with lower ward stay cost than OLR(6755vs 9826 USD).The costs related to equipment(2496USD vs 1630 USD)and theatre(5563 vs 4444)were reported higher for LPR.The total cost was lower in the LPR(8825 USD)compared to OLR(13380 USD).CONCLUSION:This systematic review support the economic advantage of laparoscopic over open approach to liver and pancreatic resection. | Paolo Limongelli Chiara Vitiello Andrea Belli Madhava Pai Salvatore Tolone Gianmattia del Genio Luigi Brusciano Giovanni Docimo Nagy Habib Giulio Belli Long Richard Jiao Ludovico Docimo | 2014 | World Journal of Gastroenterology2014，20，46： | 5 |
| 3 | Effect of everolimus on the immunomodulation of the human neutrophil inflammatory response and activation显示文摘 | Damien Vitiello | 2015 | Cellular & Molecular Immunology2015，12，1： | 4 |
| 4 | Commentary of the mRNA vaccines COVID-19显示文摘The World Health Organization(WHO)declared global SARS-CoV-2(COVID-19)pandemic status on March 11,2020[1].To date,data record approximately 106 million infected individuals and 2.32 million deaths due to pandemic COVID-19,worldwide.The most common symptoms of SARS-CoV-2 infection reported are:elevation of body temperature,fatigue,cough,loss of smell.In a percentage of patients,especially elderly individuals with comorbidities,COVID-19 infection can cause severe organ injury[2].Since the onset of the COVID-19 pandemic,numerous pharmacological treatments have been used off label,to treat the viral infection,with the primary aim of avoiding the most serious complications and organ injury. | Antonio Vitiello Francesco Ferrara | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，5： | 2 |
| 5 | Development of a lipopepetide-based therapeutic vaccine to treat chronic HBV infection显示文摘 | Ishioka G Howard M | 1995 | J Clin Invest1995，95，： | 1 |
| 6 | Gene expression profiling revealsputative HOXA1O downstream targets in the periimp lantationmouse uterus显示文摘 | Vitiello D Pinard R Taylor HS | 2008 | Reprod Sci2008，15，5： | 1 |
| 7 | Complications associated with pediatric cardiac catheterization显示文摘 | Vitiello R McCrindle BW Nykanen D | 1998 | J Am Coil Cardioi1998，32，5： | 1 |
| 8 | Epidemiology of restless legs syndrome: a synthesis of the literature 显示文摘 | Ohayon MM O'Hara R Vitiello MV | 2012 | Sleep Meal Rev2012，16，4： | 1 |
| 9 | Gene expression profiling reveals putative HOXA10 downstream targets in the periimplantation mouse uterus显示文摘 | Vitiello D Pinard R Taylor HS | 2008 | Reprod Sci2008，15，5： | 1 |
| 10 | Development of a lipopepetidebased therapeutic vaccine to treat chronic HBV infection 显示文摘 | Vitiello A Ishioka G Howard M | 1995 | J Clin Invest1995，95，1： | 1 |
| 11 | Sleep complaints cosegregate with illness in older adults: clinical research imformed by and informing epidemiological studies of sleep显示文摘 | VITIELLO MV MOE KE PRING PN | 2002 | J Psychosom Res2002，53，1： | 1 |
| 12 | Loss of circadian rhythmicity in blood testosterone levels with ageing in normal men 显示文摘 | BBEMNER W J VITIELLO M V PRINZ P N | 1983 | Clin Endocrinol Metal)1983，56，： | 1 |
| 13 | Sleep complaints con- gregate with illness in older aduhs:clinical research by and informing epidemiologieal studies of sleep显示文摘 | Vitiello MV Moe KE Prinz PN | 2002 | Psychoses Res2002，53，1： | 1 |
| 14 | Prolactin modulates IL-8 production induced by porins or LPS through different signaling mechanisms 显示文摘 | D'Isanto M Vitiello M Raieta K | 2004 | Immunobiology2004，209，7： | 1 |
| 15 | Embedded adrenal cells graft reduced local and early nonspecific inflammatory phenomena which follow agarose beads implantation 显示文摘 | Cadic C Vitiello S Gin H | 1992 | Cell Transplant1992，1，5： | 1 |
| 16 | A depressed adolescent at high risk of suicidal behavior显示文摘 | Vitiello B Pearson JL | 2008 | Am J Psychiatry2008，165，3： | 1 |
| 17 | Peripheral Catecholamines are Involved in the Neuroendocrine and Immune Effects of LPS显示文摘 | Prollet C D Li K S Vitiello S | 1995 | Brain Behav Immun1995，9，： | 1 |
| 18 | Dissipation and quantization显示文摘 | Massimo Blasone Petr Jizba Giuseppe Vitiello | 2001 | Physics Letters A2001，，3： | 1 |
| 19 | Rapid eye movement sleep measures of dementia patiens and optimally health aged individuals显示文摘 | Vitiello MV Bokan JA | 1984 | Biol Psychiatry1984，19，9： | 1 |
| 20 | Development of a lipopep tide-based therpeutic vaccine to treat chronic HBV infection显示文摘 | Vitiello A Ishioka G Grey MH | 1995 | J Clin Invest1995，95，1： | 1 |
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