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| 1 | Prognostic and predictive biomarkers in metastatic colorectal cancer anti-EGFR therapy显示文摘AIM: To reviewing genetic and epigenetic make-up of metastatic colorectal cancers(m CRCs) addicted to epidermal growth factor receptor(EGFR) signalling.METHODS: The present study summarizes the potential value of prognostic and predictive biomarkers in selecting m CRC patients treated with anti-EGFR therapy. A meta-analysis was performed using a systematic search of Pub Med, Medline and Web of Science to identify eligible papers until March 21 st, 2016 using these following terms: ‘‘colorectal cancer'', 'predictive biomarkers' ', 'anti-EGFR therapy', 'KRAS', 'NRAS'', 'PIK3CA', 'TP53', 'PTEN', ‘‘EGFR', 'MET', 'HER2', 'epiregulin', 'amphiregulin', 'prognostic biomarkers', 'BRAF', 'miR NA' and 'antibody-dependent cell-mediated cytotoxicity(ADCC) activity'. Two investigators independently evaluated and extracted data from each identified studies based on selected criteria of inclusion and exclusion. RESULTS: The introduction of agents targeting EGFR such as cetuximab and panitumumab increased overall survival of mC RCs. Nevertheless, it has firstly became evident that response rates to cetuximab regimens in unselected patient populations were typically lower than 30%. Clinical data confirmed the predictive value of RAS mutations for resistance to cetuximab and panitumumab leading to the license of these monoclonal antibodies exclusively for the management of patients with RAS-wild type colorectal cancers. So far the identification of predictive biomarkers have generated interesting, though preliminary and, at times, conflicting data on the importance of tumour mR NA levels of EGFR ligands, of activating mutations in other genes such as NRAS and PIK3 CA. The prognostic value of selected micro RNAs level and ADCC activity is under investigation, while the prognostic impact of BRAF status remains controversial.CONCLUSION: This review focuses on the personalized treatment of m CRC and discusses the potential of new prognostic and predictive biomarkers in selecting patients treated with anti-EGFR therapy. | Cristiana Lo Nigro Vincenzo Ricci Daniela Vivenza Cristina Granetto Teresa Fabozzi Emanuela Miraglio Marco C Merlano | 2016 | World Journal of Gastroenterology2016，22，30： | 5 |
| 2 | Evaluation of antibody-dependent cell-mediatedcy totoxicity activity and cetuximab response in KRAS wildtype metastatic colorectal cancer patients显示文摘AIM:To investigate the prognostic role of invariant natural killer T(iNKT) cells and antibody-dependent cell-mediated cytotoxicity(ADCC) in wild type KRAS metastatic colorectal cancer(mC RC) patients treated with cetuximab.METHODS: Forty-one KRAS wt mC RC patients,treated with cetuximab and irinotecan-based chemotherapy in Ⅱ and Ⅲ lines were analyzed. Genotyping of single nucleotide polymorphism(SNP)s in the FCGR2A,FCGR3A and in the 3' untranslated regions of KRAS and mutational analysis for KRAS,BRAF and NRAS genes was determined either by sequencing or allelic discrimination assays. Enriched NK cells were obtained from lymphoprepperipheral blood mononuclear cell and iN KT cells were defined by co-expression of CD3,TCRVα24,TCRVβ11. ADCC was evaluated as ex vivo NK-dependent activity,measuring lactate dehydrogenase release.RESULTS: At basal,mCRC patients performing ADCC activity above the median level(71%) showed an improved overall survival(OS) compared to patients with ADCC below(median 16 vs 8 mo;P=0.026). We did not find any significant correlation of iN KT cells with OS(P=0.19),albeit we observed a trend to a longer survival after 10 mo in patients with iN KT above median basal level(0.382 cells/microliter). Correlation of OS and progression-free survival(PFS) with interesting SNPs involved in ADCC ability revealed not to be significant. Patients carrying alleles both with A in FCGR2 A and TT in FCGR3A presented a trend of longer PFS(median 9 vs 5 mo;P=0.064). Chemotherapy impacted both iN KT cells and ADCC activity. Their prognostic values get lost when we analysed them after 2 and 4 mo of treatment.CONCLUSION: Our results suggest a link between iN KT cells,basal ADCC activity,genotypes in FCGR2A and FCGR3A,and efficacy of cetuximab in KRAS wt mC RC patients. | cristiana lo nigro vincenzo ricci daniela vivenza martino monteverde giuliana strola francesco lucio federica tonissi emanuela miraglio cristina granetto mirella fortunato marco carlo merlano | 2016 | World Journal of Gastrointestinal Oncology2016，8，2： | 2 |
| 3 | Ghrelin gene polymorphisms and ghrelin, insulin, IGF-I, leptin and anthropometric data in children and adolescents 显示文摘 | Vivenza D Rapa A Castellino N | 2004 | Eur J Endoerinol2004，151，1： | 1 |
| 4 | A novel HESX1 splice mutation causes isolated GH deficiency by interfering with mRNA processing显示文摘 | Vivenza D Godi M Faienza M F Mellone S Moia S Rapa A Petri A Bellone S Riccomagno S Cavallo L | | 0，，： | 1 |
| 5 | Cerebral vasospasm after head injury 显示文摘 | Pasqualin A Vivenza C Lieata C | 1984 | Neuosurgery1984，15，1： | 1 |
| 6 | Circulating ghrelin levels in the newborn are positively associated with gestational age 显示文摘 | Bellone S Rapa A Vivenza D | 2004 | Clin Endoerinol (Oxf)2004，60，5： | 1 |
| 7 | Ghrelin gene polymorphisms and ghrelin, insulin, IGF-I, leptin and anthropometric data in children and adolescents显示文摘 | Vivenza D Rapa A Castellino N | 2004 | Eur J Endocrinol2004，151，1： | 1 |
| 8 | Cerebral vasospasm afterhead injury显示文摘 | Pasqualin A Vivenza C Rosta L | 1984 | Neurosurgery1984，15，6： | 1 |
| 9 | Circulating ghrelin levels in the newborn are positively associated with gestational age显示文摘 | Bellone S Rapa A Vivenza D | 2004 | Clin Endocrinol(Oxf)2004，60，： | 1 |
| 10 | Cerebral vasospasm after head injury显示文摘 | Pasqualin A Vivenza C Licata C | 1984 | Neuosurgery1984，1，： | 1 |
| 11 | Ghrelin gene polymor- phisms and ghrelin, insulin, IGF-I, leptin and anthropometric data in children and adolescents 显示文摘 | Vivenza D Rapa A Castenino N | 2004 | Eur J Endocrinol2004，151，1： | 1 |
| 12 | Circulating ghrelin levels as tianction of gender, pubertal status and adiposity in childhood 显示文摘 | Bellone S Rapa A Vivenza D | 2002 | J Endocrinol Invest2002，25，5： | 1 |
| 13 | Cerebral vasospasm after head injury显示文摘 | Pasqualin A Vivenza C Rosta L | 1984 | Neurosurgery1984，15，6： | 1 |
| 14 | Ghrelin gene polyorphisms and ghrelin,insulin,IGF-I,leptin and anthropoetric data in children and adolescent 显示文摘 | Vivenza D Rapa A CasteUinoN | 2004 | Eur J Endocrinol2004，151，1： | 1 |
| 15 | Cerebral vaso- spasm after head injury显示文摘 | Pasqualin A Vivenza C Rosta L | 1984 | Neurosurgery1984，15，： | 1 |
| 16 | Clarithromycin resistance of Helicobacter pylori strains isolated from children' gastric antrum and fundus as assessed by fluorescent in-situ hybridization and culture on four-sector agar plates 显示文摘 | Caristo E Parola A Rapa A Vivenza D Raselli B Dondi E Boldorini R Oderda G | 2008 | Helicobacter2008，13，6： | 1 |
| 17 | Heterozygous mutation of HESX1 causing hypopituitarism and multiple anatomical malformations without features of septo-optic dysplasia 显示文摘 | Corneli G Vivenza D Prodam F | 2008 | J Endocrinol Invest2008，31，8： | 1 |
| 18 | Ghrelin genepolymorphisms and ghrelin, insulin, IGF-I, leptin andanthropometric data in children and adolescents 显示文摘 | Vivenza D Rapa A Castellino N | 2004 | Eur JEndocrinol2004，151，： | 1 |
| 19 | Increased interleukin - 10 in Helicobacter pylori infection could be involved in the mechanism protecting from allergy显示文摘 | Oderda G Vivenza D Rapa A | 2007 | J Pediatr Gastroenterol Nutr2007，45，3： | 1 |
| 20 | MDM2 309 polymorphism predicts outcome in platinum-treated local ly advanced head and neck cancer 显示文摘 | Vivenza D Gasco M Monteverde M | 2012 | Oral oncology2012，48，7： | 1 |
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