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| 1 | Helicobacter pylori infection as a cause of iron deficiency anaemia of unknown origin显示文摘AIM: To assess the aetiological role of Helicobacter pylori (H. pylori) infection in adult patients with ironrefractory or iron-dependent anaemia of previously unknown origin. METHODS: Consecutive patients with chronic irondeficient anaemia (IDA) with H. pylori infection and a negative standard work-up were prospectively evaluated. All of them had either iron refractoriness or iron dependency. Response to H. pylori eradication was assessed at 6 and 12 mo from follow-up. H. pylori infection was considered to be the cause of the anaemia when a complete anaemia resolution without iron supplements was observed after eradication. RESULTS: H. pylori was eradicated in 88 of the 89 patients. In the non-eradicated patient the four eradicating regimens failed. There were violations of protocol in 4 patients, for whom it was not possible to ascertain the cause of the anaemia. Thus, 84 H. pylori eradicated patients (10 men; 74 women) were available to assess the effect of eradication on IDA. H. pylori infection was considered to be the aetiology of IDA in 32 patients (38.1%; 95%CI: 28.4%-48.8%). This was more frequent in men/postmenopausal women than in premenopausal women (75% vs 23.3%; P < 0.0001) with an OR of 9.8 (95%CI: 3.3-29.6). In these patients, anaemia resolution occurred in the first follow-up visit at 6 mo, and no anaemia or iron deficiency relapse was observed after a mean follow-up of 21 ± 2 mo. CONCLUSION: Gastric H. pylori infection is a frequent cause of iron-refractory or iron-dependent anaemia of previously unknown origin in adult patients. | Helena Monzón Montserrat Forné Maria Esteve Mercé Rosinach Carme Loras Jorge C Espinós Josep M Viver Antonio Salas Fernando Fernández-Baares | 2013 | World Journal of Gastroenterology2013，19，26： | 13 |
| 2 | Role of macrophage CD44 in the disposal of inflammatory cell corpses显示文摘 | Vivers S Dransfield I Hart SP | 2002 | Clin Sci2002，103，5： | 1 |
| 3 | Incidence of collagenous and lymphocytic colitis: a 5-year population-based study显示文摘 | Fernando Fernández-Ba?ares Antonio Salas Montserrat Forné Maria Esteve Jorge Espinós Josep Maria Viver | 1999 | The American Journal of Gastroenterology1999，，2： | 1 |
| 4 | Role of macrophage CD44 in the disposal of inflammatory cell corpses显示文摘 | Vivers S Dransfield I Hart SP | 2002 | Clin Sci2002，103，5： | 1 |
| 5 | Divalent cation-dependent and -independent augmentation of macrophage phagocytosis of apoptotic neutrophils by CD44 antibody显示文摘 | Vivers S Heasman SJ Hart SP | 2004 | Clin Exp Immunol2004，138，3： | 1 |
| 6 | Lipoxin A4 redistributes myosin II A and Cdc42 in macrophages : implications for phagocytosis of apop- totic leukocvtes显示文摘 | Reville K Crean J K Vivers S | 2006 | J Immunol:2006，176，3： | 1 |
| 7 | Lipoxin A4 redistributes myosin ⅡA and Cdc42 in macrophagcs: implications for phagocytosis of apoptotic leukocytes显示文摘 | Reville K Crean JK Vivers S | 2006 | J Immunol2006，176，3： | 1 |
| 8 | Role of macrophage CD44 in the disposal of inflammatory cell corpses 显示文摘 | Vivers S Dransfield I Hart SP | 2002 | Clin Sci2002，103，5： | 1 |
| 9 | Impact of mass screening for gluten-sensitive enteropathy in working population显示文摘AIM:To assess:(1)frequency and clinical relevanceof gluten sensitive enteropathy(GSE)detected by serology in a mass screening program;(2)sensitivity of antitransglutaminase(tTGA)and antiendomysium antibodies(EmA);and(3)adherence to gluten-free diet(GFD)and follow-up. METHODS:One thousand,eight hundred and sixtyeight subjects recruited from an occupational health department underwent analysis for tTGA and EmA and, if positive,duodenal biopsy,DQ2/DQ8 genotyping, clinical feature recording,blood tests,and densitometry were performed.Since>98%of individuals had tTGA <2 U/mL,this value was established as the cut-off limit of normality and was considered positive when confirmed twice in the same sample.Adherence to a GFD and follow up were registered. RESULTS:Twenty-six(1.39%)subjects had positive tTGA and/or EmA,and 21 underwent biopsy:six Marsh Ⅲ(oneⅢa,fourⅢb,oneⅢc),nine MarshⅠand six Marsh 0(frequency of GSE 1:125).The sensitivity of EmA for GSE was 46.6%(11.1%for MarshⅠ,100% for MarshⅢ),while for tTGA,it was 93.3%(88.8% for MarshⅠ,100%for MarshⅢ).All 15 patients with abnormal histology had clinical features related to GSE.MarshⅠandⅢsubjects had more abdominal pain than Marsh 0(P=0.029),and a similar trend was observed for distension and diarrhea.No differences in the percentage of osteopenia were found between MarshⅠandⅢ(P=0.608).Adherence to follow-up was 69.2%.Of 15 GSE patients,66.7%followed a GFD with 80%responding to it. CONCLUSION:GSE in the general population is frequent and clinically relevant,irrespective of histological severity.tTGA is the marker of choice.Mass screening programs are useful in identifying patients who can benefit from GFD and follow-up. | Meritxell Mariné Fernando Fernández-Baares Montserrat Alsina Carme Farré Montserrat Cortijo Rebeca Santaolalla Antonio Salas Margarita Tomàs Elias Abugattas Carme Loras Ingrid Ordás Josep M Viver Maria Esteve | 2009 | World Journal of Gastroenterology2009，15，11： | 0 |
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