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| 1 | Drain amylase value as an early predictor of pancreatic fistula after cephalic duodenopancreatectomy显示文摘AIM:To determine predictors of clinically relevant pancreatic fistulas(CRPF)by measuring drain fluid amylase(DFA)in the early postoperative period.METHODS:This prospective clinical study included382 patients with periampullary tumors that were surgically resected at our department between March 2005and October 2012.A cephalic duodenopancreatectomy (DP)was performed on all patients.Two closed suction drains were placed at the end of the surgery.The highest postoperative DFA value was recorded and analyzed during the first three postoperative days and on subsequent days if the drains were kept longer.Pancreatic fistula(PF)was classified according to the International Study Group of Pancreatic Fistula(ISGPF)criteria.Postoperative complications were defined according to the Dindo-Clavien classification.All data were statistically analyzed.The optimal thresholds of DFA levels on the first,second and third postoperative days were estimated by constructing receiver operating curves,generated by calculating the sensitivities and specificities of the DFA levels.The DFA level limits were used to differentiate between the group without PF and the groups with biochemical pancreatic fistula(BPF)and CRPF.RESULTS:Pylorus-preserving duodenopancreatectomy was performed on 289(75.6%)patients,while the remaining patients underwent a classic Whipple procedure(CW).The total incidence of PF was 37.7%(grade A22.8%,grade B 11.0%and grade C 3.9%).Soft pancreatic texture(SPT)was present in 58.3%of patients who developed PF.Mortality was 4.2%.The median DFA value on the first postoperative day(DFA1)in patients who developed PF was 4520 U/L(range 350-99000 U/L)for grade A fistula(BPF)with a SPT and a diameter of the main pancreatic duct(MPD)of≤3 mm.For grade B/C(CRPF),the median DFA1 value was 8501 U/L(range377-92060 U/L)with a SPT and MPD of≤3 mm.These values were significantly higher when compared to the patients who did not have PF(122;range 5-37875 U/L).The upper limit of DFA values for the first 3 postoperative days in the examined stages of PF were:DFA1 1200U/L for the BPF and CRPF;DFA3 350 U/L for BPF and DFA3 800 U/L for CRPF.The determined values were highly significant and demonstrated a reliable diagnostic test for both BPF and CRPF.CONCLUSION:DFA1≥1200 U/L is an important predictive factor for PF of any degree.The trend of DFA3(decrease of<50%)compared to DFA1 is a significant factor in the differentiation of CRPF from transient BPF. | Vladimir D Dugalic Djordje M Knezevic Vladan N Obradovic Miroslava G Gojnic-Dugalic Slavko V Matic Aleksandra R Pavlovic-Markovic Predrag D Dugalic Srbislav M Knezevic | 2014 | World Journal of Gastroenterology2014，20，26： | 7 |
| 2 | New frontiers for the materials genome initiative显示文摘The Materials Genome Initiative(MGI)advanced a new paradigm for materials discovery and design,namely that the pace of new materials deployment could be accelerated through complementary efforts in theory,computation,and experiment.Along with numerous successes,new challenges are inviting researchers to refocus the efforts and approaches that were originally inspired by the MGI.In May 2017,the National Science Foundation sponsored the workshop“Advancing and Accelerating Materials Innovation Through the Synergistic Interaction among Computation,Experiment,and Theory:Opening New Frontiers”to review accomplishments that emerged from investments in science and infrastructure under the MGI,identify scientific opportunities in this new environment,examine how to effectively utilize new materials innovation infrastructure,and discuss challenges in achieving accelerated materials research through the seamless integration of experiment,computation,and theory.This article summarizes key findings from the workshop and provides perspectives that aim to guide the direction of future materials research and its translation into societal impacts. | Juan J.de Pablo Nicholas E.Jackson Michael A.Webb Long-Qing Chen Joel E.Moore Dane Morgan Ryan Jacobs Tresa Pollock Darrell G.Schlom Eric S.Toberer James Analytis Ismaila Dabo Dean M.DeLongchamp Gregory A.Fiete Gregory M.Grason Geoffroy Hautier Yifei Mo Krishna Rajan Evan J.Reed Efrain Rodriguez Vladan Stevanovic Jin Suntivich Katsuyo Thornton Ji-Cheng Zhao | 2019 | npj Computational Materials2019，，1： | 7 |
| 3 | Transepithelial transport of putrescine across monolayers of the human intestinal epithelial cell line, Caco-2显示文摘AIM To study the transepithelial transport characteristics of the polyamine putrescine in human intestinal Caco-2 cell monolayers to elucidate the mechanisms of the putrescine intestinal absorption.METHODS The transepithelial transport and the cellular accumulation of putrescine was measured using Caco 2 cell monolayers grown on permeable filters.RESULTS Transepithelial transport of putrescine in physiological concentrations (>0.5 mM)from the apical to basolateral side was linear. Intracellular accumulation of putrescine was higher in confluent than in fully differentiated Caco-2 cells, but still negligible (less than 0.5%) of the overall transport across the monolayers in apical-to-basolateral direction. EGF enhanced putrescine accumulation in Caco-2 cells by four-fold, as well as putrescine conversion to spermidine and spermine by enhancing the activity of Sadenosylmethionine decarboxylase. However,EGF did not have any significant influence on putrescine flux across the Caco-2 cell monolayers. Excretion of putrescine from Caco-2cells into the basolateral medium did not exceed 50 picomoles, while putrescine passive flux from the apical to the basolateral chamber,contributed hundreds of micromoles polyamines to the basolateral chamber.CONCLUSION Transepithelial transport of putrescine across Caco-2 cell monolayers occurs in passive diffusion, and is not influenced when epithelial cells are stimulated to proliferate by a potent mitogen such as EGF. | Vladan Milovic Lyudmila Turchanowa Jürgen Stein Wolfgang F.Caspary | 2001 | World Journal of Gastroenterology2001，7，2： | 5 |
| 4 | Improving dispersion of SnO 2 nanoparticles in Ag–SnO 2 electrical contact materials using template method显示文摘 | Vladan ?osovi? Aleksandar ?osovi? Nade?da Talijan Dragana ?ivkovi? Dragan Manasijevi? Du?ko Mini? | 2013 | Journal of Alloys and Compounds2013，，： | 2 |
| 5 | Polyaniline-coated PET conductive yarns: study of electrical, mechanical, and electro-mechanical properties显示文摘 | Bohwon Kim Vladan Koncar | 2006 | Journal of Applied Polymer Science2006，101，： | 1 |
| 6 | Melatonin and abeta, macular degeneration and alzheimers disease: same disease, different outcomes显示文摘 | Vladan B Panfoli I | 2012 | Med Hypothesis Discov Innov Ophthalmol2012，1，2： | 1 |
| 7 | Determining Bookkeeping Cash Maximum of Serbian Army Units by Using Multicriteria Optimization显示文摘 | Ivan Milojevic Milan Mihajlovic Vladan Vladisavljevic | 2015 | Journal of Mathematics and System Science2015，5，1： | 1 |
| 8 | 显示文摘 | Kim Bohwon Koncar Vladan Devaux Eric | 2004 | Synthetic Metals2004，146，： | 1 |
| 9 | Content adaptive enhancement of multiview depth maps for free viewpoint video显示文摘 | EKMEKCIOGLU Erhan VELISAVUEVI C Vladan WOR- RALL Stewart T | 2010 | IEEE Journal in Signal Processing2010，，： | 1 |
| 10 | Interconnection and Damping Assignment Approach to Control of PM Synchronous Motors 显示文摘 | Vladan Petrovie Romeo Ortega Stankovie A M | 2001 | IEEE Transactions on Control Systems Technology2001，9，6： | 1 |
| 11 | Advance in the precoat filtration process显示文摘 | Boittelle Caroline Poupot Christian Milisic Vladan | 2008 | Separation Science and Technology2008，43，7： | 1 |
| 12 | Schizophrenia: improving the continuity of care to ensure optimal patient outcomes 显示文摘 | Vladan N Robert LB Mark BH | 2012 | Dis Mon2012，58，7： | 1 |
| 13 | Investigation of the taper of kerfs cut in steels by AWJ 显示文摘 | Hlavae L M Vladan G Stefan P | 2015 | The International Journal of Advanced Manufacturing Technology2015，77，9： | 1 |
| 14 | Thermal–hydraulic analysis of a steam boiler with rifled evaporating tubes显示文摘 | Dragan R. Tucakovic Vladimir D. Stevanovic Titoslav Zivanovic Aleksandar Jovovic Vladan B. Ivanovi? | 2006 | Applied Thermal Engineering2006，，2： | 1 |
| 15 | Design and Development of a Flexible Strain Sensor for Textile Structures Based on a Conductive Polymer Composite 显示文摘 | Cedric C Vladan K Maryline L | 2007 | Sensors2007，，7： | 1 |
| 16 | 显示文摘 | Eric Devaux Vladan Koncar Bohwon IKim | 2007 | Transac tions of the Institute of Measurement and Control2007，29，34： | 1 |
| 17 | Expert Systems in Finance-A Cross-section of the Field 显示文摘 | Ljubica Nedovic Vladan Devedzic | 2002 | Expert Systems with Applications2002，23，1： | 1 |
| 18 | Polyamines in the gut lumen: bioavailability and biodistribution显示文摘 | Vladan Milovic | 2001 | European Journal of Gastroenterology & Hepatology2001，，9： | 1 |
| 19 | Electrical and morphological properties of PP and PET conductive polymer fibers 显示文摘 | Bohwon Kim Vladan Koncar Eric Devaux Claude Dufour Pierre Viallier | 2004 | Synthetic Metals2004，，146： | 1 |
| 20 | Wearable obstacle detection system fully integrated to textile structures for visually impaired people显示文摘 | Senem Kursun Bahadir Vladan Koncar Fatma Kalaoglu | 2012 | Physical2012，，： | 1 |
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