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| 1 | Reaction of antibodies to Campylobacter jejuni and cytolethal distending toxin B with tissues and food antigens显示文摘BACKGROUND The bacteria Campylobacter jejuni(C. jejuni) is commonly associated with GuillaneBarré syndrome(GBS) and irritable bowel syndrome(IBS), but studies have also linked it with Miller Fisher syndrome, reactive arthritis and other disorders, some of which are autoimmune. It is possible that C. jejuni and its toxins may be crossreactive with some human tissues and food antigens, potentially leading to autoimmune responses.AIM To measure the immune reactivity of C. jejuni and C. jejuni cytolethal distending toxin(Cdt) antibodies with tissue and food antigens to examine their role in autoimmunities.METHODS Using enzyme-linked immunosorbent assay(ELISA) methodology, specific antibodies made against C. jejuni and C. jejuni Cdt were applied to a variety of microwell plates coated with 45 tissues and 180 food antigens. The resulting immunoreactivities were compared to reactions with control wells coated with human serum albumin(HSA) which were used as negative controls and with wells coated with C. jejuni lysate or C. jejuni Cdt which served as positive controls.RESULTS At 3 SD above the mean of control wells coated with HSA or 0.41 OD, the mouse monoclonal antibody made against C. jejuni showed moderate to high reactions with zonulin, somatotropin, acetylcholine receptor, β-amyloid and presenilin.This immune reaction was low with an additional 25 tissue antigens including asialoganglioside, and the same antibody did not react at all with another 15 tissue antigens. Examining the reaction between C. jejuni antibody and 180 food antigens, we found insignificant reactions with 163 foods but low to high immune reactions with 17 food antigens. Similarly, we examined the reaction of C. jejuni Cdt with the same tissues and food antigens. The strongest reactions were observed with zonulin, intrinsic factor and somatotropin. The reaction was moderate with 9 different tissue antigens including thyroid peroxidase, and reaction was low with another 10 different antigens, including neuronal antigens.The reaction of C. jejuni Cdt antibody with an additional 23 tissue antigens was insignificant. Regarding the reaction of C. jejuni Cdt antibody with different food antigens, 160 out of 180 foods showed insignificant reactions, while 20 foods showed reactions ranging from low to high.CONCLUSION Our findings indicate that C. jejuni and its Cdt may play a role in inflammation and autoimmunities beyond the gut. | Aristo Vojdani Elroy Vojdani | 2019 | World Journal of Gastroenterology2019，25，9： | 3 |
| 2 | Quantitative study of the effects of morphine on the mouse spleen and inguinal lymph node 显示文摘 | Vojdani Z Dehghani F Seyedi F | 2010 | Arch Iran Med2010，13，4： | 1 |
| 3 | Regulatory T Cell, a potent immunoregulatory target for CAM researchers: modulating tumor immunity, autoimmunity and aUoreactive immunity (Ⅲ)显示文摘 | Vojdani A Erde J | 2006 | Evid Based Complement Altemat Med2006，3，3： | 1 |
| 4 | A Transmission Services Costing Framework 显示文摘 | Wakefield R A Graves J S Vojdani A F | 1997 | IEEE Transactions on Power Systems1997，12，2： | 1 |
| 5 | Effects of curing thermal residual stresses on fatigue crack propagation of aluminum plates repaired by FML patches显示文摘 | TOUDESHKY H H SADIGHI M VOJDANI A | 2013 | Composite Structures2013，100，6： | 1 |
| 6 | Transmission dispatch and congestion management in the emerging energy market structures显示文摘 | B Wollenberg A Vojdani | 1998 | IEEE Transactions on Power Systems1998，13，4： | 1 |
| 7 | Antibodies to neuronspecific antigens in children with autism: possible cross-reaction with encephalitogenic proteins from milk, Chlamydia pnewnoniae and Streptcoccus groupA显示文摘 | Vojdani A Campbell AW Aayanwu E | 2002 | Newroimmund2002，129，12： | 1 |
| 8 | Cellular and humoral immune abnormalities in Gulf War veterans显示文摘 | Vojdani A Thrasher JD | 2004 | Environ-Health-Perspect2004，112，8： | 1 |
| 9 | The effect of thermal and mechanical cycling on bond strength of a ceramic to nickel-chromium (Ni-Cr) and cobalt-chromium (Co-Cr) alloys 显示文摘 | Vojdani M Shaghaghian S Khaledi A | 2012 | Indian J Dent Res2012，23，4： | 1 |
| 10 | New evidence for antioxidant properties of vitamin C 显示文摘 | VOJDANI A | 2005 | Cancer Detect Prey2005，24，6： | 1 |
| 11 | Smart integration显示文摘 | Vojdani Ali | 2008 | IEEE Power and Energy Magazine2008，6，6： | 1 |
| 12 | Antibodies to neuron-specific antigens in children with autism : possible Clogsreaction with encephalitogenic proteins from milk显示文摘 | Vojdani A Campbell A Anyanwu A | 2002 | Neuroimmunology2002，129，： | 1 |
| 13 | Transmission dispatch and congestion management in the emerging energy market structures显示文摘 | Shirmohammadi D Wollenberg B Vojdani A | 1998 | IEEE Transactions on Power Systems1998，13，4： | 1 |
| 14 | Low natural killer cell cytotoxic activity in autism: The role of glutathione, IL-2 and IL-15 显示文摘 | Vojdani A Mumper E Granpeesheh D | 2008 | Journal of Neuroimmunology2008，205，： | 1 |
| 15 | Detection of IgE, IgG, IgA and IgM antibodies against raw and processed food antigens显示文摘 | Vojdani A | 2009 | Nutr Metab (Lond)2009，6，： | 1 |
| 16 | Antibodies to neuron-specific antigens in children with autism: possibie cross- reaction with encephalitogenic proteins from milk,Chlamydia pneu- moniae and Streptococcus group A显示文摘 | Vojdani A Campbell AW Anyanwu E | 2002 | J Neuroimmunol2002，129，12： | 1 |
| 17 | Antibodies to neuron-specific antigens in children with autism:possible cross-reaction with encephalitogenic proteins from milk, Chlarnydia pneumoniae and Streptococcus group A 显示文摘 | Vojdani A Campbell AW Anyanwu E | 2002 | J Neuroimmunol2002，129，12： | 1 |
| 18 | Antibodies to neuron - specific antigens in children with autism : possible cross -reaction with encephalitogenic proteins from milk, Chlamydia pneumoniae and Streptococcusgroup A 显示文摘 | Vojdani A Campbell AW Anyanwu E | 2002 | J Neuroimmunol2002，129，12： | 1 |
| 19 | Genes involved in osmoregulation during turgor-driven expansin of developing cotton fibers are differential regulated 显示文摘 | Smart L B Vojdani F Maeshima M | 1998 | PlantPhysiol1998，116，： | 1 |
| 20 | Potasium sorbate permeability of methyl-cellilose and hydroxypropyl methylcellulose coatings:effect of fatty acids显示文摘 | Vojdani F Torres J A | 1990 | J Food Sci1990，55，： | 1 |
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