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| 1 | Systematic review of colorectal cancer screening guidelines for average-risk adults: Summarizing the current global recommendations显示文摘AIM To summarize and compare worldwide colorectal cancer(CRC) screening recommendations in order to identify similarities and disparities.METHODS A systematic literature search was performed using MEDLINE, EMBASE, Scopus, CENTRAL and ISI Web of knowledge identifying all average-risk CRC screening guideline publications within the last ten years and/or position statements published in the last 2 years. In addition, a hand-search of the webpages of National Gastroenterology Society websites, the National Guideline Clearinghouse, the BMJ Clinical Evidence website,Google and Google Scholar was performed. RESULTS Fifteen guidelines were identified. Six guidelines were published in North America, four in Europe, four in Asia and one from the World Gastroenterology Organization. The majority of guidelines recommend screening average-risk individuals between ages 50 and 75 using colonoscopy(every 10 years), or flexible sigmoidoscopy(FS, every 5 years) or fecal occult blood test(FOBT, mainly the Fecal Immunochemical Test, annually or biennially). Disparities throughout the different guidelines are found relating to the use of colonoscopy, rank order between test, screening intervals and optimal age ranges for screening. CONCLUSION Average risk individuals between 50 and 75 years should undergo CRC screening. Recommendations for optimal surveillance intervals, preferred tests/test cascade as well as the optimal timing when to start and stop screening differ regionally and should be considered for clinical decision making. Furthermore, local resource availability and patient preferences are important to increase CRC screening uptake, as any screening is better than none. | Florence Bénard Alan N Barkun Myriam Martel Daniel von Renteln | 2018 | World Journal of Gastroenterology2018，24，1： | 16 |
| 2 | A Critical Role of AMT2;1 in Root-To-Shoot Translocation of Ammonium in Arabidopsis显示文摘在植物根的铵举起被 AMT/MEP/Rh-type 铵 transporters 调停。从在 Arabidopsis 根被表示的五 AMT,四 AMT1 类型 transporters 而没有生理的功能到目前为止被分到属于 MEP 亚科的唯一的相当或相同的事物,贡献铵举起, AMT2; 1。基于在铵供应下面,抄本 AMT2 铺平的观察; 1 增加了,它的倡导者活动优先地变了到 pericycle,我们估计了 AMT2 的贡献; 1 到木部装载。当暴露了到 15标记 N 的铵, amt2; 1 变异的线 translocated 更少 tracer 到射击和在木部树液的包含的更少铵。而且,在 amt1 ; 1 amt1 ; 2 amt1 ; 3 amt2 ; 1 四倍的异种( qko ), AMT2 的合作表示; 1 与任何一个 AMT1 ; 2 或 AMT1 ; 3 显著地提高的 15 N translocation 到射击,显示在 AMT2 之间的一个合作行动; 1 并且 AMT1 transporters 。在 N 缺乏下面, proAMT2; 1-GFP 线在外皮的根房间主要显示出提高的倡导者活动,它与一致,提高的铵流入由 AMT2 交谈了; 1 在 millimolar 底层集中。我们的结果除了在低亲密关系的范围中等作出贡献到根举起显示那, AMT2;主要在铵的 root-to-shoot translocation 的 1 个函数,响应 ?植物取决于它的 cell-type-specific 表达式营养的地位并且到本地铵坡度。 | Ricardo F.H. Giehl Alberto M. Laginha Fengying Duan Doris Rentsch Lixing Yuan Nicolaus von Wirén | 2017 | Molecular Plant2017，10，11： | 10 |
| 3 | Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors显示文摘Pancreatic carcinomas with acinar differentiation are rare,accounting for 1%-2% of adult pancreatic tumors; they include pancreatic acinar cell carcinoma(PACC),pancreatoblastoma,and carcinomas of mixed differentiation. Patients with PACC have a prognosis better than pancreatic ductal adenocarcinomas but worse than pancreatic neuroendocrine tumors. Reports of overall survival range from 18 to 47 mo. A literature review on PACCs included comprehensive genomic profiling and whole exome sequencing on a series of more than 70 patients as well as other diagnostic studies including immunohistochemistry. Surgical resection of PACC is the preferred treatment for localized and resectable tumors. The efficacy of adjuvant treatment is unclear. Metastatic PACCs are generally not curable and treated with systemic chemotherapy. They are moderately responsive to chemotherapy with different regimens showing various degrees of response in case reports/series. Most of these regimens were developed to treat patients with pancreatic ductal adenocarcinomas or colorectal adenocarcinomas. Review of PACC's molecular profiling showed a number of gene alterations such as: SMAD4,BRAF,BRCA2,TP53,RB1,MEN1,JAK-1,BRCA-1,BRCA-2,and DNA mismatch repair abnormalities. PACCs had multiple somatic mutations with some targetable with available drugs. Therefore,molecular profiling of PACC should be an option for patients with refractory PACC. | Ahmad Al-Hader Rami N Al-Rohil Haiyong Han Daniel Von Hoff | 2017 | World Journal of Gastroenterology2017，23，45： | 8 |
| 4 | PDX1.1-dependent biosynthesis of vitamin B6 protects roots from ammonium-induced oxidative stress显示文摘Despite serving as a major inorganic nitrogen source for plants,ammonium causes toxicity at elevated con-centrations,inhibiting root elongation early on.While previous studies have shown that ammonium-inhibited root development relates to ammonium uptake and formation of reactive oxygen species(ROS)in roots,it remains unclear about the mechanisms underlying the repression of root growth and how plants cope with this inhibitory effect of ammonium.In this study,we demonstrate that ammonium-induced apo-plastic acidification co-localizes with Fe precipitation and hydrogen peroxide(H_(2)O_(2))accumulation along the stele of the elongation and differentiation zone in root tips,indicating Fe-dependent ROS formation.By screening ammonium sensitivity in T-DNA insertion lines of ammonium-responsive genes,we identified PDX1.1,which is upregulated by ammonium in the root stele and whose product catalyzes de novo biosyn-thesis of vitamin B6.Root growth of pdx1.1 mutants is hypersensitive to ammonium,while chemical complementation or overexpression of PDX1.1 restores root elongation.This salvage strategy requires non-phosphorylated forms of vitamin B6 that are able to quench ROS and rescue root growth from ammo-nium inhibition.Collectively,these results suggest that PDX1.1-mediated synthesis of non-phosphorylated B6 vitamers acts as a primary strategy to protect roots from ammonium-dependent ROS formation. | Ying Liu Rodolfo A.Maniero Ricardo F.H.Giehl Michael Melzer Priscille Steensma Gabriel Krouk Teresa B.Fitzpatrick Nicolaus von Wirén | 2022 | Molecular Plant2022，15，5： | 3 |
| 5 | Haploid barley from the intergenetic cross Hordeum vulagre×Psathyrostachys fragilis显示文摘 | von Bothmer R Jacobsen N Jorgensen R B | 1984 | Euphytica1984，33，： | 2 |
| 6 | Nutrient-hormone relations:Driving root plasticity in plants显示文摘Optimal plant development requires root uptake of 14 essential mineral elements from the soil.Since the bioavailability of these nutrients underlies large variation in space and time,plants must dynamically adjust their root architecture to optimize nutrient access and acquisition.The information on external nutrient availability and whole-plant demand is translated into cellular signals that often involve phytohormones as intermediates to trigger a systemic or locally restricted developmental response.Timing and extent of such local root responses depend on the overall nutritional status of the plant that is transmitted from shoots to roots in the form of phytohormones or other systemic long-distance signals.The integration of these systemic and local signals then determines cell division or elongation rates in primary and lateral roots,the initiation,emergence,or elongation of lateral roots,as well as the formation of root hairs.Here,we review the cascades of nutrient-related sensing and signaling events that involve hormones and highlight nutrient-hormone relations that coordinate root developmental plasticity in plants. | Zhongtao Jia Ricardo F.H.Giehl Nicolaus von Wirén | 2022 | Molecular Plant2022，15，1： | 2 |
| 7 | Learning and optimization using the clonal selection principle 显示文摘 | Castro L N D Von Zuben F J | 2002 | IEEE Transactions on Evolutionary Computation2002，6，3： | 1 |
| 8 | Final safety results of BO17704(A-VAiL):a phase III randomized study of first-line bevacizumab(BV)and cisplatin/gemcitabine(CG)in patients(pts)with ad-vanced or recurrent nonsquamous non-small cell lung cancer(NSCLC)显示文摘 | Hirsh V Ramlau R von Pawel J Zatloukal P Vera G Leighl N Mezger J Archer V Reck M | 2009 | J Clin Oncol2009，，： | 1 |
| 9 | Oxidized low densi- ty lipoproteins, statin therapy and severity of coronary artery dis- ease显示文摘 | Ndrepepa G Braun S von Beckerath N | 2005 | Clin Chim Acta2005，360，12： | 1 |
| 10 | Impact of P-glycoprotein on clopidogrel absorption显示文摘 | Taubert D von Beckerath N Grimberg G | 2006 | Clin Pharmacol Ther2006，80，5： | 1 |
| 11 | The F-Box protein Skp2 participates in c-Myc protelosornal degradation and acts as a cofactor for c-Myc-regulated transcription显示文摘 | von der Lehr N Johansson S Wu SQ | | 0，，05： | 1 |
| 12 | Plasticity of the Arabidopsis root system under nutrient deficiencies显示文摘 | Gruber BD Giehl RFH Friedel S von Wirén N | 2013 | Plant Physiol2013，163，1： | 1 |
| 13 | Absorption, metabolization, and antiplatelet effects of 300-, 600-, and 900-rag loading doses of clopidogrel: results of the ISAR-CHOICE (Intraeoronary Stenting and Antithrombotic Regimen: Choose Between 3 High Oral Doses for Immediate Clopidogrel Effect ) trim 显示文摘 | VON BECKCRATH N TAUBERT D POGATSA-MURRAY G | 2005 | Circulation2005，112，19： | 1 |
| 14 | The Construction of a Boolean Competitive Neural Network Using Ideas from Immunology显示文摘 | Von Zuben F J De Deus J G A | 2003 | Neurocomputing2003，50，： | 1 |
| 15 | Estimation of age at death based on quantitation of the 4977-bp deletion of human mitochondrial DNA in skeletal muscle显示文摘 | von Wurmb N Schimansky B | 1999 | Forensic Sci Int1999，105，2： | 1 |
| 16 | Systematic review of genomie integration sites of human papillomavirus genomes in epithelial dysplasia and invasive cancer of the lower genital tract显示文摘 | Wentaensen N Vinokurova S von Knebel Doeberitz M | 2004 | Cancer Res2004，64，： | 1 |
| 17 | High-level production of D-mannitol with membrane cell-recycle bioreactor 显示文摘 | Weymam N Von Kiviharju K Leisola M | 2002 | Journal of Industry Microbiology & Biotechnology2002，29，： | 1 |
| 18 | presentation and outcome of strangulated external hernia in adistrict general hospital显示文摘 | Ghisletta N Von FM Von FM | | 0，，： | 1 |
| 19 | Transanal endoscopic microsurgical excision of rectal tumors : indications and results 显示文摘 | Demartines N von Fltle MO Harder FH | 2001 | World J Surg2001，25，7： | 1 |
| 20 | The construction of a boolean competitive neural network using ideas from immunology显示文摘 | DE C L N VON Z F J DE D J G A | 2003 | Neurocomputing2003，50，： | 1 |
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