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| 1 | Fecal lactoferrin accurately reflects mucosal inflammation in inflammatory bowel disease显示文摘BACKGROUND Studies have demonstrated a potential role for fecal biomarkers such as fecal calprotectin(FC)and fecal lactoferrin(FL)in monitoring inflammatory bowel diseases(IBD)-Crohn's disease(CD)and ulcerative colitis(UC).However,their correlation to endoscopic scores,disease severity and affected intestinal surface has not been extensively investigated.AIM To correlate FL,and for comparison white blood cell(WBC)and C-reactive protein(CRP),with endoscopic scores,disease extent and location in CD and UC.METHODS Retrospective analysis in 188 patients who had FL,CRP and WBC determined within 30 d of endoscopy.Disease location,disease extent(number of intestinal segments involved),disease severity(determined by endoscopic scores),timing of FL testing in relation to colonoscopy,as well as the use of effective fast acting medications(steroids and biologics)between colonoscopy and FL measurement,were recorded.RESULTS In 131 CD and 57 UC patients,both CRP and FL-but not WBC-distinguished disease severity(inactive,mild,moderate,severe).In patients receiving fastacting(steroids or biologics)treatment in between FL and colonoscopy,FL showed a higher correlation to endoscopic scores when tested before vs after the procedure(r=0.596,P<0.001,vs r=0.285,P=0.15 for the Simple Endoscopic Score for CD;and r=0.402,P=0.01 vs r=0.054 P=0.84 for Disease Activity Index).Finally,FL was significantly correlated with the diseased mucosal surface(colon-ileocolon>small bowel)and the number of inflamed colon segments.CONCLUSION FL and CRP separated disease severity categories with FL showing lower discriminating P-values.FL showed a close correlation with the involved mucosal surface and with disease extent and was more closely correlated to endoscopy when determined before the procedure–this indicating that inflammatory activity changes associated with therapy might be rapidly reflected by FL levels.FL can accurately and timely characterize intestinal inflammation in IBD. | Marrieth G Rubio Kofi Amo-Mensah James M Gray Vu Q Nguyen Sam Nakat Douglas Grider Kim Love James H Boone Dario Sorrentino | 2019 | World Journal of Gastrointestinal Pathophysiology2019，10，5： | 4 |
| 2 | OSP/Clau- din-11 forms a complex with a novel member of the tetraspanin su- per family and ctl integrin and regulates proliferation and migration of oligodendrocytes 显示文摘 | Tiwari-Woodruff S K Buznikov A G Vu T Q | 2001 | J Cell Biol2001，153，： | 1 |
| 3 | Skyframe: a framework for skyline query processing in peer-to-peer systems 显示文摘 | Wang Shi-yuan Vu Q H Ooi B C | 2009 | The VLDB Journal2009，18，： | 1 |
| 4 | Evidence for high trans- lational potential of mesenchymal stromal cell therapy to improve recovery from ischemic stroke 显示文摘 | Eckert M A Vu Q Xie K | 2013 | J Cereb Blood Flow Metab2013，33，9： | 1 |
| 5 | Effect of condensable impurity in CO2/CH4 gas feeds on performance of mixed matrix membranes using carbon molecular sieves显示文摘 | Vu D Q Koros W J Miller S J | 2003 | Journal of Membrane Science2003，221，： | 1 |
| 6 | Fabrication of glass fiber reinforced composite films for flexible organic light emitting diode devices 显示文摘 | Ryu S C Kim J W Vu Q H | 2009 | Molecular Crystals and Liquid Crystals2009，514，1： | 1 |
| 7 | Matrix metalloproteinase 9 and vascular endothelial growth factor are essential for osteoclast recruitment into developing long bones显示文摘 | Engsig MT Chen Q J Vu TH | 2000 | J Cell Biol2000，151，4： | 1 |
| 8 | Discovery of (2,3-difluoro-6- methoxyphenyl)methanone (R547), a potent and selective cyclin-dependent kinase inhibitor with significant in vivo antitumor activity显示文摘 | Chu XJ DePinto W Bartkovitz D So SS Vu BT Packman K Lukacs C Ding Q Jiang N Wang K Goelzer P Yin X Smith MA Higgins BX Chen Y Xiang Q Moliterni J Kaplan G Graves B Lovey A Fotouhi N | 2006 | J Med Chem2006，49，22： | 1 |
| 9 | 显示文摘 | Kim Anh T Minh Q Vu N | 2003 | J Lumin2003，，102103： | 1 |
| 10 | Electrode materials for lithium-ion batteries-how to prepare them and what makes them special显示文摘 | VU A QIAN Y Q STEIN A | 2012 | Ad- vanced Energy Materials2012，，10： | 1 |
| 11 | Silsesquioxane-siloxane copolymers from polyhedral silsesquioxanes 显示文摘 | LICHTENHAN J D VU N Q CARTER J A | 1993 | Macromolecules1993，26，8： | 1 |
| 12 | Silsesquioxane-siloxane copolymers from polyhedral silsesquioxanes 显示文摘 | Lichtenhan J D Vu N Q Carter J A | 1993 | Macromolecules1993，26，： | 1 |
| 13 | Bacterial interactions and transport in geological formation of alumino-silica clays显示文摘 | Vu K Yang Q Wang BY | 2015 | Colloids and Surfaces B Biointerfaces2015，125，： | 1 |
| 14 | 显示文摘 | William J Koros Stephen J Miller | 2003 | Journal of Membrane Science2003，，211： | 1 |
| 15 | A behavioral analysis of web sharers and browsers in Hong Kong using targeted association rule mining 显示文摘 | Rong Jia Vu H Q Law R | 2011 | Tourism Management2011，33，4： | 1 |
| 16 | Silsesquioxane siloxane copolymers from polyhedral silsesquioxanes显示文摘 | Lichtenhan J D Vu N Q Carter J A | 1993 | Macromolecules1993，26，8： | 1 |
| 17 | Vibration analysis of steel frames with semi-rigid connections on an elastic foundation 显示文摘 | Vu A Q Leon R T | 2008 | Steel and Composite Structures2008，8，4： | 1 |
| 18 | Silsesquioxane-siloxane copolymers from polyhedral sils- esquioxanes 显示文摘 | LICHTENHAN J D VU N Q CARTER J A | 1993 | Macromolecules1993，26，8： | 1 |
| 19 | Polypyrrole/ Al2O3 nanocomposites:preparation,characterisation and electromagnetic shielding properties显示文摘 | VU Q T DUONG N T DUONG N H | | 0，，03： | 1 |
| 20 | Cut-edge corrosion of a Zn-55Al-coated steel: A comparison between sulphate and chloride solutions 显示文摘 | VU A Q VUILLEMIN U OLTRA R ALLELY C | 2011 | Corrosion Science2011，53，： | 1 |
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