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68篇 您的检索式：作者名="Vyse"

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	题名	作者	年代	出处	被引量
1	Targeting EGFR exon 20 insertion mutations in non-small cell lung cancer显示文摘Inframe insertions of three or more base pairs in exon 20 of the epidermal growth factor receptor(EGFR)gene were among the first EGFR mutations to be identified as oncogenic drivers in non-small cell lung cancer(NSCLC).However,unlike the classical EGFR L858R point mutation or exon 19 deletions,which represent the majority of EGFR mutations in NSCLC,low frequency EGFR exon 20 insertion mutations are associated with de novo resistance to targeted EGFR inhibitors and correlate with a poor patient prognosis.Here,we review the developments over the last 5 years in which pre-clinical studies,including elucidation of the crystal structure of an EGFR exon 20 insertion mutant kinase,have revealed a unique mechanism of kinase activation and steric conformation that define the lack of response of these EGFR mutations to clinically approved EGFR inhibitors.The recent development of several novel small molecule compounds that selectively inhibit EGFR exon 20 insertions holds promise for future therapeutic options that will be effective for patients with this molecular subtype of NSCLC.	Simon Vyse Paul H.Huang	2019	Signal Transduction and Targeted Therapy2019，4，1：	3
2	Genetic susceptibility to systemic lupus erythematosus显示文摘	Vyse TJ Kotzin BL		0，，：	1
3	Paper machine efficiency : the most impor- tant parameter, how to get it and how to keep it 显示文摘	Mardon J Vyse R Ely D	1992	Pulp & Paper Canada1992，92，12：	1
4	The genetics of lupus: a functional perspective 显示文摘	Guerra S G Vyse T J Cunninghame Graham D S	2012	Arthritis Res Ther2012，，3：	1
5	Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans显示文摘	Aitman T J Dong R Vyse T J etal	2006	Nature2006，439，7078：	1
6	Copy number variation in the human genome and its implication in autoimmunity 显示文摘	Schaschl H Aitman T J Vyse T J	2009	Clin Exp Immunol2009，156，1：	1
7	Genetic analysis of autoimmune disease显示文摘	Vyse T J Todd J A	1996	Cell1996，85，3：	1
8	C-reactive protein in rheumatology: biology and genetics 显示文摘	Rhodes B Famrohr BG Vyse TJ	2011	Nat Rev Rheumatol2011，7，：	1
9	The genetics of SLE an update in the light of genome - wide association studies 显示文摘	Rhodes B Vyse TJ	2008	Rheumatology2008，47，11：	1
10	Paper machine efficiency: the most impor- tant parameter, how to get it and how to keep it 显示文摘	Mardon J Vyse R Ely D	1992	Pulp & Paper Canada1992，92，12：	1
11	Genetic analysis of antoimmune disease显示文摘	Vyse T G Todd J A	1996	Cell1996，85，1：	1
12	Novel methods for the detection of microbial antibodies in oral fluid显示文摘	McKie A Vyse A Maple C	2002	Lancet Infect Dis2002，2，1：	1
13	Copy number polymorphism in Fcgr 3 predisposes to glomerulonephritis in rats and humans 显示文摘	Aitman TJ Dong R Vyse TJ	2006	Nature2006，439，：	1
14	The genetics of SLE:An update in the light of genome-wide association studies 显示文摘	Rhodes B Vyse TJ	2008	Rheumatology ( Oxford )2008，47，11：	1
15	The genetics of systemic lupus erythematosus显示文摘	Roberton C A Vyse T J	2002	Exp Nephrol2002，8，45：	1
16	Novel methods for the detec- tion of microbial antibodies in oral fluid显示文摘	McKie A Vyse A Maple C	2002	Lancet Infect Dis2002，2，1：	1
17	The genetics of lupus: a functional perspective显示文摘	Guerra SG Vyse TJ Cunninghame Graham DS	2012	Arthritis Res Ther2012，14，3：	1
18	Genetic susceptibility to systemic lupus ery- thematosus显示文摘	Vyse T J Kotzin B L	1998	Annu Rev I mmunol1998，16，：	1
19	Copy number variation in the hu-man genome and its implication in autoimmunity显示文摘	Schaschl H Aitman TJ Vyse TJ	2009	Clin Exp Im-munol2009，156，1：	1
20	Association of the co-stimulator0X40L with systemic lupus erythematosus显示文摘	Manku H Graham DS Vyse TJ	2009	J Mol Med2009，87，3：	1

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