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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病源性轻度认知障碍诊断标准推荐显示文摘美国国立老化研究所(NIA)和阿尔茨海默病协会(ADA)组织了一个工作组,负责阿尔茨海默病(AD)痴呆前症状阶段——即本文所称的AD源性轻度认知障碍(MCI)的诊断标准的制订及完善。该工作组制订了以下两套标准:(1)在缺乏相应条件进行先进影像技术及脑脊液检查时,医务人员适用的核心临床标准;(2)适用于包括临床试验在内的科学研究的研究标准。后者纳入了基于影像技术及脑脊液检查的生物标志物的应用。并根据所出现的生物标志物的性质,将最终MCI诊断的确定性程度分为4个级别。而要使生物标志物有效应用于诊断,并在社区医疗服务中规范使用,尚需做大量的工作。 | McKhann GM Knopman DS Chertkow H Hyman BT Jack CR Jr Kawas CH Klunk WE Koroshetz WJ Manly JJ Mayeux R Mohs RC Morris JC Rossor MN Schehens P Carrillo MC Thies B Weintraub S Phelps CH 贾建平(译) 陆璐(译) 张逸驰(译) 黄丽黄(译) 礼媛(译) | 2012 | 中华神经科杂志2012，45，5： | 51 |
| 2 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病痴呆诊断标准的推荐显示文摘由美国国立老化研究所(NIA)和阿尔茨海默病(AD)协会组织了一个工作组,负责修订1984年版AD痴呆的诊断标准。旨在确保修订后的标准具有足够的灵活性,既可供缺乏神经心理学测验、先进的影像技术和脑脊液检查措施的普通医务人员使用,也可供具备上述措施的科研、临床试验的专业研究者使用。新的标准广泛适用于各种原因的痴呆以及专门针对AD痴呆的标准,保留了1984年版标准中的“很可能的AD痴呆”的总体框架。在过去27年的经验基础上,工作组对临床诊断标准做了一些修改,保留了“可能的AD痴呆”的术语,但对其进行了更有针对性的重新定义。在科研用的“很可能的和可能的AD痴呆”的诊断标准中纳入了生物标志物证据。AD痴呆的核心临床标准仍将是临床实践中诊断的基础,但用生物标志物证据来提高AD痴呆诊断的病理生理学特异性也被人们寄予厚望。要实现AD痴呆的生物标志物诊断,还有许多工作摆在面前。 | McKhann GM Knopman DS Chertkow H Hyman BT Jack CR Jr Kawas CH Klunk WE Koroshetz WJ Manly J J Mayeux R Mohs RC Morris JC Rossor MN Scheltens P Carrillo MC Thies B Weintraub S Phelps CH 贾建平(译) 陆璐(译) 张逸驰(译) 黄丽(译) 韩阅(译) | 2012 | 中华神经科杂志2012，45，5： | 52 |
| 3 | The complete reference genome for grapevine (Vitis vinifera L.) genetics and breeding显示文摘Grapevine is one of the most economically important crops worldwide.However,the previous versions of the grapevine reference genome tipically consist of thousands of fragments with missing centromeres and telomeres,limiting the accessibility of the repetitive sequences,the centromeric and telomeric regions,and the study of inheritance of important agronomic traits in these regions.Here,we assembled a telomere-to-telomere(T2T)gap-free reference genome for the cultivar PN40024 using PacBio HiFi long reads.The T2T reference genome(PN_T2T)is 69 Mb longer with 9018 more genes identified than the 12X.v0 version.We annotated 67%repetitive sequences,19 centromeres and 36 telomeres,and incorporated gene annotations of previous versions into the PN_T2T assembly.We detected a total of 377 gene clusters,which showed associations with complex traits,such as aroma and disease resistance.Even though PN40024 derives from nine generations of selfing,we still found nine genomic hotspots of heterozygous sites associated with biological processes,such as the oxidation–reduction process and protein phosphorylation.The fully annotated complete reference genome therefore constitutes an important resource for grapevine genetic studies and breeding programs. | Xiaoya Shi Shuo Cao Xu Wang Siyang Huang Yue Wang Zhongjie Liu Wenwen Liu Xiangpeng Leng Yanling Peng Nan Wang Yiwen Wang Zhiyao Ma Xiaodong Xu Fan Zhang Hui Xue Haixia Zhong Yi Wang Kekun Zhang Amandine Velt Komlan Avia Daniela Holtgräwe Jérôme Grimplet JoséTomás Matus Doreen Ware Xinyu Wu Haibo Wang Chonghuai Liu Yuling Fang Camille Rustenholz Zongming Cheng Hua Xiao Yongfeng Zhou | 2023 | Horticulture Research2023，10，5： | 3 |
| 4 | Will dietary omega-3 fatty acids change the composition of human milk ?显示文摘 | Harris WS Conner WE Lindsey S | 1984 | Am J Clin Nutr1984，40，： | 2 |
| 5 | MicroRNAs as potential clinical biomarkers: emerging approaches for their detection显示文摘 | SK Srivastava A Bhardwaj SJ Leavesley WE Grizzle S Singh AP Singh | 2013 | Biotechnic & Histochemistry2013，，7： | 2 |
| 6 | An empirical evaluation of the argon diffusion geometry in muscovite显示文摘 | Bowring S A | 1994 | Earth and Planetary Science Letters1994，124，： | 1 |
| 7 | Accelerated ventricular rhythm in childhood显示文摘 | Gaum WE Biancaniello T Kaplan S | 1979 | Am J Cardiol1979，43，1： | 1 |
| 8 | 1,1 vivo antitumor effi cacy of STAT3 blockade using a transcription factor decoy approach: implications for cancer therapy显示文摘 | Xi S Gooding WE Grandis JR | 2005 | Oncogene2005，24，6： | 1 |
| 9 | Blunt splenic injury: Operation versus angiographic embolization显示文摘 | Wahl WE Ahms KS Chen S | 2004 | Surgery2004，136，89： | 1 |
| 10 | Screening of blood donations by hepatitis C virus polymerase chain reaction (HCV-PCR) improves safety of blood products by window period reduction显示文摘 | Hitzler WE Runkel S | 2001 | Clin Lab2001，47，56： | 1 |
| 11 | Carbon-based air electrodes carrying MnO2 in zinc-air batteries 显示文摘 | We Z D Huang W Z Zhang S Z | 2000 | Powder Sources2000，91，2： | 1 |
| 12 | Randomized dose-controlled study of topiramate as first-line therapy in epilepsy 显示文摘 | ARROYO S DODSON WE PRIVITERA MD | 2005 | Acta Neurol Scand2005，112，4： | 1 |
| 13 | Inhibitors of HIV-1 replication that inhibit HIV integrase显示文摘 | Robinson WE Reinecke MG Abdel-Malek S | 1996 | Proc Natl Acad Sci USA1996，93，13： | 1 |
| 14 | Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production显示文摘 | Naugler WE Sakurai T Kim S | 2007 | Science2007，317，5834： | 1 |
| 15 | Imaging cortical association tracts in the human brain using diffusion-tensor-based axonal tracking显示文摘 | Mori S Kaufmann WE Davatzikos C | 2002 | Magn Reson Med2002，47，2： | 1 |
| 16 | The current status of cone beam computed tomography imaging in orthodontics 显示文摘 | Kapila S Conley RS Harrell WE Jr | 2011 | Dentomaxillofac Radiol2011，40，1： | 1 |
| 17 | Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production 显示文摘 | Naugler WE Sakurai T Kim S | 2007 | Science2007，317，： | 1 |
| 18 | Dynamic magnetic resonance imaging of regional contrast access as an additional prognostic factor in pediatric osteosarcoma 显示文摘 | Reddick WE Wang S Xiong X | 2001 | Cancer2001，91，12： | 1 |
| 19 | Resistance of hepatitis B virus to antiviral drugs: current aspects and directions for future investigation 显示文摘 | Delaney WE Locamini S Shaw T | 2001 | Antivir Chem Chemother2001，12，1： | 1 |
| 20 | Balloon-occluded retrograde trans- venous obliteration of gastric varices : conception, evolution, and history 显示文摘 | Saad WE Khaja MS Hirota S | 2012 | Tech Vasc Interv Radio12012，15，3： | 1 |
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