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| 1 | Dendritic cell-based immunotherapy显示文摘用树枝状的房间(DC ) 的免疫疗法基于种痘是为利用病人自己的潜力的一条同意的途径在变形荷尔蒙倔强的癌症消除肿瘤房间的免疫系统。尽管许多 DC 疫苗在诊所,并且在与临床的结果联系的一些情况中被测试了并且证明产生免疫性,外套在那里不仍然是怎么生产 DC 疫苗上的一致。能在我们将讨论什么从临床的研究关于人的 DC 生物学远这样被了解了,并且来临怎么当前在诊所使用 DC 疫苗的这评论被改进提高反肿瘤免疫。 | Rachel L Sabado Sreekumar Balan Nina Bhardwaj | 2017 | Cell Research2017，27，1： | 63 |
| 2 | 绿茶儿茶酚: 对心血管疾病的防御作用(英文)显示文摘Green tea,Camellia sinensis(Theaceae),a major source of flavonoids such as catechins,has recently shown multiple cardiovascular health benefits through various experimental and clinical studies.These studies suggest that green tea catechins prevent the incidence of detrimental cardiovascular events,and also lower the cardiovascular mortality rate.Catechins present in green tea have the ability to prevent atherosclerosis,hypertension,endothelial dysfunction,ischemic heart diseases,cardiomyopathy,cardiac hypertrophy and congestive heart failure by decreasing oxidative stress,preventing inflammatory events,reducing platelet aggregation and halting the proliferation of vascular smooth muscle cells.Catechins afford an anti-oxidant effect by inducing anti-oxidant enzymes,inhibiting pro-oxidant enzymes and scavenging free radicals.Catechins present anti-inflammatory activity through the inhibition of transcriptional factor NF-κB-mediated production of cytokines and adhesion molecules.Green tea catechins interfere with vascular growth factors and thus inhibit vascular smooth muscle cell proliferation,and also inhibit thrombogenesis by suppressing platelet adhesion.Additionally,catechins could protect vascular endothelial cells and enhance vascular integrity and regulate blood pressure.In this review various experimental and clinical studies suggesting the role of green tea catechins against the markers of cardiovascular disorders and the underlying mechanisms for these actions are discussed. | Pooja Bhardwaj Deepa Khanna | 2013 | 中国天然药物2013，11，4： | 10 |
| 3 | Plant Small RNAs: Biogenesis, Mode of Action and Their Roles in Abiotic Stresses显示文摘Small RNAs (sRNAs) are 18-30 nt non-coding regulatory elements found in diverse organisms, which were initially identified as small double-stranded RNAs in Caenorhabditis elegans. With the development of new and improved technologies, sRNAs have also been identified and characterized in plant systems. Among them, micro RNAs (miRNAs) and small interfering RNAs (siRNAs) are found to be very important riboregulators in plants. Various types of sRNAs differ in their mode of biogenesis and in their function of gene regulation. sRNAs are involved in gene regulation at both transcriptional and post-transcriptional levels. They are known to regulate growth and development of plants. Furthermore, sRNAs especially plant miRNAs have been found to be involved in various stress responses, such as oxidative, mineral nutrient deficiency, dehydration, and even mechanical stimulus. Therefore, in the present review, we focus on the current understanding of biogenesis and regulatory mechanisms of plant sRNAs and their responses to various abiotic stresses. | Praveen Guleria Monika Mahajan Jyoti Bhardwaj Sudesh Kumar Yadav | 2011 | Genomics, Proteomics & Bioinformatics2011，9，6： | 10 |
| 4 | Toward commercial realization of quantum dot based white light-emitting diodes for general illumination显示文摘We demonstrate the first commercial production–ready white light-emitting diodes(LEDs)for the general illumination market with red colloidal quantum dots(QDs)applied in an on–chip configuration.We show the red QDs with tunable peak emission and narrow full width at half-maximum in combination with a conventional phosphor material can lead to LED conversion efficiency improvements of 5% to 15% over commercial phosphor based LEDs at correlated color temperatures(CCTs)ranging from 5000 to 2700 K.Furthermore,the challenges associated with reliability under high temperature,high blue flux intensity,and high humidity operation have been overcome to meet consumer market requirements.Finally,a demonstrator lamp at 3000 K color temperature and 90 color rendering index(CRI)with QD based LEDs show a larger efficiency gain up to 17%,attributed to the reduced blue LED droop from the lower drive current and the lower heat sink temperature when compared to a standard phosphor based LED lamp output. | KEN TSHIMIZU MARCEL BOHMER DANIEL ESTRADA SUMIT GANGWAL STEFAN GRABOWSKI HELMUT BECHTEL EDWARD KANG KENNETH JVAMPOLA DANIELLE CHAMBERLIN OLEG BSHCHEKIN JYOTI BHARDWAJ | 2017 | Photonics Research2017，5，2： | 5 |
| 5 | Electrospinning: A fascinating fiber fabrication technique显示文摘 | Nandana Bhardwaj Subhas C. Kundu | 2010 | Biotechnology Advances2010，，3： | 4 |
| 6 | A review of ecological risk assessment and associated health risks with heavy metals in sediment from India显示文摘Heavy metal(HM)pollution in sediment is a serious concern particularly in developing nations,warranting an extensive survey to understand the current situation and propose possible remedial measures.This paper compiles the data of HMs cadmium(Cd),iron(Fe),cobalt(Co),manganese(Mn),arsenic(As),lead(Pb),chromium(Cr),copper(Cu),zinc(Zn)and nickel(Ni)in aquatic sediment from India from 1979 to 2017.It was found that mean values of Cu,Co,Zn,Pb,As,and Cr in Indian sediment were high in comparison to the Australian Interim Sediment Quality Guidelines,World Surface Rock Average,and the Threshold Effect Level for freshwater ecosystems.Anthropogenic activities,lithogenic factors,and sand intrusion are the main factors associated with HM pollution as observed using cluster analysis and principal component analysis.The results of contamination indices indicate that HM contamination ranged from average to high,in the sediment.The ecological risk assessment results showed that 11%HMs present very high risk.The cancer risk,due to the high contents of Cd,As,and Cr the ingestion pathway,showed high risk of cancer through food/water contaminated with sediment.At source reduction of HMs in industrial effluents by effluent treatment plants,and plantation of phytoremediating rooted macrophytes in sediment may help in HM mitigation of the sediment. | Vinod Kumar Anket Sharma Shevita Pandita Renu Bhardwaj Ashwani Kumar Thukral Artemi Cerda | 2020 | International Journal of Sediment Research2020，35，5： | 4 |
| 7 | Enhanced thermoelectric performance in p-type ZrCoSb based half-Heusler alloys employing nanostructuring and compositional modulation显示文摘ZrCoSb based half-Heusler(HH)alloys have been widely studied as a p-type thermoelectric(TE)material for power generation applications in the mid-temperature regime.However,their intrinsically high thermal conductivity has been found to be detrimental for the improvement in their thermoelectric figure-of-merit(ZT),which presently is far below unity.In the current work,a state-of-the-art ZT~1.1 at 873 K was realized in an optimized composition of nanostructured Zr1-xHfxCoSb_(0.9)Sn_(0.1) HH alloys by employing compositional modulation i.e.grain-by-grain compositional variations,which leads to a substantial increase in its power factor coupled with a concurrent decrease in its thermal conductivity.Significant reduction in the phonon mean-free-path is observed on Hf substitution,which is comparable to the average crystallite size(~25 nm),thus leading to a very low thermal conductivity of~2.2Wm^(-1)K^(-1) at 873 K,which is amongst the lowest reported in HH alloys.The TE device characteristics,estimated using cumulative temperature dependence model for quantitative evaluation of TE performance,yielded an output power density of~10 Wcm2 with a leg efficiency of~10%in the optimized composition of nanostructured Zr_(1-x)Hf_(x)CoSb_(0.9)Sn_(0.1) HH alloys,which is comparable to the reported efficiencies of other state-of-the-art TE materials. | Nagendra S.Chauhan Sivaiah Bathula Avinash Vishwakarma Ruchi Bhardwaj Kishor Kumar Johari Bhasker Gahtori Ajay Dhar | 2019 | Journal of Materiomics2019，5，1： | 3 |
| 8 | Nanomaterials for sensing of formaldehyde in air: Principles, applications, and performance evaluation显示文摘Despite the improvement in sensing technologies, detection of small and highly reactive molecules like formaldehyde remains a highly challenging area of research. Applications of nanomaterials/nanostructures and their composites have increased as effective sensing platforms (e.g., reaction time, sensitivity, and selectivity) for the detection of aqueous or gaseous formaldehyde based on diverse sensing principles. In this review, the basic aspects of important nanomaterial-based sensing systems (e.g., electrochemical, electrical, biological, and mass variation sensors) were evaluated in relation to performance, cost, and practicality of sensing gas phase formaldehyde. Accordingly, existing knowledge gaps in such applications were assessed in various respects along with suitable recommendations for building a new roadmap for the expansion of chemical sensing technology of gas phase formaldehyde. | Deepak Kukkar Kowsalya Vellingiri Rajnish Kaur Sanjeev Kumar Bhardwaj Akash Deep Ki-Hyun Kim | 2019 | Nano Research2019，12，2： | 3 |
| 9 | Histological and histochemical changes in placenta of diabetic pregnant females and its comparision with normal placenta显示文摘 | Vineeta Tewari Ajoy Tewari Nikha Bhardwaj | 2011 | Asian Pacific Journal of Tropical Disease2011，，1： | 2 |
| 10 | Superior safety of direct oral anticoagulants compared to Warfarin in patients with atrial fibrillation and underlying cancer: a national veterans affairs database study显示文摘Background Studies evaluating safety of warfarin and direct oral anticoagulants(DOACs) for prevention of stroke in patients with atrial fibrillation(AF) are lacking. Methods & Results All patients(n = 196,521) receiving care at veteran’s affairs with active cancer and AF from 2010–2015 were included. One-year mortality was significantly higher in unadjusted analysis with warfarin(44.9%) compared to dabigatran(25%, P < 0.001), rivaroxaban(24.4%, P < 0.001) and apixaban(30%, P < 0.001) and after adjusting for age, sex and type of cancer mortality(OR = 2.66, 95% CI: 2.52–2.82, P < 0.001). Risk of ischemic stroke(13.5% vs. 11.1%, 12.0%, 14.0%) was similar, however risk of hemorrhagic stroke was significantly higher among patients receiving warfarin(1.2%) compared to patients receiving dabigatran(0.5%), rivaroxaban(0.7%) and apixaban(0.8%) respectively, P = 0.04. Conclusions We demonstrated the superior safety profile of DOACs compared to warfarin among patients with underlying cancer and AF. Warfarin was associated with higher mortality, similar ischemic stroke risk but higher risk of hemorrhagic stroke. | Abhishek C Sawant Arnav Kumar Wilmon Mccray Sheldon Tetewsky Linda Parone Srilekha Sridhara Meghana Prakash Hiriyur Prakash Gary Tse Tong LIU Nidhi Kanwar Aishwarya Bhardwaj Sahoor Khan Christopher Manion Ankush Lahoti Ashish Pershad Peter Elkin John Corbelli | 2019 | Journal of Geriatric Cardiology2019，16，9： | 2 |
| 11 | Evaluation of functional outcome and stability of sutureless scleral tunnel fixated IOLs in children with ectopia lentis显示文摘AIM:To evaluate functional outcome of sutureless scleral tunnel intraocular lens(SSTIOL)in children with crystalline lens subluxation of more than 7 clock hours.METHODS:A prospective interventional study was conducted consisting of 45 eyes of 44 children in age group 6-18 y having>7 clock hours of lens subluxation who underwent lensectomy-vitrectomy followed by SSTIOL implantation.Primary outcome was improvement in best corrected visual acuity(BCVA)and secondary outcomes were assessment of intraocular lens(IOL)tilt using ultrasound biomicroscopy(UBM),mean change in astigmatism at last follow-up of 1 y and associated complications.RESULTS:The mean preoperative and postoperative BCVA was 1.05±0.28 and 0.64±0.45(log MAR)respectively(P=0.001)at last follow-up.The mean astigmatism preoperatively and postoperatively was-4.17±2.69 D and-1.86±1.25 D respectively(P=0.011).Significant IOL tilt(>5 degrees)was present in 5 cases.The mean percentage endothelial loss was 3.65%±1.92%.The most serious complication encountered was retinal detachment seen in 2 cases.CONCLUSION:SSTIOL implantation provides efficient visual rehabilitation in children provided there is stringent case selection.We recommend caution in children having white-to-white distance>12 mm and presence of peripheral retinal degenerations. | Anju Rastogi Prateek Kumar Shweta Dhiman Manisha Mishra Kamlesh AnAND Ankita Bhardwaj | 2020 | International Journal of Ophthalmology(English edition)2020，13，1： | 2 |
| 12 | Weight loss interventions in living donor liver transplantation as a tool in expanding the donor pool: A systematic review and metaanalysis显示文摘BACKGROUND With increasing rates of liver transplantation and a stagnant donor pool,the annual wait list removals have remained high.Living donor liver transplantation(LDLT)is an established modality in expanding the donor pool and is the primary method of liver donation in large parts of the world.Marginal living donors,including those with hepatic steatosis,have been used to expand the donor pool.However,due to negative effects of steatosis on graft and recipient outcomes,current practice excludes overweight or obese donors with more than 10%macro vesicular steatosis.This has limited a potentially important source to help expand the donor pool.Weight loss is known to improve or resolve steatosis and rapid weight loss with short-term interventions have been used to convert marginal donors to low-risk donors in a small series of studies.There is,however,a lack of a consensus driven standardized approach to such interventions.AIM To assess the available data on using weight loss interventions in potential living liver donors with steatotic livers and investigated the feasibility,efficacy,and safety of using such donors on the donor,graft and recipient outcomes.The principal objective was to assess if using such treated donor livers,could help expand the donor pool.METHODS We performed a comprehensive literature review and meta-analysis on studies examining the role of short-term weight loss interventions in potential living liver donors with hepatic steatosis with the aim of increasing liver donation rates and improving donor,graft,and recipient outcomes.RESULTS A total of 6 studies with 102 potential donors were included.Most subjects were males(71).All studies showed a significant reduction in body mass index postintervention with a mean difference of-2.08(-3.06,1.10,I2=78%).A significant reduction or resolution of hepatic steatosis was seen in 93 of the 102(91.2%).Comparison of pre-and post-intervention liver biopsies showed a significant reduction in steatosis with a mean difference of-21.22(-27.02,-15.43,I2=56%).The liver donation rates post-intervention was 88.5(74.5,95.3,I2=42%).All donors who did not undergo LDLT had either recipient reasons or had fibrosis/steatohepatitis on post intervention biopsies.Post-operative biliary complications in the intervention group were not significantly different compared to controls with an odds ratio of 0.96[(0.14,6.69),I2=0].The overall post-operative donor,graft,and recipient outcomes in treated donors were not significantly different compared to donors with no steatosis.CONCLUSION Use of appropriate short term weight loss interventions in living liver donors is an effective tool in turning marginal donors to low-risk donors and therefore in expanding the donor pool.It is feasible and safe,with comparable donor,graft,and recipient outcomes,to non-obese donors.Larger future prospective studies are needed. | Sushrut Trakroo Nakul Bhardwaj Rajat Garg Jamak Modaresi Esfeh | 2021 | World Journal of Gastroenterology2021，27，24： | 2 |
| 13 | Anti-listerial synergism of leaf essential oil of Metasequoia glyptostroboides with nisin in whole,low and skim milks显示文摘Objective:To examine the individual and synergistic anti-listcrial effect of nisin and leaf essential oil of Metasequoia glyptostroboides(M.glyptostroboides) against one of the leading foodhorne pathogens Listeria monocytogenes(L.monocytogenes) ATCC 19116 in milk samples.Methods:The whole(8%),low(1%) and skim(no fat content) milk samples were inoculated with L.monocytogenes ATCC 19116 along with leaf essential oil of M.glyptostroboides or nisin alone as well in eomhinations.Results:In this study,the leaf essential oil at the concentrations of 2% and 5% revealed strong anti-listerial effect against L.monocytogenes ATCC 19116 in all categories of milk samples.Nisin at the concentrations of 250 and 500 IU/mL displayed a strong inhibitory effect against ATCC 19116 as compared to the control group.Additionally,synergistic combinations of leaf essential oil(1%) and nisin(62.5,125.250 and 500 IU/mL) also had a remarkable anti-listerial synergism in all the tested milk samples including whole,low and skim milk after 14 days.Conclusions:As a major finding,the leaf essential oil of M.glyptostroboides might he a useful candidate for using in food industry to control the growth of foodhorne pathogenic bacteria as confirmed by its potent anti-listerial Synergistic effect with nisin against L.monocytogenes ATCC 19116 in different milk samples. | Vivek K.Bajpai Jung In Yoon Monika Bhardwaj Sun Chul Kang | 2014 | Asian Pacific Journal of Tropical Medicine2014，7，8： | 2 |
| 14 | MicroRNAs as potential clinical biomarkers: emerging approaches for their detection显示文摘 | SK Srivastava A Bhardwaj SJ Leavesley WE Grizzle S Singh AP Singh | 2013 | Biotechnic & Histochemistry2013，，7： | 2 |
| 15 | A Randomized Controlled Trial of Antioxidant Supplementation for Pain Relief in Patients With Chronic Pancreatitis显示文摘 | Payal Bhardwaj Pramod Kumar Garg Subir Kumar Maulik Anoop Saraya Rakesh Kumar Tandon Subrat Kumar Acharya | 2009 | Gastroenterology2009，，1： | 2 |
| 16 | Formulation and evaluation of novel stomach specific floating microspheres bearing famotidine for treatment of gastric ulcer and their radiographic study显示文摘Objective:To develop and characterize multiple-unit-type oral floating microsphere of famotidine to prolong gastric residence time and to target stomach ulcer.Methods:The floating microspheres were prepared by modified solvent evaporation method,Eudragil S-100 was used as polymer.Microspheres were characterized for the micromeritic properties,floating behavior,entrapment efficiency and scanning electron microscopy.The invitro release studies and floating behavior were studied in simulated gastric fluid at pH 1.2.Different drug release kinetics models were also applied for all the batches.Selected formulations were also subjected for X-ray radiographic study.Results:Floating microspheres were successfully prepared by modified solvent evaporation technique.Microspheres showed passable flow properties.The maximum yield of microspheres was up to(95.11±0.35)%.On the basis of optical microscopy particle size range was found to be ranging from(52.18±182.00) to(91.64±5.16) μm.Scanning electron microscopy showed their spherical size,perforated smooth surface and a cavity inside microspheres.Microspheres were capable to float up to 20 h in simulated gastric fluid.X-ray radiographic studies also proved its better retention in the stomach.Conclusions:On the basis of the results,such dosage forms may be a good candidate for stomach targeting and may be dispensed in hard gelatin capsules. | Rishikesh Gupta Sunil Kumar Prajapati Snigdha Pattnaik Peeyush Bhardwaj | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，9： | 2 |
| 17 | Role of antioxidants in prophylaxis and therapy: A pharmaceutical perspective显示文摘 | Ratnam DV Ankola DD Bhardwaj V | 2006 | J Control Release2006，113，3： | 1 |
| 18 | MicroRNA- 150 directly targets MUC4 and suppresses growth and malignant behavior of pancreatic cancer cells显示文摘 | Srivastava SK Bhardwaj A Singh S | 2011 | Carcino- genesis2011，32，12： | 1 |
| 19 | Manipulating dendritic cell bi- ology for the active immunotherapy of cancer显示文摘 | O'Neill DW Adams S Bhardwaj N | 2004 | Blood2004，104，8： | 1 |
| 20 | Treatment of invasive or metastatic thymoma 显示文摘 | Chahinian AP Bhardwaj S Mcycr RJ | 1981 | Cancer1981，47，7： | 1 |
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