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| 1 | 知识产权的多元属性及研究范式(英文)显示文摘在诸多民事权利制度中,知识产权具备更多科技含量和知识要素。一般认为:著作权发生在文化创作领域,与文化创新、文化产业息息相关;专利权产生于技术应用领域,与科技创新、科技产业紧密相连;商标权则运作于工商经营领域,涉及商品销售、市场贸易等诸多问题。在知识经济的时代条件下,知识产权的制度实施效果,关系到一国的经济发展、科技进步、文化与教育的繁荣;而在经济全球化的国际背景中,知识产权保护又事关国际政治、国际经贸、国际文化与科技的交流和合作。这就决定了,从民法学理论出发研究知识产权属性,当是应有之义;而结合人权理论、经济学、管理学以及政策科学,多视角、全方位来考察知识产权功能,亦非常必要。这有助于在不同学科层面揭示知识产权的基本蕴意,保持知识产权研究中的问题导向及方法的开放性。 | 吴汉东 Wang Wen’e | 2013 | Social Sciences in China2013，34，1： | 36 |
| 2 | Cerebral ischemia and neuroregeneration显示文摘Cerebral ischemia is one of the leading causes of morbidity and mortality worldwide. Although stroke(a form of cerebral ischemia)-related costs are expected to reach 240.67 billion dollars by 2030, options for treatment against cerebral ischemia/stroke are limited. All therapies except anti-thrombolytics(i.e., tissue plasminogen activator) and hypothermia have failed to reduce neuronal injury, neurological deficits, and mortality rates following cerebral ischemia, which suggests that development of novel therapies again st stroke/cerebral ischemia are urgently needed. Here, we discuss the possible mechanism(s) underlying cerebral ischemia-induced brain injury, as well as current and future novel therapies(i.e., growth factors, nicotinamide adenine dinucleotide, melatonin, resveratrol, protein kinase C isozymes, pifithrin, hypothermia, fatty acids, sympathoplegic drugs, and stem cells) as it relates to cerebral ischemia. | Reggie H.C.Lee Michelle H.H.Lee Celeste Y.C.Wu Alexandre Couto e Silva Harlee E.Possoit Tsung-Han Hsieh Alireza Minagar Hung Wen Lin | 2018 | Neural Regeneration Research2018，13，3： | 30 |
| 3 | Community-based scenario modelling and disaster risk assessment of urban rainstorm waterlogging显示文摘情形建模和对自然灾难的风险评价是在灾难研究的热点之一。然而,起来直到现在,城市的自然灾难风险评价缺乏普通过程和节目。这篇论文作为灾难选择暴风雨 waterlogging 研究,它是为在中国的大多数城市的最经常发生的危险之一。作为一个例子,我们使用了小规模的综合方法论在上海的 Jingan 区域估计关于暴风雨 waterlogging 危险的风险。基于灾难风险的基本概念,这篇论文使用情形建模在不同回来时期表示小规模的城市的暴风雨 waterlogging 灾难的风险。通过危险和暴露的这分析,我们模仿不同灾难情形并且为小规模的城市的暴风雨 waterlogging 灾难风险评价建议一个全面分析方法和过程。包括一个城市的地面模型,一个城市的降雨模型和一个城市的排水模型,一条基于格子的地理信息系统(GIS ) 途径被使用模仿淹没区域和深度。为居住大楼和内容的阶段损坏曲线然后被从领域调查的 waterlogging 的数据,它进一步使用了分析危险,暴露和损失评价的损失产生。最后,为灾难损坏的 exceedance 概率曲线用每个模仿的事件和各自的 exceedance 可能性的损坏被构造。一个框架也为通过 exceedance 概率曲线和年度平均 waterlogging 损失联合 waterlogging 风险,风险和管理计划被开发。这是为小规模的城市的自然灾难情形模拟和风险评价的新探索。 | YIN Zhan'e YIN Jie XU Shiyuan WEN Jiahong | 2011 | Journal of Geographical Sciences2011，21，2： | 25 |
| 4 | 胎盘生长因子和色素上皮衍生因子在非小细胞肺癌中的表达及其与预后的关系显示文摘目的探讨胎盘生长因子(PlGF)和色素上皮衍生因子(PEDF)在非小细胞肺癌中的表达特点及与肿瘤新生血管形成的关系,了解这两种因子在判断非小细胞肺癌患者预后中的意义。方法采用超敏过氧化酶免疫组织化学法检测手术切除的81例非小细胞肺癌标本中PlGF和PEDF的表达水平,并利用CD31染色进行微血管计数,统计分析这两个因子与微血管密度(MVD)的关系,及其在非小细胞肺癌患者预后中的意义。结果PlGF和PEDF在81例非小细胞肺癌患者中的阳性率分别为43·2%(35例)和53·1%(43例)。PlGF阳性表达与高值MVD相关;PEDF阳性表达与低值MVD相关;PlGF和PEDF的表达状况存在负相关。单因素和多因素分析均提示PlGF是非小细胞癌患者独立的预后指标。结论PlGF和PEDF均可在非小细胞肺癌组织中表达,二者在血管生成的过程中具有相互拮抗的作用。与PEDF相比,PlGF在非小细胞肺癌发展以及预测患者预后方面具有更大的作用。 | 张力建 陈晋峰 陆爱萍 柯杨 Robert E Mansel Wen G Jiang | 2005 | 中华医学杂志2005，85，47： | 10 |
| 5 | 医用Ti84Mo16合金表面改性研究显示文摘基于表面活性涂层培养目的,选择粉末冶金工艺制备微孔态Ti84Mo16合金基体。基体进行热处理和碱处理,进而浸入人体模拟液中进行活性涂层沉积。实验结果表明;经过四周培养,钛钼合金表面能够成功培养出类骨涂层——羟基磷灰石Ca10(PO4)6(OH)2,这为解决钛合金植入物和人体组织之间结合力不足的问题提供了一个非常有效的途径。 | 赵明威 王晓江 WEN C E | 2009 | 热加工工艺2009，38，8： | 9 |
| 6 | Impact of CYP3A4*1G Polymorphism on Fentanyl Analgesia Assessed by Analgesia Nociception Index in Chinese Patients Undergoing Hysteroscopy显示文摘Background:The clinical efficacy of fentanyl for pain control differs greatly across individuals.The purpose of this study was to investigate the impact of CYP3A4*1G polymorphism including wild-type homozygote (CYP3A4*1/*1,GG),mutant heterozygote (CYP3A4*1/*1G,GA),and mutant homozygote (CYP3A4*1G/*1G,AA)on fentanyl analgesia in Chinese patients undergoing hysteroscopy by the assessment of analgesia nociception index (ANI). Methods:A total of 200 gynecologic patients scheduled for elective hysteroscopy under general anesthesia at Peking University People's Hospital from May to December in 2017 were enrolled in this study.Venous blood was withdrawn for genotyping of CYP3A4*1G before operation.Fentanyl 1μg/kg was administered preoperatively followed by target-controlled infusion of propofol for induction and maintenance.Intraoperative analgesic efficacy of fentanyl was assessed by ANI monitoring at T0(entering room),T1(cervical dilation), T2(start of cervical aspiration),and T3(end of cervical aspiration)time points.The duration of propofol infusion and total dosage of propofol were recorded as well. Results:The patients were divided into three groups according to CYP3A4*1G polymorphism,including 143 in GG group,47in GA group, and 10 in AA group.There was no significant difference in clinical demographics among three groups.The frequency of CYP3A4*1G variant alleles accounted for 16.8%and the distribution of variant alleles was consistent with Hardy-Weinberg equilibrium.Using a multilevel model,ANI values at T1(63.81±19.61),T2(63.63±17.82),and T3(65.68±17.79)were significantly lower than that at T0 (77.16±12.93)in the study population (F =23.50,P <0.001),suggesting that higher levels of pain at T 1,T2,and T3 than T0.Patients with GG genotype showed significantly lower ANI than those with GA or AA genotypes during hysteroscopy under the same dose of fentanyl. Conclusion:CYP3A4*1G polymorphism associated with the analgesic efficacy of intraoperative fentanyl in the patients undergoing hysteroscopy under general anesthesia. | Qi Yan Yi Su Lan Gao Nan Ding Hong-Ying Zhang Wen E Yue Wang Yi Feng Hai-Yan An | 2018 | Chinese Medical Journal2018，，22： | 8 |
| 7 | Sol-gel derived HA/TiO_2 double coatings on Ti scaffolds for orthopaedic applications显示文摘Hydroxyapatite/titania (HA/TiO2) double layers were coated onto Ti scaffolds throughout for orthopaedic applications by sol-gel method. Differential scanning calorimetry (DSC), thermogravimetric analysis (TG) and X-ray diffractometry (XRD) were used for the characterisation of the phase transformations of the dried gels and coated surface structures. Scanning electron microscope (SEM) equipped with energy dispersive spectrometry (EDS) was used for the observation and evaluation of the morphology and phases of the surface layers and for the assessment of the in vitro tests. The in vitro assessments were performed by soaking the HA/TiO2 double coated samples into the simulated body fluid (SBF) for various periods. The TiO2 dipping-coating method at a speed of 12 cm/min, followed by a heat treatment at 600 ℃ for 20 min. The HA la lyaeyre wr wasa ssu cbosaetqeude bnytl ya dipping-coated on the outer surface at the same speed and then heat-treated at difference temperatures. The results indicat that the HA phase begins to crystallize after a heat treatment at 560 ℃. The crystallinity increases obviously at 760 ℃. SEM observations find no delamination or crack at the interfaces of HA/TiO2 and TiO2/Ti. The HA/TiO2 coated Ti scaffolds displays excellent bone-like apatite forming ability when it is soaked into SBF. Ti scaffolds after HA/TiO2 double coatings can be anticipated as promising implant materials for orthopaedic | XU W HU W Y LI M H MA Q Q P. D. HODGSON WEN C E | 2006 | 中国有色金属学会会刊:英文版2006，16，B01： | 5 |
| 8 | FCC DeSO_x and DeNO_x additive technology显示文摘The fluid catalytic cracking(FCC) is the principal gasoline producing process in the refinery. Considerable amounts of harmful sulfur oxides and nitrogen oxides (SO x and NO x) are generated with the FCC operation. Impacted by strengthening environmental regulations and the current global emphasis on environmental protection and pollution abatement, refiners have been meaning to look for effective ways to control and reduce SO x and NO x emissions. FCC DeSO x and DeNO x additives is the most promising measure. The present paper reviews the developments in FCC DeSO x and DeNO x additive technology based on the respective authors’ works, the future directions of the technology are also discussed. | WEN Bin, HE Min\|yuan\+* (Research Institute of Petroleum Processing, SINOPEC, Beijing 100083, China. E\|mail: wenzhang@bj.col.com.cn) | 2000 | Journal of Environmental Sciences2000，12，3： | 4 |
| 9 | Genome-wide association mapping of vitamins B1 and B2 in common wheat显示文摘Vitamin B is essential for maintaining normal life activities in humans and animals who have to intake the microelement from the outside, especially from cereal products. In the present study 166 Chinese and foreign wheat cultivars planted in two environments were characterized for variation in vitamin B1 and B2 contents. A genome-wide association study(GWAS) using the wheat 90 K SNP assay identified 17 loci for vitamin B1 and 7 for vitamin B2 contents. Linear regression analysis showed a significantly positive correlation of the number of favorable alleles with vitamin B1 and B2 contents. Marker-trait associations(MTAs) at IWB43809(6AS, 0cM) and IWB69903(6AS, 13cM) were new and stable, and significantly associated with vitamin B1 content across two environments. The loci identified in this study and associated SNP markers could be used for improvement of vitamin B1 and B2 contents to obtain superior quality along with grain yield in wheat. | Jieyun Li Jindong Liu Wei'e Wen Pingzhi Zhang Yingxiu Wan Xianchun Xia Yan Zhang Zhonghu He | 2018 | The Crop Journal2018，6，3： | 4 |
| 10 | 荧光实时定量PCR检测NSCLC中PEDF基因表达状态的研究显示文摘背景与目的SYBRGreenⅠ是一种较为常用的非探针类定量PCR的方法,其主要优点在于操作过程简单,结果具有一定特异性。本研究的目的是建立检测色素上皮衍生因子(pigmentepitheliumderivedfactor,PEDF)mRNA的SYBRGreenⅠ实时定量PCR的方法,了解肺癌组织及其远癌肺组织中PEDF的表达水平,研究肺癌组织中PEDF的表达水平与各种临床病理特征之间的关系。方法利用RTPCR的方法扩增并纯化PEDF以及内对照GAPDHmRNA的目的片段,倍比稀释后作为定量模板。利用相对定量的方法,检测21例肺癌及相应远癌肺组织中PEDFmRNA相对于GAPDHmRNA的表达量,进行相对定量分析。结果21例肺癌组织及相应的远癌肺组织中均可检出PEDF的表达,肺癌组织中PEDF的相对表达量为0.5505±0.3590(0.11~1.11),远癌肺组织中为0.7219±0.2582(0.29~1.31)(P=0.024)。早期(Ⅰ~Ⅱ期)肺癌患者和肿瘤较小时(T1)PEDF的表达量显著高于晚期(Ⅲ~Ⅳ期,P=0.010)和肿瘤较大者(T2~4,P=0.007)。结论所建立的SYBRGreenⅠ实时定量PCR方法可以成功地检测PEDF基因的表达量。初步检测结果显示PEDF可能是一种肺癌发生发展过程中的保护因素。 | 张力建 陈晋峰 柯杨 Robert E Mansel Wen G Jiang | 2006 | 中国肺癌杂志2006，9，2： | 4 |
| 11 | Comparison on the leaching kinetics of chalcocite and pyrite with or without bacteria显示文摘The acid leaching,ferric leaching,and bioleaching of chalcocite and pyrite minerals were conducted in two sets of 3L stirred reactors.The dissolution rates of copper and iron were correlated with leaching conditions.In the acid leaching process,the dissolution rate of chalcocite was around 40wt.% while that of pyrite was less than 4%.In the ferric leaching process with high ferric concentration,only 10 wt.% of iron in pyrite was leached out at the same retention time though the copper recovery over 60 wt.% in chalcocite.For the bioleaching process,the chalcocite leaching rate was highly increased,nearly 90 wt.% of copper was leached out,and the iron dissolution of pyrite exceeded 70 wt.%.For the two minerals,the bioleaching shows the highest leaching rate compared with the acid leaching or ferric leaching.In uncontrolled bioleaching process,pyrite could be dissolved effectively.The experimental data were fitted to the shrinking core and particle model.The results show that in all the leaching tests,the chalcocite leaching was mainly controlled by diffusion,while for the pyrite leaching,chemical reaction is the main rate-determining step. | RUAN Renman ZHOU E LIU Xingyu WU Biao ZHOU Guiying WEN Jiankang | 2010 | Rare Metals2010，29，6： | 3 |
| 12 | Plant growth,antioxidative enzyme,and cadmium tolerance responses to cadmium stress in Canna orchioides显示文摘The cadmium tolerance capacity of Canna orchioides was evaluated using glasshouse experiment to lay a theoretical foundation to broad applications of this species in cadmium(Cd)polluted areas.The plant growth,Cd absorption,and antioxidative enzyme activities of canna plants treated with different Cd concentrations(0,100,and 200mg·kg^(-1)per dry soil)for 30 days were investigated.The results indicated that the growth of roots,leaves and stems was restricted following Cd addition.The bio-concentration factor was the highest in the roots,followed by the leaves,rhizomes,and stems.Compared with the control,the translocation factor decreased sharply after 100mg·kg^(-1)or 200mg·kg^(-1)Cd treatment,whereas the tolerance index decreased significantly under 200mg·kg^(-1)Cd exposure.The Cd accumulation rate and total Cd accumulation significantly increased under 200mg·kg^(-1)Cd treatment than the control.Themalondialdehyde content remained unchanged at different Cd concentrations,while the relative electrical conductivity of the root increased significantly following 200mg·kg^(-1)Cd treatment.Cd stress increased significantly the activity of superoxide dismutase(SOD),peroxidase(POD),and ascorbate peroxidase(APX)in the leaves,whereas only SOD was raised in the roots.The catalase(CAT)and POD activity in the roots did not differ significantly at different Cd concentrations.Conversely,APX in the roots decreased significantly under Cd stress,which suggests that the protective mechanisms in the leaves differ from those in the roots.These results indicated that C.orchioides has a high tolerance for Cd.Furthermore,the reactive oxygen species caused by Cd stress could be effectively scavenged by the antioxidative system.The present study proved that C.orchioides constitutes a promising ornamental plant for use in the restoration of areas contaminated with Cd. | Wen’e Zhang Xuejun Pan Qian Zhao Ting Zhao | 2021 | Horticultural Plant Journal2021，7，3： | 3 |
| 13 | 全球化时代的国家认同:危机与重构(英文)显示文摘全球化时代的到来,对国家认同产生了诸多的挑战。要应对这一挑战,需要我们从理论的层面加以科学阐释。考察国家认同的概念可以看到,国家认同实质上是包含制度、利益、文化、非国家共同体认同的'四位一体',其基本特征包含生成机制的原生性和构建性、表现形式的意识性和行动性、内容体系的政治性和行动性、维持机制的情感性和利益性,以及发展状态的稳定性和发展性。全球化时代国家认同危机包含着政治、经济、文化三个层面,民族国家认同危机产生的根源是国家治理的失效。要在全球化背景下推动国家认同的构建,着力点在于:推动政治体制改革,探索治理民主模式,构建国家认同的制度性前提;促进经济发展,维护公平正义,构建国家认同的利益性保障;发展民族文化,加强价值整合,丰富国家认同的文化内涵;正视不同层次共同体的发展,促进国家认同的共同体整合。 | 王卓君 何华玲 Wang Wen'e | 2014 | Social Sciences in China2014，35，2： | 2 |
| 14 | Efficacy of transient elastography in screening for large esophageal varices in patients with suspicious or proven liver cirrhosis显示文摘 | Huay‐Min WANG Gin‐Ho LO Wen‐Chi CHEN Ping‐I HSU Hsien‐Chung YU Chiun‐Ku LIN Hoi‐Hung CHAN Wei‐Lun TSAI Feng‐Woei TSAY Tsan‐Ping LIU E‐Ming WANG Kwok‐Hung LAI | 2012 | Journal of Digestive Diseases2012，，8： | 2 |
| 15 | Supply-Demand Analysis of Urban Emergency Shelters Based on Spatiotemporal Population Estimation显示文摘Supply–demand analysis is an important part of the planning of urban emergency shelters.Using Pudong New Area,Shanghai,China as an example,this study estimated daytime and nighttime population of the study area based on fine-scale land use data,census data,statistical yearbook information,and Tencent user-density big data.An exponential function-based,probability density estimation method was used to analyze the spatial supply of and demand for shelters under an earthquake scenario.The results show that even if all potential available shelters are considered,they still cannot satisfy the demand of the existing population for evacuation and sheltering,especially in the northern region of Pudong,under both the daytime and the nighttime scenarios.The proposed method can reveal the spatiotemporal imbalance between shelter supply and demand.We also conducted a preliminary location selection analysis of shelters based on the supply–demand analysis results.The location selection results demonstrate the advantage of the proposed method.It can be applied to identify the areas where the supply of shelters is seriously inadequate,and provide effective decision support for the planning of urban emergency shelters. | Xiaodong Zhang Jia Yu Yun Chen Jiahong Wen Jiayan Chen Zhan'e Yin | 2020 | International Journal of Disaster Risk Science2020，11，4： | 2 |
| 16 | Deep potentials for materials science显示文摘To fill the gap between accurate(and expensive)ab initio calculations and efficient atomistic simulations based on empirical interatomic potentials,a new class of descriptions of atomic interactions has emerged and been widely applied;i.e.machine learning potentials(MLPs).One recently developed type of MLP is the deep potential(DP)method.In this review,we provide an introduction to DP methods in computational materials science.The theory underlying the DP method is presented along with a step-by-step introduction to their development and use.We also review materials applications of DPs in a wide range of materials systems.The DP Library provides a platform for the development of DPs and a database of extant DPs.We discuss the accuracy and efficiency of DPs compared with ab initio methods and empirical potentials. | Tongqi Wen Linfeng Zhang Han Wang Weinan E David J Srolovitz | 2022 | Materials Futures2022，1，2： | 2 |
| 17 | Processing of biocompatible porous Ti and Mg显示文摘 | WEN C E MABUCHI M Yamada Y | 2001 | Scripta Materialia2001，45，10： | 1 |
| 18 | Islet β cell expression of constitutively active Akt1/PKB α induces striking hypertrophy, hyperplasia, and hyperinsulinemia 显示文摘 | Bernal Mizrachi E Wen W Stahlhut S | 2001 | J Clin Invest2001，308，11： | 1 |
| 19 | Tabu Search Approach to Alarm Processingin Power Systems显示文摘 | Wen E S Chang C S | 1997 | IEE Proceedings-Generation Transmission and Distribution1997，144，1： | 1 |
| 20 | Comparison of stereotactic radiosurgery and brachytherapy in the treatment of recurrent glioblastoma multiforme显示文摘 | Shrieve DC Alexander E 3rd Wen PY | 1995 | Neurosurgery1995，36，2： | 1 |
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