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| 1 | Radiofrequency ablation for early oesophageal squamous neoplasia:Outcomes form United Kingdom registry显示文摘AIM:To report outcomes on patients undergoing radiofrequency ablation(RFA)for early oesophageal squamous neoplasia from a National Registry.METHODS:A Prospective cohort study from 8 tertiary referral centres in the United Kingdom.Patients with squamous high grade dysplasia(HGD)and early squamous cell carcinoma(ESCC)confined to the mucosa were treated.Visible lesions were removed by endoscopic mucosal resection(EMR)before RFA.Following initial RFA treatment,patients were followed up 3monthly.Residual flat dysplasia was treated with RFA until complete reversal dysplasia(CR-D)was achieved or progression to invasive Squamous cell cancer defined as infiltration into the submucosa layer or beyond.The main outcome measures were CR-D at 12 mo from start of treatment,long term durability,progression to cancer and adverse events.RESULTS:Twenty patients with squamous HGD/ESCC completed treatment protocol.Five patients(25%)had EMR before starting RFA treatment.CR-D was 50%at12 mo with a median of 1 RFA treatment,mean 1.5(range 1-3).Two further patients achieved CR-D with repeat RFA after this time.Eighty per cent with CR-D remain dysplasia free at latest biopsy,with median follow up 24 mo(IQR 17-54).Six of 20 patients(30%)progressed to invasive cancer at 1 year.Four patients(20%)required endoscopic dilatations for symptomatic structuring after treatment.Two of these patients have required serial dilatations thereafter for symptomatic dysphagia with a median of 4 dilatations per patient.The other 2 patients required only a single dilatation to achieve an adequate symptomatic response.One patient developed cancer during follow up after end of treatment protocol.CONCLUSION:The role of RFA in these patients re-mains unclear.In our series 50%patients responded at12 mo.These figures are lower than limited published data. | Rehan J Haidry Mohammed A Butt Jason Dunn Matthew Banks Abhinav Gupta Howard Smart Pradeep Bhandari Lesley Ann Smith Robert Willert Grant Fullarton Morris John Massimo Di Pietro Ian Penman Marco Novelli Laurence B Lovat | 2013 | World Journal of Gastroenterology2013，19，36： | 7 |
| 2 | Complicated fecal microbiota transplantation in a tetraplegic patient with severe Clostridium difficile infection显示文摘A 65-year-old male suffering from acute spinal cord injury leading to incomplete tetraplegia presented with severe recurrent Clostridium difficile(C. difficile) infection subsequent to antibiotic treatment for pneumonia. After a history of ineffective antimicrobial therapies, including metronidazole, vancomycin, fidaxomicin, rifaximin and tigecycline, leading to several relapses, the patient underwent colonoscopic fecal microbiota transplantation from his healthy son. Four days subsequent to the procedure, the patient showed a systemic inflammation response syndrome. Without detecting an infectious cause, the patient received antimicrobial treatment, including tigecycline, metronidazole, vancomycin via polyethylene glycol and an additional enema for a period of seven days, leading to a prompt recovery and no reported C. difficile infection relapse during a 12 wk follow up. | Thorsten Brechmann Justyna Swol Veronika Knop-Hammad Jrg Willert Mirko Aach Oliver Cruciger Wolff Schmiegel Thomas A Schildhauer Uwe Hamsen | 2015 | World Journal of Gastroenterology2015，21，12： | 3 |
| 3 | Truncating mutations in Peutz-Jeghers syndrome are associated with more polyps, surgical interventions and cancers显示文摘 | Heidi Salloch Anke Reinacher-Schick Karsten Schulmann Christian Pox J?rg Willert Andrea Tannapfel Stefan Heringlake Timm O. Goecke Stefan Aretz Susanne Stemmler Wolff Schmiegel | 2010 | International Journal of Colorectal Disease2010，，1： | 2 |
| 4 | Topological sparse learning of dynamic form patterns显示文摘 | Guthier T Willert V Eggert J | 2014 | Neural Computation2014，27，1： | 1 |
| 5 | Writ proteins arelipid-modified and can act as stem cell growth factors显示文摘 | Willert K Brown J D Danenberg E | 2003 | Nature2003，423，6938： | 1 |
| 6 | Low salinities adversely affect photosynthetic performance of the mangrove,Avicennia marina显示文摘 | Tuffers A Naidoo G von Willert D J | 2001 | Wetlands Ecology and Management2001，9，3： | 1 |
| 7 | Leaf epidermal hydathodes and the ecophysiologieal consequences of foliar water uptake in species of Crassula from the Namib desert in southern Mrica 显示文摘 | MARTIN C E VON WILLERT D J | 2000 | Plant Boil2000，2，： | 1 |
| 8 | Gas exchange responses of a mangrove species,Avicennia marina,to waterlogged and drained conditions显示文摘 | Naidoo G Rogalla H von Willert D J | 1997 | Hydrobiologia1997，352，1： | 1 |
| 9 | Wnt proteins lipid-modi- fied and can act as stem cell growth factors 显示文摘 | Willert K Brown J D Danenberg E | 2003 | Nature2003，423，6938： | 1 |
| 10 | Changes in gas exchange and chlorophyll fluorescence characteristics of two mangroves and a mangrove associate in response to sahnity in the natural environment显示文摘 | Naidoo G Tufters A V von Willert D J | 2002 | Trees2002，16，： | 1 |
| 11 | Physiological characteristics of geophytes in semi-arid Namaqualand,South Africa显示文摘 | ROSSA B D J VON WILLERT | 1999 | Plant Ecology1999，142，： | 1 |
| 12 | A role for Wnt signalling in self-renewal of haematopoietic stem cells显示文摘 | Reya T Duncan AW Ailles L Domen J Scherer DC Willert K | 2003 | Nature2003，423，6938： | 1 |
| 13 | The development and maintenance of human viseral pain hypersensitivity is dependent on the Nmethyl-d-aspartate receptor显示文摘 | Willert R P Woolf C J Hobson A | 2004 | Gastroenterology2004，26，5： | 1 |
| 14 | Wnt proteins are lipid-modified and can act as stem cell growth factors显示文摘 | Willert K Brown J D Danenberg E | 2003 | Nature2003，423，6938： | 1 |
| 15 | Thrombocytopenia and severe hyperbilirubinemia in the neonatal period secondary to congenital thrombotic thrombocytopenic purpura and ADAMTS13 deficiency显示文摘 | Schiff DE Roberts WD Willert J | | 0，，： | 1 |
| 16 | Wnt proteins are lipid-modified and can act as stem cell growth factors 显示文摘 | Willert K Brown J D Danenberg E | 2003 | Nature2003，423，6938： | 1 |
| 17 | Endoscopically assisted video capsule endoscopy of the small bowel in patients with functional gastric outlet obstruetion显示文摘 | HOLLERBACH S KRAUS K WILLERT J | 2003 | Endoscopy2003，35，3： | 1 |
| 18 | Dynamic changes in leaf bulk water relations during stomatal oscillations in mangrove species: continuous analysis using a dewpoint hygrometer显示文摘 | Herppich W B von Willert D J | 1995 | Physiologia Plantarum1995，49，3： | 1 |
| 19 | The development and maintenance of human visceral pain hypersensitivity is dependent on the N-methyl-D-aspartate receptor显示文摘 | WILLERT R P WOOLF C J HOBSON A R | 2004 | Gastroenterology2004，126，3： | 1 |
| 20 | Wnt proteins are lipidmodified and can act as stem cell growth factors显示文摘 | Willert K Brown J D Danenberg E | 2003 | Na- ture2003，423，： | 1 |
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