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| 1 | Comprehensive management of full-thickness luminal defects: The next frontier of gastrointestinal endoscopy显示文摘Full thickness gastrointestinal defects such as perforations, leaks, and fistulae are a relatively common result of many of the endoscopic and surgical procedures performed in modern health care. As the number of these procedures increases, so too will the number of resultant defects. Historically, these were all treated by open surgical means with the associated morbidity and mortality. With the recent advent of advanced endoscopic techniques, these defects can be treated definitively while avoiding an open surgical procedure. Here we explore the various techniques and tools that are currently available for the treatment of gastrointestinal defects including through the scope clips, endoscopic suturing devices, over the scope clips, sealants, endoluminal stents, endoscopic suction devices, and fistula plugs. As fistulae represent the most recalcitrant of defects, we focus this editorial on a multimodal approach of treatment. This includes optimization of nutrition, treatment of infection, ablation of tracts, removal of foreign bodies, and treatment of distal obstructions. We believe that by addressing all of these factors at the time of attempted closure, the patient is optimized and has the best chance at longterm closure. However, even with all of these factors addressed, failure does occur and in those cases, endoscopic therapies may still play a role in that they allow the patient to avoid a definitive surgical therapy for a time while nutrition is optimized, and infections are addressed. | Joshua S Winder Eric M Pauli | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，8： | 13 |
| 2 | Discriminative learning of local image descriptors显示文摘 | BROWN M GANG H WINDER S | 2011 | IEEE Transactions on Pattern Anal- ysis and Machine Intelligence2011，33，1： | 1 |
| 3 | On the current status of quartz crystal microbalance studies of superconductivity-dependent sliding friction显示文摘 | MASON B L WINDER S M KRIM J | 2001 | Tribology Letters2001，10，12： | 1 |
| 4 | Sensitization of low bandgap polymer bulk heterojunction solar cells显示文摘 | WINDER C MATT G HUMMELEN C JAMSSEN R A J SARICIFTCI N S BRABEC C J | 2002 | Thin Solid Films2002，404，： | 1 |
| 5 | Cultural studies of Morchella elata 显示文摘 | WINDER R S | 2006 | Mycological Research2006，110，5： | 1 |
| 6 | Inactivation of acety1 - CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise 显示文摘 | Winder W W MacLean P S Lucas J C | 1996 | Am J Physiol1996，270，： | 1 |
| 7 | Modeling Industrial Ecosystems and the Problem of Evolution显示文摘 | Baldwin J S K Ridgway B Winder | 2004 | Progress in Industrial Ecolo-gy2004，1，： | 1 |
| 8 | Low bandgap polymers for photon harvesting in bulk heterojunetion solar cells显示文摘 | Winder C Sariciftci N S | 2004 | J Mater Chem2004，14，： | 1 |
| 9 | Modelling industrialecosystems and the problem of evolution显示文摘 | Baldwin J S Ridgway K Winder B | 2004 | Progressin Industrial Ecology2004，1，13： | 1 |
| 10 | The application of supercritical carbon dioxide in polymerization reaction显示文摘 | GILES M R HOWDLE S M WINDER R | 2000 | J Polymer2000，41，18： | 1 |
| 11 | Effect of LiF/metal Electrodes on the Performance of Plastic Solar Cells显示文摘 | Brabec C J Shaheen S E Winder C | 2002 | Applied Physics Letters2002，80，7： | 1 |
| 12 | Activation of AMP-activated protein kinase inereases mi- toehondrial enzymes in skeletal musele显示文摘 | WINDER W W HOLMES B F RUBINK D S | 2000 | J Appl Physi- ol2000，88，6： | 1 |
| 13 | High-quality video view interpolation us- ing a layered representation 显示文摘 | ZITNICK L KANG S B UYTTENDAELE M WINDER S SZELISKI R | 2004 | ACM Transactions on Graphics2004，23，3： | 1 |
| 14 | On the current status of quartz crystal microbalance studies of superconductivity dependent sliding friction 显示文摘 | Mason B L Winder S M Krim J | 2001 | Tribology Letters2001，10，12： | 1 |
| 15 | The interaction of dystrophin with beta-dystroglycan is regulated by tyrosine phosphorylation显示文摘 | Ilsley J L Sudol M Winder S J | 2001 | Cell Signal2001，13，9： | 1 |
| 16 | Toxicity assessment of industrial chemicals and airborne contaminants:transition from in vivo to in vitro test methods:a review显示文摘 | BAKAND S WINDER C HAYES A | 2005 | Inhal Toxicol2005，，17： | 1 |
| 17 | Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal musele显示文摘 | Winder W W Holmes B F Rubink D S | 2000 | J Appl Physiol2000，88，6： | 1 |
| 18 | Global metabolic profiling of Escherichia coli cultures:anevaluation of methods for quenching and extraction of intracellularmetabolites显示文摘 | Winder C L Dunn W B Schuler S Broadhurst D Jarvis R StephensG M | 2008 | Anal Chem2008，80，： | 1 |
| 19 | A low-bandgap semiconducting polymer for photovohaic devices and infrared emitting diodes显示文摘 | Brabec C J Winder C Sariciftci N S | 2002 | Adv Funct Mater2002，12，： | 1 |
| 20 | In vitro cytoxicity testing of airborne formaldehyde collected in serum-free culture media显示文摘 | BAKAND S HAYES A WINDER C | 2005 | Toxicol Ind Health2005，21，78： | 1 |
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