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| 1 | On the cell biology of pit cells,the liver-specific NK cells显示文摘INTRODUCTION Natural killer (NK) cells are functionally defined by their ability to kill certain tumor cells and virus-infected cells without prior | Luo DZ Vermijlen D Ahishali B Triantis V Plakoutsi G Braet F Vanderkerken K Wisse E | 2000 | World Journal of Gastroenterology2000，6，1： | 8 |
| 2 | Participation of CD45,NKR-P1A and ANK61 antigen in rat hepatic NK cell(pit cell)-mediated target cell cytotoxicity显示文摘AIM Several triggering receptors have beendescribed to be involved in natural killer(NK)cell-mediated target cytotoxicity.In these studies,NKcells derived from blood or spleen were used.Pitcells are liver-specific NK cells that possess ahigher level of natural cytotoxicity and a differentmorphology when compared to blood NK cells.The aim of this study was to characterize the roleof the NK-triggering molecules NKR-P1A,ANK61antigen,and CD45 in pit cell-mediated killing oftarget cells.METHODS 51Cr-release and DNA fragmentationwere used to quantify target cell lysis andapoptosis,respectively.RESULTS Flow cytometric analysis showed thatpit cells expressed CD45,NKR-P1A,and ANK61antigen.Treatment of pit cells with monoclonalantibody(mAb)to CD45(ANK74)not onlyinhibited CC531s or YAC-1 target lysis but alsoapoptosis induced by pit cells.The mAbs to NKR-P1A(3.2.3)and ANK61 antigen(ANK61)had no effect on pit cell-mediated CC531s or YAC-1 targetcytolysis or apoptosis,while they did increase theFcγ receptor positive(FcγR+)P815 cytolysis andapoptosis.This enhanced cytotoxicity could beinhibited by 3,4-dichloroisocoumarin,an inhibitorof granzymes.CONCLUSION These results indicate that CD45participates in pit cell-mediated CC531s and YAC-1target cytolysis and apoptosis.NKR-P1A andANK61 antigen on pit cells function as activationstructures against FcγR+ P815 cells,which wasmediated by the perforin/granzyme pathway. | David Vermiilen Bülent Ahishali Vasilis Triantis Karin Vanderkerken Peter J. K.Kuppen Eddie Wisse | 2000 | World Journal of Gastroenterology2000，6，4： | 4 |
| 3 | Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery 显示文摘 | SOUTO E B WISSING S A BARBOSA C M | 2004 | Int J Pharm2004，278，1： | 1 |
| 4 | Testosterone mediates expression of the selenoprotein PHGPx by induction of spermatogenesis and not by direct transcriptional gene activation显示文摘 | Maiorino M Wissing J B Brigelius-Flohé R | 1998 | FASEB J1998，12，13： | 1 |
| 5 | Evaluation of the physical stability of SLN and NLC before and after incor-poration into hydrogel formulations 显示文摘 | Souto E B Wissing S A Barbosa C M | 2004 | Eur J Pharm Biopharm2004，58，1： | 1 |
| 6 | Central administration of interleukin-4 exacerbates hypothalamic inflammation and weight gain during high-fat feeding显示文摘 | Oh-I S Thaler J P Ogimoto K Wisse B E Morton G J Schwartz M W | | 0，，01： | 1 |
| 7 | Purification and characterization of multiple forms of phosphatidylinositol-specific phospholipases D from suspension culture Catharathus roseus cells显示文摘 | Grabo P Kornak B | 1996 | Plant Sci1996，117，： | 1 |
| 8 | Crucial mitochondrial impairment upon CDC48 mutation in apoptotic yeast显示文摘 | Braun R J Zischka H Madeo F Eisenberg T Wissing S B ttner S | 2006 | J Biol Chem2006，281，25： | 1 |
| 9 | Three new ellagic acid derivatives from the bark of Eschweilera coriacea from the suriname rainforest显示文摘 | Yang S W Zhou B N Wisse J H | 1998 | J Nat Prod1998，61，7： | 1 |
| 10 | Unstable fracture of the tibiatreated with a raemead intramedullary interlocking nail显示文摘 | WISS A STETSON B | 1995 | Clin Orthop1995，，315： | 1 |
| 11 | Gravity- balanced arm support with energy-free adjustment 显示文摘 | Van Dorsser W D Barents R Wisse B M | 2007 | ASME Journal of Medical Devices2007，1，： | 1 |
| 12 | Cytotoxicity and gene expression profiles in cell cultures exposed to whole smoke from three types of cigarettes 显示文摘 | Lu B Kerepesi L Wisse L | 2007 | Toxicol Sci2007，98，2： | 1 |
| 13 | De-velopment of a controlled release formulation based onSLN and NLC for topical clotrimazole delivery显示文摘 | SOUTO E B WISSING S A BARBOSA C M | 2004 | Int JPharm2004，278，1： | 1 |
| 14 | Leader self-concept andself-interested behavior: The moderating role of power显示文摘 | WISSE B RUS D | 2012 | Journal of personnel Psychology2012，11，1： | 1 |
| 15 | Leptin activates a novel CNS mechanism for insulin-independent normalization of severe diabetic hyperglycemia显示文摘 | German J P Thaler J P Wisse B E | 2011 | Endocrinology2011，152，2： | 1 |
| 16 | Testosterone mediates expression of the selenoprotein PHGPx by induction of spermatogenesis and not by direct transcriptional gene activation显示文摘 | Maiorino M Wissing J B Brigelius-Flohe R | 1998 | FASEB J1998，12，13： | 1 |
| 17 | Cytotoxicity and gene expression profiles in cell cultures exposed to whole smoke from three types of cigarettes 显示文摘 | Lu B Kerepesi L Wisse L | 2007 | Toxicological Sciences2007，98，2： | 1 |
| 18 | Unstable fracture of the tibia treated with a reamedintramedullary interloking nail显示文摘 | Wiss A Stetson B | 1995 | Clin Orthop1995，315，： | 1 |
| 19 | Leaderself-definition and leader self-serving behavior显示文摘 | RUS D KNIPPENBERG D WISSE B M | 2010 | LeadershipQuarterly2010，21，3： | 1 |
| 20 | An AIF orthologue regulates apoptosis in yeast显示文摘 | Wissing S Ludovico P Herker E B ttner S Engelhardt SM Decker T | 2004 | J Cell Biol2004，166，： | 1 |
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