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| 1 | Enhanced caveolin-1 expression in smooth muscle cells: Possible prelude to neointima formation显示文摘AIM: To study the genesis of neointima formation in pulmonary hypertension(PH), we investigated the role of caveolin-1 and related proteins. METHODS: Male Sprague Dawley rats were given monocrotaline(M, 40 mg/kg) or subjected to hypobaric hypoxia(H) to induce PH. Another group was given M and subjected to H to accelerate the disease process(M + H). Right ventricular systolic pressure, right ventricular hypertrophy, lung histology for medial hypertrophy and the presence of neointimal lesions were examined at 2 and 4 wk. The expression of caveolin-1 and its regulatory protein peroxisome proliferator-activated receptor(PPAR) γ, caveolin-2, proliferative and antiapoptotic factors(PY-STAT3, p-Erk, Bcl-x L), endothelial nitric oxide synthase(e NOS) and heat shock protein(HSP) 90 in the lungs were analyzed, and the results from M + H group were compared with the controls, M and H groups. Double immunofluorescence technique was used to identify the localization of caveolin-1 in pulmonary arteries in rat lungs and in human PH lung tissue. RESULTS: In the M + H group, PH was more severe compared with M or H group. In the 4 wk M+H group, several arteries with reduced caveolin-1 expression in endothelial layer coupled with an increased expression in smooth muscle cells(SMC), exhibited neointimal lesions. Neointima was present only in the arteries exhibiting enhanced caveolin-1 expression in SMC. Lung tissue obtained from patients with PH also revealed neointimal lesions only in the arteries exhibiting endothelial caveolin-1 loss accompanied by an increased caveolin-1 expression in SMC. Reduction in e NOS and HSP90 expression was present in the M groups(2 and 4 wk), but not in the M + H groups. In both M groups and in the M + H group at 2 wk, endothelial caveolin-1 loss was accompanied by an increase in PPARγ expression. In the M + H group at 4 wk, increase in caveolin-1 expression was accompanied by a reduction in the PPARγ expression. In the H group, there was neither a loss of endothelial caveolin-1, eNOS or HSP 90, nor an increase in SMC caveolin-1 expression; or any alteration in PPARγ expression. Proliferative pathways were activated in all experimental groups. CONCLUSION: Enhanced caveolin-1 expression in SMC follows extensive endothelial caveolin-1 loss with subsequent neointima formation. Increased caveolin-1 expression in SMC, thus, may be a prelude to neointima formation. | Jing Huang John H Wolk Michael H Gewitz James E Loyd James West Eric D Austin Rajamma Mathew | 2015 | World Journal of Cardiology2015，7，10： | 2 |
| 2 | Associations between problems with crying, sleeping and/or feeding in infancy and long-term behavioural outcomes in childhood: a me- ta-analysis 显示文摘 | Hemmi MH Wolke D Schneider S | 2011 | Arch Dis Child2011，96，7： | 1 |
| 3 | An epidemiologic longitudinal study of sleeping problems and feeding experience of preterm and term children in southern Finland:comparison with a southern German population sample显示文摘 | Wolke D Sohne B Riegel K | 1998 | J Pediatr1998，133，： | 1 |
| 4 | Development of a method for the detection of waterborne microspofidia显示文摘 | HOFFMAN R M WOLK D M SPENCER S K | 2007 | Journal of Microbiological Methods2007，70，2： | 1 |
| 5 | Crying and feedingproblems in infancy and cognitive outcome in prcschool chU-dren born at risk:a prospective population study显示文摘 | Wolke D Schmid G Schreier A | 2009 | J DevBehav Pediatr2009，30，3： | 1 |
| 6 | Update on amyloid imaging: from healthy aging to Alzheimer' s disease显示文摘 | Wolk D A Klunk W | 2009 | Curr Neurol Neurosci Rep2009，9，： | 1 |
| 7 | Neurologic and developmental disability at six years of age after extremely preterm birth显示文摘 | Marlow N Wolke D Bracewell MA | | 0，，： | 1 |
| 8 | Factors and time of sample collection for correlating storage potential of McIntosh,Spartan,and Golden Delicious apples显示文摘 | WOLK W D LAU O L NEILSEN G H | 1998 | J Am Soc Hortic Sci1998，123，： | 1 |
| 9 | Preliminary evaluation of the use of macrophage aggregates (MA) as fish health monitors显示文摘 | Wolke R E Murchelano R A Dickstein C D | | 0，，02： | 1 |
| 10 | An epide miolgic longitudinal study of sleeping problems and feeding experience of preterm and term children in southern Finlard: comparison with a southern german population sample 显示文摘 | WOLK D SOHNE B RIEGEL K | 1998 | J Pediatr1998，133，： | 1 |
| 11 | Direct and relational bullying among primary school children and academic achievement显示文摘 | Woods S Wolke D | 2004 | J Sch Psychol2004，42，2： | 1 |
| 12 | Intakes of fish and marine fatty acids and the risks of cancers of the breast and prostate and of other hormone- related cancers: a review of the epidemiologic evidence显示文摘 | TERRY P D ROHAN T E WOLK A | 2003 | Arn J Clin Nutr2003，77，3： | 1 |
| 13 | Principles of molecular microbiology testing methods 显示文摘 | Wolk D Mitchell S Patel R | 2001 | ect Dis Clin North Am2001，15，4： | 1 |
| 14 | Sub- cellular localization, stability, andtrans-cleavage compe- tence of the Hepatitis C Virus NS3-NS4A complex ex- pressed in tetracycline-regulated cell lines 显示文摘 | WOLK B SANSONNO D KR_ASSLICH H G | 2000 | J Virol2000，74，5： | 1 |
| 15 | Prenatal family adversity and maternal mental health and vulnerability to peer victimisation at school显示文摘 | LEREYA WOLKE D | 2013 | Child Psy- chol Psych2013，54，6： | 1 |
| 16 | An epidemiologic longitudinal study of sleeping problems and feeding experience of preterm and term children in southern Finland: comparison with a southern German population sample显示文摘 | Wolke D S6hne B Riegel K | 1998 | J Pediatr1998，133，2： | 1 |
| 17 | Principles of molecular microbiol- ogy testing method显示文摘 | Wolk D Mitchell S Patel R | 2001 | Infect Dis Clin North Am2001，15，4： | 1 |
| 18 | Resilience to bullying victimization:The role of individual, family and peer characteristics 显示文摘 | SAPOUNA M WOLKE D | 2013 | Child Abuse Neg12013，37，11： | 1 |
| 19 | Experimental Analysis of Passive Intermodulation at Waveguide Flange Bolted Connections 显示文摘 | Vicente C Wolk D Hartnagel H L | 2007 | IEEE Transaction on Microwave Theory and Techniques2007，55，5： | 1 |
| 20 | Associations between problems with crying, sleeping and/or feeding in infancy and long-term behavioural outcomes in childhood: a meta- analysis显示文摘 | Hemmi MH Wolke D Schneider S | 2011 | Arch Dis Child2011，96，7： | 1 |
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