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| 1 | 婚姻状况与心血管病风险的关系:系统评价和荟萃分析显示文摘虽然80%的未来心血管病风险可以从已知的心血管危险因素预测,如老年、男性、高血压、高血脂症、吸烟和糖尿病,但其余20%风险的决定因素仍不明确。婚姻对健康和死亡的益处已经在不同种族的两性中得到证实,并且与各种社会人口学特征无关。 | Wong CW Kwok CS Narain A Gulati M Mihalidou AS Wu P Alasnag M Myint PK Mamas MA 刘莉 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 5 |
| 2 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 3 | A new method for gray level picture thresholding using the entropy of the histogram显示文摘 | Kapur J N Sahoo PK Wong A K C | 1985 | Computer Vision Graphics and Image Process1985，29，3： | 1 |
| 4 | Acute CD4+ T lymphocyte-dependent interleukin-1-driven arthritis selectively requires interleukin-2 and interleukin-4,joint macrophages,granulocyte-macrophage colony-stimulating factor,interleukin-6,and leukemia inhibitory factor显示文摘 | Lawlor KE Wong PK Campbell IK van Rooijen N Wicks IP | 2005 | Arthritis Rheum2005，52，12： | 1 |
| 5 | Epidemiologic risk profile of infection with different groups of human papillomaviruses 显示文摘 | Chan PK Ho WC Wong MC | 2009 | J Med Virol2009，81，9： | 1 |
| 6 | Loss of ATM impairs proliferation of neural stem cells through oxidative stress-mediated p38 MAPK signaling显示文摘 | Kim J Wong PK | 2009 | Stem Cells2009，27，8： | 1 |
| 7 | Lack of Toll-like receptor 4or myeloid differentiation factor 88reducesatherosclerosis and alters plaque phenotype in mice defi-cient in apolipoprotein E显示文摘 | Michelsen KS Wong MH Shah PK | 2004 | Proc Natl Acad Sci USA2004，101，10： | 1 |
| 8 | Hydrogen sulfide attenuates lipopolysaccharide-induced inflammation by inhibition of p38 MAPK in microglia显示文摘 | Hu LF Wong PT Moore PK | 2007 | J Neurochem2007，100，4： | 1 |
| 9 | Acute CD4+ Tlymphecyte- dependent interleukin-l-driven arthritis selectively requires interleu- kin-2 and interleukin-4, jointmacrophages, granulecyte-macrophage- colony-stimulating factor, interleukin-6, and leukemia inhibitory fac- tor显示文摘 | Lawlor KE Wong PK Campbell IK | 2005 | Arthritis Rheum2005，52，12： | 1 |
| 10 | The role of the interleukin-6 family of cytokines in inflammatory arthritis and bone turnover 显示文摘 | Wong PK Campbell IK Egan PJ | 2003 | Arthritis Rheum2003，48，5： | 1 |
| 11 | Seizures involving the supplementary sensorimotor area in children: a video-EEG analysis显示文摘 | Connolly MB Langill L Wong PK | 1995 | Epilesia1995，36，10： | 1 |
| 12 | Human coronavirus NL63 in children:epidemiology,disease spectrum,and genetic diversity显示文摘 | Lcung TF Chan PK Wong WK | | 0，，2： | 1 |
| 13 | SOCS-3 nega- tively regulates innate and adaptive immune mecha- nisms in acute IL-l-dependent inflammatory arthritis显示文摘 | Wong PK Egan PJ Croker BA | 2006 | J Clin Invest2006，116，6： | 1 |
| 14 | Antagonist-mediated down?regulation of Toll- like receptors increases the prevalence of human papilloma virus infection in systemic lupus erythematosus显示文摘 | Yu SL Chan PK Wong CK | 2012 | Arthritis Res Ther2012，14，2： | 1 |
| 15 | Monocyte recruitment to endothelial cells in response to oscillatory shear stress显示文摘 | Hsiai TK Cho SK Wong PK | 2003 | FASEB J2003，17，12： | 1 |
| 16 | Three-dimensional mechanical dyssynchrony and myocardial deformation of the left ventricle in patients with tricuspid atresia after fontan procedure显示文摘 | Ho PK Lai CT Wong SJ | | 0，，： | 1 |
| 17 | Parvovirus B19infection causing red cell aplasia in renal transplantationon tacrolimus显示文摘 | Wong TY Chan PK Leung CB | 1999 | Am J Kidney Dis1999，34，6： | 1 |
| 18 | The role of the interleukin-6 family of cytokines in inflammatory arthritis and bone turnover显示文摘 | Wong PK Campbell IK Egan PG | 2003 | Arthritis Rheum2003，48，5： | 1 |
| 19 | Diagnosing acute appendi- citis: are we overusing radiologic investigations 显示文摘 | Wong KK Cheung TW Tam PK | 2008 | J Pediatr Surg2008，43，： | 1 |
| 20 | The Use of Networks in Human Resource Acquisition for Entrepreneurial Firms: Multiple 'Fit' Considerations 显示文摘 | LEUNG A ZHANG J WONG PK | 2006 | Journal of Business Venturing2006，21，66： | 1 |
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