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| 1 | A comparison of transition state of phenol in H-atom abstraction by methyl and methylperoxyl radicals显示文摘DFT method was employed to locate transition state for H-atom transfer from phenol by methyl radical and methylperoxyl radical. The reaction pathway energy profiles and the structure of transition state show that a common feature is the out-of-plane structure of the transition state: in contrast to the en- ergetic minima of a hydrogen-bonded intermediate, the hydrogen bond in transition structures is con- siderably twisted out of the aromatic ring. From the values of enthalpy (△H) and activation energy (Ea) obtained, it is found that the rate of the reaction of peroxyl radical with phenolic antioxidant is higher than that of alkyl radical with antioxidant. Spin density distributions show that the electron transmis- sion is between methyl (methylperoxyl) radical and phenol. | SUN YouMin WU JunSen LIU ChengBu | 2007 | Chinese Science Bulletin2007，52，9： | 2 |
| 2 | Numerical simulation of aerodynamic interactions among helicopter rotor,fuselage,engine and body of revolution显示文摘Numerical simulations of helicopter aerodynamic interactions among the main rotor,fuselage,engine inlets/outlets and slung loads of specific geometries have been conducted by very few researchers.In this work,the steady-state compressible Reynolds-averaged navier-stokes equations are solved to study the aerodynamic interactions among helicopter rotor,fuselage,engine and body of revolution in three cases,namely MI-171V5,ROBIN and UH-60A.In the first case,the downwash flow provided by the rotor of the uniform actuator disc model induces a significant deflection of the airflow velocity.The vortex-shaped distribution and evolution are discussed in detail.The engine can effectively change the overall flow field.The asymmetry of the flow field is observed by using the non-uniform actuator disc model.Qualitative analysis of ROBIN and quantitative computation of UH-60A show a consistent accuracy of the rotating reference frame model for rotor.The blade tip vortex motion of UH-60A is simulated and its radial position prediction is compared to empirical formulas.While performing flow of UH-60A in hover,both the fuselage normal force and rotor lift decrease because of the impact of the body of revolution. | CAO YiHua WU ZhenLong HUANG JunSen | 2014 | Science China(Technological Sciences)2014，57，6： | 2 |
| 3 | Genome-wide characterization of alternative splicing in blood cells of COVID-19 and respiratory infections of relevance显示文摘Dear Editor,Alternative splicing of eukaryotic transcripts refers to the posttranscriptional process in which the coding regions(exons)of a precursor transcript are joined in different combinations through the removal or retention of non-coding intervening sequences(introns)to produce distinct mature messenger RNA(mRNA)transcripts and further generate one or more mature mRNAs(Lee and Rio,2015).Alternative splicing is revealed dysregulation in infectious diseases.Many pathogens hijack the splicing mechanism of host cells to complete their replications,accompanied by dysregulated innate immune response or cell damage,leading to the changes of alternative splicing landscape in host cells(Ashraf et al.,2019;Tomezsko et al.,2020;Kremsdorf et al.,2021).The regulation mechanism of alternative splicing by viral pathogens,such as hepatitis B virus(Duriez et al.,2017),human immunodeficiency virus 1(Tomezsko et al.,2020),Zika virus(Bonenfant et al.,2020)and enterovirus 71(Li et al.,2020),have been explored. | Rui Huang Wenbo Chen Xueya Zhao Yuefei Ma Qiong Zhou Junsen Chen Muyi Zhang Dingran Zhao Yu Hou Chunjiang He Ying Wu | 2023 | Virologica Sinica2023，38，2： | 0 |
| 4 | Human Monoclonal Antibodies: On the Menu of Targeted Therapeutics Against COVID-19显示文摘Coronavirus disease 2019(COVID-19), reminiscent of the severe acute respiratory syndrome(SARS) outbreak in 2003,has been a tragic disaster to people all over the world. As there is no specific drug for COVID-19, neutralizing antibodies are attracting more and more attention as one of the most effective means to combat the pandemic. Here, we introduced the etiological and serological characteristics of COVID-19, discussed the current stage of development of human monoclonal antibodies against SARS-CoV-2 and summarized the antigenic epitopes in the S glycoprotein, which may deepen the understanding of the profile of immune recognition and response against SARS-CoV-2 and provide insight for the design of effective vaccines and antibody-based therapies. | Junsen Chen Rui Huang Yiwen Nie Xinyue Wen Ying Wu | 2020 | Virologica Sinica2020，35，6： | 0 |
| 5 | Rearrangement of Actin Cytoskeleton by Zika Virus Infection Facilitates Blood–Testis Barrier Hyperpermeability显示文摘In recent years,various serious diseases caused by Zika virus(ZIKV)have made it impossible to be ignored.Confirmed existence of ZIKV in semen and sexually transmission of ZIKV suggested that it can break the blood–testis barrier(BTB),or Sertoli cell barrier(SCB).However,little is known about the underlying mechanism.In this study,interaction between actin,an important component of the SCB,and ZIKV envelope(E)protein domainⅢ(EDⅢ)was inferred from coimmunoprecipitation(Co-IP)liquid chromatography–tandem mass spectrometry(LC–MS/MS)analysis.Confocal microscopy confirmed the role of actin filaments(F-actin)in ZIKV infection,during which part of the stress fibers,the bundles that constituted by paralleled actin filaments,were disrupted and presented in the cell periphery.Colocalization of E and reorganized actin filaments in the cell periphery of transfected Sertoli cells suggests a participation of ZIKV E protein in ZIKV-induced F-actin rearrangement.Perturbation of F-actin by cytochalasin D(CytoD)or Jasplakinolide(Jas)enhanced the infection of ZIKV.More importantly,the transepithelial electrical resistance(TEER)of an in vitro mouse SCB(mSCB)model declined with the progression of ZIKV infection or overexpression of E protein.Co-IP and confocal microscopy analyses revealed that the interaction between F-actin and tight junction protein ZO-1 was reduced after ZIKV infection or E protein overexpression,highlighting the role of E protein in ZIKV-induced disruption of the BTB.We conclude that the interaction between ZIKV E and F-actin leads to the reorganization of F-actin network,thereby compromising BTB integrity. | Yiwen Nie Lixia Hui Moujian Guo Wei Yang Rui Huang Junsen Chen Xinyue Wen Meng Zhao Ying Wu | 2021 | Virologica Sinica2021，36，4： | 0 |
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