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| 1 | Relationships between mucinous gastric carcinoma, MUC2 expression and survival显示文摘瞄准:为了调查四的表示,在一系列胃的癌分泌了形成胶化的粘蛋白( MUC2 , MUC5AC , MUC5B 和 MUC6 ),分类 Lauren 的,素菜烩肉的,并且 Goseki 的分类,与到所有的特殊注意,不同部件(专业和未成年者)在肿瘤并且到介绍在临床的数据上面列在后面。方法:MUC2, MUC5AC, MUC5B 和 MUC6 的表示用免疫组织化学和原位杂交被调查。结果:在胃的癌的分泌形成胶化的粘蛋白的表示是特别地复杂的,各粘蛋白 being 没限制到平的任何组织病理学说的类型在一个给定的肿瘤认为所有部件(专业和未成年者) 是现在。在有粘液(Goseki II 或 IV ) 和高积极 MUC2 表示的一个更高的内容的病人有最糟的幸存。结论:在胃的癌症的粘蛋白基因表达式模式的复杂性可以在没在使用的词法分类系统认出的房间水平反映区别的一个精确状态。MUC2 的高表示不过与 WHO 分类的粘蛋白的子类型并且与 Goseki 一个特别肿瘤的主要部件识别的分类的组 II 被联系。粘液的数量和质量与幸存有关。 | Emmanuelle Leteurtre Farid Zerimech Guillaume Piessen Agnès Wacrenier Xavier Leroy Marie-Christine Copin Christophe Mariette Jean-Pierre Aubert Nicole Porchet Marie-Pierre Buisine | 2006 | World Journal of Gastroenterology2006，12，21： | 4 |
| 2 | Frequent mutations of the CA simple sequence repeat in intron 1 of EGFR in mismatch repair-deficient colorectal cancers显示文摘AIM:To investigate the polymorphic simple sequencerepeat in intron 1 of the epidermal growth factor receptorgene(EGFR)(CA-SSRⅠ),which is known to affect theefficiency of gene transcription as a putative target of themismatch repair(MMR)machinery in colorectal tumors.METHODS:The CA-SSRⅠgenotype was analyzed ina total of 86 primary colorectal tumors,selected upontheir microsatellite instability(MSI)status[42 with highfrequency MSI(MSI-H)and 44 microsatellite stable(MSS)]and their respective normal tissue.The effect of the CA-SSRⅠgenotype on the expression of the EGFR gene wasevaluated in 18 specimens using quantitative real-timereverse transcription PCR and immunohistochemistry.RESULTS:Mutations in CA-SSRⅠwere detected in 86%(36 of 42)of MSI-H colorectal tumors and 0%(0 of 44)ofMSS tumors,indicating the EGFR gene as a novel putativespecific target of the defective MMR system(P<0.001).Impaired expression of EGFR was detected in most ofthe colorectal tumors analyzed[6/12(50%)at the mRNAlevel and 15/18(83%)at the peptide level].However,noassociation was apparent between EGFR expression andCA-SSRⅠstatus in tumors or normal tissues.CONCLUSION:Our results suggest that CA-SSRⅠsequence does not contribute to the regulation of EGFRtranscription in colon,and should thus not be consideredas a promising predictive marker for response to EGFRinhibitors in patients with colorectal cancer. | Marie-Pierre Buisine Agnès Wacrenier Christophe Mariette Emmanuelle Leteurtre Fabienne Escande Sana Aissi Amandine Ketele Annette Leclercq Nicole Porchet Thécla Lesuffleur | 2008 | World Journal of Gastroenterology2008，14，7： | 3 |
| 3 | Effect of se- lection for improved body weight and composition on muscle and meat characteristics in Muscovy duck 显示文摘 | Baeza E Dessay C Wacrenier N | 2002 | Br Pouh Sci2002，43，： | 1 |
| 4 | Effects of selection for improved body weight and composition on muscle and meat characteristics in Muscovy duck显示文摘 | BAEZA E DESSAY C WACRENIER N | 2002 | Br Poult Sci2002，43，4： | 1 |
| 5 | Effects of selection for improved body weight and composition on muscle and meat characteristics in Muscovy duck显示文摘 | Baeza E Dessay C Wacrenier N | 2002 | Brit Poult Sci2002，43，4： | 1 |
| 6 | Weiss system revisited:a clinicopathologic and immunohistochemical study of 49 adrenocortical tumors显示文摘 | Aubert S Wacrenier A Leroy X | 2002 | The American journal of surgical pathology2002，26，12： | 1 |
| 7 | Mucin gene transcripts in benign and borderline mucinous tumours of ovary:an in situ hybridixzation study显示文摘 | Boman F Buisine MP Wacrenier A | 2001 | J Pathol2001，193，3： | 1 |
| 8 | Mucin gene transcripts in benign and borderline mucinous tumours of the ovary : an in situ hybridization study 显示文摘 | Boman F Buisine M P Wacrenier A | 2001 | J Pathol2001，193，3： | 1 |
| 9 | Mucin gene transcripts in benign andborderline mucinous tumours of the ovary: an in situ hybridization study显示文摘 | Boman F Buisine MP Wacrenier A | 2001 | J Pathol2001，193，： | 1 |
| 10 | Weiss system re- visited: a clinicopathologic and immunohistochemical study of 49 adrenocortical tumors显示文摘 | AUBERT S WACRENIER A LEROY X | 2002 | Am J Surg Pathol2002，26，12： | 1 |
| 11 | Schwannoma of the sinonasal tract: a clinicopathologic and immunohistechemical study of 5 cases显示文摘 | Boub D Wacrenier A Chevalier D | 2003 | Arch Pathol Lab Med2003，127，9： | 1 |
| 12 | Mucin gene transcripts in benign and borderline mucinous tumors of the ovary:an in situ hybridization study显示文摘 | Boman F Buisine MP Wacrenier A | 2001 | J Pathol2001，193，： | 1 |
| 13 | Weiss syslem revisited : a clinicopathologic and immunohistochemical study of 49 adrenocortical tumors 显示文摘 | Aubert S Wacrenier A Leroy X | 2002 | Am J Surg Pathol2002，26，： | 1 |
| 14 | Mucin gene transcripts in benign and borderline mucinous tumours of the ovary :an in situ hybridization study 显示文摘 | Boman M Buisine MP Wacrenier A | 2001 | J Pathol2001，193，3： | 1 |
| 15 | Mucin gene transcripts in benign and borderline mucinous tumours of the ovary:an in situ hybridization study显示文摘 | Boman F Buisine MP Wacrenier A | | 0，，03： | 1 |
| 16 | Effect of selection for improved body composition on muscle and meat eharacteristies of broilers from experimental and commercial lines 显示文摘 | Berri Wacrenier Millet | 2001 | Poultry Science2001，80，7： | 1 |
| 17 | Weiss system revisited: a elinieopathologie and immunohistoehemieal study of 49 adrenoeorti- cal tumors 显示文摘 | Aubert S Wacrenier A Leroy X | 2002 | Am J Surg Pathol2002，26，12： | 1 |
| 18 | Effect of selection for improved body weight and composition on muscle and meat characteristics in Muscovy duck显示文摘 | BAEZA E DESSAY C WACRENIER N | 2002 | British Poultry Science2002，43，4： | 1 |
| 19 | Muscle development, insulin-like growth factor-I and myostatin mRNA levels in chickens selected for in- creased breast muscle yield显示文摘 | GUERNEC A BERRI C B WACRENIER C N | 2003 | Growth Horm IGF Res2003，13，1： | 1 |
| 20 | Weiss system re- visited: a clinicopathologic and immunohistochemical study of 49 adrenocortical tumors 显示文摘 | Aubert S Wacrenier A Leroy X | 2002 | Am J Surg Pathol2002，26，12： | 1 |
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