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| 1 | Diffusion-weighted magnetic resonance imaging and micro-RNA in the diagnosis of hepatic fibrosis in chronic hepatitis C virus显示文摘BACKGROUND Diffusion-weighted magnetic resonance imaging has shown promise in the detection and quantification of hepatic fibrosis. In addition, the liver has numerous endogenous micro-RNAs(miRs) that play important roles in the regulation of biological processes such as cell proliferation and hepatic fibrosis.AIM To assess diffusion-weighted magnetic resonance imaging and miRs in diagnosing and staging hepatic fibrosis in patients with chronic hepatitis C.METHODS This prospective study included 208 patients and 82 age-and sex-matched controls who underwent diffusion-weighted magnetic resonance imaging of the abdomen, miR profiling, and liver biopsy. Pathological scoring was classified according to the METAVIR scoring system. The apparent diffusion coefficient (ADC) and miR were calculated and correlated with pathological scoring.RESULTS The ADC value decreased significantly with the progression of fibrosis, from controls(F0) to patients with early fibrosis(F1 and F2) to those with late fibrosis(F3 and F4)(median 1.92, 1.53, and 1.25 × 10^(-3) mm^2/s, respectively)(P = 0.001).The cut-off ADC value used to differentiate patients from controls was 1.83 × 10^(-3) mm^2/s with an area under the curve(AUC) of 0.992. Combining ADC and miR-200 b revealed the highest AUC(0.995) for differentiating patients from controls with an accuracy of 96.9%. The cut-off ADC used to differentiate early fibrosis from late fibrosis was 1.54 × 10^(-3) mm^2/s with an AUC of 0.866. The combination of ADC and miR-200 b revealed the best AUC(0.925) for differentiating early fibrosis from late fibrosis with an accuracy of 80.2%. The ADC correlated with miR-200 b(r =-0.61, P = 0.001), miR-21(r =-0.62, P = 0.001), and miR-29(r = 0.52,P = 0.001).CONCLUSION Combining ADC and miRs offers an alternative surrogate non-invasive diagnostic tool for diagnosing and staging hepatic fibrosis in patients with chronic hepatitis C. | Tarek Besheer Hatem Elalfy Mohamed Abd El-Maksoud Ahmed Abd El-Razek Saher Taman Khaled Zalata Wagdy Elkashef Hossam Zaghloul Heba Elshahawy Doaa Raafat Wafaa Elemshaty Eman Elsayed Abdel-Hady El-Gilany Mahmoud El-Bendary | 2019 | World Journal of Gastroenterology2019，25，11： | 9 |
| 2 | Religious attitudes in adoles- cents with Obsessive Compulsive Symptoms OCS and disorder OCD 显示文摘 | Rady A Salama H Wagdy M | 2012 | Glob J Health Sci2012，4，6： | 1 |
| 3 | Effect of sampling jitter on some sine wave measurements 显示文摘 | Wagdy M F Awad S S | 1990 | IEEE Transactions on Instrumentation and Measurement1990，39，1： | 1 |
| 4 | Patient radiation dose during percutane- ous interventional closure of interatrial communications 显示文摘 | Wagdi P Ritter M | | J Cardiol0，，： | 1 |
| 5 | Manifestations of se- vere vitamin D deficiency in adolescents = effects of intramus- cular injection of a megadose of cholecalciferol显示文摘 | Soliman AT Adel A Wagdy M | 2011 | J Trop Ped2011，57，3： | 1 |
| 6 | Effect of various dither forms on quantization errors of ideal A/D converters显示文摘 | WAGDY M F | 1989 | IEEE Trans Instrum Measur1989，38，4： | 1 |
| 7 | Effect of additive dither on the resolution of ADC's with single-bit or multibit errors 显示文摘 | WAGDY Z FAWZY M | 1996 | IEEE Transactions on Instru- mentation and Measurement1996，45，2： | 1 |
| 8 | How to Motivate and Evaluate Managers with International Transfer Pricing System显示文摘 | Wagdy M | 1989 | Management International Review1989，，1： | 1 |
| 9 | Prognostic value of vasodilator myocardial perfusion imaging in patients with left bundle-branch block显示文摘 | Wagdy HM Hodge D Christian TF el al | 1998 | Circulation1998，97，： | 1 |
| 10 | Acute myocardial infarction after wasp stings in a patient with normal coronary arteries显示文摘 | Wagdi P Mehan VK Bttrgi H | 1994 | Am Heart J1994，128，： | 1 |
| 11 | A comparative study between flattening filter-free beams and flattening filter beams in radiotherapy treatment显示文摘Flattening filter-free(FFF) beams generated by medical linear particle accelerators(linacs) have recently been used in radiotherapy clinical practice.FFF beams have fundamental physical parameter differences with respect to standard flattening filter(FF) beams,such that the generally used dosimetric parameters and definitions are not always viable.This study investigates dosimetric parameters for use in the quality assurance of FFF beams generated by medical linacs in radiotherapy.The main characteristics of the photon beams are analyzed using specific data generated by a Varian True Beam linac having both FFF and FF beams of 6 and 10 MV(megavolt) energy,respectively.Definitions for dose profile parameters are suggested,starting from the renormalization of the FFF with respect to the corresponding FF beam.From this point,the flatness concept is translated into one of 'un-flatness',and other definitions are proposed,maintaining a strict parallelism between FFF and FF parameter concepts.The quality controls used in establishing a quality assurance program when introducing FFF beams into the clinical environment are given,maintaining similarity to those used for standard FF beams,and recommendations for the introduction of FFF beams into clinical radiotherapy application for breast cancer patients are provided as an example for comparison between FFF and FF for dose distribution and coverage for a target volume.Although there are many advantages of using a FFF beam,especially for advanced radiotherapy techniques,there are a few limitations(e.g.,using a relatively higher energy photon beam for stereotactic radiotherapy(SRT),limited speed of current multileaf collimators(MLCs),and off-axis distance-dependent modulation in intensitymodulated radiation therapy(IMRT)) as well as challenges(e.g.,criteria for beam quality evaluation and penumbra,establishment of dosimetry methods,and consequences of photon target burn-up) that need to be addressed for establishing the FFF beam as a viable alternative to the FF beam. | Ali Wagdy Khaled EI Shahat Huda Ashry Amaal El Shershaby Ehab Abdo | 2017 | Oncology and Translational Medicine2017，3，6： | 1 |
| 12 | FENSAP-ICE's ThreeDimensional In-Flight Ice Accretion Module: ICE3D 显示文摘 | Heloise B Francois M Wagdi G H | 2003 | Journal of Aircraft2003，40，2： | 1 |
| 13 | Manifestations of severe vitamin D deficiency in adolescents: effects of in- tramuscular injection of a megadose of cholecalciferol 显示文摘 | Soliman AT Adel A Wagdy M | 2011 | J Trop Pediatr2011，57，： | 1 |
| 14 | Patient radiation dose during percutaneous interventional closure of interatrial communications显示文摘 | Wagdi P Ritter M | 2009 | J Cardiol2009，53，： | 1 |
| 15 | More on Jitter Effects on Sinewave Measurements 显示文摘 | Awad S S Wagdy M F | 1991 | IEEE Trans on Instrumentation and Measurement1991，40，3： | 1 |
| 16 | Effect of Sampling Jitter on Some Sine Wave Measurements显示文摘 | Wagdy M F Awad S S | 1990 | IEEE Trans on I M1990，39，1： | 1 |
| 17 | Characterization of the rabbit gastric epithelial lineage progenitors in short-term culture显示文摘 | S. Karam G. Alexander V. Farook A. Wagdi | 2001 | Cell and Tissue Research2001，，1： | 1 |
| 18 | Effect of additive dither on the reso-lution of ADC ,s with single-bit or mulibit errors 显示文摘 | Wagdy Z Fawzy M | 1996 | IEEE Transactions on Instrumentation and Measurement1996，45，2： | 1 |
| 19 | Effect of additive dither on the resolution of ADC's with single-bit or multibit errors显示文摘 | WAGDY Z FAWZY M | 1996 | IEEE Transactions on Instrumentation and Measurement1996，45，2： | 1 |
| 20 | Eulerian modeling of in-flight ic- ing due to supercooled large droplets 显示文摘 | Raimund H Wagdi G H | 2008 | Journal of Air- craft2008，45，4： | 1 |
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