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| 1 | Circulating inflammatory factors associated with worse long-term prognosis in colorectal cancer显示文摘AIM To investigate association of circulating inflammatory factors at the time of colorectal cancer(CRC) surgery with survival.METHODS Plasma levels from 174 CRC patients(69 females and 105 men), with median age 70 years(range 29-90), localized in the colon(n = 105) or rectum(n = 69), with stage Ⅰ(n = 24), stage Ⅱ(n = 54), stage Ⅲ(n = 67) and stage Ⅳ(n = 29) were measured using commercially available Bio-Plex Pro? Human Chemokine Panel 40-Plex, including 40 different chemokines, cytokines and interleukins. The prognostic association of each inflammatory factor was analysed as CRC-specific and total mortality.RESULTS Out of 174 patients, 66 died during the follow-up, 40 because of CRC specific mortality. High tertile levels of 8 factors were significantly associated with increased CRC-specific mortality, of which CCL1, CCL20, CCL24, CX3CL1, IL-4 and TNF-α remained significant in a multivariate Cox regression analysis. High tertile levels of 14 factors were associated with increased total mortality, of which CCL1, CCL15, CCL20, CX3CL1, CXCL13, IFN-γ, IL-2, IL-4 and IL-10 remained significant after adjustment for clinical covariates. For most of the inflammatory factors the association between higher tertile levels and an increased mortality in general appeared two years after surgery. High tertile levels of TNF-α and CCL24 were exclusively associated with CRC-specific mortality. The distribution of these factors were not associated with TNM stage with exception for CCL20.CONCLUSION High plasma levels of inflammatory factors are associated with increased risk of mortality among CRC patients and could be potential biomarkers for revealing prognosis. | Renate S Olsen Johnny Nijm Roland E Andersson Jan Dimberg Dick Wagsater | 2017 | World Journal of Gastroenterology2017，23，34： | 8 |
| 2 | The chemokine and scavenger receptor XCXL16/SR-PSOX is expressed in human vascular smooth muscle cells and is induced by interferon gamma显示文摘 | Wagsater D Olofsson PS Norgren L | 2004 | Biochem Biophys Res Commun2004，325，4： | 1 |
| 3 | Lipopo- lysaccharlde - induced cytoklne and chemoklne expression in human carotid lesions显示文摘 | Ken Jatta Dick Wagsater Lars Norgren | 2005 | J Vasc Res2005，42，： | 1 |
| 4 | CD137 is expressed in human atherosclerosis and promotes development of plaque inflammation in hypereholesterolemic mice显示文摘 | PS Olofsson LA Soderstrom D Wagsater | 2008 | Circulation2008，117，10： | 1 |
| 5 | Increased expression of leukotriene C4 synthase and predominant formation of cysteinyl-leukotrienes in human abdominal aortic aneurysm显示文摘 | Di Gennaro A Wagsater D Mayranpaa MI | 2010 | Proc Natl Acad Sci USA2010，107，21： | 1 |
| 6 | T-cell activation leads to reduced collagen maturation in atherosclerotic plaques of apoE-/-mice显示文摘 | Ovchinnikova O Robertson A-KL Wagsater D | 2009 | Am J Pathol2009，174，2： | 1 |
| 7 | All -trans retinoic acid regulates CXCL16/SR-PSOX expression显示文摘 | Wagsater D Sheikine Y Sirsjo A | 2005 | Int J Mol Med2005，16，4： | 1 |
| 8 | Analysis of MICA gene transcripts in human rectal cancers显示文摘 | Dimberg J Hugander A | 2003 | Anticancer Research2003，23，3： | 1 |
| 9 | et al Decreased expression of the chemokine CCL21 in human colorectal adenocarcinomas显示文摘 | MUMTAZ M WAGSATER D LOFGREN S | 2009 | Oncol Rep2009，21，1： | 1 |
| 10 | CD137 is expressed in human atherosclerosis and promotes develop- ment of plaque inflammation in hypercholesterolemic mice 显示文摘 | Olofsson PS Soderstrom LA Wagsater D | 2008 | Circulation2008，117，10： | 1 |
| 11 | Expression of chemokin6 receptor CXCR6 in human colorectal adenocarcinomas显示文摘 | Wagsater D Dimberg J | 2004 | Anti- cancer Res2004，24，6： | 1 |
| 12 | MMP-2 and MMP -9 are prominent matrix metalloproteinases during atherosclerosis develop- ment in the Ldlr(-/-)Apob(100/100) mouse显示文摘 | Wagsater D Zhu C Bjfirkegren J | 2011 | Int J Mot Med2011，28，2： | 1 |
| 13 | Unrav-eling divergent gene expression profiles in bicuspid and tri-cuspid aortic valve patients with thoracic aortic dilatation : theASAP study 显示文摘 | FOLKERSEN L WAGSATER D PALOSCHI V | 2011 | Mol Med2011，17，1112： | 1 |
| 14 | Effects of PDGF-C and PDGF-D on monocyte migration and MMP-2 and MMP-9 expression显示文摘 | Wagsater D Zhu C Bjorck HM | 2009 | Atherosclerosis2009，202，2： | 1 |
| 15 | The chemokine and scavenger receptor CXCL16/SR-PSOX is expressed in human vascular smooth muscle cells and is induced by 1NF gamma 显示文摘 | Wagsater D Olofsson PS Norgren L | 2004 | Biochem Biophys Res Commun2004，325，4： | 1 |
| 16 | The chemokine and scavenger receptor CXCL16/SR-PSOX is expressed in human vascular smooth muscle cells and is induced by interferon gamma 显示文摘 | Wagsater D Olofsson PS Norgren L | 2004 | Biochem Biophys Res Commun2004，325，： | 1 |
| 17 | Serine protease inhibitor A3 in atherosclerosis and aneurysm disease显示文摘 | Wagsater D Johansson D Fontaine V | | 0，，02： | 1 |
| 18 | ADAMTS-4 and-8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques显示文摘 | Wagsater D Bjork H Zhu C | 2008 | Atherosclerosis2008，196，： | 1 |
| 19 | Expression of interleukin- 17 in human colorectal cancer 显示文摘 | Wagsater D Lofgren S Hugander A | 2006 | Anticancer Res2006，26，6： | 1 |
| 20 | The chemokine and scavenger receptor CXCL16/SR-PSOX is expressed in human vascular smooth muscle cells and is induced by interferon gam- ma 显示文摘 | Wagsater D Olofsson PS Norgren L | 2004 | Biochem Biophys Res Commun2004，325，4： | 1 |
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