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| 1 | Fat poetry:a kingdom for PPARγ显示文摘Adipose tissue is not an inert cell mass contributing only to the storage of fat, but a sophisticated ensemble of cel-lular components with highly specialized and complex functions. In addition to managing the most important energyreserve of the body, it secretes a multitude of soluble proteins called adipokines, which have beneficial or, alternatively,deleterious effects on the homeostasis of the whole body. The expression of these adipokines is an integrated responseto various signals received from many organs, which depends heavily on the integrity and physiological status of theadipose tissue. One of the main regulators of gene expression in fat is the transcription factor peroxisome proliferator-activated receptor γ (PPAR_γ), which is a fatty acid- and eicosanoid-dependent nuclear receptor that plays key roles inthe development and maintenance of the adipose tissue. Furthermore, synthetic PPAR_γ agonists are therapeutic agentsused in the treatment of type 2 diabetes. This review discusses recent knowledge on the link between fat physiology and metabolic diseases, and the roles ofPPAR_γ in this interplay via the regulation of lipid and glucose metabolism. Finally, we assess the putative benefits oftargeting this nuclear receptor with still-to-be-identified highly selective PPAR_γ modulators. | Silvia I Anghel Walter Wahli | 2007 | Cell Research2007，17，6： | 9 |
| 2 | Roles of PPARs in health and disease显示文摘 | Kersten S Desvergne B Wahli W | | 0，，： | 2 |
| 3 | Peroxisome-proliferatoractivated receptors and cancers: complex stories显示文摘 | Michalik L Desvergne B Wahli W | 2004 | Nat Rev Cancer2004，4，： | 2 |
| 4 | Transcriptional regulation of metabolism 显示文摘 | DESVERGNE B MICHALIK L WAHLI W | 2006 | Physiol Rev2006，86，2： | 1 |
| 5 | Peroxisome proliferator-activated receptor and cancers:complex stories显示文摘 | Michalil L Desvergne B Wahli W | | 0，，： | 1 |
| 6 | Peroxisome proliferator-activated receptors:Nuclear control of metabolism显示文摘 | B WAHLI W | 1999 | Endocrine Reviews1999，20，： | 1 |
| 7 | Roles of PPARs in health and disease 显示文摘 | Kersten S Desvergne B A Wahli W | 2000 | Nature2000，405，： | 1 |
| 8 | PPARs : transcriptional ef- fectors of fatty acids and their derivatives 显示文摘 | Hihi A K Michalik L Wahli W | 2002 | CMLS2002，59，5： | 1 |
| 9 | Peroxisome proliferator-activated receptors:nuclear control of metabolism显示文摘 | Desvergne B Wahli W | 1999 | Endocr Rev1999，20，5： | 1 |
| 10 | Roles of PPARs in health and disease显示文摘 | Kersten S Desvergne B Wahli W | 2000 | Nature2000，405，6785： | 1 |
| 11 | Peroxisome proliferator-activated receptors:insight into multiple cellular functions显示文摘 | P WAHLI W | 2000 | Mutat Res2000，448，： | 1 |
| 12 | Involvement of PPAR nuclear receptors in tissue injury and wound repair显示文摘 | Michalik L Wahli W | 2006 | J Clini Invest2006，116，3： | 1 |
| 13 | Peroxisome proliferator-activated receptors: a nuclear receptor signaling pathway in lipid physiology显示文摘 | Lemberger T Desvergne B Wahli W | 1996 | Annu Rev Cell Dev Biol1996，12，： | 1 |
| 14 | Peroxisome proliferator-activated receptors: nuclear control of metabolism显示文摘 | Desvergne B Wahli W | 1999 | Endocrine Review1999，20，5： | 1 |
| 15 | A simplified in situ hybridization protocol using non-radioactively labeled probes to detect abundant and rare mRNAs on tissue sections显示文摘 | Braissant O Wahli W | 1998 | Biochemica1998，，1： | 1 |
| 16 | Peroxisome proliferator-activated receptors:nuclear control of metabolism显示文摘 | DESVERGNE B WAHLI W | 1999 | Endocr Rev1999，20，： | 1 |
| 17 | Roles of PPARs in health and disease显示文摘 | Kersten S Desvergne B Wahli W | 2000 | J Nature2000，405，： | 1 |
| 18 | Roles of PPARs in health and disease显示文摘 | Kersten S Devergne B Wahli W | 2000 | Nature2000，405，6785： | 1 |
| 19 | Peroxisome proliferatoractivated receptors:nuclear control of metabolism显示文摘 | DESVERGNE B WAHLI W | 1999 | Endocr Rev1999，20，5： | 1 |
| 20 | Peroxisone proliferator - activated receptors and cancers : complex stories 显示文摘 | Michalic L Desvergne B Wahli W | 2004 | Nat Rev Cancer2004，4，1： | 1 |
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