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| 1 | Biliary acute pancreatitis:a review显示文摘INTRODUCTIONIt is axiomatic that the most effective and soundlybased plan of treatment of any disorder is one aimedat the mechanism or mechanisms responsible for itsdevelopment.This basic notion,coupled withrecent reports in which,surprisingly there is atotal lack of reference to the probable involvementof autonomic-arc-reflexes in the | Osvaldo M.Tiscomia Susana Hamamura Enriqueta S.deLehmann Graciela Otero Hipolito Waisman Patricia Tiscornia-Wasserman Simmy Bank | 2000 | World Journal of Gastroenterology2000，6，2： | 6 |
| 2 | 肠道菌群促进血管紧张素Ⅱ诱导的高血压和血管功能障碍显示文摘肠道微生物对宿主生理反应及对免疫功能的发展来说必不可少。肠道菌群对血压和全身血管功能等这些由免疫细胞功能决定的生理过程的影响知之甚少。方法:与常规饲养的小鼠(conventionally raised rats,CONV-R)比较,未受任何细菌影响的无菌小鼠(GF)表现出较为严重的全身性辅助性T细胞1型滞后。 | 刘莉 叶鹏 Karbach SH Schnfelder T Brandao I Wilms E Hrmann N Jckel S Schüler R Finger S Knorr M Lagrange J Brandt M Waisman A Kossmann S Schüfer K Münzel T Reinhardt C Wenzel P | 2016 | 中华高血压杂志2016，24，10： | 5 |
| 3 | CYLD deletion triggers nuclear factor-κB-signaling and increases cell death resistance in murine hepatocytes显示文摘AIM:To analyze the role of CYLD for receptor-mediated cell death of murine hepatocytes in acute liver injury models.METHODS:Hepatocyte cell death in CYLD knockout mice(CYLD-/-)was analyzed by application of liver injury models for CD95-(Jo2)and tumor necrosis factor(TNF)-α-[D-Gal N/lipopolysaccharide(LPS)]induced apoptosis.Liver injury was assessed by measurement of serum transaminases and histological analysis.Apoptosis induction was quantified by cleaved PARP staining and Western blotting of activated caspases.Nuclear factor(NF)-κB,ERK,Akt and jun amino-terminal kinases signaling were assessed.Primary Hepatocytes were isolated by two step-collagenase perfusion and treated with recombinant TNF-αand with the CD95-ligand Jo2.Cell viability was analyzed by MTT-assay.RESULTS:Livers of CYLD-/-mice showed increased anti-apoptotic NF-κB signaling.In both applied liver injury models CYLD-/-mice showed a significantly reduced apoptosis sensitivity.After D-Gal N/LPS treatment CYLD-/-mice exhibited significantly lower levels of alanine aminotransferase(ALT)(295 U/L vs 859 U/L,P<0.05)and aspartate aminotransferase(AST)(560 U/L vs 1025 U/L,P<0.01).After Jo injection CYLD-/-mice showed 2-fold lower ALT(50 U/L vs 110 U/L,P<0.01)and lower AST(250 U/L vs 435 U/L,P<0.01)serumlevels compared to WT mice.In addition,isolated CYLD-/-primary murine hepatocytes(PMH)were less sensitive towards death receptor-mediated apoptosis and showed increased levels of Bcl-2,XIAP,c IAP1/2,survivin and c-FLIP expression upon TNF-and CD95-receptor triggering,respectively.Inhibition of NF-κB activation by the inhibitor of NF-κB phosphorylation inhibitor BAY 11-7085 inhibited the expression of antiapoptotic proteins and re-sensitized CYLD-/-PMH towards TNF-and CD95-receptor mediated cell death.CONCLUSION:CYLD is a central regulator of apoptotic cell death in murine hepatocytes by controlling NF-κB dependent anti-apoptotic signaling. | Toni Urbanik Bruno Christian Koehler Laura Wolpert Christin Elbner Anna-Lena Scherr Thomas Longerich Nicole Kautz Stefan Welte Nadine Hovelmeyer Dirk Jager Ari Waisman Henning Schulze-Bergkamen | 2014 | World Journal of Gastroenterology2014，20，45： | 3 |
| 4 | Mammotome core biosy for mammary microcalcification: analysis of 160 biopsies from 142 women with surgical and radiologic follow up显示文摘 | Cangiarella J Waisman J Symmans WF | 2001 | Cancer2001，91，1： | 1 |
| 5 | Can firms learn by observing? Evidence from cross-border M&As 显示文摘 | Francis B B Hasan I Sun X Waisman M | 2014 | Journal of Corporate Finance2014，25，： | 1 |
| 6 | Chemotherapy-induced activation of hemostasis : effect of a low molecular weight heparin ( daheparin sodium) on plasma markers of hemostatic activation显示文摘 | Weitz LC Israel VK Waisman JR | 2002 | Thromb Haemost2002，88，2： | 1 |
| 7 | Tissue selec tive action of tamoxifen methiodide,raloxifene and tamoxifen on creatine kinas e B activity in vitro and in vivo显示文摘 | Waisman A Kaye AM | 1996 | J Steroid Biochem Mol Biol1996，59，56： | 1 |
| 8 | Cost-effectiveness of a hypertension management programme in an elderly population: a Markov model显示文摘 | Perman G Rossi E Waisman GD | 2011 | Cost Elf Resour Anoc2011，9，1： | 1 |
| 9 | Postoperative cerebrospinal fluid leakage after lumbar spine operations conservative treatment 显示文摘 | Waisman M Schweppe Y | 1991 | Spine1991，16，1： | 1 |
| 10 | Characteristics and scaling of tungsten-wire array Z pinch implosion dynamics at 20 MA显示文摘 | Cuneo M E Waisman E M Lebedev S V | 2005 | Physical Review E2005，71，04： | 1 |
| 11 | Postoperative cerebrospinal fluid leakage after lumbar spine operations: conservation treatment 显示文摘 | Waisman M Sehweppe Y | 1991 | Spine1991，16，1： | 1 |
| 12 | Annexin Ⅱ tetramer:structure and function显示文摘 | Waisman D M | | 0，，1： | 1 |
| 13 | Th17 cells regulate liver fibrosis by tar- geting multiple cell types: many birds with one stone 显示文摘 | Gao B Waisman A | 2012 | Gastroenterology2012，143，3： | 1 |
| 14 | Giant adrenal myelolipoma and testicular inter- stitial cell tumor in a man with congenital 21 - hydroxylase deficiency 显示文摘 | Boudreaux D Waisman J Skinner DG | 1979 | Am J Surg Pathol1979，3，2： | 1 |
| 15 | The C terminus of annexin Ⅱ mediates binding to F-actin 显示文摘 | Filipenko NR Waisman DM | 2001 | J Biol Chem2001，276，7： | 1 |
| 16 | B7-H1 and CD8(+)Treg:The e-nigmatic role of B7-H1 in peripheral tolerance显示文摘 | Waisman A Yogev N | 2009 | Euro-pean Journal of Immunology2009，39，6： | 1 |
| 17 | Autoantibodies to the centrosome (cen-triole) react with determinants present in the glycolytic enzyme enolase 显示文摘 | Rattner JB Martin L Waisman DM | 1991 | J Immunol1991，146，7： | 1 |
| 18 | A model for ablated-plasma distribution and width for wire-array Z-pinch implosions显示文摘 | Waisman E M Cuneo M E Stygar W A | 2006 | Phys Plasmas2006，13，06： | 1 |
| 19 | Expcrimental hyperuricemic nephropathy:A model for human urate deposition disease显示文摘 | Bluestone R Brady S Waisman J | 1975 | Arthritis Rheum1975，，： | 1 |
| 20 | Characteristics and scaling of tungsten-wire-array Z-pinch implosion dynamics at 20 MA 显示文摘 | Cuneo M E Waisman E M Lebedev S V | 2005 | Physical Review E2005，71，04： | 1 |
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