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| 1 | Protocol liver biopsy is the only examination that can detect mid-term graft fibrosis after pediatric liver transplantation显示文摘AIM:To assessed the clinical significance of protocol liver biopsy(PLB)in pediatric liver transplantation(LT).METHODS:Between July 2008 and August 2012,89and 55 PLBs were performed in pediatric patients at two and five years after LT,respectively.We assessed the histopathological findings using the Metavir scoring system,including activity(A)and fibrosis(F),and we identified factors associated with scores of≥A1 and≥F1.Our results clarified the timing and effectiveness of PLB.RESULTS:The incidences of scores of≥A1 and≥F1 were 24.7%and 24.7%,respectively,at two years after LT and 42.3%and 34.5%,respectively,at five years.Independent risk factors in a multivariate analysis of a score of≥A1 at two years included≥2 h ofcold ischemic time,no acute cellular rejection and an alanine amino transaminase(ALT)level of≥20 IU/L(P=0.028,P=0.033 and P=0.012,respectively);however,no risk factors were identified for a score of≥F1.Furthermore,no independent risk factors associated with scores of≥A1 and≥F1 at five years were identified using multivariate analysis.A ROC curve analysis of ALT at two years for a score of≥A1 demonstrated the recommended cutoff value for diagnosing≥A1 histology to be 20 IU/L.The incidence of scores of≥A2 or≥F2 at two years after LT was 3.4%(three cases),and all patients had an absolute score of≥A2.In contrast to that observed for PLBs at five years after LT,the incidence of scores of≥A2 or≥F2 was 20.0%(11 cases),and all patients had an absolute score of≥F2.In all cases,the dose of immunosuppressants was increased after the PLB,and all ten patients who underwent a follow-up liver biopsy improved to scores of≤A1 or F1.CONCLUSION:PLB at two years after LT is an unnecessary examination,because the serum ALT level reflects portal inflammation.In addition,immunosuppressive therapy should be modulated to maintain the ALT concentration at a level less than 20 IU/L.PLB at five years is an excellent examination for the detection of early reversible graft fibrosis because no serum markers reflect this finding. | Yukihiro Sanada Koshi Matsumoto Taizen Urahashi Yoshiyuki Ihara Taiichi Wakiya Noriki Okada Naoya Yamada Yuta Hirata Koichi Mizuta | 2014 | World Journal of Gastroenterology2014，20，21： | 5 |
| 2 | Improved electric properties of (Pb,La)TiO3 thin films using compositionally and structurally compatible LaNiO3 thin films as bottom electrodes显示文摘 | BAO D WAKIYA N SHINORAKI K | 2001 | Appl Phys Lett2001，78，21： | 1 |
| 3 | Synthesis and Dielectric Properties of Ba1-xR2x/3Nb2O6 (R: Rare Earth) with Tetragonal Tungsten Bronze Structure显示文摘 | Wakiya N Wang JK Saiki A | 1999 | Journal of the European Ceramic Society1999，19，67： | 1 |
| 4 | Oxygen sensitivity of perovskite-type dielectric thin films 显示文摘 | Toru Hara Takashi Ishiguro Naoki Wakiya | 2009 | Mater Sci Eng B2009，161，3： | 1 |
| 5 | HRTEM Investigation of the 90° Domain Structure and Ferroelectric Properties of Multi-layered PZT Thin Films显示文摘 | Naoki Wakiya Kazuo Shinozaki | 2003 | Microelectronic Engineering2003，66，4： | 1 |
| 6 | Affinity-matured anti-glycoprotein NMB recombinant immunotoxins targeting malignant gliomas and melanomas显示文摘 | Kuan CT Wakiya K Keir ST | 2011 | Int J Cancer2011，129，1： | 1 |
| 7 | Im- proved electrical properties of( Pb, La)TiO thin films u- sing compositionally and structurally compatible LaNiO3 thin films as bottom electrodes 显示文摘 | BAO D H WAKIYA N SHINOZAKI K | 2001 | Appl Phys Lett2001，78，： | 1 |
| 8 | Effects of outside air temperature on the preparation of antineoplastic drug solutions in biological safety cabinets显示文摘 | Masayuki Umemura Akio Itoh Yuichi Ando Kiyofumi Yamada Yoshifumi Wakiya Toshitaka Nabeshima | 2015 | Journal of Oncology Pharmacy Practice2015，，： | 1 |
| 9 | Study for the Increase of Micro Regenerative Pump Head显示文摘 | Hironori Horiguchi Keisuke Wakiya Yoshinobu Tsujimoto | 2009 | International Journal of Fluid Machinery and Sys- terms2009，，3： | 1 |
| 10 | Structural, dielectric, and ferroelectric properties of PbTiO3 thin films by a simple sol -gel technique 显示文摘 | Bao D H Yao X Wakiya N | 2002 | Mater Sci Engin B2002，94，： | 1 |
| 11 | HRTEM investigation of the 90° domain structure and ferroelectric properties of multi-layered PZT thin films 显示文摘 | Kiguchi T Wakiya N Shinozaki K | 2003 | Microelectron Eng2003，66，： | 1 |
| 12 | A Comparison of Open Surgery and Endovascular Intervention for Hepatic Artery Complications After Pediatric Liver Transplantation显示文摘 | T. Wakiya Y. Sanada K. Mizuta T. Urahashi Y. Ihara N. Yamada N. Okada S. Egami M. Nakata K. Hakamada Y. Yasuda | 2013 | Transplantation Proceedings2013，，1： | 1 |
| 13 | Band-gap Energies of Sol-gel-derived Sr Ti O3Thin Films显示文摘 | Bao D Yao X Wakiya N | 2001 | Applied Physics Letters2001，79，23： | 1 |
| 14 | Synthesis and dielectric properties of Ba1-xR2x/3 Nb2O6 (R: rare earth)with tetragonal tungsten bronze structure显示文摘 | WAKIYA N WANG J K SAIKI A | 1999 | J Europ Ceram Soc1999，19，： | 1 |
| 15 | Glycoprotein non- metastatic melanoma protein B, a potential molecular thera- peutic target in patients with glioblastoma multiforme 显示文摘 | Kuan CT Wakiya K Dowel1 JM | 2006 | Clin Cancer Res2006，12，71： | 1 |
| 16 | Thermal-stability of Pb(Zn1/3 Nb2/3 )O3 (PZN) and consideration of stabilization conditions of perovskite-type compounds显示文摘 | Wakiya N Ishizawa N Shinozaki K | 1995 | Materials Research Bulletin1995，30，9： | 1 |
| 17 | MRP3: A molecular target for human glioblastoma muhiforme immunotherapy显示文摘 | Kuan C T Wakiya K Herndon J E 2nd | 2010 | BMC Cancer2010，10，1： | 1 |
| 18 | Hepatic artery reconstruc- tion with the jejunal artery of the Roux-en-Y limb in pediatric living donor liver retransplantation 显示文摘 | Wakiya T Sanada Y Mizuta K | 2012 | Pediatr Transplant2012，16，3： | 1 |
| 19 | Band-Gap Energies of Sol-Gel-Derived SrTiO3 Thin Films 显示文摘 | Bao D H Yao X Wakiya N | 2001 | Appl Phys Lett2001，79，： | 1 |
| 20 | Phase diagram andmicrostructure in the ZnO-Pr2O3 system显示文摘 | CHUN S Y WAKIYA N FUNAKUBO H | 1997 | J Am Ceram Soc1997，80，4： | 1 |
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