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| 1 | Identification and characterization of genes that control fat deposition in chickens显示文摘Background: Fat deposits in chickens contribute significantly to meat quality attributes such as juiciness, flavor,taste and other organoleptic properties. The quantity of fat deposited increases faster and earlier in the fastgrowing chickens than in slow-growing chickens. In this study, Affymetrix Genechip? Chicken Genome Arrays 32773transcripts were used to compare gene expression profiles in liver and hypothalamus tissues of fast-growing and slow-growing chicken at 8 wk of age. Real-time RT-PCR was used to validate the differential expression of genes selected from the microarray analysis. The mRNA expression of the genes was further examined in fat tissues. The association of single nucleotide polymorphisms of four lipid-related genes with fat traits was examined in a F2resource population.Results: Four hundred genes in the liver tissues and 220 genes hypothalamus tissues, respectively, were identified to be differentially expressed in fast-growing chickens and slow-growing chickens. Expression levels of genes for lipid metabolism(SULT1B1, ACSBG2, PNPLA3, LPL, AOAH) carbohydrate metabolism(MGAT4B, XYLB, GBE1, PGM1,HKDC1)cholesttrol biosynthesis(FDPS, LSS, HMGCR, NSDHL, DHCR24, IDI1, ME1) HSD17B7 and other reaction or processes(CYP1A4, CYP1A1, AKR1B1, CYP4V2, DDO) were higher in the fast-growing White Recessive Rock chickens than in the slow-growing Xinghua chickens. On the other hand, expression levels of genes associated with multicellular organism development, immune response, DNA integration, melanin biosynthetic process, muscle organ development and oxidation-reduction(FRZB, DMD, FUT8, CYP2C45, DHRSX, and CYP2C18) and with glycol-metabolism(GCNT2, ELOVL 6, and FASN), were higher in the XH chickens than in the fast-growing chickens. RT-PCR validated high expression levels of nine out of 12 genes in fat tissues. The G1257069A and T1247123C of the ACSBG2 gene were significantly associated with abdominal fat weight. The G4928024A of the FASN gene were significantly associated with fat bandwidth, and abdominal fat percentage. The C4930169T of the FASN gene was associated with abdominal fat weight while the A59539099G of the ELOVL 6 was significantly associated with subcutaneous fat. The A8378815G of the DDT was associated with fat band width.Conclusion: The differences in fat deposition were reflected with differential gene expressions in fast and slow growing chickens. | Hirwa Claire D'Andre Wallace Paul Xu Shen Xinzheng Jia Rong Zhang Liang Sun Xiquan Zhang | 2014 | Journal of Animal Science and Biotechnology2014，5，1： | 7 |
| 2 | Artificial intelligence in gastroenterology: A state-of-the-art review显示文摘The development of artificial intelligence(AI)has increased dramatically in the last 20 years,with clinical applications progressively being explored for most of the medical specialties.The field of gastroenterology and hepatology,substantially reliant on vast amounts of imaging studies,is not an exception.The clinical applications of AI systems in this field include the identification of premalignant or malignant lesions(e.g.,identification of dysplasia or esophageal adenocarcinoma in Barrett’s esophagus,pancreatic malignancies),detection of lesions(e.g.,polyp identification and classification,small-bowel bleeding lesion on capsule endoscopy,pancreatic cystic lesions),development of objective scoring systems for risk stratification,predicting disease prognosis or treatment response[e.g.,determining survival in patients post-resection of hepatocellular carcinoma),determining which patients with inflammatory bowel disease(IBD)will benefit from biologic therapy],or evaluation of metrics such as bowel preparation score or quality of endoscopic examination.The objective of this comprehensive review is to analyze the available AI-related studies pertaining to the entirety of the gastrointestinal tract,including the upper,middle and lower tracts;IBD;the hepatobiliary system;and the pancreas,discussing the findings and clinical applications,as well as outlining the current limitations and future directions in this field. | Paul T Kröner Megan ML Engels Benjamin S Glicksberg Kipp W Johnson Obaie Mzaik Jeanin E van Hooft Michael B Wallace Hashem B El-Serag Chayakrit Krittanawong | 2021 | World Journal of Gastroenterology2021，27，40： | 6 |
| 3 | Complications associated with the Nuss procedure: continued evolution of the learning curve显示文摘 | Ravindra K. Vegunta Paul E. Pacheco Lizabeth J. Wallace Richard H. Pearl | 2008 | The American Journal of Surgery2008，，3： | 2 |
| 4 | An analysis of multiple staging management strategies for carcinoma of the esophagus: computed tomography, endoscopic ultrasound, positron emission tomography, and thoracoscopy/laparoscopy显示文摘 | Michael B Wallace Paul J Nietert Craig Earle Mark J Krasna Robert H Hawes Brenda J Hoffman Carolyn E Reed | 2002 | The Annals of Thoracic Surgery2002，，4： | 2 |
| 5 | The repertoire of nonverbal behavior: categories, origins, usage, and coding 显示文摘 | Ekman Paul Friesen Wallace V | 1969 | Semiotica1969，，1： | 1 |
| 6 | The Repertoire of Nonverbal Behavior: Categories, Origins, Usage, and Coding显示文摘 | PAUL EKMAN WALLACE V. FRIESEN | 2009 | Semiotica2009，，1： | 1 |
| 7 | Tighten- ing environmental standards:the benefit-cost or the no-cost paradigm 显示文摘 | Karen Palmer Wallace E Oates Paul R Portney | 1995 | Journal of Economic Perspectives1995，9，4： | 1 |
| 8 | Glutamate receptors and circuits in the vertebrate retina显示文摘 | Wallace B. Thoreson Paul Witkovsky | 1999 | Progress in Retinal and Eye Research1999，，6： | 1 |
| 9 | Impact of conditioning regimen on peripheral blood hematopoietic cell transplant显示文摘AIM To investigate infused hematopoietic cell doses and their interaction with conditioning regimen intensity +/-total body irradiation(TBI) on outcomes after peripheral blood hematopoietic cell transplant(PBHCT).METHODS Our retrospective cohort included 247 patients receiving a first, T-replete, human leukocyte antigen-matched allogeneic PBHCT and treated between 2001 and2012. Correlations were calculated using the Pearson product-moment correlation coefficient. Overall survival and progression free survival curves were generated using the Kaplan-Meier method and compared using the log-rank test.RESULTS Neutrophil engraftment was significantly faster after reduced intensity TBI based conditioning [reduced intensity conditioning(RIC) + TBI] and > 4 × 10~6 CD34+cells/kg infused. A higher total nucleated cell dose led to a higher incidence of grade II-IV acute graft-versus-host disease in the myeloablative + TBI regimen group(P = 0.03), but no significant difference in grade III-IV graft-versus-host disease. A higher total nucleated cell dose was also associated with increased incidence of moderate/severe chronic graft-versus-host disease, regardless ofconditioning regimen. Overall and progression-free survival were significantly better in patients with a RIC + TBI regimen and total nucleated cell dose > 8 ×10~8/kg(3 years, overall survival: 70% vs 38%, P = 0.02, 3 years, progression free survival: 64% vs 38%, P = 0.02).CONCLUSION TBI and conditioning intensity may alter the relationship between infused cell doses and outcomes after PBHCT. Immune cell subsets may predict improved survival after unmanipulated PBHCT. | Michael Burns Anurag K Singh Carrie C Hoefer Yali Zhang Paul K Wallace George L Chen Alexis Platek Timothy B Winslow Austin J Iovoli Christopher Choi Maureen Ross Philip L McCarthy Theresa Hahn | 2019 | World Journal of Clinical Oncology2019，10，2： | 1 |
| 10 | Evaluation of the hydrogen -fueled rotary engine for hybrid vehicle applications显示文摘 | Paul A Salanki James S Wallace | | SAE Paper0，，： | 1 |
| 11 | The repertoire of nonverbal behavior:categories,origins,usage,and coding显示文摘 | Paul Friesen Wallace V | 1969 | Semiotica1969，，1： | 1 |
| 12 | Change the referent? A meta-analytic investigation of direct and referent-shift consensus models for organizational elimate显示文摘 | Wallace J C Edwards B D Paul J | 2016 | Journal of Management2016，42，4： | 1 |
| 13 | Electroless recovery of silver by inherently conducting polymer powders,membranes and composite materials显示文摘 | Roza Dimeska Paul S Murray Stephen F Ralph Gordon G Wallace | 2006 | Polymer2006，47，13： | 1 |
| 14 | Reproducibility and changes in the apparent diffusion coefficients of solid tumours treated with combretastatin A4 phosphate and bevacizumab in a two-centre phase I clinical trial显示文摘 | Dow-Mu Koh Matthew Blackledge David J. Collins Anwar R. Padhani Toni Wallace Benjamin Wilton N. Jane Taylor J. James Stirling Rajesh Sinha Pat Walicke Martin O. Leach Ian Judson Paul Nathan | 2009 | European Radiology2009，，： | 1 |
| 15 | Tightening Environmental Standards:The Benefit-Cost or the no-cost Paradigm?显示文摘 | Karen Palmer Wallace E Oates Paul R Pottney | 1995 | Journal of Economic Perspectives1995，9，4： | 1 |
| 16 | Volatiles in subduction zone magmas:concentrations and fluxes based on melt inclusion and volcanic gas data显示文摘 | Paul J Wallace | 2005 | Journal of Volcanology and Geothermal Research2005，140，： | 1 |
| 17 | Needle-based confocal endomicroscopy for in vivo histology of intra-abdominal organs: first results in a porcine model (with videos )显示文摘 | Valentin Becker Michael B. Wallace Paul Fockens Stefan von Delius Timothy A. Woodward Massimo Raimondo Rogier P. Voermans Alexander Meining | 2010 | Gastrointestinal Endoscopy2010，，7： | 1 |
| 18 | Tightening environmental standards:The benefit-cost or the no-cost paradigm?显示文摘 | Karen P Wallace E O Paul R P | 1995 | The Journal of Economic Perspectives1995，9，4： | 1 |
| 19 | A computer model of entrained coal gasifica-tion显示文摘 | PETER Ruprecht WOLFGANG Schafer PAUL Wallace | 1988 | Fuel1988，67，6： | 1 |
| 20 | Structural andpsychological empowerment climates, performance, and themoderating role of shared felt accountability: A managerialperspective显示文摘 | Wallace J C Johnson P D Mathe K Paul J | 2011 | Journal of Applied Psychology2011，96，4： | 1 |
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