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| 1 | Paediatric cholestatic liver disease:Diagnosis,assessment of disease progression and mechanisms of fibrogenesis显示文摘Cholestatic liver disease causes significant morbidity and mortality in children.The diagnosis and management of these diseases can be complicated by an inability to detect early stages of fibrosis and a lack of adequate interventional therapy.There is no single gold standard test that accurately reflects the presence of liver disease,or that can be used to monitor fibrosis progression,particularly in conditions such as cystic fibrosis.This has lead to controversy over how suspected liver disease in children is detected and diagnosed.This review discusses the challenges in using commonly available methods to diagnose hepatic fibrosis and monitor disease progression in children with cholestatic liver disease.In addition,the review examines the mechanisms hypothesised to be involved in the development of hepatic fibrogenesis in paediatric cholestatic liver injury which may ultimately aid in identifying new modalities to assist in both disease detection and therapeutic intervention. | Tamara N Pereira Meagan J Walsh Peter J Lewindon Grant A Ramm | 2010 | World Journal of Gastrointestinal Pathophysiology2010，1，2： | 7 |
| 2 | 巨噬细胞、细胞因子和脓毒症显示文摘巨噬细胞激活以及巨噬细胞因子白介素1(IL-1)、白介素6(IL-6)和肿瘤坏死因子(TNF)分泌的增加与脓毒症的发生发展有着密切的联系。采用这些细胞因子的桔抗物(如TNF单抗、消炎痛等)以及用小剂量内毒素诱导内毒素耐受性均能降低巨噬细胞因子分泌反应并提高脓毒症动物的生存率。本文对有关进展作综合介绍。 | Walsh CJ León P O'Riordain MG Ayala A 密磊 | 1993 | 国外医学(创伤与外科基本问题分册)1993，14，1： | 3 |
| 3 | Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study显示文摘 | Julia Granerod Helen E Ambrose Nicholas WS Davies Jonathan P Clewley Amanda L Walsh Dilys Morgan Richard Cunningham Mark Zuckerman Ken J Mutton Tom Solomon Katherine N Ward Michael PT Lunn Sarosh R Irani Angela Vincent David WG Brown Natasha S Crowcroft | 2010 | The Lancet Infectious Diseases2010，，12： | 2 |
| 4 | Periodontal probing depth and subgingival temperature in smokers and non-smokers显示文摘 | Trikilis N Rawlinson A Walsh TF | 1999 | J Clin Periodontol1999，26，1： | 2 |
| 5 | Three distinct modes in a cold atmospheric pressure plasma jet显示文摘 | Walsh J L Iza F Janson N B | 2010 | Journal of Physics D: Applied Physics2010，43，7： | 1 |
| 6 | The simultaneous determination of the major,minor and trace constituents of sihiate rocks using inductively conpled plasma spectrometry显示文摘 | Walsh J N | 1980 | Spectrachimica1980，，35： | 1 |
| 7 | New insights in the second generation antihistamines显示文摘 | WALSH GM AMMUMZIATO L FROSSARD N | 2001 | Drugs2001，61，2： | 1 |
| 8 | Can maximal cardiopul- monary capacity be recognized by a plateau in oxygen up- take?显示文摘 | Myers J Walsh D Buchanan N | 1989 | Chest1989，96，： | 1 |
| 9 | Mycophenolate mofetil or intravenous cyclophosphamide for lupus nephritis with poor kidney function:a subgroup analysis of the Aspreva Lupus Management Study显示文摘 | Walsh M Solomons N Lisk L | | 0，，05： | 1 |
| 10 | The effect of hydrothermal conditions on the mesoporous structure of TiO2nanotubes显示文摘 | Bavykin D V Parmon V N Lapkin A A Walsh F C | | 0，，22： | 1 |
| 11 | Cardioprotection by adiponectin显示文摘 | Ouchi N Shibata R Walsh K | | 0，，05： | 1 |
| 12 | The influence of the geo-logical setting on the morphogenetic evolution of the TremitiArchipelago (Apulia, Southeastern Italy) 显示文摘 | Andriani G F Walsh N Pagliarulo R | 2005 | Natural Hazardsand Earth System Science2005，5，1： | 1 |
| 13 | Membrane transport proteins in human melanoma: associations withturnout aggressiveness and metastasis显示文摘 | Walsh N Kennedy S Larkin AM | | Br J Cancer0，102，： | 1 |
| 14 | Axially coordinated porphyrins as new rotaxane stoppers显示文摘 | Chichak K Walsh M C Branda N R | 2000 | Chem Commu2000，，： | 1 |
| 15 | Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study 显示文摘 | Kumarasamy KK Toleman MA Walsh TR Bagaria J Butt F Balakrishnan R Chaudhary U Doumith M Giske CG Irfan S Krishnan P Kumar AV Maharjan S Mushtaq S Noorie T Paterson DL Pearson A Perry C Pike R Rao B Ray U Sarma JB Sharma M Sheridan E Thirunarayan MA Turton J Upadhyay S Warner M Welfare W Livermore DM Woodford N | 2010 | Lancet Infect Dis2010，10，9： | 1 |
| 16 | Catalytic mapping of the vibriobactin biosynthetic enzyme VibF显示文摘 | Marshall CG Hillson N J Walsh CT | 2002 | Biochemistry2002，41，1： | 1 |
| 17 | Efficient photodiodes from interpenetrating polymer networks显示文摘 | Halls J J M Walsh C A Greenham N C | 1995 | Nature1995，376，6540： | 1 |
| 18 | Gas enhancement techniques in landfill simulators显示文摘 | Kinman R N Nutini D L Walsh J J | 1987 | Waste management and research1987，5，1： | 1 |
| 19 | Osteoimmunology: interplay between the immune system and bone metabolism显示文摘 | Walsh MC Kim N Kadono Y | 2006 | Annu Rev Immunol2006，24，： | 1 |
| 20 | Transgenic mice overexpressioning tratrate-resistant acid phosphatase exhibit an increased rate of bone turnover显示文摘 | ANGEL NZ WALSH N FORWOOD MR | 2000 | Bone Miner Res2000，15，： | 1 |
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