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| 1 | Phased,chromosome-scale genome assemblies of tetraploid potato reveal a complex genome,transcriptome,and predicted proteome landscape underpinning genetic diversity显示文摘Cultivated potato is a clonally propagated autotetraploid species with a highly heterogeneous genome.Phased assemblies of six cultivars including two chromosome-scale phased genome assemblies revealed extensive allelic diversity,including altered coding and transcript sequences,preferential allele expression,and structural variation that collectively result in a highly complex transcriptome and predicted proteome,which are distributed across the homologous chromosomes.Wild species contribute to the extensive allelic diversity in tetraploid cultivars,demonstrating ancestral introgressions predating modern breeding efforts.As a clonally propagated autotetraploid that undergoes limited meiosis,dysfunctional and deleterious alleles are not purged in tetraploid potato.Nearly a quarter of the loci bore mutations are predicted to have a high negative impact on protein function,complicating breeder’s efforts to reduce genetic load.The StCDF1 locus controls maturity,and analysis of six tetraploid genomes revealed that 12 allelic variants of StCDF1 are correlated with maturity in a dosage-dependent manner.Knowledge of the complexity of the tetraploid potato genome with its rampant structural variation and embedded deleterious and dysfunctional alleles will be key not only to implementing precision breeding of tetraploid cultivars but also to the construction of homozygous,diploid potato germplasm containing favorable alleles to capitalize on heterosis in F1 hybrids. | Genevieve Hoopes Xiaoxi Meng John P.Hamilton Sai Reddy Achakkagari Fernanda de Alves Freitas Guesdes Marie E.Bolger Joseph J.Coombs Danny Esselink Natalie R.Kaiser Linda Kodde Maria Kyriakidou Brian Lavrijssen Natascha van Lieshout Rachel Shereda Heather K.Tuttle Brieanne Vaillancourt Joshua C.Wood Jan Mde Boer Nolan Bornowski Peter Bourke David Douches Herman Jvan Eck Dave Ellis Max J.Feldman Kyle M.Gardner Johannes C.P.Hopman Jiming Jiang Walter S.De Jong Joseph C.Kuhl Richard G.Novy Stan Oome Vidyasagar Sathuvalli Ek Han Tan Remco A.Ursum M.Isabel Vales Kelly Vining Richard G.F.Visser Jack Vossen G.Craig Yencho Noelle L.Anglin Christian W.B.Bachem Jeffrey B.Endelman Laura M.Shannon Martina V.Stromvik Helen H.Tai Bjorn Usadel C.Robin Buell Richard Finkers | 2022 | Molecular Plant2022，15，3： | 4 |
| 2 | Globus pharyngis and gastroesophageal equivalents显示文摘 | Walter EK SchmidtC | 1997 | Laryngorhinootologie1997，76，： | 1 |
| 3 | QIIME allows analysis of high-throughput community sequencing data 显示文摘 | Caporaso JG Kuczynski J Stombaugh J Bittinger K Bushman FD Costello EK Fierer N Pena AG Goodrich JK Gordon JI Huttley GA Kelley ST Knights D Koenig JE Ley RE Lozupone CA Mcdonald D Muegge BD Pirrung M Reeder J Sevinsky JR Tumbaugh PJ Walters WA Widmann J Yatsunenko T Zaneveld J Knight R | 2010 | Nat Methods2010，7，5： | 1 |
| 4 | Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 Revision显示文摘 | Jan L. Bro?ek Jean Bousquet Carlos E. Baena-Cagnani Sergio Bonini G. Walter Canonica Thomas B. Casale Roy Gerth van Wijk Ken Ohta Torsten Zuberbier Holger J. Schünemann | 2010 | The Journal of Allergy and Clinical Immunology2010，，3： | 1 |
| 5 | 1,25-dihydroxyvitamin D-stimulated calmodulin binding proteins:a sustained effect on distal tubules显示文摘 | Walters WR | 2002 | Am J Physiol Renal Physiol2002，282，1： | 1 |
| 6 | Rett syndrome:revised diagnostic criteriaand nomenclature显示文摘 | JeffreyL Walter EK Daniel G | 2010 | Ann Neurol2010，68，6： | 1 |
| 7 | Rett syndrome:revised diagnostic criteria and nomenclature显示文摘 | Jeffrey L Walter EK Daniel G | | 0，，06： | 1 |
| 8 | QIIME Allows Analysis of High-throughput Community Sequencing Data显示文摘 | Caporaso JG Kuczynski J Stombaugh J Bittinger K Bushman FD Costello EK Fierer N Pe(n)a AG Goodrich JK Gordon JI Huttley GA Kelley ST Knights D Koenig JE Ley RE Lozupone CA McDonald D Muegge BD Pirrung M Reeder J Sevinsky JR Turnbaugh P J Walters WA Widman | | 0，，05： | 1 |
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