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| 1 | Efficacy of Yangyin Yiqi Huoxue Granule (养阴益气活血颗粒) in Treatment of Ischemic Stroke Patients with Qi-Yin Deficiency and Blood Stasis Syndrome: A Randomized, Double-Blind, Multicenter, Phase-2 Clinical Trial显示文摘Objective To evaluate the efficacy and safety of Yangyin Yiqi Huoxue Granule(养阴益气活血颗粒,YYHG)in the treatment of ischemic stroke(IS)patients with qi-yin deficiency and blood stasis syndrome(QYDBSS),and to explore its effective dosage.Methods The total of 288 patients were randomly assigned to the YYHG high-dose,YYHG low-dose,positive control(administered Xiaoshuantong Granule,XSTG,消栓通颗粒),or placebo control(administered inert granule)groups(72 cases per group)by software-drived competitive block randomization.The trial was conducted for a 28-day period,with a 180-day follow-up period.The primary outcome was the comprehensive curative evaluation,and secondary outcomes were the National Institute of Health Stroke Scale(NIHSS)score,Barthel activities of daily living(ADL)index score,the quality of life index(QLI)score,and the Chinese medicine syndrome(CMS)score.All analyses were done on an intention-to-treat basis.The clinical safety was also assessed.Results The total of 288 participants were recruited between June 1,2008 and September 30,2009,and 287 patients received intervention;the treatment groups were well balanced at baseline.The comprehensive cure rates of YYHG high-dose,low-dose,positive and placebo control groups were 63.38%,31.94%,36.11%and 6.14%,respectively;there was a statistical difference between the two groups(P<0.01),while the high-dose YYHG treatment group was significantly higher than the other 3 groups(P<0.01).The improvement of NIHSS,ADL,QLI and CMS scores of the YYHG high-dose and low-dose groups was significantly better than that of the positive control group and the placebo control group(P<0.05).In terms of improving the classification of the NIHSS scale and the assessment of the ADL scale,the YYHG high-dose group was significantly better than the other three groups(P<0.05),and the YYHG low-dose group was better than the placebo control group(P<0.01).At the same time,except for the QLI score,the high-dose group was better than the low-dose group(P<0.05).In terms of safety,adverse reactions after YYHG treatment were generally mild(3.78%),and no serious adverse reactions have been reported.Conclusion YYHG is safe and effective in the treatment of IS patients with QYDBSS. | WANG Yu YANG Jie-hong WAN Hai-tong HE Yu XU Bin Al Chang-shan ZHOU Hui-fen YU Li WAN Hao-fang BIE Xiao-dong | 2021 | Chinese Journal of Integrative Medicine2021，27，11： | 4 |
| 2 | Flepeated-bateh production of kojie acid in a cell- retention fermenter using Aspergillus oryzae M3B9 显示文摘 | H M Wan C C Chen R Giridhar el al | 2005 | Ind Mierobiol Biotechnol2005，32，： | 1 |
| 3 | Surveiltanee and gene analysis of hemagglutinin of infltmaza virus during the outbreak of 1998-1999 in Beijing area 显示文摘 | Liu C G Zhu R N Wan L T el al | 2000 | Chin J Microbiol Immunol2000，20，4： | 1 |
| 4 | Mutation analysis of Crouzon syndrome in Taiwanese patients 显示文摘 | Chang CP Wan L Tsai CH et al | 2006 | J Clin Lab Anal2006，20，： | 1 |
| 5 | CHARACTERISTICS OF CHANGE IN TEMPERATURE DURING THE PAST 50 YEARS IN JILIN PROVINCE OF CHINA显示文摘Based on the monthly mean temperatu re,the changing processes and tendencies of temperature during1951-2000in Jilin Province,which i s in Northeast China,are analyzed.A nd the spatial characteristics of th e change are submitted.In the past 50years the te mperature of Jilin Province was increasing just like the other areas in th e world.Since 1990,the increasing of temperature has been more obvious th an that in the previous 40a.From the west to the east,the province has larger tem perature rising.According to Principal Component Analysis(PCA)of temperature field,Jilin Province is divided int o 3regions and the degree of becoming warmer is different from region to re gion.During the period of 1951to 2000,the annual temperature in Jilin Province has been rising,so has the temperature in winter and summer.The average temperature in t he 1990s was 0.5-2.0℃higher than that in the 1950s.From the west to the east,the increasing of temperature becam e smaller. | ZHAO Xin -yi,WAN Jun,WU Xiu -qin(Department of Urban and Environment al Sciences,Peking University,Beijing 100871,P.R.China) | 2002 | Chinese Geographical Science2002，12，4： | 1 |
| 6 | Early hypercytokinemia is associated with interferon-induced transmembrane protein-3 dysfunction and predictive of fatal H7N9 infection显示文摘 | Wang ZF Zhang AL Wan YM | 2014 | Proc Natl Acad Sci USA2014，111，： | 1 |
| 7 | Trends in total precipitation and frequency of daffy precipitation extremes over China 显示文摘 | Zhai P M Zhang X B Wan H ct al | 2005 | Journal of Climate2005，18，1： | 1 |
| 8 | Clinical measures of disease severity and outcome in psoriasis:a critical appraisal of their quality显示文摘 | Asheroft DM Wan Po AL Williams HC | 1999 | Br J Dermatol1999，141，2： | 1 |
| 9 | The removal of organophosphorus pesticides from water using a new amino-substituted calixarene-based magnetic sporopollenin显示文摘 | Kamboh M A Wan Aini Wan lbrahim Hamid Rashidi Nodeh et al | 2016 | New Journal of Chemistry2016，，： | 1 |
| 10 | Clinical measures of disease severity and outcome in psoriasis: a critical appraisal of their quality 显示文摘 | Ashcroft DM Wan Po AL Williams HC | 1999 | Br J Dermatol1999，141，2： | 1 |
| 11 | Combining induced mutation and protoplasting for strain improvement of Aspe- rgillus oryzae for kojic acid production 显示文摘 | Wan H M Chen C C Chang T S ct al | 2004 | Biotechnology lctt-crs2004，26，： | 1 |
| 12 | The results of vestibularevoked myogenic potentials, with consideration of age-relatedchanges, in vestibular neuritis, benign paroxysmal positionalvertigo, and Meniere’s disease 显示文摘 | MIN HS GEUN YS WAN KS ct al | 2008 | Acta Oto-laryngologica2008，128，： | 1 |
| 13 | Antioxidant and ct - glucosidase inhibitory phenolics isolated from highbush blueberry flowers 显示文摘 | Wan CP Yuan T Cirello AL | 2012 | Food Chem2012，135，7： | 1 |
| 14 | Tuning photoconductive properties of organic-inorganic hybrid perovskite nanocomposite device via organic layer's thickness 显示文摘 | LI C WAN J ZHENG Y et al | 2012 | Mater Lett2012，76，： | 1 |
| 15 | A new type of tea pigments-from the chemical oxidation of epicatechin gallate and isolated from tea 显示文摘 | Wan Xiaochun Harry E Nursten Cai Ya ct al | 1997 | J Sci Food Agric1997，，74： | 1 |
| 16 | Thermodynamics of diamond film deposition at low pressure from chlorinated precursors 显示文摘 | Liu Z J Zhang D W Wan Y Z el al | 1999 | Applied Physics A1999，68，： | 1 |
| 17 | Poly(ethylene terephthalate)reinforced by N, N'-diphenyl biphenyl-3,3 ', 4, 4'-tetracarbo-xydiimide moieties显示文摘 | Xiao Jun Wan Xinhua Zhang Dong et al | 2002 | Journal of Polymer Science Part A:Polymer Chemistry2002，40，： | 1 |
| 18 | Clinical measures of disease severity and outcome in psoriasis:a critical appraisal of their quality显示文摘 | Ashcroft DM Wan Po AL Williams HC | 1999 | Br J Dermatol1999，141，2： | 1 |
| 19 | Fluoridt* release fromdenial cements and composites : A mechaiiislic study 显示文摘 | Clian WD Yang L Wan H el al | 2006 | Dent Mater2006，22，4： | 1 |
| 20 | Mouse T cells receive costimulalory signals from LIGHT, a TNF family member 显示文摘 | Shi G Luo H Wan X ct al | 2002 | Blood2002，100，9： | 1 |
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